Resuscitation with 7.5% NaCl in 6% dextran-70 during hemorrhagic shock in swine: effects on organ blood flow.

Abstract:

:We previously reported that small volume infusions of 7.5% NaCl in 6% dextran-70 (HSD) are superior to equal volumes of normal saline (NS) or 7.5% NaCl in the ability to resuscitate animals from an otherwise lethal hemorrhage. In the present experiment, we evaluated organ blood flow in unanesthetized swine bled 46 ml/kg in 15 min and subsequently infused with a volume of HSD (n = 5) or NS (n = 5) equal to 25% of the shed blood. Radiomicrospheres were injected before hemorrhage, immediately after hemorrhage, and 5 and 30 min after treatment. At the end of hemorrhage, cardiac output had fallen to one-third of baseline values. Five minutes after the infusion of HSD, cardiac output had returned to baseline levels, while cardiac output in the NS-treated controls had increased to only one-half of prehemorrhage values. Blood flows to the brain, diaphragm, skin, muscle, and fat were not different between the two groups. Infusion with HSD, however, produced flows to the myocardium, kidneys, liver, small intestine, and pancreas that were significantly greater than post-hemorrhage and NS-treated control values. NS was unable to increase these flows significantly above post-hemorrhage levels. We conclude that small volumes of HSD can significantly improve organ blood flow after hemorrhagic shock. This improvement in flow may explain the increased survival observed with this solution and may attenuate some of the later complications of hemorrhagic shock.

journal_name

Crit Care Med

journal_title

Critical care medicine

authors

Maningas PA

doi

10.1097/00003246-198712000-00009

subject

Has Abstract

pub_date

1987-12-01 00:00:00

pages

1121-6

issue

12

eissn

0090-3493

issn

1530-0293

journal_volume

15

pub_type

杂志文章
  • Cost of acute renal failure requiring dialysis in the intensive care unit: clinical and resource implications of renal recovery.

    abstract:OBJECTIVE:Acute renal failure can be treated with continuous renal replacement therapy (CRRT) or intermittent hemodialysis. There is no difference in mortality, although patients treated with CRRT may have a higher rate of renal recovery. Given these considerations, an estimate of the costs by modality may help in choo...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/01.CCM.0000045182.90302.B3

    authors: Manns B,Doig CJ,Lee H,Dean S,Tonelli M,Johnson D,Donaldson C

    更新日期:2003-02-01 00:00:00

  • Feasibility and effects of the semirecumbent position to prevent ventilator-associated pneumonia: a randomized study.

    abstract:CONTEXT:Reducing aspiration of gastric contents by placing mechanically ventilated patients in a semirecumbent position has been associated with lower incidences of ventilator-associated pneumonia (VAP). The feasibility and efficacy of this intervention in a larger patient population, however, are unknown. OBJECTIVE:A...

    journal_title:Critical care medicine

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1097/01.ccm.0000198529.76602.5e

    authors: van Nieuwenhoven CA,Vandenbroucke-Grauls C,van Tiel FH,Joore HC,van Schijndel RJ,van der Tweel I,Ramsay G,Bonten MJ

    更新日期:2006-02-01 00:00:00

  • Distinct pathways of lipopolysaccharide priming of human neutrophil respiratory burst: role of lipid mediator synthesis and sensitivity to interleukin-10.

    abstract:OBJECTIVE:Exposure of neutrophils to low doses of bacterial lipopolysaccharides enhances their readiness to respond with inflammatory mediator generation including oxygen radical formation to a subsequently applied inflammatory stimulus ("priming"). In the present study, we investigated the role of lipid mediator synth...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-200210000-00020

    authors: Sibelius U,Hattar K,Hoffmann S,Mayer K,Grandel U,Schenkel A,Seeger W,Grimminger F

    更新日期:2002-10-01 00:00:00

  • Effectiveness Analysis of a Part-Time Rapid Response System During Operation Versus Nonoperation.

