ROM7/BEM4 encodes a novel protein that interacts with the Rho1p small GTP-binding protein in Saccharomyces cerevisiae.

abstract：:We report that the genes for the homologous Saccharomyces cerevisiae RAD10 and human ERCC-1 DNA excision repair proteins harbor overlapping antisense transcription units in their 3' regions. Since naturally occurring antisense transcription is rare in S. cerevisiae and humans (this is the first example in human cells)...

journal_title：Molecular and cellular biology

authors： van Duin M,van Den Tol J,Hoeijmakers JH,Bootsma D,Rupp IP,Reynolds P,Prakash L,Prakash S

更新日期：1989-04-01 00:00:00

abstract：:Thyroid hormone receptors are encoded by the TRalpha (NR1A1) and TRbeta (NR1A2) loci. These genes are transcribed into multiple variants whose functions are unclear. Analysis by gene inactivation in mice has provided new insights into the functional complexity of these products. Different strategies designed to modify...

journal_title：Molecular and cellular biology

authors： Gauthier K,Plateroti M,Harvey CB,Williams GR,Weiss RE,Refetoff S,Willott JF,Sundin V,Roux JP,Malaval L,Hara M,Samarut J,Chassande O

更新日期：2001-07-01 00:00:00

abstract：:The six human telomeric proteins TRF1, TRF2, RAP1, TIN2, POT1, and TPP1 can form a complex called the telosome/shelterin, which is required for telomere protection and length control. TPP1 has been shown to regulate both POT1 telomere localization and telosome assembly through its binding to TIN2. It remains to be det...

journal_title：Molecular and cellular biology

authors： Chen LY,Liu D,Songyang Z

更新日期：2007-08-01 00:00:00

abstract：:Telomeres are essential for protecting the ends of chromosomes and preventing chromosome fusion. Telomere loss has been proposed to play an important role in the chromosomal rearrangements associated with tumorigenesis. To determine the relationship between telomere loss and chromosome instability in mammalian cells, ...

journal_title：Molecular and cellular biology

authors： Lo AW,Sprung CN,Fouladi B,Pedram M,Sabatier L,Ricoul M,Reynolds GE,Murnane JP

更新日期：2002-07-01 00:00:00

abstract：:The synthesis of 60S ribosomal subunits in Saccharomyces cerevisiae requires Tif6p, the yeast homologue of mammalian eukaryotic translation initiation factor 6 (eIF6). In the present work, we have isolated a protein kinase from rabbit reticulocyte lysates on the basis of its ability to phosphorylate recombinant human ...

journal_title：Molecular and cellular biology

authors： Basu U,Si K,Deng H,Maitra U

更新日期：2003-09-01 00:00:00

abstract：:Gamma interferon (IFN-γ) is an inflammatory cytokine that has complex effects on myogenesis. Here, we show that the IFN-γ-induced inhibition of myogenesis is mediated by the major histocompatibility complex (MHC) class II transactivator, CIITA, which binds to myogenin and inhibits its activity. In IFN-γ-treated myobla...

journal_title：Molecular and cellular biology

authors： Londhe P,Davie JK

更新日期：2011-07-01 00:00:00

abstract：:Eight strains of Chinese hamster ovary (CHO) cells having an assembly-defective beta-tubulin were found among revertants of strain Cmd 4, a mutant with a conditional lethal mutation in a beta-tubulin gene (F. Cabral, M. E. Sobel, and M. M. Gottesman, Cell 20:29-36, 1980). The altered beta-tubulins in these strains hav...

journal_title：Molecular and cellular biology

authors： Boggs B,Cabral F

更新日期：1987-08-01 00:00:00

abstract：:Integrin signaling plays critical roles in cell adhesion, spreading, and migration, and it is generally accepted that to regulate these integrin functions accurately, localized actin remodeling is required. However, the molecular mechanisms that control the targeting of actin regulation molecules to the proper sites a...

journal_title：Molecular and cellular biology

authors： Chae YC,Kim KL,Ha SH,Kim J,Suh PG,Ryu SH

更新日期：2010-11-01 00:00:00

abstract：:TDP-43, or TAR DNA-binding protein 43, is a pathological marker of a spectrum of neurodegenerative disorders, including amyotrophic lateral sclerosis and frontotemporal lobar degeneration with ubiquitin-positive inclusions. TDP-43 is an RNA/DNA-binding protein implicated in transcriptional and posttranscriptional regu...

journal_title：Molecular and cellular biology

authors： Dewey CM,Cenik B,Sephton CF,Dries DR,Mayer P 3rd,Good SK,Johnson BA,Herz J,Yu G

更新日期：2011-03-01 00:00:00

abstract：:Transcription factor CREB regulates cyclic AMP (cAMP)-dependent gene expression by binding to and activating transcription from cAMP response elements (CREs) in the promoters of target genes. The transcriptional transactivation functions of CREB are activated by its phosphorylation by cAMP-dependent protein kinase A (...

