Detecting life-threatening lactic acidosis related to nucleoside-analog treatment of human immunodeficiency virus-infected patients, and treatment with L-carnitine.

abstract：OBJECTIVES:To assess the variability in short-term sepsis mortality by hospital among Centers for Medicare and Medicaid Services beneficiaries in the United States during 2013-2014. DESIGN:A retrospective cohort design. SETTING:Hospitalizations from 3,068 acute care hospitals that participated in the Centers for Medi...

journal_title：Critical care medicine

authors： Hatfield KM,Dantes RB,Baggs J,Sapiano MRP,Fiore AE,Jernigan JA,Epstein L

更新日期：2018-11-01 00:00:00

abstract：OBJECTIVE:High-frequency oscillation has been proposed for use in adult acute respiratory distress syndrome. However, limited data are available on the effect of pressure amplitude and rate (Hz) on tidal volumes delivered during high-frequency oscillation in adults. DESIGN:Prospective, animal model, lung injury study....

journal_title：Critical care medicine

authors： Sedeek KA,Takeuchi M,Suchodolski K,Kacmarek RM

更新日期：2003-01-01 00:00:00

abstract：:Ventricular fibrillation (VF) can masquerade as asystole. We report a 54-yr-old male in cardiac arrest who, on surface ECG, appeared to be in VF or asystole. A bedside intracardiac recording using a transmyocardial pacing wire showed the true rhythm to be atrial fibrillation (AF) with high grade atrioventricular block...

journal_title：Critical care medicine

authors： Ornato JP,Gonzales ER,Garnett R

更新日期：1987-04-01 00:00:00

abstract：OBJECTIVES:Cardiac arrest etiology may be an important source of between-patient heterogeneity, but the impact of etiology on organ injury is unknown. We tested the hypothesis that asphyxial cardiac arrest results in greater neurologic injury than cardiac etiology cardiac arrest (ventricular fibrillation cardiac arrest...

journal_title：Critical care medicine

authors： Uray T,Lamade A,Elmer J,Drabek T,Stezoski JP,Missé A,Janesko-Feldman K,Garman RH,Chen N,Kochanek PM,Dezfulian C,Callaway CW,Doshi AA,Frisch A,Guyette FX,Reynolds JC,Rittenberger JC,University of Pittsburgh Post-Cardiac

更新日期：2018-06-01 00:00:00

abstract：OBJECTIVE:To investigate relationships between acute adrenergic stress, plasma catecholamine concentrations, and beta 2-adrenergic receptors. DESIGN:Prospective, descriptive study. SETTING:Emergency medical service at a university hospital. PATIENTS:Twenty-seven patients with out-of-hospital cardiac arrest (n = 11),...

journal_title：Critical care medicine

authors： Prengel AW,Lindner KH,Anhäupl T,Trunk E,Georgieff M,Lurie KG

更新日期：1997-04-01 00:00:00

abstract：OBJECTIVE:To test the hypothesis that the hypocalcemia and hypoparathyroidism that follow severe burn injury are related to up-regulation of the parathyroid gland calcium-sensing receptor (CaR), which may reduce the set-point for suppression of circulating parathyroid hormone by blood calcium. DESIGN:A controlled but ...

journal_title：Critical care medicine

authors： Murphey ED,Chattopadhyay N,Bai M,Kifor O,Harper D,Traber DL,Hawkins HK,Brown EM,Klein GL

更新日期：2000-12-01 00:00:00

abstract：OBJECTIVES:Formal guidelines recommend that therapeutic hypothermia be considered after in-hospital cardiac arrest. The rate of therapeutic hypothermia use after in-hospital cardiac arrest and details about its implementation are unknown. We aimed to determine the use of therapeutic hypothermia for adult in-hospital ca...

journal_title：Critical care medicine

authors： Mikkelsen ME,Christie JD,Abella BS,Kerlin MP,Fuchs BD,Schweickert WD,Berg RA,Mosesso VN,Shofer FS,Gaieski DF,American Heart Association’s Get With the Guidelines-Resuscitation Investigators.

