Magnesium content of serum, circulating mononuclear cells, skeletal muscle, and myocardium in congestive heart failure.


:Deranged magnesium concentrations in serum and cardiovascular structures have been implicated in the pathophysiology of hypertension, ischemic heart disease, arrhythmias, and sudden death. This study was conducted to determine the status and interrelation of serum and tissue concentrations of magnesium in patients with congestive heart failure, a clinical setting purportedly predisposed to the development of depleted levels of this cation. Magnesium concentrations of serum, circulating mononuclear cells, skeletal muscle, and myocardium were measured in 23 patients with heart failure on standard therapy. Two patients were hypomagnesemic (less than 1.6 meq/l). Poor or no correlations were found between serum and tissue magnesium concentrations and among the magnesium concentrations of the three tissues studied. Strong direct correlations were, however, noted between magnesium and potassium concentrations of the tissues examined. The prevalence of hypomagnesemia in this typical ambulatory heart failure population is relatively low (9%) and serum, circulating mononuclear cell, skeletal muscle, and myocardial magnesium concentrations correlate poorly with each other. Serum, circulating mononuclear cell, and skeletal muscle magnesium concentrations are thus of little predictive value in assessing the status of myocardial magnesium in humans with heart failure.






Ralston MA,Murnane MR,Kelley RE,Altschuld RA,Unverferth DV,Leier CV




Has Abstract


1989-09-01 00:00:00












  • Central arterial compliance is associated with age- and habitual exercise-related differences in cardiovagal baroreflex sensitivity.

    abstract::Background- Cardiovagal baroreflex sensitivity (BRS) declines with age but is favorably modulated by habitual aerobic exercise. We tested the hypothesis that compliance (transducing capacity) of an elastic artery in which baroreceptors are located is associated with these age-exercise interactions. Methods and Results...


    pub_type: 杂志文章


    authors: Monahan KD,Tanaka H,Dinenno FA,Seals DR

    更新日期:2001-10-02 00:00:00

  • Natural history and classification of occlusive thromboaortopathy (Takayasu's disease).

    abstract::Fifty-four Japanese patients with occlusive thromboaortopathy (OTAP), including four males, were classified according to evidence of complications attributed to OTAP at the time when the diagnosis was established: Group I, uncomplicated OTAP with or without the involvement of the pulmonary artery. Group II, mono-compl...


    pub_type: 杂志文章


    authors: Ishikawa K

    更新日期:1978-01-01 00:00:00

  • First chronic platelet glycoprotein IIb/IIIa integrin blockade. A randomized, placebo-controlled pilot study of xemilofiban in unstable angina with percutaneous coronary interventions.

    abstract:BACKGROUND:Clinical studies have demonstrated the efficacy of intravenous administration of agents that block platelet glycoprotein IIb/IIIa receptors in the setting of percutaneous coronary revascularization. Although the optimal duration of treatment has not been determined, more prolonged receptor blockade has been ...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Simpfendorfer C,Kottke-Marchant K,Lowrie M,Anders RJ,Burns DM,Miller DP,Cove CS,DeFranco AC,Ellis SG,Moliterno DJ,Raymond RE,Sutton JM,Topol EJ

    更新日期:1997-07-01 00:00:00

  • Inaccuracy of estimated resting oxygen uptake in the clinical setting.

    abstract:BACKGROUND:The Fick principle (cardiac output = oxygen uptake ( O2)/systemic arterio-venous oxygen difference) is used to determine cardiac output in numerous clinical situations. However, estimated rather than measured O2 is commonly used because of complexities of the measurement, though the accuracy of estimation re...


    pub_type: 杂志文章


    authors: Narang N,Thibodeau JT,Levine BD,Gore MO,Ayers CR,Lange RA,Cigarroa JE,Turer AT,de Lemos JA,McGuire DK

    更新日期:2014-01-14 00:00:00

  • Both hepatic and extrahepatic ABCA1 have discrete and essential functions in the maintenance of plasma high-density lipoprotein cholesterol levels in vivo.

