L-arginine: nitric oxide pathway in endotoxemia and human septic shock.

Abstract:

OBJECTIVE:To investigate the relationship between nitric oxide production, endotoxemia, and hemodynamic alterations in human septic shock. DESIGN:Prospective study. SETTING:A 32-bed intensive care unit in a university referral hospital. PATIENTS:Two groups of septic patients with shock (n = 13) or without shock (n = 16) and an additional group of nonseptic patients as control group (n = 25). MEASUREMENTS:Plasma nitrite and nitrate concentrations were measured as an index of nitric oxide generation. Nitrite and nitrate concentrations were correlated with plasma endotoxin and hemodynamic variables. MAIN RESULTS:Increased plasma nitrite and nitrate concentrations were found in patients with septic shock (p < .01). Nitrite and nitrate correlated directly with endotoxin concentration (r2 = .21, p < .05) and cardiac output (r2 = .49, p < .05), and inversely with systolic blood pressure (r2 = .24, p < .01). CONCLUSIONS:This study demonstrated the activation of the L-arginine:nitric oxide pathway in human endotoxemic septic shock, suggesting that nitric oxide may be an important mediator of the hemodynamic disturbances in this pathophysiologic situation.

journal_name

Crit Care Med

journal_title

Critical care medicine

authors

Gómez-Jiménez J,Salgado A,Mourelle M,Martín MC,Segura RM,Peracaula R,Moncada S

doi

10.1097/00003246-199502000-00009

subject

Has Abstract

pub_date

1995-02-01 00:00:00

pages

253-8

issue

2

eissn

0090-3493

issn

1530-0293

journal_volume

23

pub_type

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