Pharmacokinetic studies of chloroethylnitrosocarbamoyl-amino acid derivatives in vivo and in vitro.

abstract：BACKGROUND/AIM:Lipitor is a cholesterol-lowering drug and Celebrex is a Cyclooxygenase-2 inhibitor. We investigated the effects of Lipitor and Celebrex on human prostate cancer VCaP cells cultured in vitro and grown as orthotopic xenograft tumors in SCID mice. MATERIALS AND METHODS:Apoptosis was measured by morphologi...

journal_title：Anticancer research

authors： Huang H,Cui XX,Chen S,Goodin S,Liu Y,He Y,Li D,Wang H,Van Doren J,Dipaola RS,Conney AH,Zheng X

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND:It has been suggested that prognosis in familial breast cancer could be influenced by the parent of origin, with a worse prognosis when inherited paternally. This study aimed to investigate the effect of the parent of origin on prognosis. PATIENTS AND METHODS:Index patients were divided into two study group...

journal_title：Anticancer research

authors： Wendt C,Lindblom A,Arver B,VON Wachenfeldt A,Margolin S

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND/AIM:In addition to its cytocidal effects as a microtubule dynamics inhibitor, eribulin mesylate (eribulin) regulates the tumour microenvironment. We examined the clinical significance of tumour infiltrating lymphocytes (TILs) and transforming growth factor-β (TGF-β), which are local markers of host immunity,...

journal_title：Anticancer research

authors： Kashiwagi S,Asano Y,Goto W,Takada K,Morisaki T,Kouhashi R,Yabumoto A,Tanaka S,Takashima T,Ohsawa M,Hirakawa K,Ohira M

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:The effectiveness of postoperative adjuvant chemotherapy for surgically staged grade 3 endometrial cancer was investigated. PATIENTS AND METHODS:Sixty-three consecutive patients with grade 3 endometrial cancer (49 with surgical stage I-II disease and 14 with stage III disease) were treated surgically. Posto...

journal_title：Anticancer research

authors： Takeshima N,Ota T,Omatsu K,Hasumi K,Takizawa K

更新日期：2008-05-01 00:00:00

abstract：BACKGROUND/AIM:Salvage androgen-deprivation therapy (ADT) is standard treatment for recurrent prostate cancer after curative therapy. However, the prognostic impact of different treatment modalities on the time to castration resistance remains unclear. In this study, we investigated the prognosis of men treated with sa...

journal_title：Anticancer research

authors： Obata H,Shiota M,Akitake N,Takeuchi A,Kashiwagi E,Dejima T,Kiyoshima K,Inokuchi J,Tatsugami K,Eto M

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND:Bisphosphonates (BPs) are considered the standard of care in metastatic breast cancer (MBC) patients with bone metastases. Because the survival for these patients may be prolonged compared with those patients with visceral metastases, they may be prescribed BPs for several years. The effects of this long-ter...

journal_title：Anticancer research

authors： Simmons C,Amir E,Dranitsaris G,Clemons M,Wong B,Veith R,Cole DE

更新日期：2009-07-01 00:00:00

abstract：:The specificities and surface markers of murine autocytotoxic cells induced by in vitro culture with interleukin 2 (IL2) were studied. Culturing murine spleen cells with recombinant human IL2 resulted in the generation of cytotoxic cells which killed syngeneic lymphoblasts and syngeneic activated macrophages (M phi). ...

journal_title：Anticancer research

authors： Suzuki H,Ikemoto M,Kamitani T,Hoshino K,Yano S

更新日期：1989-03-01 00:00:00

abstract：:A number of human tumor cell lines originating in tissues which normally express high levels of P-glycoprotein were examined for the expression of mdr-1 RNA and P-glycoprotein and their sensitivity to doxorubicin and vincristine. There was a wide variation in expression levels and in drug sensitivity among the cell li...

journal_title：Anticancer research

authors： Duensing TD,Slate DL

更新日期：1994-01-01 00:00:00

abstract：:Using reverse transcriptase polymerase chain reaction amplification it was possible to detect the presence of oestrogen sulphatase mRNA in different hormone-dependent (MCF-7, T-47D) and hormone-independent (MDA-MB-231, MDA-MB-468) mammary cancer cell lines. The expression of this mRNA is significantly higher in T-47D ...

journal_title：Anticancer research

authors： Pasqualini JR,Maloche C,Maroni M,Chetrite G

更新日期：1994-07-01 00:00:00

abstract：:The effects of silybinin, an antioxidant, on the pharmacokinetics of tamoxifen and its metabolite, 4-hydroxytamoxifen, were investigated in rats. A single dose of tamoxifen was administered intravenously (2 mg/kg) and orally (10 mg/kg) without or with silybinin (0.5, 2.5 and 10 mg/kg) to rats. Silybinin significantly ...

journal_title：Anticancer research

authors： Kim CS,Choi SJ,Park CY,Li C,Choi JS

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Despite a substantial body of epidemiological evidence, there is only a limited indication that gonadotropins and steroids have growth regulating functions in ovarian cancer. To elucidate the role of gonadotropins in regulating steroid metabolism in human ovarian cancer, we analyzed the modulation of estradi...

