Cardiovascular function during the postresuscitation phase after cardiac arrest in pigs: a comparison of epinephrine versus vasopressin.

Abstract:

OBJECTIVE:The administration of vasopressin during cardiopulmonary resuscitation (CPR) provides significantly more vital organ blood flow when compared with epinephrine during cardiac arrest in pigs. The effects of this potent vasoconstrictor on postresuscitation cardiovascular function remain unknown. The purpose of this study was to compare the effects of vasopressin and epinephrine on cardiovascular function in the postresuscitation phase after CPR. DESIGN:Prospective, randomized, experimental study. SETTING:University research laboratory. SUBJECTS:Domestic pigs, 12 to 14 wks of age. INTERVENTIONS:Sixteen pigs were randomly allocated to receive either 0.045 mg/kg of epinephrine or 0.4 U/kg of vasopressin after 4 mins of cardiac arrest. MEASUREMENTS AND MAIN RESULTS:Hemodynamics, left ventricular contractility, and myocardial blood flow were measured for an interval of 240 mins after successful CPR. Differences between animals treated with epinephrine vs. vasopressin were most pronounced 15 mins after restoration of spontaneous circulation. At this time, mean aortic pressure was 64 +/- 6 (SEM) mm Hg in the epinephrine group and 84 +/- 6 mm Hg (p < .05) in the vasopressin group. Systemic vascular resistance was 1285 +/- 72 dyne.sec/cm5 in the epinephrine group and 2314 +/- 130 dyne.sec/cm5 (p < .001) in the vasopressin group. Cardiac index was 140 +/- 9 mL/min/kg in animals treated with epinephrine and 99 +/- 9 mL/min/kg (p < .01) in animals treated with vasopressin. Myocardial contractility (dp/ dtmax/P) was 52.8 +/- 3.4/sec with epinephrine as compared with 36.3 +/- 2.9 sec-1 (p < .01) with vasopressin. Left ventricular epicardial blood flow was 241 +/- 35 mL/min/100 g with epinephrine and 142 +/- 22 mL/min/100 g (p < .05) with vasopressin. Four hours after CPR, no significant differences were observed between groups. CONCLUSIONS:In the early postresuscitation phase, vasopressin provided higher systemic blood pressures and there was a reversible depressant effect on myocardial function when compared with epinephrine. Overall cardiovascular function was not irreversibly or critically impaired after the administration of vasopressin in this pig model of cardiac arrest.

journal_name

Crit Care Med

journal_title

Critical care medicine

authors

Prengel AW,Lindner KH,Keller A,Lurie KG

doi

10.1097/00003246-199612000-00014

subject

Has Abstract

pub_date

1996-12-01 00:00:00

pages

2014-9

issue

12

eissn

0090-3493

issn

1530-0293

journal_volume

24

pub_type

杂志文章
  • Difficult Bag-Mask Ventilation in Critically Ill Children Is Independently Associated With Adverse Events.

    abstract:OBJECTIVES:Bag-mask ventilation is commonly used prior to tracheal intubation; however, the epidemiology, risk factors, and clinical implications of difficult bag-mask ventilation among critically ill children are not well studied. This study aims to describe prevalence and risk factors for pediatric difficult bag-mask...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/CCM.0000000000004425

    authors: Daigle CH,Fiadjoe JE,Laverriere EK,Bruins BB,Lockman JL,Shults J,Krawiec C,Harwayne-Gidansky I,Page-Goertz C,Furlong-Dillard J,Nadkarni VM,Nishisaki A,National Emergency Airway Registry for Children (NEAR4KIDS) Investigators and

    更新日期:2020-09-01 00:00:00

  • Influenza epidemiology--past, present, and future.

    abstract::In April 2009, Mexican, American, and Canadian authorities announced that a novel influenza virus with pandemic potential had been identified in large segments of the population. Within weeks, it became apparent that the world was dealing with the first influenza pandemic in >40 yrs. Despite the unpredictable nature o...

    journal_title:Critical care medicine

    pub_type: 历史文章,杂志文章,评审

    doi:10.1097/CCM.0b013e3181cbaf34

    authors: Lagacé-Wiens PR,Rubinstein E,Gumel A

    更新日期:2010-04-01 00:00:00

  • Intravenous amiodarone in the treatment of refractory arrhythmias.

