National estimates of severe sepsis in United States emergency departments.

abstract：:Clonidine may be a source of serious toxicity when ingested by toddlers. We describe 11 cases of clonidine ingestion by toddlers (mean dose 0.15 mg/kg; range 0.01 to 0.57). The source of the clonidine was a grand-parent in six of 11 cases. Symptoms included altered level of consciousness (n = 11), miosis (n = 5), brad...

journal_title：Critical care medicine

authors： Fiser DH,Moss MM,Walker W

更新日期：1990-10-01 00:00:00

abstract：OBJECTIVE:To present electron micrographs of lung tissue obtained from a patient exposed to high ventilatory pressures in the context of pulmonary dysfunction and pulmonary hypertension. DESIGN:Case report. SETTING:Adult intensive care unit of a university-affiliated teaching hospital. PATIENTS:A patient exposed to ...

journal_title：Critical care medicine

authors： Hotchkiss JR,Simonson DA,Marek DJ,Marini JJ,Dries DJ

更新日期：2002-10-01 00:00:00

abstract：BACKGROUND:Hemorrhage in trauma is a significant challenge, accounting for 30% to 40% of all fatalities, second only to central nervous system injury as a cause of death. However, hemorrhagic death is the leading preventable cause of mortality in combat casualties and typically occurs within 6 to 24 hrs of injury. In c...

journal_title：Critical care medicine

authors： Perkins JG,Cap AP,Weiss BM,Reid TJ,Bolan CD

更新日期：2008-07-01 00:00:00

abstract：OBJECTIVES:To review the immunologic role of the cytokines and the specific role that tumor necrosis factor (TNF) plays in response to infection. The influence of bacterial lipopolysaccharide on TNF, the cytokine cascade, and resultant pathologies are also reviewed. DATA SOURCES:A MEDLINE search of the international E...

journal_title：Critical care medicine

authors： Beutler B,Grau GE

更新日期：1993-10-01 00:00:00

abstract：OBJECTIVE:To define a biomarker panel to predict organ dysfunction, shock, and in-hospital mortality in emergency department (ED) patients with suspected sepsis. DESIGN:Prospective observational study. SETTING:EDs of ten academic medical centers. PATIENTS:There were 971 patients enrolled. INCLUSION CRITERIA:1) ED p...

journal_title：Critical care medicine

authors： Shapiro NI,Trzeciak S,Hollander JE,Birkhahn R,Otero R,Osborn TM,Moretti E,Nguyen HB,Gunnerson KJ,Milzman D,Gaieski DF,Goyal M,Cairns CB,Ngo L,Rivers EP

更新日期：2009-01-01 00:00:00

abstract：OBJECTIVE:Significant mortality in patients with sepsis results from the development of multiple organ dysfunction syndrome. Small-volume resuscitation with 7.5% NaCl hypertonic saline has been proposed to restore physiologic hemodynamics in hemorrhagic shock. Therefore, we hypothesized that hypertonic saline resuscita...

journal_title：Critical care medicine

authors： Shih CC,Chen SJ,Chen A,Wu JY,Liaw WJ,Wu CC

更新日期：2008-06-01 00:00:00

abstract：OBJECTIVE:To review the rationale for the regionalization of adult critical care and discuss how lessons from the trauma experience may be relevant to this debate. DESIGN:Narrative review and opinion. RESULTS:Variation in the quality of critical care among hospitals has prompted calls for regionalization of care for ...

journal_title：Critical care medicine

authors： Kahn JM,Branas CC,Schwab CW,Asch DA

更新日期：2008-11-01 00:00:00

abstract：OBJECTIVE:Sepsis is associated with a marked depression of cellular immune function. The steroid hormone dehydroepiandrosterone (DHEA) is proposed to have immunoenhancing activities. We, therefore, investigated the effect of DHEA on the mortality rate and cellular immune functions in an experimental model of sepsis. D...

journal_title：Critical care medicine

authors： Oberbeck R,Dahlweid M,Koch R,van Griensven M,Emmendörfer A,Tscherne H,Pape HC

更新日期：2001-02-01 00:00:00

abstract：OBJECTIVE:To determine whether clinically relevant airspace concentrations of beta2-adrenergic agonists stimulated maximal alveolar fluid clearance rates and to determine whether beta2 agonist therapy decreased pulmonary edema in experimental acute lung injury. DESIGN:Prospective randomized laboratory investigation. ...

journal_title：Critical care medicine

authors： McAuley DF,Frank JA,Fang X,Matthay MA

更新日期：2004-07-01 00:00:00

abstract：OBJECTIVE:To evaluate the pathophysiology involved in hypocalcemia in septic shock and to investigate the value of calcium administration. DESIGN:Prospective, randomized placebo-controlled trial with parallel groups. SETTING:Animal research laboratory at the University Hospital of Uppsala. SUBJECTS:Twenty-four pigs ...

journal_title：Critical care medicine

authors： Carlstedt F,Eriksson M,Kiiski R,Larsson A,Lind L

更新日期：2000-08-01 00:00:00

abstract：OBJECTIVE:Critical care medicine trainees and faculty must acquire and maintain the skills necessary to provide state-of-the art clinical care to critically ill patients, to improve patient outcomes, optimize intensive care unit utilization, and continue to advance the theory and practice of critical care medicine. Thi...

journal_title：Critical care medicine

authors： Dorman T,Angood PB,Angus DC,Clemmer TP,Cohen NH,Durbin CG Jr,Falk JL,Helfaer MA,Haupt MT,Horst HM,Ivy ME,Ognibene FP,Sladen RN,Grenvik AN,Napolitano LM,American College of Critical Care Medicine.