journal_title：Anticancer research

authors： Kraemer S,Jaeger WH,Lang N

更新日期：2001-05-01 00:00:00

abstract：:Uncertainty exists about the adequate treatment of adult patients with unresectable, primary, biopsy-proven glioblastoma multiforme (GBM), because the different options for this group of patients have not been evaluated in randomized clinical trials to date. Usually, these patients are lumped together in studies of ra...

journal_title：Anticancer research

authors： Nieder C,Grosu AL,Astner S,Molls M

更新日期：2005-11-01 00:00:00

abstract：:Previous studies have revealed that cultured cells treated with lipophilic natural products containing aromatic rings and basic amino group usually yielded multidrug resistant (MDR) variants. These MDR cells overexpress P-glycoprotein (P-gp), most often due to gene amplification or transcriptional activation of mdr/P-...

journal_title：Anticancer research

authors： Zhao JY,Savaraj N,Song R,Priebe W,Kuo MT

更新日期：1994-09-01 00:00:00

abstract：:A 56-year-old Caucasian smoker male patient underwent right orchiectomy and spermatic cord resection for intrascrotal transilluminating mass. Histology findings suggested diagnosis of metastasis from Renal Cell Carcinoma (RCC). After positive CT-scan for primary neoplasm, total left nephrectomy was accomplished. Patie...

journal_title：Anticancer research

authors： Lauro S,Lanzetta G,Bria E,Trasatti L,Costarelli L,Vecchione A

更新日期：1998-11-01 00:00:00

abstract：BACKGROUND:Polychlorinated biphenyls (PCBs) are ubiquitous environment-contaminating synthetic chemicals that have been associated with increased risk of hepatic cancer, melanoma, non-Hodgkin lymphoma and cancer of many other body organs. Structural binding analyses of PCB 77 and PCB 118 with peroxisome proliferator-ac...

journal_title：Anticancer research

authors： Sheikh IA,Khweek AA,Beg MA

更新日期：2016-11-01 00:00:00

abstract：AIM:The present study investigated the clinical significance of tartrate-resistant acid phosphatase type-5 (ACP5) expression in gastric cancer. MATERIALS AND METHODS:In 150 specimens of gastric cancer and adjacent normal mucosa, expression of ACP5 protein and mRNA and was determined by immunohistochemical staining and...

journal_title：Anticancer research

authors： Kawamura M,Tanaka K,Toiyama Y,Okugawa Y,Okigami M,Yasuda H,Saigusa S,Ohi M,Inoue Y,Uchida K,Mohri Y,Kusunoki M

更新日期：2014-07-01 00:00:00

abstract：:The present study was performed to investigate the prognostic impact of tumor resection on survival in children and adolescents with malignant gliomas. From the HIT-GBM data base of the Gesellschaft für Paediatrische Onkologie und Haematologie (GPOH), 85 pediatric patients with malignant non-pontine gliomas were analy...

journal_title：Anticancer research

authors： Kramm CM,Wagner S,Van Gool S,Schmid H,Sträter R,Gnekow A,Rutkowski S,Wolff JE

更新日期：2006-09-01 00:00:00

abstract：BACKGROUND:The description of the different forms of circulating PSA has opened a new strategy in the diagnosis of prostate cancer. The aim of our study was to assess the diagnostic potential of PSA and the PSA fractions in the diagnosis of benign prostate hyperplasia (BPH) and prostate cancer. PATIENTS AND METHODS:We...

journal_title：Anticancer research

authors： Filella X,Alcover J,Corral JM,Molina R,Beardo P,Ballesta AM

更新日期：2001-09-01 00:00:00

abstract：BACKGROUND:NSC697923, a ubiquitin-conjugating enzyme E2 (UBE2) inhibitor, was suggested as an agent to degrade hypoxia-inducible factor 1 alpha subunit (HIF1α), a key factor in radiation resistance. We attempted to clarify whether NSC697923 could overcome radiation resistance. MATERIALS AND METHODS:Radiation resistanc...

journal_title：Anticancer research

authors： Gombodorj N,Yokobori T,Yoshiyama S,Kawabata-Iwakawa R,Rokudai S,Horikoshi I,Nishiyama M,Nakano T

更新日期：2017-05-01 00:00:00

abstract：:Pyrimidine nucleoside phosphorylase (PyNPase) is an enzyme which converts 5'-deoxy-5-fluorouridine (5'-DFUR) to 5-fluorouracil (5-FU), and is induced by various cytokines in tumor cells. We evaluated a combination of 5'-DFUR and lentinan which is widely used as a biological response modifier (BRM), to verify antitumor...

journal_title：Anticancer research

authors： Ogawa T,Ohwada S,Sato Y,Izumi M,Nakamura S,Takeyoshi I,Kawashima Y,Ohya T,Koyama T,Morishita Y

