Clinically relevant concentrations of beta2-adrenergic agonists stimulate maximal cyclic adenosine monophosphate-dependent airspace fluid clearance and decrease pulmonary edema in experimental acid-induced lung injury.

abstract：OBJECTIVES:To determine nuclear factor kappa B (NF-kappa B) activation in mononuclear and neutrophils from critically ill patients and to compare NF-kappa B activation with circulating concentrations of interleukin (IL)-6, IL-8, and soluble intercellular adhesion molecule (sICAM)-1. DESIGN:Observational study. SETTIN...

journal_title：Critical care medicine

authors： Paterson RL,Galley HF,Dhillon JK,Webster NR

更新日期：2000-04-01 00:00:00

abstract：BACKGROUND:Endotoxin (lipopolysaccharide [LPS]) has been associated with sepsis and the high mortality rate seen in septic shock. The administration of a small amount of LPS to healthy subjects produces a mild syndrome qualitatively similar to that seen in clinical sepsis. We used this model to test the efficacy of an ...

journal_title：Critical care medicine

authors： Bunnell E,Lynn M,Habet K,Neumann A,Perdomo CA,Friedhoff LT,Rogers SL,Parrillo JE

更新日期：2000-08-01 00:00:00

abstract：OBJECTIVE:Mannitol is widely used in hospitals worldwide to treat patients with high intracranial pressure and/or cerebral edema. One of the mechanisms by which mannitol is thought to affect intracranial pressure is by increasing the patient's serum osmolarity, but not the osmolarity in the brain or cerebrospinal fluid...

journal_title：Critical care medicine

authors： Polderman KH,van de Kraats G,Dixon JM,Vandertop WP,Girbes AR

更新日期：2003-02-01 00:00:00

abstract：OBJECTIVE:Neutropenia recovery may be associated with an increased risk of respiratory function deterioration. A history of pneumonia complicating neutropenia has been identified as the leading cause of adult respiratory distress syndrome during neutropenia recovery in patients receiving anticancer chemotherapy, sugges...

journal_title：Critical care medicine

authors： Azoulay E,Attalah H,Yang K,Herigault S,Jouault H,Brun-Buisson C,Brochard L,Harf A,Schlemmer B,Delclaux C

更新日期：2003-01-01 00:00:00

abstract：OBJECTIVE:As the Surviving Sepsis Campaign was assessing patient-level data over multiple countries, we sought to evaluate the use of a pragmatic and parsimonious severity-of-illness scoring system for patients with sepsis in an attempt to provide appropriate comparisons with practical application. DESIGN:Prospective,...

journal_title：Critical care medicine

authors： Osborn TM,Phillips G,Lemeshow S,Townsend S,Schorr CA,Levy MM,Dellinger RP

更新日期：2014-09-01 00:00:00

abstract：OBJECTIVE:To investigate the cardiorespiratory effects of graded bilateral pleural effusions in the anesthetized pig. DESIGN:Prospective, randomized, controlled, laboratory study. SETTING:Animal laboratory. SUBJECTS:Eleven male Yorkshire pigs. INTERVENTIONS:Animals were anesthetized using inhaled isoflurane. Orotra...

journal_title：Critical care medicine

authors： Nishida O,Arellano R,Cheng DC,DeMajo W,Kavanagh BP

更新日期：1999-03-01 00:00:00

abstract：OBJECTIVE:The objective of the present study was to determine whether selective inflammatory cytokine concentrations within cerebrospinal fluid are useful markers for the differential diagnosis of aseptic and bacterial meningitis within neurosurgical patients. DESIGN:Prospective, open-label, observational, cohort stud...

journal_title：Critical care medicine

authors： Liu ZH,Tu PH,Chen NY,Yip PK,Bowes AL,Lee CC,Chan SH,Kung CC,Wang AY,Wu CT,Lee ST

更新日期：2015-11-01 00:00:00

abstract：OBJECTIVE:Sepsis and severe trauma result in endothelial activation and damage. The activated endothelium expresses adhesion receptors that control leukocyte trafficking. After activation, some adhesion molecules are also released into plasma as soluble forms. The present study was designed to compare the expression of...

journal_title：Critical care medicine

authors： Leone M,Boutière B,Camoin-Jau L,Albanèse J,Horschowsky N,Mège JL,Martin C,Dignat-George F

更新日期：2002-04-01 00:00:00

abstract：:In a prospective 30-month study of nosocomial infections in a pediatric ICU (PICU), the incidence, sites, and causes of infection were determined. Factors associated with increased risk of infection were investigated. In 1,388 patients who remained in the PICU for a minimum of 72 h, 116 infections occurred (6.1 infect...

journal_title：Critical care medicine

authors： Milliken J,Tait GA,Ford-Jones EL,Mindorff CM,Gold R,Mullins G

更新日期：1988-03-01 00:00:00

abstract：OBJECTIVE:Liquid lung ventilation has been demonstrated to improve cardiorespiratory function after cardiopulmonary bypass. We hypothesized that liquid lung ventilation (LLV) would decrease the pulmonary inflammatory response after cardiopulmonary bypass (CPB). DESIGN:Prospective, randomized, experimental, controlled,...

