Liquid lung ventilation reduces neutrophil sequestration in a neonatal swine model of cardiopulmonary bypass.


OBJECTIVE:Liquid lung ventilation has been demonstrated to improve cardiorespiratory function after cardiopulmonary bypass. We hypothesized that liquid lung ventilation (LLV) would decrease the pulmonary inflammatory response after cardiopulmonary bypass (CPB). DESIGN:Prospective, randomized, experimental, controlled, nonblinded study. SETTING:Animal research laboratory at a university setting. SUBJECTS:A total of 24 neonatal piglets. INTERVENTIONS:After intubation with a cuffed endotracheal tube, swine were conventionally ventilated. After surgical cannulation, each piglet was placed on conventional nonpulsatile CPB and cooled to 18 degrees C (64.4 degrees F). Subsequently, the animals were exposed to 90 mins of low-flow CPB (35 mL/kg/min). Animals were rewarmed to 37 degrees C (98.6 degrees F), removed from CPB, and ventilated for 90 min. Ten animals received conventional gas ventilation only (control), seven received initiation of LLV before CPB (prevention), and seven received initiation of LLV during the rewarming phase of CPB (treatment). After the animals were killed, the lungs were removed en bloc. The left lobe was dissected and formalin-fixed at 20 cm H2O overnight, followed by paraffin embedding. Sections were taken from the paraffin-embedded lungs. Neutrophil accumulation and lung injury were assessed by histochemical staining with leukocyte esterase and morphometrics, respectively. One hundred microscopic images were digitized from each tissue sample for lung morphometrics, and neutrophil counts were obtained from every fifth image. MEASUREMENTS AND MAIN RESULTS:Lung tissue sections showed a significantly lower number of neutrophils per alveolar area in the prevention and treatment groups than in the control group (control 681 +/- 65, prevention 380 +/- 49, treatment 412 +/- 101 neutrophils per alveolar area [cells/mm2]; p <.05 for both prevention and treatment compared with control). There were no differences in lung injury as assessed with morphometrics or hemodynamic measurements between any of the three groups. CONCLUSIONS:The data suggest that LLV reduces the CPB-induced neutrophil sequestration in the pulmonary parenchyma independent of its effects on the circulatory physiology or evidence of early lung injury.


Crit Care Med


Critical care medicine


Williams EA,Welty SE,Geske RS,Hubble CL,Craig DM,Quick G,Meliones JN,Cheifetz IM




Has Abstract


2001-04-01 00:00:00












  • Impact of a pediatric clinical pharmacist in the pediatric intensive care unit.

    abstract:OBJECTIVE:To study the impact of a clinical pharmacist in a pediatric intensive care unit. The goals of the study were to determine the type and quantity of patient care interventions recommended by a clinical pharmacist and to specifically examine cost savings (or loss) that resulted from clinical pharmacist recommend...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Krupicka MI,Bratton SL,Sonnenthal K,Goldstein B

    更新日期:2002-04-01 00:00:00

  • Preclinical evaluation of epinephrine nebulization to reduce airway hyperemia and improve oxygenation after smoke inhalation injury.

    abstract:OBJECTIVE:Acute lung injury secondary to smoke inhalation is a major source of morbidity and mortality in burn patients. We tested the hypothesis that nebulized epinephrine would ameliorate pulmonary dysfunction secondary to acute lung injury by reducing airway hyperemia and edema formation and mediating bronchodilatat...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Lange M,Hamahata A,Traber DL,Cox RA,Kulp GA,Nakano Y,Traber LD,Herndon DN,Enkhbaatar P

    更新日期:2011-04-01 00:00:00

  • Clinical Practice Guidelines for Early Mobilization in the ICU: A Systematic Review.

    abstract:OBJECTIVES:To evaluate the methodological quality and thematic completeness of existing clinical practice guidelines, addressing early mobilization of adults in the ICU. DATA SOURCES:Systematic review of Medline, Embase, CINAHL, Cochrane, and grey literature from January 2008 to February 2020. STUDY SELECTION:Two rev...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Lang JK,Paykel MS,Haines KJ,Hodgson CL

