Ascorbic acid reverses endothelial vasomotor dysfunction in patients with coronary artery disease.

abstract：BACKGROUND:The incidence of cardiovascular disease (CVD), coronary heart disease (CHD), and type 2 diabetes mellitus (T2DM) has not been well defined in persons with the metabolic syndrome (at least 3 of the following: abdominal adiposity, low HDL cholesterol, high triglycerides, hypertension, and impaired fasting gluc...

journal_title：Circulation

authors： Wilson PW,D'Agostino RB,Parise H,Sullivan L,Meigs JB

更新日期：2005-11-15 00:00:00

abstract：BACKGROUND:Heart failure treatment depends partly on the underlying cause of the disease. We evaluated cardiovascular magnetic resonance (CMR) for the problem of differentiating dilated cardiomyopathy (DCM) from left ventricular (LV) dysfunction caused by coronary artery disease (CAD). METHODS AND RESULTS:Late gadolin...

journal_title：Circulation

authors： McCrohon JA,Moon JC,Prasad SK,McKenna WJ,Lorenz CH,Coats AJ,Pennell DJ

更新日期：2003-07-08 00:00:00

abstract：:A 10 mg bolus of the angiotensin blocker saralasin was injected 113 times in 68 subjects with essential or renovascular hypertension. Ninety percent of injections caused a transient increase in blood pressure, which correlated with plasma renin activity (PRA) (r = -0.54); Mean increase at 2 minutes was 21/13.4 mm Hg (...

journal_title：Circulation

authors： Waks UA,Maxwell MH,Marks L,Zawada ET,Kaufman JJ

更新日期：1978-06-01 00:00:00

abstract：BACKGROUND:The individual makeup of atherosclerotic plaque has been identified as a dominant prognostic factor. With the use of an intravascular magnetic resonance (MR) catheter coil, we evaluated the effectiveness of high-resolution MR in the study of the development of atherosclerotic lesions in heritable hyperlipide...

journal_title：Circulation

authors： Zimmermann-Paul GG,Quick HH,Vogt P,von Schulthess GK,Kling D,Debatin JF

更新日期：1999-03-02 00:00:00

abstract：BACKGROUND:There are few studies of cardiac autonomic nervous activity (CANA) in patients with congenital heart disease. Methods and Results-We evaluated CANA in 54 patients after closure of an atrial/ventricular septal defect (group A), 54 patients after successful right ventricular outflow tract reconstruction (RVOTR...

journal_title：Circulation

authors： Ohuchi H,Suzuki H,Toyohara K,Tatsumi K,Ono Y,Arakaki Y,Echigo S

更新日期：2000-11-28 00:00:00

abstract：:BACKGROUND-Catecholamine-induced apoptosis is mediated by activation of the beta-adrenergic signaling pathway. We tested the hypothesis that beta(1)- and beta(2)-adrenergic receptor (AR) subtypes differentially affect apoptosis in adult rat ventricular myocytes in vitro. METHODS AND RESULTS-Myocytes were first exposed...

journal_title：Circulation

authors： Zaugg M,Xu W,Lucchinetti E,Shafiq SA,Jamali NZ,Siddiqui MA

更新日期：2000-07-18 00:00:00

abstract：BACKGROUND:Imaging of the flow convergence region (FCR) proximal to a regurgitant orifice has been shown to provide a method for quantifying the regurgitant flow rate. According to the continuity principle, the FCR is constituted by concentric hemispheric isovelocity surfaces centered at the orifice. The flow rate is c...

journal_title：Circulation

authors： Bargiggia GS,Tronconi L,Sahn DJ,Recusani F,Raisaro A,De Servi S,Valdes-Cruz LM,Montemartini C

更新日期：1991-10-01 00:00:00

abstract：:The effect of timolol vs placebo on the frequency of anginal episodes, nitroglycerin consumption and exercise performance was investigated in a double-blind, randomized, crossover study in 23 patients with angina pectoris. The optimal dose of timolol (10-30 mg twice daily) for each patient was titrated by exercise stu...