journal_title：Molecular and cellular biology

authors： Vallejo M,Gosse ME,Beckman W,Habener JF

更新日期：1995-01-01 00:00:00

abstract：:Addition of serum to mitogen-starved cells activates the cellular immediate-early gene (IEG) response. Serum response factor (SRF) contributes to such mitogen-stimulated transcriptional induction of many IEGs during the G0-G1 cell cycle transition. SRF is also believed to be essential for cell cycle progression, as im...

journal_title：Molecular and cellular biology

authors： Schratt G,Weinhold B,Lundberg AS,Schuck S,Berger J,Schwarz H,Weinberg RA,Rüther U,Nordheim A

更新日期：2001-04-01 00:00:00

abstract：:TFIID, comprising the TATA box binding protein (TBP) and 13 TBP-associated factors (TAFs), plays a role in nucleation in the assembly of the RNA polymerase II preinitiation complexes on protein-encoding genes. TAFs are shared among other transcription regulatory complexes (e.g., SAGA, TBP-free TAF-containing complex [...

journal_title：Molecular and cellular biology

authors： Soutoglou E,Demény MA,Scheer E,Fienga G,Sassone-Corsi P,Tora L

更新日期：2005-05-01 00:00:00

abstract：:In Blastocladiella emersonii zoospores, a set of proteins was found associated with the ribosomes and free ribonucleoprotein particles distinct from the ribosomes and polyribosomes. These proteins were designated P120, P105, P64, P56, and P42 based on their molecular weights determined by gel electrophoresis. Synthesi...

journal_title：Molecular and cellular biology

authors： Jaworski AJ,Stumhofer P

更新日期：1981-04-01 00:00:00

abstract：:CD26 is a T-cell costimulatory molecule with dipeptidyl peptidase IV enzyme activity in its extracellular region. We have previously reported that the addition of recombinant soluble CD26 resulted in enhanced proliferation of human T lymphocytes induced by the recall antigen tetanus toxoid (TT) via upregulation of CD8...

journal_title：Molecular and cellular biology

authors： Ohnuma K,Yamochi T,Uchiyama M,Nishibashi K,Iwata S,Hosono O,Kawasaki H,Tanaka H,Dang NH,Morimoto C

更新日期：2005-09-01 00:00:00

abstract：:TFIID is a multiprotein complex consisting of the TATA box binding protein and multiple tightly associated proteins (TAFIIs) that are required for transcription by selected activators. We previously reported cloning and partial characterization of human TAFII130 (hTAFII130). The central domain of hTAFII130 contains fo...

journal_title：Molecular and cellular biology

authors： Saluja D,Vassallo MF,Tanese N

更新日期：1998-10-01 00:00:00

abstract：:Wnt signaling is thought to be mediated via interactions between beta-catenin and members of the LEF-1/TCF family of transcription factors. Here we study the mechanism of transcriptional regulation by LEF-1 in response to a Wnt-1 signal under conditions of endogenous beta-catenin in NIH 3T3 cells, and we examine wheth...

journal_title：Molecular and cellular biology

authors： Hsu SC,Galceran J,Grosschedl R

更新日期：1998-08-01 00:00:00

abstract：:Aromatic aminotransferase II, product of the ARO9 gene, catalyzes the first step of tryptophan, phenylalanine, and tyrosine catabolism in Saccharomyces cerevisiae. ARO9 expression is under the dual control of specific induction and nitrogen source regulation. We have here identified UASaro, a 36-bp upstream element ne...

journal_title：Molecular and cellular biology

authors： Iraqui I,Vissers S,André B,Urrestarazu A

更新日期：1999-05-01 00:00:00

abstract：:The gene responsible for multidrug resistance (mdr), which encodes the P-glycoprotein, is a member of a multigene family. We have identified distinct mdr gene transcripts encoded by three separate mdr genes in the mouse. Expression levels of each mdr gene are dramatically different in various mouse tissues. Specific m...

journal_title：Molecular and cellular biology

authors： Croop JM,Raymond M,Haber D,Devault A,Arceci RJ,Gros P,Housman DE

更新日期：1989-03-01 00:00:00

abstract：:In the budding yeast Saccharomyces cerevisiae, mutations in the essential gene CDC1 cause defects in Golgi inheritance and actin polarization. However, the biochemical function of Cdc1p is unknown. Previous work showed that cdc1 mutants accumulate intracellular Ca(2+) and display enhanced sensitivity to the extracellu...

journal_title：Molecular and cellular biology

authors： Losev E,Papanikou E,Rossanese OW,Glick BS

更新日期：2008-05-01 00:00:00

abstract：:Transcriptional activation by nuclear hormone receptors is mediated by the 160-kDa family of nuclear receptor coactivators. These coactivators associate with DNA-bound nuclear receptors and transmit activating signals to the transcription machinery through two activation domains. In screening for mammalian proteins th...

