In vitro activities of daptomycin, vancomycin, quinupristin- dalfopristin, linezolid, and five other antimicrobials against 307 gram-positive anaerobic and 31 Corynebacterium clinical isolates.

abstract：:Pairs of 11 antimicrobial agents were tested in vitro for their ability to act synergistically against three strains of Mycobacterium avium complex isolated from patients with acquired immune deficiency syndrome. From the combinations tested, four drugs (ethambutol, rifampin, ciprofloxacin, and erythromycin) were sele...

journal_title：Antimicrobial agents and chemotherapy

authors： Yajko DM,Kirihara J,Sanders C,Nassos P,Hadley WK

更新日期：1988-09-01 00:00:00

abstract：:The present studies were conducted to better define the mechanism of action of polyethylene hexamethylene biguanide (PEHMB) (designated herein as NB325), which was shown in previous studies to inhibit infection by the human immunodeficiency virus type 1 (HIV-1). Fluorescence-activated flow cytometric analyses of activ...

journal_title：Antimicrobial agents and chemotherapy

authors： Thakkar N,Pirrone V,Passic S,Zhu W,Kholodovych V,Welsh W,Rando RF,Labib ME,Wigdahl B,Krebs FC

更新日期：2009-02-01 00:00:00

abstract：:Aspergillus fumigatus is the primary etiologic agent of invasive aspergillosis (IA), a major cause of death among immunosuppressed patients. Echinocandins (e.g., caspofungin) are increasingly used as second-line therapy for IA, but their activity is only fungistatic. Heat shock protein 90 (Hsp90) was previously shown ...

journal_title：Antimicrobial agents and chemotherapy

authors： Lamoth F,Juvvadi PR,Soderblom EJ,Moseley MA,Steinbach WJ

更新日期：2015-08-01 00:00:00

abstract：:R factors were detected in Vibrio anguillarum strains from vibrio-diseased freshwater fish, ayu (Plecoglossus altivelis), in Japan. It was found that 65 out of the 68 random isolates from epidemics of vibrio disease in 1973 carried transferable drug resistance factors. The most common type determined resistance to sul...

journal_title：Antimicrobial agents and chemotherapy

authors： Aoki T,Egusa S,Arai T

更新日期：1974-11-01 00:00:00

abstract：:While it is well-known that adjunctive corticosteroid use improves the outcome of moderate-to-severe Pneumocystis jirovecii pneumonia (PcP) in patients with human immunodeficiency virus (HIV), there are limited data on its efficacy in non-HIV-infected patients with PcP. Patients undergoing fiber-optic bronchoscopy wit...

journal_title：Antimicrobial agents and chemotherapy

authors： Moon SM,Kim T,Sung H,Kim MN,Kim SH,Choi SH,Jeong JY,Woo JH,Kim YS,Lee SO

更新日期：2011-10-01 00:00:00

abstract：:We have previously identified a target site in HIV-1 RNA that was particularly accessible to a ribozyme and a short hairpin RNA (shRNA). To design small interfering RNAs (siRNAs) targeting this site, we evaluated the effects of siRNAs with different lengths on HIV-1 production. The potency and efficacy of these siRNAs...

journal_title：Antimicrobial agents and chemotherapy

authors： Scarborough RJ,Adams KL,Daher A,Gatignol A

更新日期：2015-09-01 00:00:00

abstract：:Treatment of acutely infected human brain cell and enriched microglial cell cultures with diazepam inhibited human immunodeficiency virus type 1 (HIV-1) p24 antigen expression. Similarly, diazepam suppressed HIV-1 expression in chronically infected promonocytic (U1) cells and acutely infected monocyte-derived macropha...

journal_title：Antimicrobial agents and chemotherapy

authors： Lokensgard JR,Gekker G,Hu S,Arthur AF,Chao CC,Peterson PK

更新日期：1997-11-01 00:00:00

abstract：:The 2-amino-5-halo-pyrimidinones, which are potent interferon inducers and antiviral agents, were found to be protective against lethal cytomegalovirus (CMV) challenge in weanling or neonatal mice when administered before virus challenge. This protection was dependent upon the dosage of pyrimidinone administered. Wean...