journal_title：Circulation

authors： Aronow WS,Turbow M,Van Camp S,Lurie M,Whittaker K

更新日期：1980-01-01 00:00:00

abstract：:A significant fraction of patients in whom mechanical left ventricular assist devices are implanted for refractory cardiac failure after open heart surgery have had the complication of right heart failure. To evaluate the effects of left ventricular assistance and pressure unloading on right ventricular function, we p...

journal_title：Circulation

authors： Farrar DJ,Compton PG,Dajee H,Fonger JD,Hill JD

更新日期：1984-10-01 00:00:00

abstract：BACKGROUND:Although early intravenous beta-blocker therapy during acute myocardial infarction (AMI) reduces the incidence of fatal arrhythmias in patients not treated with thrombolytic agents, its antiarrhythmic effect in thrombolysed patients remains controversial. We investigated prospectively the arrhythmia incidenc...

journal_title：Circulation

authors： Heidbüchel H,Tack J,Vanneste L,Ballet A,Ector H,Van de Werf F

更新日期：1994-03-01 00:00:00

abstract：BACKGROUND:Cystic kidneys and vascular aneurysms are clinical manifestations seen in patients with polycystic kidney disease, a cilia-associated pathology (ciliopathy). Survivin overexpression is associated with cancer, but the clinical pathology associated with survivin downregulation or knockout has never been studie...

journal_title：Circulation

authors： Aboualaiwi WA,Muntean BS,Ratnam S,Joe B,Liu L,Booth RL,Rodriguez I,Herbert BS,Bacallao RL,Fruttiger M,Mak TW,Zhou J,Nauli SM

更新日期：2014-02-11 00:00:00

abstract：BACKGROUND:The endocrine-disrupting chemical bisphenol A (BPA) is widely used in food and beverage packaging. Higher urinary BPA concentrations were cross-sectionally associated with heart disease in National Health and Nutrition Examination Survey (NHANES) 2003-2004 and NHANES 2005-2006, independent of traditional ris...

journal_title：Circulation

authors： Melzer D,Osborne NJ,Henley WE,Cipelli R,Young A,Money C,McCormack P,Luben R,Khaw KT,Wareham NJ,Galloway TS

更新日期：2012-03-27 00:00:00

abstract：BACKGROUND:Unlike the Western world, valvular disease ranks among the major cardiovascular afflictions in Africa. Acute rheumatic fever and chronic rheumatic valvular disease in their most virulent form are still commonly encountered and impose a huge burden on limited healthcare resources. METHODS AND RESULTS:We perf...

journal_title：Circulation

authors： Essop MR,Nkomo VT

更新日期：2005-12-06 00:00:00

abstract：BACKGROUND:Application of pyruvate was shown to improve contractile function in isolated animal myocardium and hemodynamics in patients with congestive heart failure. We assessed the influence of pyruvate on systolic and diastolic myocardial function and its subcellular mode of action in isolated myocardium from end-st...

journal_title：Circulation

authors： Hasenfuss G,Maier LS,Hermann HP,Lüers C,Hünlich M,Zeitz O,Janssen PM,Pieske B

更新日期：2002-01-15 00:00:00

abstract：BACKGROUND:The mechanisms linking obesity to hypertension have not been established, but sodium retention and excessive sympathetic tone are key contributors. The natriuretic peptides are important regulators of sodium homeostasis and neurohormonal activation, raising the possibility that obese individuals have an impa...

journal_title：Circulation

authors： Wang TJ,Larson MG,Levy D,Benjamin EJ,Leip EP,Wilson PW,Vasan RS

更新日期：2004-02-10 00:00:00

abstract：BACKGROUND:Microvascular dysfunction in hypertrophic cardiomyopathy (HCM) may create an ischemic substrate conducive to sudden death, but it remains unknown whether the extent of hypertrophy is associated with proportionally poorer perfusion reserve. Comparisons between magnitude of hypertrophy, impairment of perfusion...