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND:Cervical cancer prevention is performed by taking Pap smears. The correct execution of the smear is crucial as an inadequate smear might result in underdiagnosis. The second means of cervical cancer prevention is visual inspection of the cervix uteri with acetic acid, while often both methods are combined. W...

journal_title：Anticancer research

authors： Hoellen F,Bohlmann MK,Brade J,Rody A,Diedrich K,Husstedt WD,Hornemann A

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND/AIM:We retrospectively investigated the relationship between pathological complete response (pCR) and tumor volume (TV) reduction during neoadjuvant chemoradiation therapy (NACRT) in non-small cell lung cancer (NSCLC). PATIENTS AND METHODS:We evaluated patients who received NACRT (50 Gy/25 fractions with pl...

journal_title：Anticancer research

authors： Takahashi S,Go T,Anada M,Kinoshita T,Nishide T,Yokomise H,Shibata T

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND/AIM:As a result of activation of transcription factors engaged in epithelial-mesenchymal transition (EMT), such as Twist, inhibition of epithelial markers and an increased expression of mesenchymal markers are observed. One of the specific markers of cancer-associated fibroblasts is podoplanin (PDPN) - a muc...

journal_title：Anticancer research

authors： Grzegrzolka J,Wojtyra P,Biala M,Piotrowska A,Gomulkiewicz A,Rys J,Podhorska-Okolow M,Dziegiel P

更新日期：2017-10-01 00:00:00

abstract：:Immunohistochemical analysis of the p53 tumor suppressor gene was performed in 69 human pancreatic ductal adenocarcinomas, using a highly specific anti-p53 antibody. Nuclear immunoreactivity was found in 40 tumors, yielding an overall frequency of 58%. Immunoblotting confirmed that nuclear immunoreactivity was associa...

journal_title：Anticancer research

authors： Yokoyama M,Yamanaka Y,Friess H,Buchler M,Korc M

更新日期：1994-11-01 00:00:00

abstract：BACKGROUND:Dihydropyrimidine dehydrogenase (DPD) is the rate-limiting enzyme of 5-fluorouracil (5-FU) catabolism. Several studies have demonstrated the clinical importance of DPD in cancer patients, suggesting that the efficacy of 5-FU may be related to DPD activity in tumor tissue. In the present study, DPD activity a...

journal_title：Anticancer research

authors： Inada T,Ogata Y,Kubota T,Tomikawa M,Yamamoto S,Andoh J,Ozawa I,Hishinuma S,Shimizu H,Kotake K

更新日期：2000-07-01 00:00:00

abstract：BACKGROUND:Despite the key role of mutational analysis in targeted therapy, the difficulty in acquisition of adequate tumor tissues for molecular genotyping in advanced non-small cell lung cancer (NSCLC) has led to the need for a fast and efficient method for detecting genetic alterations for targeted therapy. PATIENT...

journal_title：Anticancer research

authors： Maeng CH,Lee HY,Kim YW,Choi MK,Hong JY,Jung HA,Lee KS,Kim H,Kwon OJ,Sun JM,Ahn JS,Park K,Um SW,Ahn MJ

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:Both liposomal doxorubicin (LD) and docetaxel (D) have a broad range of activity against solid tumors, including advanced pancreatic cancer (APC), as single agents, while their combination has produced encouraging response rates in the treatment of several malignancies. We have conducted a Phase-II study in ...

journal_title：Anticancer research

authors： Syrigos KN,Michalaki B,Alevyzaki F,Machairas A,Mandrekas D,Kindilidis K,Karatzas G

更新日期：2002-11-01 00:00:00

abstract：:Five functionalized benz(c)acridines - 5,6-dimethylbenz(c)acridine; 5,6,7-trimethylbenz(c)acridine; 7-chloro-5,6-dimethylbenz(c)acridine; 7-amino-5,6-dimethylbenz(c)acridine; 7-oxo-5,6-dimethylbenz(c)-acridine and 5,6-dimethylbenz(a)phenazine - were tested for mutagenic activity in the Ames Salmonella typhimurium assa...

journal_title：Anticancer research

authors： Walker BA,Rogan EG,Cromwell NH

更新日期：1984-11-01 00:00:00

abstract：BACKGROUND:Primary prostate carcinoma cells constitutively secrete interleukin-6 (IL-6), and high levels of IL-6 receptor are detected in prostate carcinoma tissues. These findings have implicated IL-6 in the growth and differentiation of prostate carcinomas. Herein, we examined the regulation of IL-6 receptor complex ...

journal_title：Anticancer research

authors： Mori S,Murakami-Mori K,Bonavida B

更新日期：1998-11-01 00:00:00

abstract：AIM:Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is a promising target for cancer therapy. We have already started a phase I study of CRM197, a specific HB-EGF inhibitor, for advanced ovarian cancer. In this study, we evaluated possible clinical adaptations of CRM197 in combination with conventio...

journal_title：Anticancer research

authors： Tsujioka H,Fukami T,Yotsumoto F,Ueda T,Hikita S,Takahashi Y,Kondo H,Kuroki M,Miyamoto S

更新日期：2011-07-01 00:00:00