    abstract:OBJECTIVES:To evaluate the effect of a part-time rapid response system on the occurrence rate of cardiopulmonary arrest by comparing the times of rapid response system operation versus nonoperation. DESIGN:Retrospective cohort study. SETTING:A 1,360-bed tertiary care hospital. PATIENTS:Adult patients admitted to the...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/CCM.0000000000002314

    authors: Kim Y,Lee DS,Min H,Choi YY,Lee EY,Song I,Park JS,Cho YJ,Jo YH,Yoon HI,Lee JH,Lee CT,Do SH,Lee YJ

    更新日期:2017-06-01 00:00:00

  • Need for advanced cardiac life-support training in rural, community hospitals.

    abstract:OBJECTIVE:To define the relative needs of the staffs of rural, community hospitals for training in advanced cardiac life support (ACLS), identify weaknesses, and modify a standard ACLS course to meet these needs. DESIGN:Prospective assessment of knowledge and skills relating to the practice of ACLS. SETTING:Rural, co...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-199405000-00006

    authors: Birnbaum ML,Kuska BM,Stone HL,Robinson NE

    更新日期:1994-05-01 00:00:00

  • Protecting healthcare workers from pandemic influenza: N95 or surgical masks?

    abstract:OBJECTIVE:The successful management of an influenza pandemic will be reliant on the expertise of healthcare workers at high risk for occupationally acquired influenza. Recommended infection control measures for healthcare workers include surgical masks to protect against droplet-spread respiratory transmissible infecti...

    journal_title:Critical care medicine

    pub_type: 杂志文章,评审

    doi:10.1097/ccm.0b013e3181b9e8b3

    authors: Gralton J,McLaws ML

    更新日期:2010-02-01 00:00:00

  • What's in a day? Determining intensive care unit length of stay.

    abstract:OBJECTIVE:Intensive care unit (ICU) length of stay (LOS) and hospital LOS are common indices used to compare performance of hospitals and are yardsticks used in efforts to contain costs, yet there is no standardized method of quantitating this outcome variable. Attempts have been made to correct LOS according to diseas...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-200006000-00071

    authors: Marik PE,Hedman L

    更新日期:2000-06-01 00:00:00

  • The effect of daily bathing with chlorhexidine on the acquisition of methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus, and healthcare-associated bloodstream infections: results of a quasi-experimental multicenter trial.

    abstract:OBJECTIVE:Spread of multidrug-resistant organisms within the intensive care unit (ICU) results in substantial morbidity and mortality. Novel strategies are needed to reduce transmission. This study sought to determine if the use of daily chlorhexidine bathing would decrease the incidence of colonization and bloodstream...

    journal_title:Critical care medicine

    pub_type: 杂志文章,多中心研究

    doi:10.1097/CCM.0b013e31819ffe6d

    authors: Climo MW,Sepkowitz KA,Zuccotti G,Fraser VJ,Warren DK,Perl TM,Speck K,Jernigan JA,Robles JR,Wong ES

    更新日期:2009-06-01 00:00:00

  • Hydrocortisone prevents immunosuppression by interleukin-10+ natural killer cells after trauma-hemorrhage.

    abstract:OBJECTIVE:Trauma induces a state of immunosuppression, which is responsible for the development of nosocomial infections. Hydrocortisone reduces the rate of pneumonia in patients with trauma. Because alterations of dendritic cells and natural killer cells play a central role in trauma-induced immunosuppression, we inve...

    journal_title:Critical care medicine

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1097/CCM.0000000000000658

    authors: Roquilly A,Broquet A,Jacqueline C,Masson D,Segain JP,Braudeau C,Vourc'h M,Caillon J,Altare F,Josien R,Retière C,Villadangos J,Asehnoune K

    更新日期:2014-12-01 00:00:00

  • Changes in brain tissue oxygenation after treatment of diffuse traumatic brain injury by erythropoietin.

    abstract:OBJECTIVES:To investigate the effects of recombinant human erythropoietin on brain oxygenation in a model of diffuse traumatic brain injury. DESIGN:Adult male Wistar rats. SETTING:Neurosciences and physiology laboratories. INTERVENTIONS:Thirty minutes after diffuse traumatic brain injury (impact-acceleration model),...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/CCM.0b013e31827ca64e

    authors: Bouzat P,Millet A,Boue Y,Pernet-Gallay K,Trouve-Buisson T,Gaide-Chevronnay L,Barbier EL,Payen JF