    abstract::Oral amiodarone's slow absorption handicaps rapid treatment of life-threatening arrhythmias. We used iv amiodarone to treat ten patients with hemodynamically significant atrial arrhythmias and life-threatening ventricular arrhythmias refractory to all conventional medical treatment. Arrhythmias were controlled in nine...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-198509000-00012

    authors: Alves LE,Rose EP,Cahill TB Jr

    更新日期:1985-09-01 00:00:00

  • Intravenous insulin nomogram improves blood glucose control in the critically ill.

    abstract:OBJECTIVE:To improve control of blood glucose concentrations in critically ill patients through use of a bedside, nurse-managed, intravenous insulin nomogram. DESIGN:Retrospective, before-after cohort study. SETTING:Fifteen-bed mixed medical/surgical intensive care unit in a tertiary, teaching hospital. PATIENTS:A t...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-200109000-00010

    authors: Brown G,Dodek P

    更新日期:2001-09-01 00:00:00

  • Adverse effects of high-dose epinephrine on cerebral blood flow during experimental cardiopulmonary resuscitation.

    abstract:OBJECTIVE:To study the effects of high-dose epinephrine, compared with standard-dose epinephrine, on the dynamics of superficial cortical cerebral blood flow as well as global cerebral oxygenation during experimental cardiopulmonary resuscitation. We hypothesized that high-dose epinephrine might be unable to improve ce...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-200005000-00028

    authors: Gedeborg R,Silander HC,Ronne-Engström E,Rubertsson S,Wiklund L

    更新日期:2000-05-01 00:00:00

  • A comparison of standard, "MAST"-augmented, and open-chest CPR in dogs. A preliminary investigation.

    abstract::Hemodynamic, respiratory, and cerebral variables during 2 h of standard external CPR were studied in 5 dogs. In an additional 12 dogs, possible augmentation of these variables by Military Anti-Shock Trousers (MAST) was evaluated. In 9 dogs, external and internal cardiac massage were compared. During ventricular fibril...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-198003000-00012

    authors: Bircher N,Safar P,Stewart R

    更新日期:1980-03-01 00:00:00

  • Delivery of metered dose inhaler aerosols to paralyzed and nonparalyzed rabbits.

    abstract:OBJECTIVE:To assess whether paralysis alters pulmonary deposition of albuterol delivered by metered dose inhaler and spacer to small animals. DESIGN:A parallel group study of intubated and ventilated rabbits. INTERVENTIONS:Animals in group 1 (n = 7) were paralyzed with intravenous pancuronium, and ventilated at a rat...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-199701000-00026

    authors: Fok TF,al-Essa M,Monkman S,Dolovich M,Girard L,Coates G,Kirpalani H

    更新日期:1997-01-01 00:00:00

  • Phenotyping Cardiac Arrest: Bench and Bedside Characterization of Brain and Heart Injury Based on Etiology.

    abstract:OBJECTIVES:Cardiac arrest etiology may be an important source of between-patient heterogeneity, but the impact of etiology on organ injury is unknown. We tested the hypothesis that asphyxial cardiac arrest results in greater neurologic injury than cardiac etiology cardiac arrest (ventricular fibrillation cardiac arrest...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/CCM.0000000000003070

    authors: Uray T,Lamade A,Elmer J,Drabek T,Stezoski JP,Missé A,Janesko-Feldman K,Garman RH,Chen N,Kochanek PM,Dezfulian C,Callaway CW,Doshi AA,Frisch A,Guyette FX,Reynolds JC,Rittenberger JC,University of Pittsburgh Post-Cardiac

    更新日期:2018-06-01 00:00:00

  • The role of ω-3 fatty acid supplemented parenteral nutrition in critical illness in adults: a systematic review and meta-analysis.

    abstract:OBJECTIVE:To determine whether the supplementation of parenteral nutrition with ω-3 fatty acids confers treatment benefits to critically ill adult patients. DATA SOURCE:We performed computerized searches for relevant articles from 1996 to June 2011 on MEDLINE, EMBASE, and the Cochrane register of controlled trials and...

    journal_title:Critical care medicine

    pub_type: 杂志文章,meta分析,评审

    doi:10.1097/CCM.0b013e3182657578

    authors: Palmer AJ,Ho CK,Ajibola O,Avenell A

    更新日期:2013-01-01 00:00:00

  • Impact of Initial Central Venous Pressure on Outcomes of Conservative Versus Liberal Fluid Management in Acute Respiratory Distress Syndrome.

    abstract:OBJECTIVES:In acute respiratory distress syndrome, conservative fluid management increases ventilator-free days without affecting mortality. Response to fluid management may differ based on patients' initial central venous pressure. We hypothesized that initial central venous pressure would modify the effect of fluid m...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/CCM.0000000000001555

    authors: Semler MW,Wheeler AP,Thompson BT,Bernard GR,Wiedemann HP,Rice TW,National Institutes of Health National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome Network.