    abstract:BACKGROUND:Extrahepatic tissues have long been considered critical contributors of cholesterol to nascent HDL particles in the reverse cholesterol transport pathway, in which ABCA1 plays the crucial role. Recent studies, however, including both overexpression and deletion of ABCA1 selectively in the liver, have highlig...


    pub_type: 杂志文章


    authors: Singaraja RR,Van Eck M,Bissada N,Zimetti F,Collins HL,Hildebrand RB,Hayden A,Brunham LR,Kang MH,Fruchart JC,Van Berkel TJ,Parks JS,Staels B,Rothblat GH,Fiévet C,Hayden MR

    更新日期:2006-09-19 00:00:00

  • Effects of L-749,329, an ET(A)/ET(B) endothelin receptor antagonist, in a porcine coronary artery injury model of vascular restenosis.

    abstract:BACKGROUND:Previous studies in animal models of angioplasty have suggested a role in neointimal hyperplasia for endothelins (ETs), potent vasoconstricting peptides that also exert growth-promoting effects. The present studies were undertaken to test the hypothesis that endothelin receptor blockade can reduce neointimal...


    pub_type: 杂志文章


    authors: Huckle WR,Drag MD,Acker WR,Powers M,McFall RC,Holder DJ,Walsh TF,Schwartz RS,Greenlee WJ,Johnson RG Jr

    更新日期:2001-04-10 00:00:00

  • Linking: a dynamic electrophysiologic phenomenon in macroreentry circuits.

    abstract::The term "linking" has been used specifically to describe the mechanism for perpetuation of functional anterograde bundle branch block: namely, repetitive transseptal retrograde concealed penetration by impulses propagating along the contralateral bundle. We present selected examples that demonstrate tht linking-type ...


    pub_type: 杂志文章


    authors: Lehmann MH,Denker S,Mahmud R,Addas A,Akhtar M

    更新日期:1985-02-01 00:00:00

  • Clinical features of arrhythmogenic right ventricular dysplasia/cardiomyopathy associated with mutations in plakophilin-2.

    abstract:BACKGROUND:Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) is an inherited cardiomyopathy characterized by right ventricular dysfunction and ventricular arrhythmias. A recent study reported mutations in PKP2, encoding the desmosomal protein plakophilin-2, associated with ARVD/C. The purpose of our st...


    pub_type: 杂志文章


    authors: Dalal D,Molin LH,Piccini J,Tichnell C,James C,Bomma C,Prakasa K,Towbin JA,Marcus FI,Spevak PJ,Bluemke DA,Abraham T,Russell SD,Calkins H,Judge DP

    更新日期:2006-04-04 00:00:00

  • Low-dose aspirin inhibits platelet-induced contraction of the human isolated coronary artery. A role for additional 5-hydroxytryptamine receptor antagonism against coronary vasospasm?

    abstract:BACKGROUND:The beneficial effect of low-dose aspirin in the prevention of coronary vasospasm is well documented. In this study, we investigated the contractile effect of human washed platelets on the human isolated coronary artery. We concentrated on the effect of low-dose aspirin (40 mg/d) taken by the platelet donor ...


    pub_type: 杂志文章


    authors: Bax WA,Renzenbrink GJ,van der Linden EA,Zijlstra FJ,van Heuven-Nolsen D,Fekkes D,Bos E,Saxena PR

    更新日期:1994-02-01 00:00:00

  • Radiofrequency catheter ablation of left lateral accessory pathways via the coronary sinus.

    abstract:BACKGROUND:The purpose of this study was to describe a new technique for catheter ablation of left lateral accessory pathways (APs) by radiofrequency energy applied at the epicardium through the coronary sinus wall using a unipolar configuration. METHODS AND RESULTS:In an overall group of 212 patients with left latera...


    pub_type: 杂志文章


    authors: Haissaguerre M,Gaita F,Fischer B,Egloff P,Lemetayer P,Warin JF

    更新日期:1992-11-01 00:00:00

  • Concealed ventricular parasystole uncovered in the form of ventricular escapes of variable coupling.