    更新日期:2013-05-01 00:00:00

  • Radial artery pressure monitoring underestimates central arterial pressure during vasopressor therapy in critically ill surgical patients.

    abstract:OBJECTIVES:Radial artery pressure is known to differ from central arterial pressure in normal patients (distal pulse amplification) and in the early postcardiopulmonary bypass period. The adequacy of the radial artery as a site for blood pressure monitoring in critically ill patients receiving high-dose vasopressors ha...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-199810000-00014

    authors: Dorman T,Breslow MJ,Lipsett PA,Rosenberg JM,Balser JR,Almog Y,Rosenfeld BA

    更新日期:1998-10-01 00:00:00

  • Educational objectives for house staff in the pediatric intensive care unit.

    abstract::The educational objectives in use in our Pediatric ICU are described. These have importance for educational programs in critical care medicine, in particular, where patient care needs can easily overwhelm educational needs. It is important not to overlook our role as teachers in the development of proper attitudes and...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-197705000-00008

    authors: Kravath RE

    更新日期:1977-05-01 00:00:00

  • Neglect of quality-of-life considerations in intensive care unit family meetings for long-stay intensive care unit patients.

    abstract:OBJECTIVE:To examine the frequency with which quality of life and treatment limitation were discussed in formal family meetings for long-stay intensive care unit patients with high risk for mortality and morbidity. DESIGN:Descriptive observational study. SETTING:Five intensive care units. PATIENTS:One hundred sixtee...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/CCM.0b013e318232d8c4

    authors: Douglas SL,Daly BJ,Lipson AR

    更新日期:2012-02-01 00:00:00

  • Morbid obesity is an independent determinant of death among surgical critically ill patients.

    abstract:OBJECTIVE:To determine whether extreme obesity (morbid obesity; body mass index > or =40 kg/m(2)) is an independent risk factor for death among critically ill patients; this objective is most salient in the subset of patients who sustain a prolonged intensive care unit stay during which the burdens of care imposed by o...

    journal_title:Critical care medicine

    pub_type: 评论,杂志文章

    doi:10.1097/01.CCM.0000205758.18891.70

    authors: Nasraway SA Jr,Albert M,Donnelly AM,Ruthazer R,Shikora SA,Saltzman E

    更新日期:2006-04-01 00:00:00

  • Use of therapeutic hypothermia after in-hospital cardiac arrest.

    abstract:OBJECTIVES:Formal guidelines recommend that therapeutic hypothermia be considered after in-hospital cardiac arrest. The rate of therapeutic hypothermia use after in-hospital cardiac arrest and details about its implementation are unknown. We aimed to determine the use of therapeutic hypothermia for adult in-hospital ca...

    journal_title:Critical care medicine

    pub_type: 杂志文章,多中心研究

    doi:10.1097/CCM.0b013e318287f2c4

    authors: Mikkelsen ME,Christie JD,Abella BS,Kerlin MP,Fuchs BD,Schweickert WD,Berg RA,Mosesso VN,Shofer FS,Gaieski DF,American Heart Association’s Get With the Guidelines-Resuscitation Investigators.

    更新日期:2013-06-01 00:00:00

  • Tumor necrosis factor in the pathogenesis of infectious diseases.

    abstract:OBJECTIVES:To review the immunologic role of the cytokines and the specific role that tumor necrosis factor (TNF) plays in response to infection. The influence of bacterial lipopolysaccharide on TNF, the cytokine cascade, and resultant pathologies are also reviewed. DATA SOURCES:A MEDLINE search of the international E...

    journal_title:Critical care medicine

    pub_type: 杂志文章,评审

    doi:

    authors: Beutler B,Grau GE

    更新日期:1993-10-01 00:00:00

  • Comparison of multiple organ dysfunction scores in the prediction of hospital mortality in the critically ill.