    更新日期:2016-04-01 00:00:00

  • Lactated Ringer Is Associated With Reduced Mortality and Less Acute Kidney Injury in Critically Ill Patients: A Retrospective Cohort Analysis.

    abstract:OBJECTIVES:To assess the impact of the percentage of fluid infused as Lactated Ringer (%LR) during the first 2 days of ICU admission in hospital mortality and occurrence of acute kidney injury. DESIGN:Retrospective cohort. SETTING:Analysis of a large public database (Multiparameter Intelligent Monitoring in Intensive...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/CCM.0000000000001948

    authors: Zampieri FG,Ranzani OT,Azevedo LC,Martins ID,Kellum JA,Libório AB

    更新日期:2016-12-01 00:00:00

  • Management of upper airway obstruction in the intensive care unit.

    abstract::Three patients under observation in ICUs developed mechanical upper airway obstruction requiring surgical intervention for airway control. One patient was treated by tracheotomy placed through a vertical midline incision and 2 patients were treated by cricothyroidotomy followed by elective tracheostomy and closure of ...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-198108000-00004

    authors: Schecter WP,Wilson RS

    更新日期:1981-08-01 00:00:00

  • Clinical and economic outcomes of involving pharmacists in the direct care of critically ill patients with infections.

    abstract:OBJECTIVE:To determine whether the absence or presence of clinical pharmacists in intensive care units (ICUs) results in differences in mortality rates, length of ICU stay, and ICU charges for Medicare patients with nosocomial-acquired infections, community-acquired infections, and sepsis. DESIGN, SETTING, AND PATIENT...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/CCM.0b013e31818f2269

    authors: MacLaren R,Bond CA,Martin SJ,Fike D

    更新日期:2008-12-01 00:00:00

  • Physiology and pharmacokinetics of a novel hemoglobin-based oxygen carrier in humans.

    abstract:OBJECTIVE:To evaluate the physiology and pharmacokinetics of a novel hemoglobin-based oxygen carrier of bovine origin. DESIGN:Randomized, single-blind, placebo-controlled, dose-escalation study. SETTING:The Upjohn Research Clinics (Kalamazoo, MI). SUBJECTS:Normal healthy adult men between the ages of 18 and 45 yrs. ...

    journal_title:Critical care medicine

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00003246-199605000-00006

    authors: Hughes GS Jr,Antal EJ,Locker PK,Francom SF,Adams WJ,Jacobs EE Jr

    更新日期:1996-05-01 00:00:00

  • Effects of accidental trauma on cytokine and endotoxin production.

    abstract:OBJECTIVE:To determine the effects of accidental injury of varying severity on interleukin (IL)-1 alpha, IL-6, IL-8, tumor necrosis factor-alpha (TNF-alpha), and endotoxin release. DESIGN:Prospective, multi-unit, longitudinal study. SETTING:Emergency Departments and intensive care units of two university hospitals. ...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-199306000-00010

    authors: Hoch RC,Rodriguez R,Manning T,Bishop M,Mead P,Shoemaker WC,Abraham E

    更新日期:1993-06-01 00:00:00

  • A direct relationship between ionized calcium and arterial pressure among patients in an intensive care unit.

    abstract::Serum ionized calcium (Ca+2), creatinine, magnesium, phosphate, and arterial pH were measured in patients on admission to the medical ICU (MICU). Patients were classified into three groups: a) hypotensive (n = 38), those who received vasopressor support for frank hypotension; b) hypertensive (n = 21), those who requir...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-198806000-00002

    authors: Desai TK,Carlson RW,Thill-Baharozian M,Geheb MA

    更新日期:1988-06-01 00:00:00

  • New pharmacologic therapies for acute heart failure.

