Changes in brain tissue oxygenation after treatment of diffuse traumatic brain injury by erythropoietin.

abstract：OBJECTIVE:Expert task forces have proposed that adult critical care medicine services should be regionalized in order to improve outcomes. However, it is currently unknown if high intensive care unit (ICU) patient volumes are associated with reduced mortality rate. The objective was to investigate whether high-volume I...

journal_title：Critical care medicine

authors： Glance LG,Li Y,Osler TM,Dick A,Mukamel DB

更新日期：2006-07-01 00:00:00

abstract：OBJECTIVE:To examine the relationship between aminoglycoside disposition kinetics and hemodynamic response to sepsis, as well as vital support therapy, in critically ill patients with sepsis. DESIGN:Cross-sectional study of critically ill patients with sepsis undergoing physiologic and aminoglycoside pharmacokinetic m...

journal_title：Critical care medicine

authors： Lugo G,Castañeda-Hernández G

更新日期：1997-05-01 00:00:00

abstract：OBJECTIVE:In rodent models, enhanced formation of nitric oxide and formation of peroxynitrite have been implicated in the pathogenesis of various forms of shock. Here we examined the effect of mercaptoethylguanidine (MEG), an inducible nitric oxide synthase inhibitor and peroxynitrite scavenger, in a severe hemorrhagic...

journal_title：Critical care medicine

authors： Szabó A,Hake P,Salzman AL,Szabó C

更新日期：1999-07-01 00:00:00

abstract：:Gastric mucosal damage produced by topical application of necrotizing agents is diminished by topical or systemic pretreatment with a variety of E and F prostaglandins. The rat restraint model of gastric mucosal injury is more analogous to clinical stress ulceration than are models using intragastric application of to...

journal_title：Critical care medicine

authors： Ephgrave KS,Horton J,Burns D

更新日期：1989-01-01 00:00:00

abstract：OBJECTIVE:Preliminary experimental data suggest that selective β1-blockers may improve ex vivo cardiac function in animal sepsis. Currently, the effects of esmolol on in vivo cardiac function and on vascular function are unknown. The present study was designed to examine the effects of the β1-selective blocker esmolol ...

journal_title：Critical care medicine

authors： Kimmoun A,Louis H,Al Kattani N,Delemazure J,Dessales N,Wei C,Marie PY,Issa K,Levy B

更新日期：2015-09-01 00:00:00

abstract：OBJECTIVES:We recently reported that bacterial lipopolysaccharide stimulates release of tumor necrosis factor (TNF)-alpha from both human vascular tissue and cultured smooth muscle cells. In the current study, we tested the hypothesis that increased intracellular cyclic adenosine 3',5'-monophosphate (cAMP) could inhibi...

journal_title：Critical care medicine

authors： Zhang LM,Castresana MR,Shaker IJ,Dalton ML,Leeper-Woodford SK,Newman WH

更新日期：1997-11-01 00:00:00

abstract：OBJECTIVE:Inadequate nutrition is common in critical illness due in part to gastric stasis. However, recent data suggest that altered small intestinal mucosal function may be a contributing factor. The aim of this study was to examine the effects of critical illness on sucrose absorption, permeability, and mucosal morp...

journal_title：Critical care medicine

authors： Burgstad CM,Besanko LK,Deane AM,Nguyen NQ,Saadat-Gilani K,Davidson G,Burt E,Thomas A,Holloway RH,Chapman MJ,Fraser RJ

更新日期：2013-05-01 00:00:00

abstract：OBJECTIVE:We investigated whether serum levels of neuron-specific enolase (NSE) and S-100beta protein could be used to evaluate cerebral injury and to predict outcome in severe sepsis and severe septic shock. DESIGN:Prospective study. SETTING:University hospital. PATIENTS AND MEASUREMENTS:In 170 consecutively enroll...

journal_title：Critical care medicine

authors： Nguyen DN,Spapen H,Su F,Schiettecatte J,Shi L,Hachimi-Idrissi S,Huyghens L

更新日期：2006-07-01 00:00:00

abstract：OBJECTIVE:The administration of vasopressin during cardiopulmonary resuscitation (CPR) provides significantly more vital organ blood flow when compared with epinephrine during cardiac arrest in pigs. The effects of this potent vasoconstrictor on postresuscitation cardiovascular function remain unknown. The purpose of t...

journal_title：Critical care medicine

authors： Prengel AW,Lindner KH,Keller A,Lurie KG

更新日期：1996-12-01 00:00:00

abstract：:Assessment of creatinine clearance (CC) in ICU patients was compared using three methods. The reference method (CC 24 h) used measurements of serum creatinine and urinary creatinine after collection of urine over a 24-h period. The other two methods were predictive methods: the Kampmann nomogram and the formula develo...

journal_title：Critical care medicine

authors： Martin C,Alaya M,Bras J,Saux P,Gouin F

更新日期：1990-11-01 00:00:00

abstract：OBJECTIVES:To examine a hygroscopic condenser after clinical use and to describe the interaction of a hygroscopic condenser and a closed circuit suction system used simultaneously. DESIGN:Prospective evaluation of hygroscopic condensers used clinically, and laboratory investigation of a hygroscopic condenser used with...

