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The safety of calcium channel blockers in human pregnancy: a prospective, multicenter cohort study.

Abstract：

OBJECTIVE:Our purpose was to examine the potential teratogenicity of calcium channel blockers. STUDY DESIGN:Six teratogen information services prospectively collected and followed up 78 women with first-trimester exposure to calcium channel blockers. Pregnancy outcome was compared (by paired t text of chi2 analysis) with that of a control group matched for maternal age and smoking. RESULTS:There was no increase in major malformation (2/66=3.0% [calcium channel blockers] vs 0% [nonteratogenic controls], p=0.27); a fivefold increase was ruled out (baseline 2%, alpha = 0.05, beta = 0.20). The defects reported were attributable to maternal diabetes or coingestion of teratogens. The increase in preterm delivery 28% [calcium channel blockers] vs 9% [nonteratogenic controls], p=0.003), attributed to maternal disease by stepwise regression, was the most important factor responsible for the observed decrease in birth weight (mean -334 gm vs nonteratogenic controls, p=0.08). CONCLUSION:This study suggests that calcium channel blockers do not represent a major teratogenic risk.

journal_name

Am J Obstet Gynecol

journal_title

American journal of obstetrics and gynecology

authors

Magee LA,Schick B,Donnenfeld AE,Sage SR,Conover B,Cook L,McElhatton PR,Schmidt MA,Koren G

doi

10.1016/s0002-9378(96)70307-1

subject

Has Abstract

pub_date

1996-03-01 00:00:00

pages

823-8

issue

3

eissn

0002-9378

issn

1097-6868

pii

S0002-9378(96)70307-1

journal_volume

174

pub_type

临床试验,杂志文章,多中心研究

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