    更新日期:2020-11-01 00:00:00

  • Salutary effects of ATP-MgCl2 on the depressed endothelium-dependent relaxation during hyperdynamic sepsis.

    abstract:OBJECTIVES:Studies have shown that endothelium-dependent relaxation (mediated by endothelium-derived nitric oxide) is depressed during the early, hyperdynamic stage of sepsis. Although it is known that ATP-MgCl2 produces beneficial effects following various adverse circulatory conditions, it remains unknown whether thi...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Wang P,Ba ZF,Cioffi WG,Bland KI,Chaudry IH

    更新日期:1999-05-01 00:00:00

  • Retention of cardiopulmonary resuscitation skills after initial overtraining.

    abstract::The authors have examined cardiopulmonary resuscitation (CPR) skills retention in a police force initially trained to instructor level performance skills as defined by the 1977 American Heart Association Instructor Manual. In 1977, the entire Winnipeg Police Force received a basic 8-h course of CPR training with recor...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Tweed WA,Wilson E,Isfeld B

    更新日期:1980-11-01 00:00:00

  • Physical Rehabilitation in Critically Ill Children: A Multicenter Point Prevalence Study in the United States.

    abstract:OBJECTIVES:With decreasing mortality in PICUs, a growing number of survivors experience long-lasting physical impairments. Early physical rehabilitation and mobilization during critical illness are safe and feasible, but little is known about the prevalence in PICUs. We aimed to evaluate the prevalence of rehabilitatio...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Kudchadkar SR,Nelliot A,Awojoodu R,Vaidya D,Traube C,Walker T,Needham DM,Prevalence of Acute Rehabilitation for Kids in the PICU (PARK-PICU) Investigators and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network.

    更新日期:2020-05-01 00:00:00

  • How to use articles about diagnostic technology: gastric tonometry.

    abstract:PURPOSE:Periodic diagnostic tests and continuous and intermittent monitoring are integral to critical care medicine. The focus of this article is understanding the impact of existing diagnostic technology, as well as that of new diagnostic technology. DATA SYNTHESIS:We use literature about gastric tonometry to illustr...

    journal_title:Critical care medicine

    pub_type: 杂志文章,评审


    authors: Keenan SP,Guyatt GH,Sibbald WJ,Cook DJ,Heyland DK,Jaeschke RZ

    更新日期:1999-09-01 00:00:00

  • Outcome of children with hematologic malignancy who are admitted to an intensive care unit.

    abstract::Sixty-four (48%) of 133 children with hematologic malignancy who were admitted to three pediatric ICUs died. Children who required management because of airway obstruction or after general anesthesia had the best outlook (mortality rate of 7% or less); those children who required major circulatory support or mechanica...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Butt W,Barker G,Walker C,Gillis J,Kilham H,Stevens M

    更新日期:1988-08-01 00:00:00

  • Accidental removal of endotracheal and nasogastric tubes and intravascular catheters.

    abstract:OBJECTIVES:To characterize the rates of accidental removal of endotracheal tubes, nasogastric tubes, central venous catheters, and arterial catheters. To assess the efficacy of corrective measures aimed at reducing the accidental removal of these devices. DESIGN:Prospective, observational, and interventional study. S...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Carrión MI,Ayuso D,Marcos M,Paz Robles M,de la Cal MA,Alía I,Esteban A

    更新日期:2000-01-01 00:00:00

  • Systemic hemodynamics, gastric intramucosal PCO2 changes, and outcome in critically ill burn patients.