journal_title：Antimicrobial agents and chemotherapy

authors： Brideau RJ,Wolcott JA

更新日期：1985-10-01 00:00:00

abstract：:The in vitro interactions between amikacin, netilmicin, tobramycin, gentamicin, and various antipseudomonal beta-lactams were studied by the agar dilution checkerboard technique against 30 Pseudomonas aeruginosa strains resistant to all tested antibiotics. Amikacin produced more frequent synergy both at the total and ...

journal_title：Antimicrobial agents and chemotherapy

authors： Giamarellou H,Zissis NP,Tagari G,Bouzos J

更新日期：1984-04-01 00:00:00

abstract：:Malaria and trypanosomiasis are diseases which afflict millions and for which novel therapies are urgently required. We have tested two well-characterized cell-penetrating peptides (CPPs) for antiparasitic activity. One CPP, designated TP10, has broad-spectrum antiparasitic activity against Plasmodium falciparum, both...

journal_title：Antimicrobial agents and chemotherapy

authors： Arrighi RB,Ebikeme C,Jiang Y,Ranford-Cartwright L,Barrett MP,Langel U,Faye I

更新日期：2008-09-01 00:00:00

abstract：:We have reported previously that methylenecyclopropane analogs of nucleosides have excellent activity against certain members of the herpesvirus family. A second generation, the 2,2-bis-hydroxymethyl derivatives, were synthesized, and 18 compounds were tested for activity in vitro against herpes simplex virus types 1 ...

journal_title：Antimicrobial agents and chemotherapy

authors： Kern ER,Kushner NL,Hartline CB,Williams-Aziz SL,Harden EA,Zhou S,Zemlicka J,Prichard MN

更新日期：2005-03-01 00:00:00

abstract：:A total of 6,991 unique patient isolates of Streptococcus pneumoniae were collected from October 1997 to June 2002 from 25 medical centers in 9 of the 10 Canadian provinces. Among these isolates, 20.2% were penicillin nonsusceptible, with 14.6% being penicillin intermediate (MIC, 0.12 to 1 microg/ml) and 5.6% being pe...

journal_title：Antimicrobial agents and chemotherapy

authors： Zhanel GG,Palatnick L,Nichol KA,Bellyou T,Low DE,Hoban DJ

更新日期：2003-06-01 00:00:00

abstract：:Unlike most antimicrobial peptides (AMPs), the main mode of action of the subclass of proline-rich antimicrobial peptides (PrAMPs) is not based on disruption of the bacterial membrane. Instead, PrAMPs exploit the inner membrane transporters SbmA and YjiL/MdtM to pass through the bacterial membrane and enter the cytoso...

journal_title：Antimicrobial agents and chemotherapy

authors： Mardirossian M,Barrière Q,Timchenko T,Müller C,Pacor S,Mergaert P,Scocchi M,Wilson DN

更新日期：2018-07-27 00:00:00

abstract：:Enucleated human polymorphonuclear leukocytes (PMN cytoplasts), which have no nuclei and only a few granules, retain many of the functions of intact neutrophils. To better define the mechanisms and intracellular sites of antimicrobial agent accumulation in human neutrophils, we studied the antibiotic uptake process in...

journal_title：Antimicrobial agents and chemotherapy

authors： Hand WL,King-Thompson NL

更新日期：1990-06-01 00:00:00

abstract：:A series of 1-cyclopropyl-8-methoxy-quinazoline-2,4-diones was synthesized and evaluated for lowering the ratio of the antimicrobial MIC in gyrase resistance mutants to that in the gyr(+) (wild type) using isogenic strains of Escherichia coli. Dione features that lowered this ratio were a 3-amino group and C-7 ring st...