更新日期：2013-06-01 00:00:00

abstract：OBJECTIVE:Recent in vivo studies of both septic humans and animals demonstrate that leukocyte delivery is attenuated to sites remote from the primary infection. The mechanisms for this are not entirely clear. L-selectin is integral to rolling, the first step in leukocyte recruitment to an inflammatory site. L-selectin ...

journal_title：Critical care medicine

authors： Ferri LE,Swartz D,Christou NV

更新日期：2001-01-01 00:00:00

abstract：:During the treatment of 26 shocked patients, measurements were made of the central blood to peripheral skin temperature gradient. No significant correlation was found between this gradient and cardiac index (CI), or systemic vascular resistance (SVR) or its index (SVRI). There was no significant correlation between th...

journal_title：Critical care medicine

authors： Woods I,Wilkins RG,Edwards JD,Martin PD,Faragher EB

更新日期：1987-09-01 00:00:00

abstract：OBJECTIVES:Radial artery pressure is known to differ from central arterial pressure in normal patients (distal pulse amplification) and in the early postcardiopulmonary bypass period. The adequacy of the radial artery as a site for blood pressure monitoring in critically ill patients receiving high-dose vasopressors ha...

journal_title：Critical care medicine

authors： Dorman T,Breslow MJ,Lipsett PA,Rosenberg JM,Balser JR,Almog Y,Rosenfeld BA

更新日期：1998-10-01 00:00:00

abstract：OBJECTIVE:Cortisol clearance is reduced in sepsis and may contribute to the development of impaired adrenocortical function that is thought to contribute to the pathophysiology of critical illness-related corticosteroid insufficiency. We sought to assess adrenocortical function using computer-assisted numerical modelin...

journal_title：Critical care medicine

authors： Dorin RI,Qualls CR,Torpy DJ,Schrader RM,Urban FK 3rd

更新日期：2015-03-01 00:00:00

abstract：OBJECTIVE:To study the effect of early and continuous venovenous hemofiltration (CVVH) on the plasma concentrations of several humoral mediators of inflammation and subsequent organ dysfunction in septic patients. DESIGN:Randomized, controlled trial. SETTING:Intensive care unit of a tertiary hospital. PATIENTS:Twent...

journal_title：Critical care medicine

authors： Cole L,Bellomo R,Hart G,Journois D,Davenport P,Tipping P,Ronco C

更新日期：2002-01-01 00:00:00

abstract：OBJECTIVES:To evaluate knowledge translation after publication of the target temperature management 33°C versus 36°C after out-of-hospital cardiac arrest trial and associated patient outcomes. Our primary hypothesis was that target temperature management at 36°C was rapidly adopted in Australian and New Zealand ICUs. S...

journal_title：Critical care medicine

authors： Salter R,Bailey M,Bellomo R,Eastwood G,Goodwin A,Nielsen N,Pilcher D,Nichol A,Saxena M,Shehabi Y,Young P,Australian and New Zealand Intensive Care Society Centre for Outcome and Resource Evaluation (ANZICS-CORE).

更新日期：2018-11-01 00:00:00

abstract：OBJECTIVES:To assess trends in the use of extracorporeal membrane oxygenation for poisoning in the United States. DESIGN:Retrospective cohort study. SETTING:The National Poison Data System, the databased owned and managed by the American Association of Poison Control Centers, the organization that supports and accred...

journal_title：Critical care medicine

authors： Cole JB,Olives TD,Ulici A,Litell JM,Bangh SA,Arens AM,Puskarich MA,Prekker ME

更新日期：2020-08-01 00:00:00

abstract：OBJECTIVE:To investigate the relationship between nitric oxide production, endotoxemia, and hemodynamic alterations in human septic shock. DESIGN:Prospective study. SETTING:A 32-bed intensive care unit in a university referral hospital. PATIENTS:Two groups of septic patients with shock (n = 13) or without shock (n =...