更新日期：2004-01-01 00:00:00

abstract：OBJECTIVES:This report examines the frequency, type, and prognostic factors of medical (nonneurologic) complications after subarachnoid hemorrhage in a large, prospective study. The influences of contemporary neurosurgical, neurological, and critical care practice on mortality and morbidity rates after aneurysmal subar...

journal_title：Critical care medicine

authors： Solenski NJ,Haley EC Jr,Kassell NF,Kongable G,Germanson T,Truskowski L,Torner JC

更新日期：1995-06-01 00:00:00

abstract：OBJECTIVES:Capillary refill time is a noninvasive method to assess tissue perfusion to determine shock status. Capillary refill time is defined as the time required to regain skin color after blanching pressure is applied. Although common methods to measure capillary refill time depend on clinicians' visual assessment,...

journal_title：Critical care medicine

authors： Nickel AJ,Jiang S,Napolitano N,Yehya N,Fitzgerald JC,Bruins BB,Lockman JL,Nadkarni VM,Nishisaki A

更新日期：2020-10-01 00:00:00

abstract：:Disseminated intravascular coagulation (DIC) is an acquired syndrome characterized by intravascular fibrin formation occurring in the course of a variety of severe diseases. In gram-negative sepsis, endotoxin is the bacterial component eliciting a cascade of tissue factor dependent hypercoagulable reactions mediated b...

journal_title：Critical care medicine

authors： ten Cate H

更新日期：2000-09-01 00:00:00

abstract：:To correlate radiant warmer bed power output with state of hydration in the critically ill infant, warmer power input was measured by a wattmeter and recorded by an on-line computer every 5 sec for 2 periods of 8-24 h each in 11 newborns with respiratory distress syndrome (mean birth weight 1.42 kg, mean gestational a...

journal_title：Critical care medicine

authors： Engle WD,Baumgart S,Fox WW,Polin RA

更新日期：1982-10-01 00:00:00

abstract：OBJECTIVE:To evaluate the occurrence of complications and patient deteriorations during the air and ground transportation of intubated pediatric patients, performed by a nonphysician-based team under the direction of an intensive care attending physician or fellow. DESIGN:Retrospective chart review. SETTING:A 600-bed...

journal_title：Critical care medicine

authors： Beyer AJ 3rd,Land G,Zaritsky A

更新日期：1992-07-01 00:00:00

abstract：OBJECTIVES:Despite having dysregulated iron metabolism, critically ill patients may receive exogenous iron for the treatment of anemia. Iron is associated with increased tissue apoptosis and may facilitate bacterial growth. We hypothesized that exogenous iron administration given after the onset of sepsis would lead to...

journal_title：Critical care medicine

authors： Javadi P,Buchman TG,Stromberg PE,Husain KD,Dunne WM,Woolsey CA,Turnbull IR,Hotchkiss RS,Karl IE,Coopersmith CM

更新日期：2004-05-01 00:00:00

abstract：OBJECTIVE:To review recent advances in the use of transforming growth factor (TGF)-beta in acute lung injury and to apply this knowledge to understanding the pathophysiology of this syndrome. DATA SOURCES AND STUDY SELECTION:Published research and review articles in the English language related to the role of TGF-beta...

journal_title：Critical care medicine

authors： Dhainaut JF,Charpentier J,Chiche JD

更新日期：2003-04-01 00:00:00

abstract：:Gastric mucosal damage occurs in critically ill patients in intensive care units and develops in the setting of severe physiologic stress. Within 24 hrs of admission to the intensive care unit, 75% to 100% of critically ill patients demonstrate evidence of stress-related mucosal disease. Stress ulcers present a risk o...

journal_title：Critical care medicine

authors： Fennerty MB

更新日期：2002-06-01 00:00:00

abstract：OBJECTIVES:To identify the prevalence, risk factors, and outcomes of intra-abdominal hypertension in a mixed multicenter ICU population. DESIGN:Prospective observational study. SETTING:Fifteen ICUs worldwide. PATIENTS:Consecutive adult ICU patients with a bladder catheter. INTERVENTIONS:None. MEASUREMENTS AND MAIN...

journal_title：Critical care medicine

authors： Reintam Blaser A,Regli A,De Keulenaer B,Kimball EJ,Starkopf L,Davis WA,Greiffenstein P,Starkopf J,Incidence, Risk Factors, and Outcomes of Intra-Abdominal (IROI) Study Investigators.