    abstract::Exit block from a parasystolic focus is recognized when automatic discharges fail to become manifest during the excitable phase of the ventricular cycle. In the present study, an apparently complete exit block and a persistently concealed ventricular parasystole (VP) resulted from an exit refractory period (ExRP) long...


    pub_type: 杂志文章


    authors: Nau GJ,Aldariz AE,Acunzo RS,Chiale PA,Elizari MV,Rosenbaum MB

    更新日期:1981-07-01 00:00:00

  • Impact of infectious burden on extent and long-term prognosis of atherosclerosis.

    abstract:BACKGROUND:Recent findings suggest a causative role of infections in the pathogenesis of atherosclerosis. In hypothesizing an association between infectious agents and the development of atherosclerosis, we would expect a correlation to the extent of atherosclerosis. Moreover, this effect could be multiplied by the num...


    pub_type: 杂志文章


    authors: Espinola-Klein C,Rupprecht HJ,Blankenberg S,Bickel C,Kopp H,Rippin G,Victor A,Hafner G,Schlumberger W,Meyer J,AtheroGene Investigators.

    更新日期:2002-01-01 00:00:00

  • Efficacy of Long-Term β-Blocker Therapy for Secondary Prevention of Long-Term Outcomes After Coronary Artery Bypass Grafting Surgery.

    abstract:BACKGROUND:Conflicting results from recent observational studies have raised questions concerning the benefit of β-blockers for patients undergoing coronary artery bypass grafting (CABG). Furthermore, the efficacy of long-term β-blocker therapy in CABG patients after hospital discharge is uncertain. METHODS AND RESULT...


    pub_type: 杂志文章


    authors: Zhang H,Yuan X,Zhang H,Chen S,Zhao Y,Hua K,Rao C,Wang W,Sun H,Hu S,Zheng Z

    更新日期:2015-06-23 00:00:00

  • Arrhythmia burden in adults with surgically repaired tetralogy of Fallot: a multi-institutional study.

    abstract:BACKGROUND:The arrhythmia burden in tetralogy of Fallot, types of arrhythmias encountered, and risk profile may change as the population ages. METHODS AND RESULTS:The Alliance for Adult Research in Congenital Cardiology (AARCC) conducted a multicenter cross-sectional study to quantify the arrhythmia burden in tetralog...


    pub_type: 杂志文章,多中心研究


    authors: Khairy P,Aboulhosn J,Gurvitz MZ,Opotowsky AR,Mongeon FP,Kay J,Valente AM,Earing MG,Lui G,Gersony DR,Cook S,Ting JG,Nickolaus MJ,Webb G,Landzberg MJ,Broberg CS,Alliance for Adult Research in Congenital Cardiology (AARCC).

    更新日期:2010-08-31 00:00:00

  • Clinical Profile and Consequences of Atrial Fibrillation in Hypertrophic Cardiomyopathy.

    abstract:BACKGROUND:Atrial fibrillation (AF), the most common sustained arrhythmia in hypertrophic cardiomyopathy (HCM), is capable of producing symptoms that impact quality of life and is associated with risk for embolic stroke. However, the influence of AF on clinical course and outcome in HCM remains incompletely resolved. ...


    pub_type: 杂志文章


    authors: Rowin EJ,Hausvater A,Link MS,Abt P,Gionfriddo W,Wang W,Rastegar H,Estes NAM,Maron MS,Maron BJ

    更新日期:2017-12-19 00:00:00

  • Acute effects of continuous positive airway pressure on cardiac sympathetic tone in congestive heart failure.

    abstract:BACKGROUND:Depressed ventricular performance and neurohormonal activation are key pathophysiological features of congestive heart failure (CHF). Although angiotensin-converting enzyme inhibitors and beta-adrenoceptor blockers exert beneficial effects in CHF, mortality remains unacceptably high, and the development of f...


    pub_type: 临床试验,杂志文章


    authors: Kaye DM,Mansfield D,Aggarwal A,Naughton MT,Esler MD

    更新日期:2001-05-15 00:00:00

  • Research related to medical treatment of cardiovascular disease.