    abstract:OBJECTIVE:To compare the scales and predictive power for hospital mortality of three recent multiple organ dysfunction scores. DESIGN:Prospective, observational, validation cohort study. SETTING:A ten-bed medical-surgical intensive care unit in a Finnish tertiary care hospital. PATIENTS:Among the 591 consecutive pat...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-200208000-00005

    authors: Pettilä V,Pettilä M,Sarna S,Voutilainen P,Takkunen O

    更新日期:2002-08-01 00:00:00

  • Extracellular Mitochondrial DNA and N-Formyl Peptides in Trauma and Critical Illness: A Systematic Review.

    abstract:OBJECTIVES:Extracellular mitochondrial DNA and N-formyl peptides released following tissue damage may contribute to systemic inflammation through stimulation of the innate immune system. In this review, we evaluate existing in vivo human data regarding a role for mitochondrial DNA and N-formyl peptides in producing sys...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/CCM.0000000000003381

    authors: Lubkin DT,Bishawi M,Barbas AS,Brennan TV,Kirk AD

    更新日期:2018-12-01 00:00:00

  • American College of Critical Care Medicine Clinical Practice Parameters for Hemodynamic Support of Pediatric and Neonatal Septic Shock.

    abstract:OBJECTIVES:The American College of Critical Care Medicine provided 2002 and 2007 guidelines for hemodynamic support of newborn and pediatric septic shock. Provide the 2014 update of the 2007 American College of Critical Care Medicine "Clinical Guidelines for Hemodynamic Support of Neonates and Children with Septic Shoc...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/CCM.0000000000002425

    authors: Davis AL,Carcillo JA,Aneja RK,Deymann AJ,Lin JC,Nguyen TC,Okhuysen-Cawley RS,Relvas MS,Rozenfeld RA,Skippen PW,Stojadinovic BJ,Williams EA,Yeh TS,Balamuth F,Brierley J,de Caen AR,Cheifetz IM,Choong K,Conway E Jr,Cor

    更新日期:2017-06-01 00:00:00

  • Insulin inhibits tumor necrosis factor-alpha induction in myocardial ischemia/reperfusion: role of Akt and endothelial nitric oxide synthase phosphorylation.

    abstract:OBJECTIVES:Intensive insulin therapy with tight glucose control is known to result in reduced morbidity and mortality in inflammation-related critical illness. Tumor necrosis factor (TNF)-alpha induction in myocardial infarction may trigger inflammation and have detrimental effects on cardiomyocytes. This study was des...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/CCM.0b013e3181782335

    authors: Li J,Zhang H,Wu F,Nan Y,Ma H,Guo W,Wang H,Ren J,Das UN,Gao F

    更新日期:2008-05-01 00:00:00

  • Hypoxia-reoxygenation is as damaging as ischemia-reperfusion in the rat liver.

    abstract:OBJECTIVE:We hypothesized that the extent of injury and release of xanthine oxidase, an oxidant generator, into the circulation would be less in normal-flow hypoxia-reoxygenation than in equal duration no-flow ischemia-reperfusion. DESIGN:Randomized study. SETTING:University-based animal research facility. SUBJECTS:...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-199806000-00034

    authors: Tan S,Yokoyama Y,Wang Z,Zhou F,Nielsen V,Murdoch AD,Adams C,Parks DA

    更新日期:1998-06-01 00:00:00

  • Effects of temperature on bleeding time and clotting time in normal male and female volunteers.

    abstract:OBJECTIVE:This study was done to assess the effects of temperature on bleeding time and clotting time in normal male and female volunteers. DESIGN:Open study utilizing normal volunteers. SETTING:University research laboratory. SUBJECTS:Fifty-four healthy male and female volunteers, ranging in age from 19 to 35 yrs, ...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-199504000-00019

    authors: Valeri CR,MacGregor H,Cassidy G,Tinney R,Pompei F

    更新日期:1995-04-01 00:00:00

  • The Impella 2.5 and 5.0 devices for ST-elevation myocardial infarction patients presenting with severe and profound cardiogenic shock: the Academic Medical Center intensive care unit experience.