    abstract:OBJECTIVES:To define the hemodynamic and gastric intramucosal PCO2 (PiCO2) changes during the first 48 hrs after burn trauma and to analyze their relationship with outcome. DESIGN:Prospective, observational study in a cohort of consecutively admitted critically ill burn patients. SETTING:Intensive care burn unit in a...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Lorente JA,Ezpeleta A,Esteban A,Gordo F,de la Cal MA,Díaz C,Arévalo JM,Tejedor C,Pascual T

    更新日期:2000-06-01 00:00:00

  • Corticosteroids and transition to delirium in patients with acute lung injury.

    abstract:OBJECTIVE:Delirium is common in mechanically ventilated patients in the ICU and associated with short- and long-term morbidity and mortality. The use of systemic corticosteroids is also common in the ICU. Outside the ICU setting, corticosteroids are a recognized risk factor for delirium, but their relationship with del...

    journal_title:Critical care medicine

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Schreiber MP,Colantuoni E,Bienvenu OJ,Neufeld KJ,Chen KF,Shanholtz C,Mendez-Tellez PA,Needham DM

    更新日期:2014-06-01 00:00:00

  • The Impella 2.5 and 5.0 devices for ST-elevation myocardial infarction patients presenting with severe and profound cardiogenic shock: the Academic Medical Center intensive care unit experience.

    abstract:OBJECTIVE:Cardiogenic shock remains an important therapeutic challenge, with high in-hospital mortality rates. Mechanical circulatory support may be beneficial in these patients. Since the efficacy of the intra-aortic balloon pump seems limited, new percutaneously placed mechanical left ventricular support devices, suc...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Engström AE,Cocchieri R,Driessen AH,Sjauw KD,Vis MM,Baan J,de Jong M,Lagrand WK,van der Sloot JA,Tijssen JG,de Winter RJ,de Mol BA,Piek JJ,Henriques JP

    更新日期:2011-09-01 00:00:00

  • A prospective survey of nutritional support practices in intensive care unit patients: what is prescribed? What is delivered?

    abstract:OBJECTIVES:To assess the amount of nutrients delivered, prescribed, and required for critically ill patients and to identify the reasons for discrepancies between prescriptions and requirements and between prescriptions and actual delivery of nutrition. DESIGN:Prospective cohort study. SETTING:Twelve-bed medical inte...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: De Jonghe B,Appere-De-Vechi C,Fournier M,Tran B,Merrer J,Melchior JC,Outin H

    更新日期:2001-01-01 00:00:00

  • Effect of acute physiologic derangements on outcome after subarachnoid hemorrhage.

    abstract:OBJECTIVE:To determine the effect that acute physiologic derangements have on outcome after subarachnoid hemorrhage (SAH) and to design a composite score summarizing these abnormalities. DESIGN:Prospective observational study. SETTING:Neuroscience intensive care unit in a tertiary care academic center. PATIENTS:Cons...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Claassen J,Vu A,Kreiter KT,Kowalski RG,Du EY,Ostapkovich N,Fitzsimmons BF,Connolly ES,Mayer SA

    更新日期:2004-03-01 00:00:00

  • Detrimental hemodynamic effects of assisted ventilation in hemorrhagic states.

    abstract:OBJECTIVE:Our goal was to demonstrate explicitly that lower-frequency positive-pressure ventilation not only preserves adequate oxygenation and acid-base status in hemorrhagic states, but also that "normal" or higher respiratory rates significantly compromise hemodynamics, even with moderate degrees of hemorrhage. DES...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Pepe PE,Lurie KG,Wigginton JG,Raedler C,Idris AH

    更新日期:2004-09-01 00:00:00

  • Incidence and Mortality of Acute Respiratory Distress Syndrome in Children: A Systematic Review and Meta-Analysis.

    abstract:OBJECTIVES:Our understanding of the acute respiratory distress syndrome in children is limited, and literature is dominated by investigations in adult patients. Recent preclinical studies suggest that the susceptibility to and severity of acute respiratory distress syndrome in children could differ from that in adults....