journal_title：Molecular and cellular biology

authors： Huang SM,Stallcup MR

更新日期：2000-03-01 00:00:00

abstract：:An empirical equation has been developed that can be used to calculate genetic map distances from tetrad data with good accuracy for distances of up to at least 120 centimorgans. ...

journal_title：Molecular and cellular biology

authors： Ma C,Mortimer RK

更新日期：1983-10-01 00:00:00

abstract：:The interaction of yeast TFIIIB with the region upstream of the SUP4 tRNATyr gene was extensively probed by use of photoreactive phosphodiesters, deoxyuridines, and deoxycytidines that are site specifically incorporated into DNA. The TATA binding protein (TBP) was found to be in close proximity to the minor groove of ...

journal_title：Molecular and cellular biology

authors： Persinger J,Sengupta SM,Bartholomew B

更新日期：1999-07-01 00:00:00

abstract：:The chicken immunoglobulin light-chain gene (IgL) encodes only a single variable gene segment capable of recombination. To generate an immune repertoire, chickens diversify this unique rearranged VL gene segment during B-cell development in the bursa of Fabricius. Sequence analysis of IgL cDNAs suggests that both gene...

journal_title：Molecular and cellular biology

authors： Kim S,Humphries EH,Tjoelker L,Carlson L,Thompson CB

更新日期：1990-06-01 00:00:00

abstract：:The homeo box gene even-skipped (eve) encodes a 376-amino-acid protein that binds with high affinity to sequences located near the 5' termini of the eve and en genes. The 5' en sites are A + T rich and contain copies of the 10-base-pair (bp) consensus sequence T-C-A-A-T-T-A-A-A-T. In contrast, the 5' eve sites are G +...

journal_title：Molecular and cellular biology

authors： Hoey T,Warrior R,Manak J,Levine M

更新日期：1988-11-01 00:00:00

abstract：:The levels of the A, B, and C subunits of protein phosphatase 2A in extracts from synchronized embryonic bovine tracheal cells were determined by immunoblotting with subunit-specific antibodies. A constant amount of each subunit was found in resting cells as well as in growing cells from all stages of the cell cycle. ...

journal_title：Molecular and cellular biology

authors： Ruediger R,Van Wart Hood JE,Mumby M,Walter G

更新日期：1991-08-01 00:00:00

abstract：:Three classes of E3 ubiquitin ligases, members of the Cbl, Hakai, and SOCS-Cul5-RING ligase families, stimulate the ubiquitination of phosphotyrosine-containing proteins, including receptor and nonreceptor tyrosine kinases and their phosphorylated substrates. Because ubiquitination frequently routes proteins for degra...

journal_title：Molecular and cellular biology

authors： Cooper JA,Kaneko T,Li SS

更新日期：2015-06-01 00:00:00

abstract：:Translation initiation in eukaryotic cells is known to be a complex multistep process which involves numerous protein factors. Here we demonstrate that leaderless mRNAs with initiator Met-tRNA can bind directly to 80S mammalian ribosomes in the absence of initiation factors and that the complexes thus formed are fully...

journal_title：Molecular and cellular biology

authors： Andreev DE,Terenin IM,Dunaevsky YE,Dmitriev SE,Shatsky IN

更新日期：2006-04-01 00:00:00

abstract：:The ARK (AXL, UFO) receptor is a member of a new family of receptor tyrosine kinases whose extracellular domain contains a combination of fibronectin type III and immunoglobulin motifs similar to those found in many cell adhesion molecules. ARK mRNA is expressed at high levels in the mouse brain, prevalently in the hi...

journal_title：Molecular and cellular biology

authors： Bellosta P,Costa M,Lin DA,Basilico C

更新日期：1995-02-01 00:00:00

abstract：:We report the cloning and functional analysis of a complete clone for the third member of the mouse mdr gene family, mdr3. Nucleotide and predicted amino acid sequence analyses showed that the three mouse mdr genes encode highly homologous membrane glycoproteins, which share the same length (1,276 residues), the same ...

journal_title：Molecular and cellular biology

authors： Devault A,Gros P

更新日期：1990-04-01 00:00:00

abstract：:The cytosolic heat shock cognate 70-kDa protein (hsc70) is required for efficient import of ornithine transcarbamylase precursor (pOTC) into rat liver mitochondria (K. Terada, K. Ohtsuka, N. Imamoto, Y. Yoneda, and M. Mori, Mol. Cell. Biol. 15:3708-3713, 1995). The requirement of hsc70 for mitochondrial import of vari...

journal_title：Molecular and cellular biology

authors： Terada K,Ueda I,Ohtsuka K,Oda T,Ichiyama A,Mori M

更新日期：1996-11-01 00:00:00