更新日期：2019-04-01 00:00:00

abstract：OBJECTIVE:To examine the pulmonary and cardiac function of children who survived an episode of acute hypoxemic respiratory failure. DESIGN:Descriptive cohort analysis. SETTING:Pediatric clinical research center of a university hospital. PATIENTS:Utilizing the criteria of PaO2 < 75 torr (< 10 kPa) with an FIO2 of > 0...

journal_title：Critical care medicine

authors： Weiss I,Ushay HM,DeBruin W,O'Loughlin J,Rosner I,Notterman D

更新日期：1996-01-01 00:00:00

abstract：OBJECTIVES:To determine the incidence and characteristics of children with brain death in the pediatric intensive care unit (ICU), and to assess the incidence of the clinical triad (Turner's triad) of central diabetes insipidus, low glucose demand, and low CO2 production. DESIGN:Retrospective review of medical records...

journal_title：Critical care medicine

authors： Staworn D,Lewison L,Marks J,Turner G,Levin D

更新日期：1994-08-01 00:00:00

abstract：OBJECTIVE:Restoration of myocardial blood flow after ischemia triggers an inflammatory response involving toll-like receptors. Toll-like receptor 2 deficiency is associated with a reduced infarct size after myocardial ischemia and reperfusion. Because a marked mortality was observed in C3HeN wild-type mice, which was a...

journal_title：Critical care medicine

authors： Mersmann J,Koch A,Tran N,Zimmermann R,Granja TF,Larmann J,Herzog C,Theilmeier G,Bornstein SR,Kirschning CJ,Zacharowski K

更新日期：2010-10-01 00:00:00

abstract：:The EEGs of 40 infants paralyzed with D-tubocurarine or pancuronium during the neonatal period were reviewed retrospectively. The 23 infants who survived were re-examined at 1-3 yr of age. Sixteen infants had normal or mildly abnormal EEGs in the neonatal period; 3 died of nonneurologic causes; the remainder were norm...

journal_title：Critical care medicine

authors： Tharp BR,Laboyrie PM

更新日期：1983-12-01 00:00:00

abstract：OBJECTIVES:To evaluate the ability of central venous-to-arterial carbon dioxide pressure difference, central venous oxygen saturation, and the combination of these two parameters to detect extubation failure in critically ill patients. DESIGN:Multicentric, prospective, observational study. SETTING:Three ICUs. PATIEN...

journal_title：Critical care medicine

authors： Mallat J,Baghdadi FA,Mohammad U,Lemyze M,Temime J,Tronchon L,Thevenin D,Fischer MO

更新日期：2020-10-01 00:00:00

abstract：OBJECTIVE:Acute lung injury with subsequent pneumonia and sepsis represents a major cause of morbidity and mortality in thermally injured patients. Production of nitric oxide by the neuronal and inducible nitric oxide synthase may be critically involved in the pathophysiology of the disease process at different time po...

journal_title：Critical care medicine

authors： Lange M,Connelly R,Traber DL,Hamahata A,Cox RA,Nakano Y,Bansal K,Esechie A,von Borzyskowski S,Jonkam C,Traber LD,Hawkins HK,Herndon DN,Enkhbaatar P

更新日期：2009-01-01 00:00:00

abstract：OBJECTIVES:There has long-been controversy about the possible superiority of norepinephrine compared to dopamine in the treatment of shock. The objective was to evaluate the effects of norepinephrine and dopamine on outcome and adverse events in patients with septic shock. DATA SOURCES:A systematic search of the MEDLI...

journal_title：Critical care medicine

authors： De Backer D,Aldecoa C,Njimi H,Vincent JL

更新日期：2012-03-01 00:00:00

abstract：OBJECTIVE:To compare the effectiveness and safety of the hemoglobin-based nitric oxide scavenger, pyridoxalated hemoglobin polyoxyethylene, against placebo in patients with vasopressor-dependent distributive shock. DESIGN:Multicenter, randomized, placebo-controlled, open-label study. SETTING:Sixty-one participating I...

journal_title：Critical care medicine

authors： Vincent JL,Privalle CT,Singer M,Lorente JA,Boehm E,Meier-Hellmann A,Darius H,Ferrer R,Sirvent JM,Marx G,DeAngelo J

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVES:Vascular beds vary in their responses to atrial natriuretic peptide and sodium nitroprusside. Both of these agents dilate blood vessels by increasing intracellular guanosine 3',5'-cyclic monophosphate (cyclic-GMP) but activate different enzymes in the vascular smooth muscle cell. We aimed to determine if the...

journal_title：Critical care medicine

authors： Zhang LM,Castresana M,Newman WH

更新日期：1994-09-01 00:00:00

abstract：OBJECTIVE:Information booklets have not been assessed by the families of intensive care unit (ICU) patients. This study explored the information that the relatives of adult ICU patients wanted to find in the information booklets. DESIGN:Multicenter survey. SETTING:Twenty-three French ICUs. SUBJECTS:One close relativ...

journal_title：Critical care medicine

authors： Soltner C,Lassalle V,Galienne-Bouygues S,Pottecher J,Floccard B,Delapierre L,Jungfer F,Sargentini C,Alberti C,Beydon L,Lifrea Group.

更新日期：2009-07-01 00:00:00