Abstract:
OBJECTIVES:To determine the incidence and characteristics of children with brain death in the pediatric intensive care unit (ICU), and to assess the incidence of the clinical triad (Turner's triad) of central diabetes insipidus, low glucose demand, and low CO2 production. DESIGN:Retrospective review of medical records. SETTING:Two multidisciplinary pediatric ICUs. PATIENTS:Medical records of pediatric patients declared brain dead and admitted to two multidisciplinary pediatric ICUs. MEASUREMENTS AND MAIN RESULTS:Patient records were reviewed for demographic data, primary diagnosis, severity of illness (Pediatric Risk of Mortality score and calculated risk of mortality), methods by which brain-death diagnosis was determined, presence of central diabetes insipidus, low glucose demand, low CO2 production in the final 24 hrs before the diagnosis was made, and whether organ donation was accomplished. The incidence of brain death among all patients admitted to the pediatric ICUs was 0.9%, accounting for 11% of patients who died during the same period. The most common presentation leading to brain-death diagnoses was trauma, followed by drowning/near drowning, and meningitis. The majority of brain-death diagnoses were made using both clinical criteria and confirmatory tests (66%). The incidence of clinical signs of Turner's triad was 41% for central diabetes insipidus, 49% for low glucose demand, and 53% for low CO2 production. Two of the three features were present in 38% of patients, and 12% of the patients had all three features. CONCLUSIONS:Our series of brain-dead patients in the pediatric ICU showed a 0.9% incidence of brain death. The most common primary diagnosis was trauma, a finding that is similar to other series. We also demonstrated that the clinical triad (Turner's triad) is present in this patient population, although only 12% of study patients demonstrated all three features.
journal_name
Crit Care Medjournal_title
Critical care medicineauthors
Staworn D,Lewison L,Marks J,Turner G,Levin Ddoi
10.1097/00003246-199408000-00014subject
Has Abstractpub_date
1994-08-01 00:00:00pages
1301-5issue
8eissn
0090-3493issn
1530-0293journal_volume
22pub_type
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journal_title:Critical care medicine
pub_type: 杂志文章
doi:10.1097/00003246-198507000-00001
更新日期:1985-07-01 00:00:00
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pub_type: 杂志文章,评审
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abstract:OBJECTIVE:To describe three female patients of one family with different phenotypes of the same mutation of the ornithine transcarbamylase gene. X-linked inherited ornithine transcarbamylase deficiency is the most frequent urea cycle disorder. Many of the hemizygous males die during the neonatal period. Women, who are ...
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更新日期:2002-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1097/00003246-199611000-00009
更新日期:1996-11-01 00:00:00
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更新日期:2015-01-01 00:00:00
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journal_title:Critical care medicine
pub_type: 杂志文章
doi:10.1097/00003246-199809000-00035
更新日期:1998-09-01 00:00:00
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doi:10.1097/00003246-198902000-00013
更新日期:1989-02-01 00:00:00
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journal_title:Critical care medicine
pub_type: 杂志文章
doi:10.1097/00003246-198711000-00002
更新日期:1987-11-01 00:00:00
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pub_type: 杂志文章
doi:10.1097/01.ccm.0000178175.54354.ea
更新日期:2005-09-01 00:00:00
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更新日期:2003-02-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1097/CCM.0000000000000051
更新日期:2014-04-01 00:00:00
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pub_type: 临床试验,杂志文章
doi:10.1097/00003246-200205000-00014
更新日期:2002-05-01 00:00:00
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doi:10.1097/00003246-197912000-00010
更新日期:1979-12-01 00:00:00
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doi:10.1097/01.CCM.0000104950.52577.97
更新日期:2004-02-01 00:00:00
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doi:10.1097/01.ccm.0000187010.14426.cc
更新日期:2005-11-01 00:00:00
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doi:10.1097/00003246-197809000-00008
更新日期:1978-09-01 00:00:00
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doi:10.1097/00003246-198306000-00007
更新日期:1983-06-01 00:00:00
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doi:10.1097/00003246-200206000-00018
更新日期:2002-06-01 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:2000-10-01 00:00:00
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更新日期:2006-11-01 00:00:00
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pub_type: 杂志文章
doi:10.1097/00003246-198207000-00001
更新日期:1982-07-01 00:00:00
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journal_title:Critical care medicine
pub_type: 杂志文章
doi:10.1097/00003246-198812000-00011
更新日期:1988-12-01 00:00:00
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doi:10.1097/00003246-199707000-00025
更新日期:1997-07-01 00:00:00
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doi:10.1097/00003246-200012000-00024
更新日期:2000-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1097/01.CCM.0000065761.51367.2D
更新日期:2003-06-01 00:00:00
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doi:10.1097/CCM.0000000000004425
更新日期:2020-09-01 00:00:00
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更新日期:1992-03-01 00:00:00