    abstract::Given the limitations of high-dose diuretics and vasodilators and the increasing literature showing that inotropes, regardless of the dose used, have a detrimental effect on mortality, a variety of new agents are under investigation for the treatment of pulmonary and systemic congestion and restoration of cardiac outp...

    journal_title:Critical care medicine

    pub_type: 杂志文章,评审

    doi:10.1097/01.CCM.0000296810.74724.8D

    authors: Tavares M,Rezlan E,Vostroknoutova I,Khouadja H,Mebazaa A

    更新日期:2008-01-01 00:00:00

  • A discard volume of twice the deadspace ensures clinically accurate arterial blood gases and electrolytes and prevents unnecessary blood loss.

    abstract:OBJECTIVE:To determine the blood discard volume, as a multiple of deadspace, that is required for accurate arterial blood gas and electrolyte testing from arterial catheters. DESIGN:Prospective, controlled, crossover trial. SETTING:Eighteen-bed intensive care unit of a metropolitan teaching hospital. PATIENTS:A tota...

    journal_title:Critical care medicine

    pub_type: 临床试验,杂志文章

    doi:10.1097/01.CCM.0000063448.98777.EF

    authors: Rickard CM,Couchman BA,Schmidt SJ,Dank A,Purdie DM

    更新日期:2003-06-01 00:00:00

  • Use of an iridium-oxide transcutaneous carbon dioxide electrode on adult surgical patients.

    abstract::A new iridium/iridium-oxide electrode heated to 42 degrees C was used to monitor transcutaneous carbon dioxide levels during surgery in 27 adult patients. The purpose of this study was to compare arterial and transcutaneous CO2 values. This metal electrode performed similarly to glass CO2 electrodes. In addition, its ...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-198510000-00015

    authors: Williams R,Riker R,Narkewicz M,Lucey JF

    更新日期:1985-10-01 00:00:00

  • Impact of Sepsis Classification and Multidrug-Resistance Status on Outcome Among Patients Treated With Appropriate Therapy.

    abstract:OBJECTIVE:To assess the impact of sepsis classification and multidrug-resistance status on outcome in patients receiving appropriate initial antibiotic therapy. DESIGN:A retrospective cohort study. SETTING:Barnes-Jewish Hospital, a 1,250-bed teaching hospital. PATIENTS:Individuals with Enterobacteriaceae sepsis, sev...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/CCM.0000000000001013

    authors: Burnham JP,Lane MA,Kollef MH

    更新日期:2015-08-01 00:00:00

  • Critical care nursing: workforce issues and potential solutions.

    abstract:OBJECTIVE:To review the history and development of critical care nurses, the supply and demand issues related to critical care nursing, critical care nursing's contribution to patient outcomes, and recommendations to ensure a steady and strong workforce. DATA SOURCE AND SELECTION:Information presented in this article ...

    journal_title:Critical care medicine

    pub_type: 杂志文章,评审

    doi:10.1097/01.CCM.0000203087.42439.53

    authors: Robnett MK

    更新日期:2006-03-01 00:00:00

  • Full Finger Reperfusion Time Measured by Pulse Oximeter Waveform Analysis in Children.

    abstract:OBJECTIVES:Capillary refill time is a noninvasive method to assess tissue perfusion to determine shock status. Capillary refill time is defined as the time required to regain skin color after blanching pressure is applied. Although common methods to measure capillary refill time depend on clinicians' visual assessment,...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/CCM.0000000000004506

    authors: Nickel AJ,Jiang S,Napolitano N,Yehya N,Fitzgerald JC,Bruins BB,Lockman JL,Nadkarni VM,Nishisaki A

    更新日期:2020-10-01 00:00:00

  • Private attending physician status and the withdrawal of life-sustaining interventions in a medical intensive care unit population.

    abstract:OBJECTIVE:To assess the influence of private attending physician status on the withdrawal of life-sustaining interventions among patients dying within a medical intensive care unit (ICU). DESIGN:Retrospective cohort analysis. SETTING:An academic tertiary care center. PATIENTS:One hundred fifty-nine consecutive patie...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-199606000-00016

    authors: Kollef MH

    更新日期:1996-06-01 00:00:00

  • A prospective, multicenter derivation of a biomarker panel to assess risk of organ dysfunction, shock, and death in emergency department patients with suspected sepsis.