journal_title：Circulation

authors： Petersen SE,Jerosch-Herold M,Hudsmith LE,Robson MD,Francis JM,Doll HA,Selvanayagam JB,Neubauer S,Watkins H

更新日期：2007-05-08 00:00:00

abstract：:Between July 1980 and November 1982, there were 935 coronary angioplasties attempted at Emory University Hospital. Of these patients, 20 developed acute occlusion. Of these 20, 19 presented within 3 hr of surgery or within 3 hr after stopping a continuous heparin infusion. Five patients required emergency surgery, but...

journal_title：Circulation

authors： Hollman J,Gruentzig AR,Douglas JS Jr,King SB 3rd,Ischinger T,Meier B

更新日期：1983-10-01 00:00:00

abstract：BACKGROUND:Lung hypoplasia and persistent pulmonary hypertension of the newborn limit survival in congenital diaphragmatic hernia (CDH). Unlike other diseases resulting in persistent pulmonary hypertension of the newborn, infants with CDH are refractory to inhaled nitric oxide (NO). Nitric oxide mediates pulmonary vaso...

journal_title：Circulation

authors： Luong C,Rey-Perra J,Vadivel A,Gilmour G,Sauve Y,Koonen D,Walker D,Todd KG,Gressens P,Kassiri Z,Nadeem K,Morgan B,Eaton F,Dyck JR,Archer SL,Thébaud B

更新日期：2011-05-17 00:00:00

abstract：BACKGROUND:Lysosomal carboxypeptidase, cathepsin A (protective protein, CathA), is a component of the lysosomal multienzyme complex along with beta-galactosidase (GAL) and sialidase Neu1, where it activates Neu1 and protects GAL and Neu1 against the rapid proteolytic degradation. On the cell surface, CathA, Neu1, and t...

journal_title：Circulation

authors： Seyrantepe V,Hinek A,Peng J,Fedjaev M,Ernest S,Kadota Y,Canuel M,Itoh K,Morales CR,Lavoie J,Tremblay J,Pshezhetsky AV

更新日期：2008-04-15 00:00:00

abstract：BACKGROUND:The Washington Radiation for In-Stent Restenosis Trial for long lesions (Long WRIST) was designed to determine the safety and efficacy of vascular brachytherapy for the treatment of diffuse in-stent restenosis. METHODS AND RESULTS:A total of 120 patients with diffuse in-stent restenosis in native coronary a...

journal_title：Circulation

authors： Waksman R,Cheneau E,Ajani AE,White RL,Pinnow E,Torguson R,Deible R,Satler LF,Pichard AD,Kent KM,Teirstein PS,Lindsay J,Washington Radiation for In-Stent Restenosis Trial for Long Lesions Studies.

更新日期：2003-04-08 00:00:00

abstract：BACKGROUND:It is uncertain whether Helicobacter pylori is associated with ischemic syndromes and whether this association is mediated by the induction of atherosclerosis. In this study, we tested the hypothesis that atherosclerotic stroke shows a selective association with virulent H pylori strains. METHODS AND RESULT...

journal_title：Circulation

authors： Pietroiusti A,Diomedi M,Silvestrini M,Cupini LM,Luzzi I,Gomez-Miguel MJ,Bergamaschi A,Magrini A,Carrabs T,Vellini M,Galante A

更新日期：2002-07-30 00:00:00

abstract：:Syncope and sudden death occurs in certain purebred Pug dogs which have been found to have intermittent sinus pauses and paroxysmal second degree heart block on electrocardiographic (ECG) study. We have established a colony of such dogs to study this problem and here report the results of histological examination of t...

