Abstract:
OBJECTIVE:To carry out a comprehensive field investigation to evaluate various conventional and recently developed biomarkers for exposure to low concentrations of benzene. METHODS:Analyses were carried out on environmental air, unmetabolised benzene in blood and urine, urinary trans, transmuconic acid, and three major phenolic metabolites of benzene: phenol, catechol, and hydroquinone. Validations of these biomarkers were performed on 131 never smokers occupationally exposed to the time weighed average benzene concentration of 0.25 ppm (range, 0.01 to 3.5 ppm). RESULTS:Among the six biomarkers studied, unmetabolised benzene in urine correlated best with environmental benzene concentration (correlation coefficient, r = 0.76), followed by benzene in blood (r = 0.64). When urinary metabolites were compared with environmental benzene, trans, trans-muconic acid showed a close correlation (r = 0.53) followed by hydroquinone (r = 0.44), and to a lesser extent with urinary phenol (r = 0.38). No correlation was found between catechol and environmental benzene concentrations. Although unmetabolised benzene in urine correlates best with benzene exposure, owing to serious technical drawbacks, its use is limited. Among the metabolites, trans, trans-muconic acid seems to be more reliable than other phenolic compounds. Nevertheless, detailed analyses failed to show that it is specific for monitoring benzene exposures below 0.25 ppm. CONCLUSION:The overall results suggest that most of the currently available biomarkers are unable to provide sufficient specificity for monitoring of low concentrations of benzene exposure. If a lower occupational exposure limit for benzene is to be considered, the reliability of the biomarker and the technical limitations of measurements have to be carefully validated.
journal_name
Occup Environ Medjournal_title
Occupational and environmental medicineauthors
Ong CN,Kok PW,Ong HY,Shi CY,Lee BL,Phoon WH,Tan KTdoi
10.1136/oem.53.5.328subject
Has Abstractpub_date
1996-05-01 00:00:00pages
328-33issue
5eissn
1351-0711issn
1470-7926journal_volume
53pub_type
杂志文章abstract:INTRODUCTION:Analyses of secular trends in work-related fatal injury in New Zealand have previously only considered the total working population, potentially hiding trends for important subgroups of workers. This paper examines trends in work-related fatalities in worker subgroups between 2005 and 2014 to indicate wher...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2020-106812
更新日期:2020-10-26 00:00:00
abstract:BACKGROUND:Fetal growth restriction has been inconsistently associated with maternal exposure to elevated levels of traffic-related air pollution. OBJECTIVE:We investigated the relationship between an individualised measure of fetal growth and maternal exposure to a specific marker for traffic-related air pollution. ...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2011-100509
更新日期:2012-11-01 00:00:00
abstract:OBJECTIVES:The aim of the present case-referent study was to investigate the incidence of myocardial infarction among male professional drivers, taking the type of vehicles and area of residence into account. METHODS:The study base comprised all men aged 30-74 in five counties in middle Sweden during 1976-81 or 1976-8...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.53.4.235
更新日期:1996-04-01 00:00:00
abstract::Fluorocarbons are widely used in industry, and manifestations of inhalation toxicity include polymer fume fever, reactive airways dysfunction, and bronchospasm. Only seven cases of alveolitis occurring acutely after inhalation have been reported. This paper presents four cases of toxic pneumonitis due to direct inhala...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.2004.015784
更新日期:2005-06-01 00:00:00
abstract:PURPOSE:While large cotton industry plants producing for the foreign market have undergone improvements of occupational hygiene lately, working conditions in power looms producing mainly for the local market are still poor. The respiratory health in workers of power looms has not been studied so far. METHODS:In a cros...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2015-102902
更新日期:2015-10-01 00:00:00
abstract:OBJECTIVES:To identify determinants of sickness absence in hospital physicians. METHODS:The Poisson regression analyses of short (1--3 days) and long (>3 days) recorded spells of sickness absence relating to potential determinants of sickness absence were based on a 2 year follow up period and cohorts of 447 (251 male...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章,多中心研究
doi:10.1136/oem.58.6.361
更新日期:2001-06-01 00:00:00
abstract:OBJECTIVES:Chronic exposure to high levels of noise may be associated with increased risk of cardiovascular disease. We therefore undertook a quantitative retrospective exposure assessment using predictive statistical modelling to estimate historical exposures to noise among a cohort of 27,499 sawmill workers as part o...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章,多中心研究
