Abstract：
:Diffuse Lewy body disease (DLBD), in its pure form, is a neuropathologic condition in demented patients that is characterized by subcortical and diffusely distributed neocortical Lewy bodies with little or no concomitant Alzheimer's disease (AD) pathology. Clinically, DLBD patients initially present with dementia of insidious onset and subsequently develop mild extrapyramidal motor dysfunction. The present study retrospectively examined the neuropsychological test performance of five patients with DLBD and compared their performance to that of equally demented patients with neuropathologically confirmed "pure" AD. The results showed that the DLBD patients were globally demented with deficits in memory, attention, language, psychomotor performance, and "executive" functions, and a strikingly severe deficit in visuospatial and visuoconstructive abilities. The visuoconstructive and psychomotor impairments of the DLBD patients were significantly worse than those of the AD patients, whereas the memory performance of the AD patients was worse than that of the DLBD patients. These results indicate that DLBD without concomitant AD pathology can produce a global dementia with aspects of both cortical and subcortical dysfunction and suggests that Lewy body pathology contributes importantly to the clinical manifestation of the Lewy body variant of AD.
journal_name
Brain Cognjournal_title
Brain and cognitionauthors
Salmon DP,Galasko D,Hansen LA,Masliah E,Butters N,Thal LJ,Katzman Rdoi
10.1006/brcg.1996.0039subject
Has Abstractpub_date
1996-07-01 00:00:00pages
148-65issue
2eissn
0278-2626issn
1090-2147pii
S0278-2626(96)90039-1journal_volume
31pub_type
杂志文章abstract：:Recently several event-related potential attention studies have described a prefrontal positivity at about the same latency as the posterior N2 (approximately 200-300 ms), variously termed the frontal selection positivity (FSP), the anterior P2 (P2a), or the frontal P3 (P3f). These components have a similar spatio-tem...
journal_title：Brain and cognition
pub_type： 杂志文章
doi：10.1016/j.bandc.2004.03.006
更新日期：2004-10-01 00:00:00
abstract：:The Stroop color-naming task is one of the most widely studied tasks involving the inhibition of a prepotent response, regarded as an executive function. Several studies have examined performance on versions of the Stroop task under conditions of acute sleep deprivation. Though these studies revealed effects on Stroop...
journal_title：Brain and cognition
pub_type： 杂志文章
doi：10.1016/j.bandc.2011.03.005
更新日期：2011-06-01 00:00:00
abstract：:Alzheimer's disease (AD) subjects, healthy elderly, and young adults interpreted a series of novel noun-noun expressions composed of familiar object words. Subjects interpreted each item by selecting one of three possible definitions: a definition in which the referents of each noun were associated together in a parti...
journal_title：Brain and cognition
pub_type： 杂志文章
doi：10.1016/j.bandc.2004.08.049
更新日期：2005-12-01 00:00:00
abstract：:Observers indicated whether a stimulus presented to one visual field or the other consisted of two sine-wave gratings (the baseline stimulus) or those same two gratings with the addition of a 2 cycle per degree (cpd) component. When the absolute spatial frequencies of the baseline stimulus were low (0.5 and 1.0 cpd), ...
journal_title：Brain and cognition
pub_type： 杂志文章
doi：10.1016/0278-2626(91)90085-m
更新日期：1991-05-01 00:00:00
abstract：:In the present study in 20 healthy subjects, event-related potentials (ERPs) were used to investigate the identification of picture stimuli. Each of 36 landscape pictures and 36 scrambled pictures was presented by a tachistoscope repeatedly until the subject made an identification response. Presentation of one picture...
journal_title：Brain and cognition
pub_type： 杂志文章
doi：10.1006/brcg.1996.0074
更新日期：1996-12-01 00:00:00
abstract：:Researchers who study human cognition and behavior, especially from a neuroscience perspective, often measure subjects' handedness. The most common measure of handedness is the Edinburgh Handedness Inventory (EHI; Oldfield, 1971). Several potential problems with the EHI have been identified during its long history. We...
journal_title：Brain and cognition
pub_type： 杂志文章,评审
doi：10.1016/j.bandc.2015.01.003
更新日期：2015-03-01 00:00:00
abstract：:Research across domains has suggested that agents, the doers of actions, have a processing advantage over patients, the receivers of actions. We hypothesized that agents as "event builders" for discrete actions (e.g., throwing a ball, punching) build on cues embedded in their preparatory postures (e.g., reaching back ...
journal_title：Brain and cognition
pub_type： 杂志文章
doi：10.1016/j.bandc.2017.09.001
更新日期：2017-12-01 00:00:00
abstract：:Visual narratives like comics and films often shift between showing full scenes and close, zoomed-in viewpoints. These zooms are similar to the "spotlight of attention" cast across a visual scene in perception. We here measured ERPs to visual narratives (comic strips) that used zoomed-in and full-scene panels either t...