journal_title：Critical care medicine

authors： Gómez-Jiménez J,Salgado A,Mourelle M,Martín MC,Segura RM,Peracaula R,Moncada S

更新日期：1995-02-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to evaluate the relationship of patient care variables to survival and functional outcome in the pediatric population with traumatic brain injury. DESIGN:Retrospective chart review. SETTING:A 16-bed pediatric critical care unit in an academic community children's hospital. PATIENT...

journal_title：Critical care medicine

authors： Hackbarth RM,Rzeszutko KM,Sturm G,Donders J,Kuldanek AS,Sanfilippo DJ

更新日期：2002-07-01 00:00:00

abstract：OBJECTIVE:To investigate the optimal rewarming rate following therapeutic hypothermia in a rate model of cardiopulmonary resuscitation. Both clinical and laboratory studies have demonstrated that mild therapeutic hypothermia following cardiopulmonary resuscitation improves myocardial and neurologic outcomes of cardiac ...

journal_title：Critical care medicine

authors： Lu X,Ma L,Sun S,Xu J,Zhu C,Tang W

更新日期：2014-02-01 00:00:00

abstract：OBJECTIVE:Sepsis-induced multi-organ failure continues to have a high mortality. The liver is an organ central to the disease pathogenesis. The objective of this study was to identify the liver proteins that change in abundance with sepsis and subsequently identify new drug targets. DESIGN:Proteomic discovery study an...

journal_title：Critical care medicine

authors： Dear JW,Leelahavanichkul A,Aponte A,Hu X,Constant SL,Hewitt SM,Yuen PS,Star RA

更新日期：2007-10-01 00:00:00

abstract：OBJECTIVE:To test whether spectral indices derived from the electroencephalogram (EEG), and especially the bispectral index (BIS), can be used as measures of neurologic status in unsedated, critically ill patients. DESIGN:Prospective, observational study. SETTING:Medical intensive care unit (ICU) of a university-affi...

journal_title：Critical care medicine

authors： Gilbert TT,Wagner MR,Halukurike V,Paz HL,Garland A

更新日期：2001-10-01 00:00:00

abstract：OBJECTIVE:With limited community services, the complex rehabilitation period after critical illness is often the responsibility of family members who, as a result, may experience negative health outcomes. The objectives of this research were to a) identify aspects of the caregiving situation that are associated with ca...

journal_title：Critical care medicine

authors： Cameron JI,Herridge MS,Tansey CM,McAndrews MP,Cheung AM

更新日期：2006-01-01 00:00:00

abstract：OBJECTIVE:Monitoring of ventilation performance during cardiopulmonary resuscitation would be desirable to improve the quality of cardiopulmonary resuscitation. To investigate the potential for measuring ventilation rate and inspiration time, we calculated the correlation in waveform between transthoracic impedance mea...

journal_title：Critical care medicine

authors： Losert H,Risdal M,Sterz F,Nysaether J,Köhler K,Eftestøl T,Wandaller C,Myklebust H,Uray T,Sodeck G,Laggner AN

更新日期：2006-09-01 00:00:00

abstract：OBJECTIVES:Over 2,500 children undergo hematopoietic stem cell transplantation in the United States each year, and up to 35% require PICU support for life-threatening complications. PICU mortality has dropped from 85% to 44%, but interpretation is confounded by significant cohort heterogeneity. Reports conflict regardi...

journal_title：Critical care medicine

authors： Zinter MS,Dvorak CC,Spicer A,Cowan MJ,Sapru A

更新日期：2015-09-01 00:00:00

abstract：OBJECTIVE:To determine the activation of nuclear factor-[kappa]B in peripheral blood CD14+ monocyte/macrophages and CD3+, CD4+, and CD8+ T cells in children with sepsis. DESIGN:Observational study. SETTING:University hospital. PATIENTS:Twenty-six children with sepsis (nine females and 17 males, aged between 10 days ...

