Detection of edema associated with myocardial ischemia by computerized tomography in isolated, arrested canine hearts.

Abstract:

:This study was undertaken to determine if computerized tomography (CT scanning) with an EMI cranial scanner could detect edema associated with myocardial ischemia in canine hearts. A localized area of decreased density in the posterior papillary muscle and surrounding myocardium was detected on serial 8 mm CT scan slices of each heart after 60 min of circumflex artery occlusion and 45 min of reflow of blood. The wet/dry weight ratios and previous electron microscope studies of the ischemic posterior papillary muscles revealed edema accumulation. After 1 hour of arterial occlusion and 12 hours of reflow (which produces extensive necrosis and a decrease in the wet/dry ratio) lesions were still discernible but were less consistently as severe. Permanent ligation of the left anterior descending coronary artery and major collateral arteries for 6 hours also resulted in a lesion of decreased density in the distribution of the occluded arteries. Thus, CT scanning can detect, and is a potential means for sequential noninvasive quantitation of myocardial edema associated with ischemia.

journal_name

Circulation

journal_title

Circulation

authors

Powell WJ Jr,wittenberg J,Maturi RA,Dinsmore RE,Miller SW

doi

10.1161/01.cir.55.1.99

subject

Has Abstract

pub_date

1977-01-01 00:00:00

pages

99-108

issue

1

eissn

0009-7322

issn

1524-4539

journal_volume

55

pub_type

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