journal_title：Brain and cognition
pub_type： 杂志文章
doi：10.1016/j.bandc.2020.105634
更新日期：2020-12-01 00:00:00
abstract：:Eighty-three normal, right-handed children performed unimanual finger tapping recitation of a tongue twister, and both tasks concurrently. Trade-offs in dual-task performance were measured as the priority assigned to each task was manipulated. Irrespective of task priority, speaking interfered to a greater degree with...
journal_title：Brain and cognition
pub_type： 杂志文章
doi：10.1016/0278-2626(82)90010-0
更新日期：1982-01-01 00:00:00
abstract：OBJECTIVE:Several studies have identified that adjuvant chemotherapy for breast cancer is associated with cognitive impairment; however, the magnitude of this impairment is unclear. This study assessed the severity and nature of cognitive impairment associated with adjuvant chemotherapy by conducting a meta-analysis of...
journal_title：Brain and cognition
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.bandc.2005.05.001
更新日期：2005-10-01 00:00:00
abstract：:There have long been speculations about the relationship between consciousness and language. This study aimed to determine whether an individual's level of introspective awareness, based on self-report, relates to accessibility of their semantic system as evaluated by the N400. Thirty-five university students complete...
journal_title：Brain and cognition
pub_type： 杂志文章
doi：10.1016/j.bandc.2018.02.005
更新日期：2018-06-01 00:00:00
abstract：:To help resolve the issue of whether developmental dyslexia (DD) is related to central auditory processing deficits or to language-specific processing deficits, we had nine dyslectic and nine nondyslectic right-handed undergraduate students perform linguistic (Experiment 1: phoneme identification) and nonlinguistic (E...
journal_title：Brain and cognition
pub_type： 杂志文章
doi：
更新日期：2002-03-01 00:00:00
abstract：:This is the second part of a review of the work of quantum physicists on the 'hard part' of the problem of mind. After an introduction which sets the scene and a brief review of contemporary work on the neural correlates of consciousness (NCC) the work of four prominent modern investigators is examined: J.C. Eccles/Fr...
journal_title：Brain and cognition
pub_type： 杂志文章,评审
doi：10.1016/j.bandc.2007.09.004
更新日期：2009-11-01 00:00:00
abstract：:Ambiguous pictures (Roschach inkblots) were lateralized for 100 msec vs. 200 msec to the right and left hemispheres (RH and LH) of 32 normal right-handed males who determined which of two previously presented words (an accurate or inaccurate one) better described the inkblot. Over the first 32 trials, subjects receivi...
journal_title：Brain and cognition
pub_type： 杂志文章
doi：10.1016/0278-2626(90)90014-f
更新日期：1990-03-01 00:00:00
abstract：:The present study aimed to examine the construct validity of three aspects of attention, namely focused, divided, and supervisory control of attention. Factor-analytic techniques were applied to scores of healthy subjects on a series of neuropsychological tests tapping these aspects of attention. The two components fo...
journal_title：Brain and cognition
pub_type： 杂志文章
doi：10.1006/brcg.2001.1320
更新日期：2001-12-01 00:00:00
abstract：:This study investigated age and responding-hand (left, right, and bimanual) related changes in visuospatial attention. Two tasks were completed by 107 neurologically normal right-handed subjects ranging in age from 5 to 70 years and distributed across four age groups. Task-specific differences between groups were appa...
journal_title：Brain and cognition
pub_type： 杂志文章
doi：10.1016/s0278-2626(03)00181-7
更新日期：2003-08-01 00:00:00
abstract：:This study used the Remember/Know (R/K) procedure combined with signal detection analyses to assess recognition memory in 20 elders with amnestic mild cognitive impairment (aMCI), 10 patients with probable Alzheimer's disease (AD) as well as matched healthy older adults. Signal detection analyses first indicated that ...
journal_title：Brain and cognition
pub_type： 杂志文章
doi：10.1016/j.bandc.2009.01.009
更新日期：2009-06-01 00:00:00
abstract：:Recent experimental research in the field of neurophysiology has led to the discovery of two classes of visuomotor neurons: canonical neurons and mirror neurons. In light of these studies, we propose here an overview of two classical themes in the cognitive science panorama: James Gibson's theory of affordances and El...
journal_title：Brain and cognition
pub_type： 杂志文章
doi：10.1016/j.bandc.2004.06.003
更新日期：2004-10-01 00:00:00
abstract：:The purpose of this study was to determine whether the severity of visual hemineglect follows a unimodal or bimodal frequency distribution. Seventy-seven consecutive patients with a unilateral cerebral infarct (36 left- and 41 right-hemisphere lesions) were evaluated. The severity of neglect was measured as the number...