journal_title：Critical care medicine

authors： Hotta N,Ichiyama T,Shiraishi M,Takekawa T,Matsubara T,Furukawa S

更新日期：2007-10-01 00:00:00

abstract：OBJECTIVE:Circulating serum levels of procalcitonin rise significantly during bacterial infection. Because calcitonin is known to be a monocyte chemoattractant, we investigated whether procalcitonin, a prohormone of calcitonin, also affects leukocyte migration. DESIGN:Prospective, controlled in vitro study. SETTING:U...

journal_title：Critical care medicine

authors： Wiedermann FJ,Kaneider N,Egger P,Tiefenthaler W,Wiedermann CJ,Lindner KH,Schobersberger W

更新日期：2002-05-01 00:00:00

abstract：OBJECTIVE:To determine the long-term outcome of noninvasive ventilation in chronic obstructive pulmonary disease patients who refused intubation for acute hypercapnic respiratory failure. DESIGN:Prospective, observational study. SETTING:Noninvasive ventilation unit in an acute regional hospital in Hong Kong. METHODS...

journal_title：Critical care medicine

authors： Chu CM,Chan VL,Wong IW,Leung WS,Lin AW,Cheung KF

更新日期：2004-02-01 00:00:00

abstract：:We previously reported that small volume infusions of 7.5% NaCl in 6% dextran-70 (HSD) are superior to equal volumes of normal saline (NS) or 7.5% NaCl in the ability to resuscitate animals from an otherwise lethal hemorrhage. In the present experiment, we evaluated organ blood flow in unanesthetized swine bled 46 ml/...

journal_title：Critical care medicine

authors： Maningas PA

更新日期：1987-12-01 00:00:00

abstract：BACKGROUND:Septic shock represents the major cause of infection-associated mortality in the intensive care unit. The possibility that combination antibiotic therapy of bacterial septic shock improves outcome is controversial. Current guidelines do not recommend combination therapy except for the express purpose of broa...

journal_title：Critical care medicine

authors： Kumar A,Zarychanski R,Light B,Parrillo J,Maki D,Simon D,Laporta D,Lapinsky S,Ellis P,Mirzanejad Y,Martinka G,Keenan S,Wood G,Arabi Y,Feinstein D,Kumar A,Dodek P,Kravetsky L,Doucette S,Cooperative Antimicrobial Thera

更新日期：2010-09-01 00:00:00

abstract：:Accurate assessment and rapid decision-making are essential to save lives and improve performance in critical care medicine. Real-time point-of-care ultrasound has become an invaluable adjunct to the clinical evaluation of critically ill and injured patients both for pre- and in-hospital situations. However, a high le...

journal_title：Critical care medicine

authors： Neri L,Storti E,Lichtenstein D

更新日期：2007-05-01 00:00:00

abstract：OBJECTIVE:Information booklets have not been assessed by the families of intensive care unit (ICU) patients. This study explored the information that the relatives of adult ICU patients wanted to find in the information booklets. DESIGN:Multicenter survey. SETTING:Twenty-three French ICUs. SUBJECTS:One close relativ...

journal_title：Critical care medicine

authors： Soltner C,Lassalle V,Galienne-Bouygues S,Pottecher J,Floccard B,Delapierre L,Jungfer F,Sargentini C,Alberti C,Beydon L,Lifrea Group.

更新日期：2009-07-01 00:00:00

abstract：OBJECTIVES:Increases in exhaled nitric oxide have been demonstrated to originate from the lungs of rats after septic lung injury. The aim of this study was to investigate whether treatment with the nitric oxide synthase inhibitor N-nitro-L-arginine methyl ester (L-NAME) would prevent lipopolysaccharide (LPS)-induced in...

journal_title：Critical care medicine

authors： Aaron SD,Valenza F,Volgyesi G,Mullen JB,Slutsky AS,Stewart TE

更新日期：1998-02-01 00:00:00