journal_title：Antimicrobial agents and chemotherapy

authors： German N,Malik M,Rosen JD,Drlica K,Kerns RJ

更新日期：2008-11-01 00:00:00

abstract：:Chronic infection with hepatitis C virus (HCV) is a major global health burden and is associated with an increased risk of liver cirrhosis and hepatocellular carcinoma. Current therapy for HCV infection has limited efficacy, particularly against genotype 1 virus, and is hampered by a range of adverse effects. Therefor...

journal_title：Antimicrobial agents and chemotherapy

authors： Berke JM,Vijgen L,Lachau-Durand S,Powdrill MH,Rawe S,Sjuvarsson E,Eriksson S,Götte M,Fransen E,Dehertogh P,Van den Eynde C,Leclercq L,Jonckers TH,Raboisson P,Nilsson M,Samuelsson B,Rosenquist Å,Fanning GC,Lin TI

更新日期：2011-08-01 00:00:00

abstract：:Plasmid-mediated resistance to polymyxins mediated by the MCR-1/2 determinants has been reported in Enterobacteriaceae worldwide. Using PCR-based and cloning strategies, a series of Moraxella spp. were screened for mcr-like genes. Moraxella spp. that are mainly animal pathogens but may also be human pathogens were ide...

journal_title：Antimicrobial agents and chemotherapy

authors： Kieffer N,Nordmann P,Poirel L

更新日期：2017-05-24 00:00:00

abstract：:Monophenol monooxygenase (monophenol, dihydroxyphenylalanine:oxygen oxidoreductase EC 1.14.18.1) was studied in melanin-positive and melanin-negative mutants of Streptomyces lincolnensis NCIB 9413, varying in the lincomycin synthesizing ability. The activities of laccase and tyrosine phenol lyase (EC 4.1.99.2) are abs...

journal_title：Antimicrobial agents and chemotherapy

authors： Michalik J,Emilianowicz-Czerska W,Switalski L,Raczyńska-Bojanowska K

更新日期：1975-11-01 00:00:00

abstract：:In vitro and in vivo studies were done on a herpes simplex virus type 2 strain recovered from a patient on acyclovir (ACV) which was ACV resistant but expressed thymidine (dThd) kinase (EC 2.7.1.21) activity. Plaque-purified clones derived from the original clinical sample were heterogeneous with respect to plaque siz...

journal_title：Antimicrobial agents and chemotherapy

authors： Ellis MN,Keller PM,Fyfe JA,Martin JL,Rooney JF,Straus SE,Lehrman SN,Barry DW

更新日期：1987-07-01 00:00:00

abstract：:A total of 91 multiply resistant bacterial strains, including Klebsiella pneumoniae (32 strains), Pseudomonas aeruginosa (16 strains), and Serratia marcescens (43 strains), were collected during hospital epidemics of nosocomial infection from 1975 to 1979. These strains were resistant to gentamicin, tobramycin, cephal...

journal_title：Antimicrobial agents and chemotherapy

authors： Hall WH,Opfer BJ,Gerding DN

更新日期：1980-02-01 00:00:00

abstract：:The nature of the SHV-1 beta-lactamase gene was analyzed in 97 epidemiologically unrelated Klebsiella pneumoniae strains isolated from clinical samples. beta-Lactamase bands that focused at a pI of 7.6 (SHV-1-type) in 74 strains, at a pI of 7.1 (LEN-1-type) in 13 strains, and at a pI of 5.4 (TEM-1-type) in 10 strains ...

journal_title：Antimicrobial agents and chemotherapy

authors： Chaves J,Ladona MG,Segura C,Coira A,Reig R,Ampurdanés C

更新日期：2001-10-01 00:00:00

abstract：:In this study, we synthesized antisense oligodeoxynucleotides (ODNs) with phosphodiester, phosphorothioate (S-ODNs), or methylphosphonate linkages complementary to the splicing acceptor site of immediate-early pre-mRNA 5 of herpes simplex virus type 1 (HSV-1). The antiviral activity of each analog on cytopathic effect...

journal_title：Antimicrobial agents and chemotherapy

authors： Shoji Y,Shimada J,Mizushima Y,Iwasawa A,Nakamura Y,Inouye K,Azuma T,Sakurai M,Nishimura T