journal_title：Brain and cognition
pub_type： 杂志文章
doi：10.1006/brcg.1993.1010
更新日期：1993-03-01 00:00:00
abstract：:Visual input was lateralized using a specially designed contact lens system. Subjects performed a sequence of two keypresses in response to a light stimulus with either the left or the right hand in a choice reaction time paradigm. Two choice reaction time conditions were used: (A) hand certainty, sequence uncertainty...
journal_title：Brain and cognition
pub_type： 杂志文章
doi：10.1016/0278-2626(89)90047-x
更新日期：1989-01-01 00:00:00
abstract：:Verbal cerebral asymmetry was examined in 96 right- and left-handed college students using dual-task methods. The manual task was finger-tapping; verbal tasks were anagram-solution in silent and aloud conditions; nonverbal tasks were solution of Raven's Progressive Matrices and forms memory. Both handedness groups wer...
journal_title：Brain and cognition
pub_type： 杂志文章
doi：10.1006/brcg.1994.1007
更新日期：1994-01-01 00:00:00
abstract：:Cognitive functioning was assessed in 69 left-handed males and females with a positive family history of left-handedness and in 77 left-handed and 55 right-handed males and females without familial left-handedness. Compared to females, males performed better on numerical reasoning and on two visuospatial tasks involvi...
journal_title：Brain and cognition
pub_type： 杂志文章
doi：10.1006/brcg.1995.1014
更新日期：1995-03-01 00:00:00
abstract：:Sentence comprehension requires the assignment of thematic relations between the verb and its noun arguments in order to determine who is doing what to whom. In some languages, such as English, word order is the primary syntactic cue. In other languages, such as German, case-marking is additionally used to assign them...
journal_title：Brain and cognition
pub_type： 杂志文章
doi：10.1016/j.bandc.2018.09.003
更新日期：2019-08-01 00:00:00
abstract：UNLABELLED:The present study investigates cortical structures associated with personality dimension of positivity (POS) by using a standardized low-resolution brain electromagnetic tomography (sLORETA), which provides EEG localization measures that are independent of the recording reference. Resting EEG and self-report...
journal_title：Brain and cognition
pub_type： 杂志文章
doi：10.1016/j.bandc.2015.04.003
更新日期：2015-07-01 00:00:00
abstract：:Responses to threat occur via two known independent processing routes. We propose that early, reflexive processing is predominantly tuned to the detection of congruent combinations of facial cues that signal threat, whereas later, reflective processing is predominantly tuned to incongruent combinations of threat. To t...
journal_title：Brain and cognition
pub_type： 杂志文章
doi：10.1016/j.bandc.2011.05.001
更新日期：2011-10-01 00:00:00
abstract：:Whereas right parietal damage can result in left hemineglect, the general population shows a subtle neglect of the right hemispace-known as pseudoneglect. A recent study has demonstrated that people collide to the right more often and attributed this bias to pseudoneglect. [Nicholls, M. E. R., Loftus, A., Meyer, K., &...
journal_title：Brain and cognition
pub_type： 临床试验,杂志文章
doi：10.1016/j.bandc.2008.04.003
更新日期：2008-11-01 00:00:00
abstract：:The orbitofrontal cortex contains the secondary taste cortex, in which the reward value of taste is represented. It also contains the secondary and tertiary olfactory cortical areas, in which information about the identity and also about the reward value of odours is represented. The orbitofrontal cortex also receives...
journal_title：Brain and cognition
pub_type： 杂志文章,评审
doi：10.1016/S0278-2626(03)00277-X
更新日期：2004-06-01 00:00:00
abstract：:The presence of acuity gradients as a moderating variable in hemifield research is not in question. Their importance as a determinant of hemifield differences is unclear, however. The major issues are as follows. First, do vertical displays provide an appropriate control for the acuity gradient? Second, do the initial...
journal_title：Brain and cognition
pub_type： 杂志文章
doi：10.1016/0278-2626(86)90039-4
更新日期：1986-07-01 00:00:00
abstract：:Previous literature suggests that Parkinson's disease is marked by deficits in timed behaviour. However, the majority of studies of central timing mechanisms in patients with Parkinson's disease have used timing tasks with a motor component. Since the motor abnormalities are a defining feature of the condition, the st...
journal_title：Brain and cognition
pub_type： 杂志文章
doi：10.1016/j.bandc.2008.01.010
更新日期：2008-08-01 00:00:00
abstract：:When subjects are required to detect a target pattern presented simultaneously with a number of similar non-target patterns in a brief exposure, marked differences of target detectability are observed as a function of the spatial location of the target (Efron, Yund, & Nichols, 1987, 1990a, b, c; Yund, Efron & Nichols,...
journal_title：Brain and cognition
pub_type： 杂志文章
doi：10.1016/0278-2626(91)90065-g
更新日期：1991-09-01 00:00:00