doi:10.1136/oem.2008.040881
更新日期:2009-06-01 00:00:00
abstract:AIMS:To determine the risk of all cause mortality, cause specific mortality, and incident cancer in meatworkers. METHODS:In a retrospective cohort study, a list of members of a meatworkers union in Australia was matched with the national death and cancer registries. Standardised mortality ratios (SMR) and standardised...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.60.9.e4
更新日期:2003-09-01 00:00:00
abstract::: Physically demanding occupations (ie, military, firefighter, law enforcement) often use fitness tests for job selection or retention. Despite numerous individual studies, the relationship of these tests to job performance is not always clear. : This review examined the relationship by aggregating previously reported...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1136/oemed-2016-103684
更新日期:2017-02-01 00:00:00
abstract:OBJECTIVES:To obtain knowledge about the use and distribution of hazardous chemicals in Danish industry. This knowledge is used to regulate the occupational environment and prevent hazardous exposure. METHODS:A national survey on the use of chemicals was carried out in 1989 in a stratified sample of 1448 Danish busine...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.52.7.454
更新日期:1995-07-01 00:00:00
abstract:OBJECTIVES:To describe the relation with age of risk of reported injury after a fall among women at work in two countries, the United Kingdom and Sweden, with particular emphasis on fractures, and to interpret these data. METHODS:Rates of accidents compiled under the national reporting regulations of each country duri...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.54.11.785
更新日期:1997-11-01 00:00:00
abstract:OBJECTIVES:To review and summarise the epidemiological evidence on the carcinogenicity of occupational exposure to inorganic lead. METHODS:Case-control and cohort studies were reviewed and combined for meta-analysis. Fixed and random effect methods were used to estimate the summary effects. RESULTS:The combined resul...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章,meta分析
doi:10.1136/oem.52.2.73
更新日期:1995-02-01 00:00:00
abstract:BACKGROUND:A growing interest in reducing occupational sitting has resulted in public health efforts to encourage intermittent standing in workplaces. However, concerns have been raised that standing for prolonged periods may expose individuals to new health hazards, including lower limb atherosclerosis. These concerns...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2020-106905
更新日期:2020-11-03 00:00:00
abstract:OBJECTIVES:To appraise epidemiological evidence of the purported association between residential exposure to power frequency magnetic fields and adult cancers. METHODS:Literature review and epidemiological evaluation. RESULTS:Seven epidemiological studies have been conducted on the risk of cancer among adults in rela...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章,评审
doi:10.1136/oem.53.8.505
更新日期:1996-08-01 00:00:00
abstract:BACKGROUND:Numerous studies have reported that day-to-day changes in particulate air pollution are associated with day-to-day changes in deaths. Recently, several reports have indicated that the software used to control for season and weather in some of these studies had deficiencies. AIMS:To investigate the use of th...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章,多中心研究
doi:10.1136/oem.2003.008250
更新日期:2004-12-01 00:00:00
abstract:OBJECTIVE:Interpretation of epidemiological studies on health effects from mobile phone use is hindered by uncertainties in the exposure assessment. We used a newly developed smartphone application (app) to validate self-reported mobile phone use and behaviour among adults. METHODS:107 participants (mean age 41.4 year...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2015-102808
更新日期:2015-11-01 00:00:00
abstract:OBJECTIVES:Because of the rarity of small bowel adenocarcinoma (SBA), little is known about the aetiology of this disease. This study aimed to identify occupational clustering of cases SBA as a systematic approach to new hypotheses on the aetiology of this disease. METHODS:A European multicentre case-control study was...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章,多中心研究
doi:10.1136/oem.57.11.760
更新日期:2000-11-01 00:00:00
abstract::Aerosol sampling has evolved with changes in technology and our understanding of the importance of assessing the biologically relevant fractions of the total aerosol. During the past decade there has been international agreement on the definitions for the inhalable, thoracic, and respirable fractions and instruments h...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章,评审
doi:10.1136/oem.56.11.747
更新日期:1999-11-01 00:00:00