    abstract:OBJECTIVE:To define a biomarker panel to predict organ dysfunction, shock, and in-hospital mortality in emergency department (ED) patients with suspected sepsis. DESIGN:Prospective observational study. SETTING:EDs of ten academic medical centers. PATIENTS:There were 971 patients enrolled. INCLUSION CRITERIA:1) ED p...

    journal_title:Critical care medicine

    pub_type: 杂志文章,多中心研究

    doi:10.1097/CCM.0b013e318192fd9d

    authors: Shapiro NI,Trzeciak S,Hollander JE,Birkhahn R,Otero R,Osborn TM,Moretti E,Nguyen HB,Gunnerson KJ,Milzman D,Gaieski DF,Goyal M,Cairns CB,Ngo L,Rivers EP

    更新日期:2009-01-01 00:00:00

  • Recognition and prevention of hospital-associated enteric infections in the intensive care unit.

    abstract::The objectives of this article were to review the causes and extent of hospital-associated infectious diarrhea and associated risks in the general hospital ward and intensive care unit (ICU), to compare microorganisms with similar symptoms to aid in recognition that will lead to timely and appropriate treatment and co...

    journal_title:Critical care medicine

    pub_type: 杂志文章,评审

    doi:10.1097/CCM.0b013e3181e69f05

    authors: Bobo LD,Dubberke ER

    更新日期:2010-08-01 00:00:00

  • Safety of intravenous nitroglycerin after administration of sildenafil citrate to men with coronary artery disease: a double-blind, placebo-controlled, randomized, crossover trial.

    abstract:OBJECTIVE:Although contraindicated, there are situations when a patient who has recently taken a phosphodiesterase 5 inhibitor (e.g., sildenafil) might need intravenous nitroglycerin (NTG) treatment. This study determined if, and at what dose, intravenous NTG could be administered safely to men with coronary artery dis...

    journal_title:Critical care medicine

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1097/01.CCM.0000269371.70738.30

    authors: Parker JD,Bart BA,Webb DJ,Koren MJ,Siegel RL,Wang H,Malhotra B,Jen F,Glue P

    更新日期:2007-08-01 00:00:00

  • Early postoperative enteral nutrition improves gut oxygenation and reduces costs compared with total parenteral nutrition.

    abstract:OBJECTIVE:To evaluate the potential clinical, metabolic, and economic advantages of enteral nutrition over total parenteral nutrition. DESIGN:Prospective, randomized clinical trial. SETTING:Department of surgery in a university hospital. PATIENTS:Two hundred and fifty-seven patients with cancer of the stomach (n = 1...

    journal_title:Critical care medicine

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00003246-200102000-00003

    authors: Braga M,Gianotti L,Gentilini O,Parisi V,Salis C,Di Carlo V

    更新日期:2001-02-01 00:00:00

  • Hemodynamic and colloid osmotic pressure alterations in the surgical patient.

    abstract::Colloid osmotic pressure (COP) was measured simultaneously with cardiorespiratory measurements in 103 surgical patients suspected of having circulatory problems. In a small subset of 28 patients, measurements were taken before, during, and after surgical operations. Similarly, data sets were taken before, during, and ...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-198303000-00010

    authors: Shippy CR,Shoemaker WC

    更新日期:1983-03-01 00:00:00

  • Lipiodol embolism following transarterial chemoembolization: an atypical case.

    abstract:OBJECTIVE:Transarterial chemoembolization is a widely used therapy for the treatment of hepatocellular carcinoma. A rare adverse event is acute respiratory distress syndrome from pulmonary embolization of Lipiodol, an iodinated oil commonly used during the procedure. The objective of this report is to describe an atypi...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/CCM.0000000000000307

    authors: Taupin D,Mukherjee V,Nathavitharana R,Green DA,Fridman D

    更新日期:2014-06-01 00:00:00

  • Temporal Trends in Incidence, Sepsis-Related Mortality, and Hospital-Based Acute Care After Sepsis.

    abstract:OBJECTIVES:A growing number of patients survive sepsis hospitalizations each year and are at high risk for readmission. However, little is known about temporal trends in hospital-based acute care (emergency department treat-and-release visits and hospital readmission) after sepsis. Our primary objective was to measure ...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/CCM.0000000000002872

    authors: Meyer N,Harhay MO,Small DS,Prescott HC,Bowles KH,Gaieski DF,Mikkelsen ME

    更新日期:2018-03-01 00:00:00