更新日期：1996-07-01 00:00:00

abstract：:The pharmacokinetics and distribution in tissue of several novel triazole antifungal agents were studied in different animal species in order to select an appropriate lead compound. The purpose of the study was also to determine species differences in pharmacokinetics for SYN azoles to select the most appropriate spec...

journal_title：Antimicrobial agents and chemotherapy

authors： Khan JK,Montaseri H,Poglod M,Bu HZ,Zuo Z,Salama SM,Daneshtalab M,Micetich RG

更新日期：2000-04-01 00:00:00

abstract：:To study whether the capability of horizontal DNA transfer is associated with metronidazole resistance in Helicobacter pylori, a total of 81 clinical isolates were tested for MICs of metronidazole (MTZ). The MIC assays were performed by using the E-test and reconfirmed by the agar dilution method. Natural competence a...

journal_title：Antimicrobial agents and chemotherapy

authors： Yeh YC,Chang KC,Yang JC,Fang CT,Wang JT

更新日期：2002-05-01 00:00:00

abstract：:Ampicillin and erythromycin were shown to act synergistically in vitro against the majority of strains of Nocardia asteroides tested. With these strains, the minimal inhibiting concentration (MIC) of each drug when combined was reduced 4- to more than 512-fold as compared with the MIC of each antibiotic acting individ...

journal_title：Antimicrobial agents and chemotherapy

authors： Finland M,Bach MC,Garner C,Gold O

更新日期：1974-03-01 00:00:00

abstract：:The inhibition of the lymphadenopathy-associated virus strain of human immunodeficiency virus (HIV) by alternating regimens of two dideoxynucleosides, 3'-azido-3'-deoxythymidine (AZT) (zidovudine) and 2',3'-dideoxycytidine (ddC), was determined in CEM cells. Cultures infected with virus for 2 h were treated with clini...

journal_title：Antimicrobial agents and chemotherapy

authors： Spector SA,Ripley D,Hsia K

更新日期：1989-06-01 00:00:00

abstract：:High-level resistance to quinolones has previously been shown to occur in Campylobacter spp. both in vitro and in patients treated with quinolones. We have selected isolates that are resistant to quinolones by plating cells from a susceptible C. jejuni strain, UA535, on medium containing nalidixic acid at 32 microgram...

journal_title：Antimicrobial agents and chemotherapy

authors： Gootz TD,Martin BA

更新日期：1991-05-01 00:00:00

abstract：:Infection with human cytomegalovirus (HCMV) continues to be a major threat for pregnant women and the immunocompromised population. Although several anti-HCMV therapies are available, the development of new anti-HCMV agents is highly desired. There is growing interest in identifying compounds that might inhibit HCMV b...

journal_title：Antimicrobial agents and chemotherapy

authors： Kapoor A,Cai H,Forman M,He R,Shamay M,Arav-Boger R

更新日期：2012-09-01 00:00:00

abstract：:We previously showed that simian immunodeficiency virus-infected macaque macrophages contacting uninfected CD4+ lymphocytes caused extensive cell fusion and synthesis of phlogistic cytokines. In this study, macaque macrophage cultures inoculated with SIVmac251 and treated simultaneously with 10 microM 3'-azidothymidin...

journal_title：Antimicrobial agents and chemotherapy

authors： McEntee MF,Flexner C,Farzadegan H,Pitha P,Narayan O

更新日期：1993-02-01 00:00:00

abstract：:Alphaviruses are arthropod-transmitted RNA viruses that can cause arthralgia, myalgia, and encephalitis in humans. Since the role of cellular kinases in alphavirus replication is unknown, we profiled kinetic changes in host kinase abundance and phosphorylation following chikungunya virus (CHIKV) infection of fibroblas...

journal_title：Antimicrobial agents and chemotherapy

authors： Broeckel R,Sarkar S,May NA,Totonchy J,Kreklywich CN,Smith P,Graves L,DeFilippis VR,Heise MT,Morrison TE,Moorman N,Streblow DN

更新日期：2019-03-27 00:00:00