abstract:OBJECTIVES:We used data from a large, population-based case-control study in Maine, New Hampshire, and Vermont to examine relationships between occupation, industry and bladder cancer risk. METHODS:Lifetime occupational histories were obtained by personal interview from 1158 patients newly diagnosed with urothelial ca...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章,多中心研究
doi:10.1136/oem.2009.052571
更新日期:2011-04-01 00:00:00
abstract:OBJECTIVE:A prospective cohort study was designed to clarify the relations between occupational exposure to carbon disulphide (CS2) and its effects on arteriosclerosis in workers in 11 Japanese rayon manufacturing factories. This report is a cross sectional baseline observation in the first study year. METHODS:Study s...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.55.7.468
更新日期:1998-07-01 00:00:00
abstract:BACKGROUND:It has been speculated on theoretical grounds that biomarkers are superior surrogates for chemical exposures to air samples in epidemiology studies. METHODS AND RESULTS:Biomarkers were classified according to their position in the exposure-disease continuum-that is, parent compound, reactive intermediate, s...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.2004.013102
更新日期:2005-11-01 00:00:00
abstract:OBJECTIVES:Epidemiological studies have shown inconsistent effects on immunological parameters in subjects exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). In this study we investigated changes in humoral immunity and prevalence of atopic diseases among workers from a Dutch historical cohort occupationally expose...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.2010.058016
更新日期:2011-06-01 00:00:00
abstract:OBJECTIVES:Night shift work has been suggested as a possible risk factor for multiple sclerosis (MS). The objective of the present analysis was to prospectively evaluate the association of rotating night shift work history and MS risk in two female cohorts, the Nurses' Health Study (NHS) and NHSII. METHODS:A total of ...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2019-106016
更新日期:2019-10-01 00:00:00
abstract:OBJECTIVE:To explore the relationship between occupations and specific occupational exposures and oesophageal cancer (OC) by histological type. METHODS:A multicentre hospital-based case-control study was conducted in two Mediterranean provinces of Spain. Occupational, sociodemographic and lifestyle information was col...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章,多中心研究
doi:10.1136/oem.2007.037929
更新日期:2008-11-01 00:00:00
abstract:BACKGROUND:Systematic assessments of the effectiveness of interventions to prevent work related eye injuries are needed. AIM:To investigate the long term effectiveness of a multicomponent prevention campaign. METHODS:The campaign (conducted in collaboration with the local Employers' Association and Trade Unions) targ...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.2004.019570
更新日期:2005-12-01 00:00:00
abstract:OBJECTIVES:To determine the prevalence and risk factors for symptoms related to gloves, and the relation between symptoms and immunological evidence of type 1 hypersensitivity to latex in a United Kingdom health care setting. METHODS:A cross sectional survey was carried out among 773 employees at a British hospital. A...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.56.12.833
更新日期:1999-12-01 00:00:00
abstract:OBJECTIVES:To investigate changes in digital circulation during and after exposure to hand transmitted vibration. By studying two frequencies and two magnitudes of vibration, to investigate the extent to which haemodynamic changes depend on the vibration frequency, the vibration acceleration, and the vibration velocity...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.54.8.566
更新日期:1997-08-01 00:00:00
abstract:OBJECTIVES:To examine the association of immune cell number and function with occupational exposure to substances contaminated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). METHODS:A cross sectional medical survey. The exposed participants were employed at two chemical plants between 1951 and 1972 in the manufactur...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.55.11.742
更新日期:1998-11-01 00:00:00
abstract::The association between occupational exposure to airway irritants and the prevalence of chronic respiratory symptoms and level of lung function, and whether these associations were modified by airway hyperresponsiveness, smoking, and a history of allergy were studied in 668 workers from synthetic fibre plants. Respira...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.51.1.3
更新日期:1994-01-01 00:00:00
abstract:BACKGROUND:Natural rubber latex allergy can cause skin and respiratory symptoms The aim of this study was to evaluate the prevalence and incidence of latex related symptoms and sensitisation among a large group of healthcare workers in Trieste hospitals, followed for three years before and after the introduction of pow...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章,多中心研究
doi:10.1136/oem.2003.011460
更新日期:2006-02-01 00:00:00