journal_title：Critical care medicine

authors： Martinez FJ,Pietchel S,Wise C,Walek J,Beamis JF

更新日期：1994-10-01 00:00:00

abstract：OBJECTIVES:Extracorporeal membrane oxygenation is increasingly used in the management of severe acute respiratory distress syndrome. With extracorporeal membrane oxygenation, select patients with acute respiratory distress syndrome can be managed without mechanical ventilation, sedation, or neuromuscular blockade. Publ...

journal_title：Critical care medicine

authors： Kurihara C,Walter JM,Singer BD,Cajigas H,Shayan S,Al-Qamari A,DeCamp MM,Wunderink R,Budinger GRS,Bharat A

更新日期：2018-11-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to quantify the effect of hypertonic saline solution on contused and noncontused brain tissue in patients with traumatic brain injury. We hypothesize that hypertonic saline would increase the volume of brain contusion while decreasing the volume of noncontused hemispheric areas. DES...

journal_title：Critical care medicine

authors： Lescot T,Degos V,Zouaoui A,Préteux F,Coriat P,Puybasset L

更新日期：2006-12-01 00:00:00

abstract：OBJECTIVE:To quantify the therapeutic efficacy of loop diuretics in acute renal failure using Bayesian evidence synthesis, because despite widespread use, the role of diuretics is controversial. DATA SOURCE:Randomized controlled trials or nonrandomized studies, 1966 to January 2007, identified from MEDLINE and EMBASE ...

journal_title：Critical care medicine

authors： Sampath S,Moran JL,Graham PL,Rockliff S,Bersten AD,Abrams KR

更新日期：2007-11-01 00:00:00

abstract：OBJECTIVE:Acute renal failure remains a major challenge in critical care medicine. Both neutrophils and chemokines have been proposed as key components in the development of acute renal failure. Although the Duffy antigen receptor for chemokines (DARC) is present in several tissues and a highly specific ligand for vari...

journal_title：Critical care medicine

authors： Zarbock A,Schmolke M,Bockhorn SG,Scharte M,Buschmann K,Ley K,Singbartl K

更新日期：2007-09-01 00:00:00

abstract：OBJECTIVE:To evaluate the cardiopulmonary effects of the novel endothelin receptor antagonist tezosentan in endotoxin-induced lung injury in sheep and to assess the dose response to tezosentan and endothelin-1 in healthy sheep. DESIGN:Prospective, randomized, controlled experimental study. SETTING:University animal l...

journal_title：Critical care medicine

authors： Kuklin VN,Kirov MY,Evgenov OV,Sovershaev MA,Sjöberg J,Kirova SS,Bjertnaes LJ

更新日期：2004-03-01 00:00:00

abstract：:We developed a method to measure accurately pressures at the airway opening (Pao) and in the trachea (Ptr) in neonates during high frequency oscillatory ventilation (HFOV) from 15-30 Hz. All component parts of the pressure-measuring system were tested as a unit against a reference transducer in a closed chamber in whi...

journal_title：Critical care medicine

authors： Boynton BR,Mannino FL,Meathe EA,Kopotic RJ,Friederichsen G

更新日期：1984-01-01 00:00:00

abstract：OBJECTIVE:To determine whether extreme obesity (morbid obesity; body mass index > or =40 kg/m(2)) is an independent risk factor for death among critically ill patients; this objective is most salient in the subset of patients who sustain a prolonged intensive care unit stay during which the burdens of care imposed by o...

journal_title：Critical care medicine

authors： Nasraway SA Jr,Albert M,Donnelly AM,Ruthazer R,Shikora SA,Saltzman E

更新日期：2006-04-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to highlight the link between induced hypothermia and increased survival duration as observed in the septic model developed by the laboratory. To reach this objective, survival duration and blood oxygen transport capacity were measured at two temperatures-38 °C (induced normothermia...

journal_title：Critical care medicine

authors： Léon K,Pichavant-Rafini K,Quéméner E,Sébert P,Egreteau PY,Ollivier H,Carré JL,L'Her E

更新日期：2012-03-01 00:00:00

abstract：OBJECTIVES:Hepatic ischemia-reperfusion is a major clinical problem with limited treatment options. The pathophysiology of hepatic ischemia-reperfusion is characterized by mitochondrial dysfunction and cellular energy deficits. Sirtuin 1 is an energy-sensing enzyme known to modulate mitochondrial biogenesis. We hypothe...

journal_title：Critical care medicine

authors： Khader A,Yang WL,Godwin A,Prince JM,Nicastro JM,Coppa GF,Wang P

更新日期：2016-08-01 00:00:00

abstract：OBJECTIVES:To determine whether aerosolized antibiotics can be delivered efficiently to the lower respiratory tract in mechanically ventilated patients and to define possible clinical responses to these agents. DESIGN:Prospective serial study with cases as their own control. SETTING:A 10-bed respiratory care unit for...

