The effect of coronary artery reperfusion on the extent of myocardial infarction.

Abstract:

:The effect of the reperfusion on myocardial infarction has been studied in the rat in order to assess the possible reversibility of myocardial damage. The present study deals with reperfusion of experimental myocardial infarction in the rat. Two groups of animals were compared: one was subjected to permanent ischemia and the other was subjected to ischemia of variable duration 1) hour to 24 hours). The differences between infarction caused by permanent ischemia and the evolution of infarction following reperfusion were studied by means of histologic (121 specimens) histoenzymatic (56 specimens), ECG (100 specimens), techniques and study of the mcirocirculation (70 specimens). The size of the infarctions caused by temporary ischemia was found to be significantly smaller in 60% of the cases as compared to the infarctions caused by permanent ischemia. Histoenzymatic study (phosphorylase activity and succinodehydrogenase activity) confirmed the existance of a marginal zone extending over one third of the surface of the ischemic myocardium: reperfusion permitted the salvage of this zone and thereby diminished the extent of necrosis. The latter findings were further confirmed by the ECG study showing earlier regression of ischemic ST changes following early reperfusion. Microcirculatory changes secondary to anoxia may account for the fact that, in a certain percentage of the cases, early reperfusion does not prevent extension of infarction.

journal_name

Am Heart J

journal_title

American heart journal

authors

Deloche A,Fabiani JN,Camilleri JP,Relland J,Joseph D,Carpentier A,Dubost C

doi

10.1016/s0002-8703(77)80255-x

subject

Has Abstract

pub_date

1977-03-01 00:00:00

pages

358-66

issue

3

eissn

0002-8703

issn

1097-6744

pii

S0002-8703(77)80255-X

journal_volume

93

pub_type

杂志文章