    abstract::Medical treatment of heart disease has improved significantly in the past 30 years. The spectacular change in the natural history of rheumatic heart disease is apparent from a 1948 article that reported that 42% of children with rheumatic heart disease died of rheumatic infection or bacterial endocarditis. Antibiotics...


    pub_type: 临床试验,历史文章,杂志文章


    authors: Ross RS

    更新日期:1979-12-01 00:00:00

  • Ethmozin, a new antiarrhythmic drug for suppressing ventricular premature complexes.

    abstract::Ethmozin, a phenothiazine derivative, is an antiarrhythmic drug synthesized in the USSR. Preliminary data suggest that it is effective against a diversity of ectopic arrhythmias. The present study, carried out in the USSR, was designed to assess efficacy and patient tolerance of this new drug. Thirty-seven patients wi...


    pub_type: 临床试验,杂志文章


    authors: Podrid PJ,Lyakishev A,Lown B,Mazur N

    更新日期:1980-02-01 00:00:00

  • Progressive tricuspid valve disease in patients with congenitally corrected transposition of the great arteries.

    abstract:BACKGROUND:The outcome of patients with corrected transposition of the great arteries (CTGA) is variably affected by associated intracardiac defects, tricuspid valve competence, and systemic right ventricular (RV) function. The relative importance of these factors in long-term outcome has not been evaluated. METHODS A...


    pub_type: 杂志文章


    authors: Prieto LR,Hordof AJ,Secic M,Rosenbaum MS,Gersony WM

    更新日期:1998-09-08 00:00:00

  • Temporal Trends in Percutaneous Coronary Intervention Appropriateness: Insights From the Clinical Outcomes Assessment Program.

    abstract:BACKGROUND:It is unknown whether the appropriate use of percutaneous coronary intervention (PCI) has improved over time and whether trends in PCI appropriateness have been accompanied by changes in the use of PCI. METHODS AND RESULTS:We applied appropriate use criteria to determine the appropriateness of all 51 872 PC...


    pub_type: 杂志文章


    authors: Bradley SM,Bohn CM,Malenka DJ,Graham MM,Bryson CL,McCabe JM,Curtis JP,Lambert-Kerzner A,Maynard C

    更新日期:2015-07-07 00:00:00

  • Tissue plasminogen activator and risk of myocardial infarction. The Rotterdam Study.

    abstract:BACKGROUND:Impaired fibrinolytic capacity, as assessed by euglobulin clot lysis time or plasma concentration of fibrinolytic parameters, has been associated with an increased risk of myocardial infarction (MI). We studied the association of a polymorphism in the gene for TPA and of plasma concentrations of TPA (antigen...


    pub_type: 杂志文章


    authors: van der Bom JG,de Knijff P,Haverkate F,Bots ML,Meijer P,de Jong PT,Hofman A,Kluft C,Grobbee DE

    更新日期:1997-06-17 00:00:00

  • Catheter ablation versus antiarrhythmic drugs for atrial fibrillation: the A4 study.

    abstract:BACKGROUND:The mainstay of treatment for atrial fibrillation (AF) remains pharmacological; however, catheter ablation has increasingly been used over the last decade. The relative merits of each strategy have not been extensively studied. METHODS AND RESULTS:We conducted a randomized multicenter comparison of these 2 ...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Jaïs P,Cauchemez B,Macle L,Daoud E,Khairy P,Subbiah R,Hocini M,Extramiana F,Sacher F,Bordachar P,Klein G,Weerasooriya R,Clémenty J,Haïssaguerre M

    更新日期:2008-12-09 00:00:00

  • Extent and direction of arterial remodeling in stable versus unstable coronary syndromes : an intravascular ultrasound study.

    abstract:BACKGROUND:The morphological characteristics of coronary plaques in patients with stable versus unstable coronary syndromes have been described in vivo with intravascular ultrasound, but the relationship between arterial remodeling and clinical presentation is not well known. METHODS AND RESULTS:We studied 85 patients...


    pub_type: 杂志文章


    authors: Schoenhagen P,Ziada KM,Kapadia SR,Crowe TD,Nissen SE,Tuzcu EM

    更新日期:2000-02-15 00:00:00

  • Trapidil in preventing restenosis after balloon angioplasty in the atherosclerotic rabbit.