journal_title：Critical care medicine

authors： Palmer LB,Smaldone GC,Simon SR,O'Riordan TG,Cuccia A

更新日期：1998-01-01 00:00:00

abstract：OBJECTIVES:To examine perceptions of nurses and physicians in regard to ethical decision-making climate in the ICU and to test the hypothesis that the worse the ethical decision-making climate, the greater the discordance between nurses' and physicians' rating of ethical decision-making climate with physicians hypothes...

journal_title：Critical care medicine

authors： Jensen HI,Hebsgaard S,Hansen TCB,Johnsen RFA,Hartog CS,Soultati I,Szucs O,Wilson ME,van den Bulcke B,Benoit DD,Piers R

更新日期：2019-12-01 00:00:00

abstract：OBJECTIVE:The aim of this study is to test the hypothesis that recruitment maneuvers (RMs) might act differently in models of pulmonary (p) and extrapulmonary (exp) acute lung injury (ALI) with similar transpulmonary pressure changes. DESIGN:Prospective, randomized, controlled experimental study. SETTING:University r...

journal_title：Critical care medicine

authors： Riva DR,Oliveira MB,Rzezinski AF,Rangel G,Capelozzi VL,Zin WA,Morales MM,Pelosi P,Rocco PR

更新日期：2008-06-01 00:00:00

abstract：OBJECTIVE:Pump-driven extracorporeal gas exchange systems have been advocated in patients suffering from severe acute respiratory distress syndrome who are at risk for life-threatening hypoxemia and/or hypercapnia. This requires extended technical and staff support. DESIGN:We report retrospectively our experience with...

journal_title：Critical care medicine

authors： Bein T,Weber F,Philipp A,Prasser C,Pfeifer M,Schmid FX,Butz B,Birnbaum D,Taeger K,Schlitt HJ

更新日期：2006-05-01 00:00:00

abstract：OBJECTIVES:To assess the relations between anemia, serum erythropoietin (EPO), iron status, and inflammatory mediators in multiply traumatized patients. DESIGN:Prospective observational study. SETTING:Intensive care unit. PATIENTS:Twenty-three patients suffering from severe trauma (injury severity score > or =30). ...

journal_title：Critical care medicine

authors： Hobisch-Hagen P,Wiedermann F,Mayr A,Fries D,Jelkmann W,Fuchs D,Hasibeder W,Mutz N,Klingler A,Schobersberger W

更新日期：2001-04-01 00:00:00

abstract：OBJECTIVES:Despite the universal proliferation of emergency medical services programs throughout the United States since 1970, only a few have ever documented a valid lifesaving effect, particularly in large, urban centers. The purpose of this study was to demonstrate the effect of specialized physician supervision on ...

journal_title：Critical care medicine

authors： Pepe PE,Mattox KL,Duke JH,Fisher PB,Prentice FD

更新日期：1993-09-01 00:00:00

abstract：OBJECTIVES:Controversy exists regarding the ideal injectate temperature for measuring cardiac output. Iced temperature injectate gives a higher signal/noise ratio and less variability in the measured cardiac output. Thus, less volume and fewer measurements are required. Advocates of room temperature injectate have sugg...

journal_title：Critical care medicine

authors： Fang HK,Krahmer RL,Rypins EB,Law WR

更新日期：1996-03-01 00:00:00

abstract：OBJECTIVES:Ventilator-associated pneumonia diagnosis remains a debatable topic. New definitions of ventilator-associated conditions involving worsening oxygenation have been recently proposed to make surveillance of events possibly linked to ventilator-associated pneumonia as objective as possible. The objective of the...

journal_title：Critical care medicine

authors： Damas P,Frippiat F,Ancion A,Canivet JL,Lambermont B,Layios N,Massion P,Morimont P,Nys M,Piret S,Lancellotti P,Wiesen P,D'orio V,Samalea N,Ledoux D

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVE:To assess the statistical association of the Acute Physiology and Chronic Health Evaluation (APACHE II) score with multiple intervention and outcome variables in surgical ICU patients. DESIGN:Continuous data collection on every patient admitted to the surgical ICU for a 21-month period. MATERIALS AND METHOD...

journal_title：Critical care medicine

authors： Rutledge R,Fakhry SM,Rutherford EJ,Muakkassa F,Baker CC,Koruda M,Meyer AA

更新日期：1991-08-01 00:00:00

abstract：OBJECTIVES:To investigate pharmacokinetics and metabolism of sodium citrate in critically ill patients. To determine the risk of citrate accumulation in the setting of liver dysfunction (cirrhosis, hepatorenal syndrome). DESIGN:Prospective cohort study. SETTING:Intensive Care Unit, Department of Medicine IV, Universi...

journal_title：Critical care medicine

authors： Kramer L,Bauer E,Joukhadar C,Strobl W,Gendo A,Madl C,Gangl A

更新日期：2003-10-01 00:00:00