    abstract:OBJECTIVE:Cardiogenic shock remains an important therapeutic challenge, with high in-hospital mortality rates. Mechanical circulatory support may be beneficial in these patients. Since the efficacy of the intra-aortic balloon pump seems limited, new percutaneously placed mechanical left ventricular support devices, suc...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/CCM.0b013e31821e89b5

    authors: Engström AE,Cocchieri R,Driessen AH,Sjauw KD,Vis MM,Baan J,de Jong M,Lagrand WK,van der Sloot JA,Tijssen JG,de Winter RJ,de Mol BA,Piek JJ,Henriques JP

    更新日期:2011-09-01 00:00:00

  • Extracorporeal Membrane Oxygenation for Poisonings Reported to U.S. Poison Centers from 2000 to 2018: An Analysis of the National Poison Data System.

    abstract:OBJECTIVES:To assess trends in the use of extracorporeal membrane oxygenation for poisoning in the United States. DESIGN:Retrospective cohort study. SETTING:The National Poison Data System, the databased owned and managed by the American Association of Poison Control Centers, the organization that supports and accred...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/CCM.0000000000004401

    authors: Cole JB,Olives TD,Ulici A,Litell JM,Bangh SA,Arens AM,Puskarich MA,Prekker ME

    更新日期:2020-08-01 00:00:00

  • Retention of cardiopulmonary resuscitation skills after initial overtraining.

    abstract::The authors have examined cardiopulmonary resuscitation (CPR) skills retention in a police force initially trained to instructor level performance skills as defined by the 1977 American Heart Association Instructor Manual. In 1977, the entire Winnipeg Police Force received a basic 8-h course of CPR training with recor...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-198011000-00011

    authors: Tweed WA,Wilson E,Isfeld B

    更新日期:1980-11-01 00:00:00

  • Critical care for clonidine poisoning in toddlers.

    abstract::Clonidine may be a source of serious toxicity when ingested by toddlers. We describe 11 cases of clonidine ingestion by toddlers (mean dose 0.15 mg/kg; range 0.01 to 0.57). The source of the clonidine was a grand-parent in six of 11 cases. Symptoms included altered level of consciousness (n = 11), miosis (n = 5), brad...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-199010000-00014

    authors: Fiser DH,Moss MM,Walker W

    更新日期:1990-10-01 00:00:00

  • Foreign-body pneumonitis associated with tracheostomy.

    abstract::Foreign-body aspiration in adults is usually associated with asphyxiation after aspiration of food particles. The present report documents a case of foreign-body aspiration that resulted from poor tracheostomy care in an alcoholic patient, and caused fulminant pneumonitis. ...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-198408000-00020

    authors: Brischetto MJ,Malouf J,Taylor RW

    更新日期:1984-08-01 00:00:00

  • Effects of clonidine on prolonged postoperative sympathetic response.

    abstract:OBJECTIVE:Surgical trauma results in diffuse sympathoadrenal activation which is thought to contribute to perioperative cardiovascular complications in high-risk patients. Regional anesthetic and analgesic techniques can attenuate this "stress response" and reduce the occurrence rate of adverse perioperative events; ho...

    journal_title:Critical care medicine

    pub_type: 临床试验,杂志文章

    doi:10.1097/00003246-199707000-00015

    authors: Dorman T,Clarkson K,Rosenfeld BA,Shanholtz C,Lipsett PA,Breslow MJ

    更新日期:1997-07-01 00:00:00

  • Epidemiology, management, and outcome of severe acute renal failure of critical illness in Australia.

    abstract:OBJECTIVE:To study the epidemiology, style of management, and outcome of intensive care patients with acute renal failure requiring replacement therapy in Australia. DESIGN:Prospective epidemiologic study. SETTING:Australian adult intensive care units providing acute renal replacement therapy. PATIENTS:Adult intensi...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-200110000-00010

    authors: Silvester W,Bellomo R,Cole L

    更新日期:2001-10-01 00:00:00

  • The effect of short-term discontinuation of high-level PEEP in patients with acute respiratory failure.

    abstract::PEEP is the most important therapeutic intervention in the management of acute respiratory failure. Transitory PEEP disconnection to perform clinically relevant maneuvers is often necessary, but its effect upon PaO2 and physiological shunt in patients requiring high-level PEEP is not clear from the literature. Nine ad...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-197902000-00003

    authors: De Campo T,Civetta JM

    更新日期:1979-02-01 00:00:00