journal_title：Critical care medicine

authors： Williams EA,Welty SE,Geske RS,Hubble CL,Craig DM,Quick G,Meliones JN,Cheifetz IM

更新日期：2001-04-01 00:00:00

abstract：OBJECTIVE:Head-to-head comparison of the success rate of jejunal placement of a new electromagnetically visualized jejunal tube with that of the endoscopic technique in critically ill patients. DESIGN:: Prospective, randomized clinical trial. SETTING:Two intensive care units at a university hospital. PATIENTS:: A to...

journal_title：Critical care medicine

authors： Holzinger U,Brunner R,Miehsler W,Herkner H,Kitzberger R,Fuhrmann V,Metnitz PG,Kamolz LP,Madl C

更新日期：2011-01-01 00:00:00

abstract：OBJECTIVES:To measure energy expenditure in critically ill children and compare it with the energy expenditure predicted by recommended formulas, and relate the measured energy expenditure to nutritional and clinical indices. DESIGN:A prospective, clinical study. SETTING:Tertiary care pediatric intensive care unit in...

journal_title：Critical care medicine

authors： Briassoulis G,Venkataraman S,Thompson AE

更新日期：2000-04-01 00:00:00

abstract：OBJECTIVE:Most intensive care deaths beyond the first few days of critical illness are attributable to nonresolving organ failure, either due to or coinciding with sepsis. One of the mechanisms that is thought to contribute to the pathogenesis of organ failure is microvascular thrombosis. Recently, we reported signific...

journal_title：Critical care medicine

authors： Langouche L,Meersseman W,Vander Perre S,Milants I,Wouters PJ,Hermans G,Gjedsted J,Hansen TK,Arnout J,Wilmer A,Schetz M,Van den Berghe G

更新日期：2008-05-01 00:00:00

abstract：OBJECTIVE:To determine the impact of the rotation of antimicrobial agents on the rates of infection, intestinal colonization, and acquisition with antimicrobial-resistant Gram-negative bacteria. DESIGN:Pre- and postintervention design. SETTING:A 19-bed, medical intensive care unit. PATIENTS:Individuals admitted to t...

journal_title：Critical care medicine

authors： Warren DK,Hill HA,Merz LR,Kollef MH,Hayden MK,Fraser VJ,Fridkin SK

更新日期：2004-12-01 00:00:00

abstract：OBJECTIVE:To describe a severe axonal polyneuropathy that follows acute respiratory failure and, in turn, causes continued ventilator dependence and paralysis after resolution of the primary illness. DESIGN:Retrospective chart review of three patients and prospective analysis of two patients. SETTING:Respiratory and ...

journal_title：Critical care medicine

authors： Gorson KC,Ropper AH

更新日期：1993-02-01 00:00:00

abstract：OBJECTIVE:In patients undergoing surgical repair of aortic dissection, false lumen perfusion during cardiopulmonary bypass may produce central nervous system damage, myocardial ischemia, aortic rupture, and death. We describe a method to detect false lumen perfusion at the beginning of retrograde aortic perfusion that ...

journal_title：Critical care medicine

authors： Voci P,Testa G,Tritapepe L,Menichetti A,Caretta Q

更新日期：2000-06-01 00:00:00

abstract：OBJECTIVE:Quality of care for patients admitted with pneumonia varies across hospitals, but causes of this variation are poorly understood. Whether hospitals with high ICU utilization for patients with pneumonia provide better quality care is unknown. We sought to investigate the relationship between a hospital's ICU a...

journal_title：Critical care medicine

authors： Sjoding MW,Prescott HC,Wunsch H,Iwashyna TJ,Cooke CR

更新日期：2015-06-01 00:00:00

abstract：:This report documents the validity of clinical measurements of oxygen consumption (VO2) and carbon dioxide production (VCO2) made with a new metabolic gas monitor (MGM) suitable for use in critically ill patients receiving mechanical ventilatory support. Paired samples of inspired and expired gases were obtained, and ...

journal_title：Critical care medicine

authors： Nelson LD,Anderson HB,Garcia H

更新日期：1987-10-01 00:00:00

abstract：OBJECTIVES:The potential advantages of lowering core temperature during sepsis are to lower energy requirement and to activate various cell-protecting pathways. We experimentally investigated whether postconditioning temperature modifications influence survival duration during experimental sepsis. DESIGN:A prospective...

journal_title：Critical care medicine

authors： L'Her E,Amerand A,Vettier A,Sebert P

更新日期：2006-10-01 00:00:00

abstract：OBJECTIVE:To determine the association of pulmonary artery catheter (PAC) use with in-hospital mortality. DESIGN:Prospective, observational study. SETTING:The medical intensive care units (MICU) of two teaching hospitals. METHODS:The study included 751 adults who were admitted to the MICU, excluding those who stayed...

