Spread of excitation in 3-D models of the anisotropic cardiac tissue. III. Effects of ventricular geometry and fiber structure on the potential distribution.

Abstract:

:In a previous paper we studied the spread of excitation in a simplified model of the left ventricle, affected by fiber structure and obliqueness, curvature of the wall and Purkinje network. In the present paper we investigate the extracellular potential distribution u in the same ventricular model. Given the transmembrane potential v, associated with the spreading excitation, the extracellular potential u is obtained as solution of a linear elliptic equation with the source term related to v. The potential distributions were computed for point stimulations at different intramural depths. The results of the simulations enabled us to identify a number of common features which appears in all the potential patterns irrespective of pacing site. In addition, by splitting the sources into an axial and conormal component, we were able to evaluate the contribution of the classical uniform dipole layer to the total potential field and the role of the superimposed axial component.

journal_name

Math Biosci

journal_title

Mathematical biosciences

authors

Colli Franzone P,Guerri L,Pennacchio M,Taccardi B

doi

10.1016/s0025-5564(98)10004-4

subject

Has Abstract

pub_date

1998-07-01 00:00:00

pages

51-98

issue

1

eissn

0025-5564

issn

1879-3134

pii

S0025-5564(98)10004-4

journal_volume

151

pub_type

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