Abstract:
:This study was undertaken to determine if computerized tomography (CT scanning) with an EMI cranial scanner could detect edema associated with myocardial ischemia in canine hearts. A localized area of decreased density in the posterior papillary muscle and surrounding myocardium was detected on serial 8 mm CT scan slices of each heart after 60 min of circumflex artery occlusion and 45 min of reflow of blood. The wet/dry weight ratios and previous electron microscope studies of the ischemic posterior papillary muscles revealed edema accumulation. After 1 hour of arterial occlusion and 12 hours of reflow (which produces extensive necrosis and a decrease in the wet/dry ratio) lesions were still discernible but were less consistently as severe. Permanent ligation of the left anterior descending coronary artery and major collateral arteries for 6 hours also resulted in a lesion of decreased density in the distribution of the occluded arteries. Thus, CT scanning can detect, and is a potential means for sequential noninvasive quantitation of myocardial edema associated with ischemia.
journal_name
Circulationjournal_title
Circulationauthors
Powell WJ Jr,wittenberg J,Maturi RA,Dinsmore RE,Miller SWdoi
10.1161/01.cir.55.1.99subject
Has Abstractpub_date
1977-01-01 00:00:00pages
99-108issue
1eissn
0009-7322issn
1524-4539journal_volume
55pub_type
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