Variability in the timing of G(1)/S transition.

Abstract:

:Cell cycle duration and phase transition times are not fixed, even within homogeneous cell populations growing under optimal environmental conditions. We investigate G(1) phase variability from the molecular point of view and propose a mathematical approach to model the protein interactions regulating the transition from the G(1) phase to the phase of DNA synthesis. The mathematical model has some connections with flow cytometry experimental data.

journal_name

Math Biosci

journal_title

Mathematical biosciences

authors

Chiorino G,Lupi M

doi

10.1016/s0025-5564(02)00085-8

subject

Has Abstract

pub_date

2002-05-01 00:00:00

pages

85-101

eissn

0025-5564

issn

1879-3134

pii

S0025556402000858

journal_volume

177-178

pub_type

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