journal_title：Critical care medicine

authors： Afessa B,Spencer S,Khan W,LaGatta M,Bridges L,Freire AX

更新日期：2001-06-01 00:00:00

abstract：OBJECTIVE:To examine the value of laser bronchoscopy in patients with inoperable carcinoma of the lung who required ventilatory assistance for acute respiratory failure. DESIGN:Retrospective review of the medical records of all patients undergoing laser bronchoscopy. SETTING:The Lahey Clinic Medical Center, a tertiar...

journal_title：Critical care medicine

authors： Stanopoulos IT,Beamis JF Jr,Martinez FJ,Vergos K,Shapshay SM

更新日期：1993-03-01 00:00:00

abstract：:Critical decreases in oxygen delivery (DO2) and mixed venous oxygen saturation (SvO2) are associated with anaerobic metabolism and, therefore, lactic acidosis. We studied 50 consecutive patients with sepsis and 50 consecutive patients with acute myocardial infarction (AMI) in whom the arterial blood lactate was greate...

journal_title：Critical care medicine

authors： Astiz ME,Rackow EC,Kaufman B,Falk JL,Weil MH

更新日期：1988-07-01 00:00:00

abstract：OBJECTIVE:To evaluate the tolerance and the efficacy of noninvasive continuous positive airway pressure (CPAP) in severe acute respiratory failure occurring in intensive care unit (ICU) neutropenic patients with hematologic malignancies, and to establish predictive variables of efficacy of this method. DESIGN:Prospect...

journal_title：Critical care medicine

authors： Hilbert G,Gruson D,Vargas F,Valentino R,Chene G,Boiron JM,Pigneux A,Reiffers J,Gbikpi-Benissan G,Cardinaud JP

更新日期：2000-09-01 00:00:00

abstract：OBJECTIVE:To determine whether four stages of weaning (acute, prewean, wean, and outcome) could be identified by using clinical instruments designed to quantify severity of illness, patient stability, or weaning readiness. The instruments used were the Acute Physiology and Chronic Health Evaluation (APACHE III), the Th...

journal_title：Critical care medicine

authors： Burns SM,Ryan B,Burns JE

更新日期：2000-07-01 00:00:00

abstract：OBJECTIVE:Sepsis and acute lung injury continue to be major causes of morbidity and mortality worldwide despite advances in our understanding of pathophysiology and the discovery of new management strategies. Recent investigations show that stem cells may be beneficial as prognostic biomarkers and novel therapeutic str...

journal_title：Critical care medicine

authors： Cribbs SK,Matthay MA,Martin GS

更新日期：2010-12-01 00:00:00

abstract：OBJECTIVES:To perform a scoping literature review of cognitive, psychiatric, and quality of life outcomes in adults undergoing extracorporeal membrane oxygenation for any indication. DATA SOURCES:We searched PubMed, EMBASE, Cochrane Library, Web of Science, CINAHL, and PsycINFO from inception to June 2019. STUDY SELE...

journal_title：Critical care medicine

authors： Khan IR,Saulle M,Oldham MA,Weber MT,Schifitto G,Lee HB

更新日期：2020-10-01 00:00:00

abstract：OBJECTIVE:To determine risk factors for nosocomial pneumonia in critically ill trauma patients. DESIGN:Prospective cohort study. SETTING:The trauma intensive care unit (ICU) of a 1500-bed tertiary-care hospital. PATIENTS:All critically ill trauma patients (n = 103) admitted consecutively between November 1995 and Oc...

journal_title：Critical care medicine

authors： Tejada Artigas A,Bello Dronda S,Chacón Vallés E,Muñoz Marco J,Villuendas Usón MC,Figueras P,Suarez FJ,Hernández A

更新日期：2001-02-01 00:00:00

abstract：OBJECTIVE:To examine the ways in which healthcare professionals work together in the ICU setting, through a consideration of the contextual, organizational, processual, and relational factors that impact their interprofessional collaboration. DESIGN:Data from over 350 hours of ethnographic observation and 35 semistruc...

journal_title：Critical care medicine

authors： Alexanian JA,Kitto S,Rak KJ,Reeves S

更新日期：2015-09-01 00:00:00

abstract：OBJECTIVE:Isoflurane, a volatile anesthetic agent, has been recognized for its potential neuroprotective properties and has antiapoptotic effects. We examined whether isoflurane posttreatment is protective against early brain injury after subarachnoid hemorrhage and determined whether this effect needs sphingosine-rela...

journal_title：Critical care medicine

authors： Altay O,Hasegawa Y,Sherchan P,Suzuki H,Khatibi NH,Tang J,Zhang JH

更新日期：2012-06-01 00:00:00

abstract：:A patient with brainstem infarction met the clinical criteria for brain death but had persistent EEG activity, complicating our decision to withdraw life support. We evaluated cerebral blood flow with xenon-enhanced computed tomography (Xe/CT), which documented the absence of posterior circulation flow and persistent,...

journal_title：Critical care medicine

authors： Darby J,Yonas H,Brenner RP

更新日期：1987-05-01 00:00:00