journal_title：Circulation

authors： James TN,Robertson BT,Waldo AL,Branch CE

更新日期：1975-12-01 00:00:00

abstract：BACKGROUND:Depressed ventricular performance and neurohormonal activation are key pathophysiological features of congestive heart failure (CHF). Although angiotensin-converting enzyme inhibitors and beta-adrenoceptor blockers exert beneficial effects in CHF, mortality remains unacceptably high, and the development of f...

journal_title：Circulation

authors： Kaye DM,Mansfield D,Aggarwal A,Naughton MT,Esler MD

更新日期：2001-05-15 00:00:00

abstract：BACKGROUND:Bias in studies of preventive medications can occur when healthier patients are more likely to initiate and adhere to therapy than less healthy patients. We sought evidence of this bias by examining associations between statin exposure and various outcomes that should not be causally affected by statin expos...

journal_title：Circulation

authors： Dormuth CR,Patrick AR,Shrank WH,Wright JM,Glynn RJ,Sutherland J,Brookhart MA

更新日期：2009-04-21 00:00:00

abstract：BACKGROUND:Small-scale clinical investigations have demonstrated that single doses of beta-blocking agents can improve left ventricular function in heart failure from idiopathic dilated cardiomyopathy (IDC). The purpose of this multicenter clinical trial was to determine the dose-effect characteristics of beta-blockade...

journal_title：Circulation

authors： Bristow MR,O'Connell JB,Gilbert EM,French WJ,Leatherman G,Kantrowitz NE,Orie J,Smucker ML,Marshall G,Kelly P

更新日期：1994-04-01 00:00:00

abstract：BACKGROUND:The recent breakthrough in the generation of induced pluripotent stem (iPS) cells, which are almost indistinguishable from embryonic stem (ES) cells, facilitates the generation of murine disease- and human patient-specific stem cell lines. The aim of this study was to characterize the cardiac differentiation...

journal_title：Circulation

authors： Mauritz C,Schwanke K,Reppel M,Neef S,Katsirntaki K,Maier LS,Nguemo F,Menke S,Haustein M,Hescheler J,Hasenfuss G,Martin U

更新日期：2008-07-29 00:00:00

abstract：BACKGROUND:In the patient with mitral regurgitation who is being considered for valvular surgery, cardiac catheterization is usually performed to quantify the severity of regurgitation and to determine its influence on left ventricular volumes and systolic function. Magnetic resonance imaging (MRI) potentially provides...

journal_title：Circulation

authors： Hundley WG,Li HF,Willard JE,Landau C,Lange RA,Meshack BM,Hillis LD,Peshock RM

更新日期：1995-09-01 00:00:00

abstract：:Because regional wall motion abnormality (RWMA) is usually noted during ischemia, we hypothesized that the presence of this finding with two-dimensional echocardiography would be superior to conventional methods of diagnosing acute myocardial infarction (AMI) in the emergency room. We also hypothesized that because th...

journal_title：Circulation

authors： Sabia P,Afrookteh A,Touchstone DA,Keller MW,Esquivel L,Kaul S

更新日期：1991-09-01 00:00:00

abstract：:The dominance of the coronary arterial system was determined angiographically in 75 adult patients with isolated aortic stenosis with or without insufficiency, 25 adult patients with pure aortic insufficiency, 51 adult patients with combined aortic stenosis and mitral valve disease, and 44 children with bicuspid aorti...

journal_title：Circulation

authors： Higgins CB,Wexler L

更新日期：1975-08-01 00:00:00

abstract：BACKGROUND:Contrast agents can cause a reduction in renal function that may be due to the generation of reactive oxygen species. Conflicting evidence suggests that administration of the antioxidant acetylcysteine prevents this renal impairment. The action of other antioxidant agents has not been investigated. METHODS ...

journal_title：Circulation

authors： Spargias K,Alexopoulos E,Kyrzopoulos S,Iokovis P,Greenwood DC,Manginas A,Voudris V,Pavlides G,Buller CE,Kremastinos D,Cokkinos DV

更新日期：2004-11-02 00:00:00