Protein-losing enteropathy: diagnosis with (99m)Tc-labeled human serum albumin scintigraphy.

Abstract:

PURPOSE:To investigate the diagnostic value of technetium 99m-labeled human serum albumin (HSA) scintigraphy in a group of patients suspected of having protein-losing enteropathy (PLE). MATERIALS AND METHODS:After intravenous injection of 740 MBq of freshly prepared (99m)Tc HSA, serial images of the abdomen were obtained from 10 minutes until 24 hours after injection. A (99m)Tc HSA scan was considered positive for PLE if there was visible tracer exudation in the gut. The diagnosis was established on the basis of standard clinical and biopsy findings. RESULTS:Thirty-nine scans were obtained: 27 scans in 26 suspected cases of PLE and 12 scans in control subjects with no known gastrointestinal disease. Twenty-five of the 26 studies in patients suspected of having PLE showed (99m)Tc HSA activity in the bowel. Among the 25 studies with positive findings, seven demonstrated PLE only on images obtained 24 hours after injection. In the control subjects, no activity was seen in the bowel. CONCLUSION:(99m)Tc HSA with serial scanning for up to 24 hours is reliable and useful for imaging PLE. Sites of protein loss may also be demonstrated. This imaging method is convenient, easy to perform, and yields results within 24 hours.

journal_name

Radiology

journal_title

Radiology

authors

Chiu NT,Lee BF,Hwang SJ,Chang JM,Liu GC,Yu HS

doi

10.1148/radiology.219.1.r01ap2986

subject

Has Abstract

pub_date

2001-04-01 00:00:00

pages

86-90

issue

1

eissn

0033-8419

issn

1527-1315

journal_volume

219

pub_type

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