Lymphomas and high-grade astrocytomas: comparison of water diffusibility and histologic characteristics.

Abstract:

PURPOSE:To determine if water diffusivity within lymphomas and high-grade astrocytomas correlates with cellularity. MATERIALS AND METHODS:Echo-planar diffusion-weighted magnetic resonance (MR) images obtained in 11 patients with brain lymphomas (19 lesions) and in 17 patients with astrocytomas (19 lesions) were retrospectively reviewed. Regions of interest were drawn on apparent diffusion coefficient (ADC) maps in enhancing tumor. ADC values were normalized by dividing ADC values of tumors by those of normal-appearing regions and expressing the quotient as a ratio. Histologic samples from 11 patients with astrocytomas (11 lesions) and seven patients with lymphoma (seven lesions) were reviewed. Cellularity was measured by calculating the percentage of nuclear area and the percentage of cytoplasmic area and expressing the results as the nuclear-to-cytoplasmic (N/C) ratio. The ADC and N/C ratios of both tumor types were compared by using a two-tailed t test. RESULTS:Mean ADC ratio of lymphomas was 1.15 (SD, 0.33; standard error of the mean [SEM], 0.10), and that of high-grade astrocytomas was 1.68 (SD, 0.48; SEM, 0.11) (P <.01). Mean N/C ratio of lymphoma was 1.45 (SD, 0.94; SEM, 0.36), and that of high-grade astrocytomas was 0.24 (SD, 0.18; SEM, 0.05) (P <.01). CONCLUSION:Measurements of water diffusivity and cellularity suggest that higher cellularity contributes to more restricted diffusion.

journal_name

Radiology

journal_title

Radiology

authors

Guo AC,Cummings TJ,Dash RC,Provenzale JM

doi

10.1148/radiol.2241010637

subject

Has Abstract

pub_date

2002-07-01 00:00:00

pages

177-83

issue

1

eissn

0033-8419

issn

1527-1315

journal_volume

224

pub_type

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