Brain tumors: detection with C-11 choline PET.

Abstract:

PURPOSE:To evaluate the effectiveness of positron emission tomography (PET) with carbon-11 choline in brain tumor imaging. MATERIALS AND METHODS:A rat glioma cell line (C6) was incubated with C-14 choline; the time course of uptake and metabolism was determined in vitro. C-11 choline was injected intravenously in tumor-bearing rats; the time course of distribution in organs was determined. C-11 choline also was injected intravenously in 20 patients (aged 6-86 years) with brain tumors and two volunteers (aged 38 and 58 years); distribution of the tracer in the brain was determined. Regional cerebral blood flow was measured by using oxygen-15 water on the same day. RESULTS:C-14 choline was metabolized to phosphoryl choline in glioma cells. The uptake of C-11 choline by glioblastoma cells was three to four times higher than that in the rat brain. All brain tumors took up more C-11 choline than did normal brain; thus, brain tumors that were not treated, as well as those that were treated with surgery or radiation therapy, were depicted. The tumor-normal brain uptake ratio of C-11 choline in brain tumor did not correlate with the O-15 water regional blood flow in the corresponding area. CONCLUSION:C-11 choline PET can depict brain tumors effectively. This method was clinically useful in patients who had undergone surgery.

journal_name

Radiology

journal_title

Radiology

authors

Shinoura N,Nishijima M,Hara T,Haisa T,Yamamoto H,Fujii K,Mitsui I,Kosaka N,Kondo T,Hara T

doi

10.1148/radiology.202.2.9015080

subject

Has Abstract

pub_date

1997-02-01 00:00:00

pages

497-503

issue

2

eissn

0033-8419

issn

1527-1315

journal_volume

202

pub_type

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