    abstract::Trapidil (triazolopyrimidine) possesses activity against platelet-derived growth factor-induced cellular proliferation in vitro and intimal proliferation in vivo. The objective of this study was to determine if trapidil could prevent restenosis in experimentally induced atherosclerotic rabbits. New Zealand White rabbi...


    pub_type: 杂志文章


    authors: Liu MW,Roubin GS,Robinson KA,Black AJ,Hearn JA,Siegel RJ,King SB 3rd

    更新日期:1990-03-01 00:00:00

  • Indium 111-monoclonal antimyosin antibody imaging in the diagnosis of acute myocarditis.

    abstract::A definitive diagnosis of myocarditis requires right ventricular biopsy. Despite its specificity, however, right ventricular biopsy may lack sensitivity due to the focal nature of the disease. Because indium 111-monoclonal antimyosin antibody imaging can be used to detect myocardial necrosis, this procedure was perfor...


    pub_type: 杂志文章


    authors: Yasuda T,Palacios IF,Dec GW,Fallon JT,Gold HK,Leinbach RC,Strauss HW,Khaw BA,Haber E

    更新日期:1987-08-01 00:00:00

  • Clinical pharmacology of propafenone.

    abstract::We determined the efficacy, pharmacokinetics, and plasma concentration-response relationships of propafenone, a promising new antiarrhythmic drug. Thirteen patients with frequent and complex ventricular premature beats were studied after receiving four increasing doses, during drug washout and during a randomized doub...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Connolly SJ,Kates RE,Lebsack CS,Harrison DC,Winkle RA

    更新日期:1983-09-01 00:00:00

  • Prevalence and prognostic significance of wall-motion abnormalities in adults without clinically recognized cardiovascular disease: the Strong Heart Study.

    abstract:BACKGROUND:Left ventricular wall motion (WM) abnormalities have recognized prognostic significance in patients with coronary or other heart diseases; however, whether abnormal WM predicts adverse events in adults without overt cardiovascular disease has not been assessed. Our objective was to determine whether echocard...


    pub_type: 杂志文章


    authors: Cicala S,de Simone G,Roman MJ,Best LG,Lee ET,Wang W,Welty TK,Galloway JM,Howard BV,Devereux RB

    更新日期:2007-07-10 00:00:00

  • Fifteen year survival study of patients with obstructive coronary artery disease.

    abstract::Survival rates were determined for a group of 598 patients in whom severe coronary disease was demonstrated by arteriography; initially they were treated medically and were followed-up for 15 years. Deaths due to noncoronary causes were uncommon (5% of total) in the first 5 year period but were frequent (36%) in the t...


    pub_type: 杂志文章


    authors: Proudfit WJ,Bruschke AV,MacMillan JP,Williams GW,Sones FM Jr

    更新日期:1983-11-01 00:00:00

  • Lysophosphatidylcholine and reactive oxygen species mediate the synergistic effect of mildly oxidized LDL with serotonin on vascular smooth muscle cell proliferation.

    abstract:BACKGROUND:Mild oxidation of LDL enhances its atherogenic potential and induces a synergistic interaction with serotonin (5HT) on vascular smooth muscle cell (VSMC) proliferation. Because of its complex chemical nature, the mitogenic components of mildly oxidized LDL (moxLDL) remain unclear. METHODS AND RESULTS:We exa...


    pub_type: 杂志文章


    authors: Watanabe T,Pakala R,Koba S,Katagiri T,Benedict CR

    更新日期:2001-03-13 00:00:00

  • Perspectives on systolic hypertension. The Framingham study.

    abstract::Diastolic hypertension has been widely and justifiably accepted as a cause of cardiovascular mortality. However, it has also been accepted that the cardiovascular sequelae of hypertension derive chiefly from the diastolic component. Because systolic and diastolic pressure are usually highly correlated it is not easy t...


    pub_type: 杂志文章


    authors: Kannel WB,Dawber TR,McGee DL

    更新日期:1980-06-01 00:00:00