    journal_title:Critical care medicine

    pub_type: 杂志文章,meta分析,评审


    authors: Schouten LR,Veltkamp F,Bos AP,van Woensel JB,Serpa Neto A,Schultz MJ,Wösten-van Asperen RM

    更新日期:2016-04-01 00:00:00

  • The lectin-like domain of tumor necrosis factor improves lung function after rat lung transplantation--potential role for a reduction in reactive oxygen species generation.

    abstract:OBJECTIVE:To test the hypothesis that the lectin-like domain of tumor necrosis factor, mimicked by the TIP peptide, can improve lung function after unilateral orthotopic lung isotransplantation. Because of a lack of a specific treatment for ischemia reperfusion-mediated lung injury, accompanied by a disrupted barrier i...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Hamacher J,Stammberger U,Roux J,Kumar S,Yang G,Xiong C,Schmid RA,Fakin RM,Chakraborty T,Hossain HM,Pittet JF,Wendel A,Black SM,Lucas R

    更新日期:2010-03-01 00:00:00

  • Ineffective triggering predicts increased duration of mechanical ventilation.

    abstract:OBJECTIVES:To determine whether high rates of ineffective triggering within the first 24 hrs of mechanical ventilation (MV) are associated with longer MV duration and shorter ventilator-free survival (VFS). DESIGN:Prospective cohort study. SETTING:Medical intensive care unit (ICU) at an academic medical center. PATI...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: de Wit M,Miller KB,Green DA,Ostman HE,Gennings C,Epstein SK

    更新日期:2009-10-01 00:00:00

  • Staged Implementation of Awakening and Breathing, Coordination, Delirium Monitoring and Management, and Early Mobilization Bundle Improves Patient Outcomes and Reduces Hospital Costs.

    abstract:OBJECTIVES:To measure the impact of staged implementation of full versus partial ABCDE bundle on mechanical ventilation duration, ICU and hospital lengths of stay, and cost. DESIGN:Prospective cohort study. SETTING:Two medical ICUs within Montefiore Healthcare Center (Bronx, NY). PATIENTS:One thousand eight hundred ...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Hsieh SJ,Otusanya O,Gershengorn HB,Hope AA,Dayton C,Levi D,Garcia M,Prince D,Mills M,Fein D,Colman S,Gong MN

    更新日期:2019-07-01 00:00:00

  • Intracranial pressure monitoring and case mix-adjusted mortality in intracranial hemorrhage.

    abstract:OBJECTIVE:Intracranial pressure (ICP) monitoring is frequently used in intensive care treatment of patients with intracranial hemorrhage. Data demonstrating an improved outcome from this intervention are lacking. We analyzed standardized mortality ratios in patients with and without ICP monitoring to determine its effi...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Valentin A,Lang T,Karnik R,Ammerer HP,Ploder J,Slany J

    更新日期:2003-05-01 00:00:00

  • Sensitivity of routine intensive care unit surveillance for detecting myocardial ischemia.

    abstract:OBJECTIVE:To assess the effectiveness of routine intensive care unit surveillance compared with frequent 12-lead electrocardiogram monitoring for detecting electrocardiogram evidence suggestive of prolonged myocardial ischemia in vascular surgery patients. DESIGN:Prospective cohort trial. SETTING:Intensive care unit....

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Martinez EA,Kim LJ,Faraday N,Rosenfeld B,Bass EB,Perler BA,Williams GM,Dorman T,Pronovost PJ

    更新日期:2003-09-01 00:00:00

  • Efficacy of flow-by during continuous positive airway pressure ventilation.

    abstract::We investigated clinically the differences in respiratory work of patients imposed by three modes of one ventilator: the flow-by system, the demand valve system, and the pressure support system. Inspiratory work using flow-by and pressure support systems was reduced sufficiently when compared to the demand valve syste...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Saito S,Tokioka H,Kosaka F

    更新日期:1990-06-01 00:00:00

  • Attitudes and preferences of intensivists regarding the role of family interests in medical decision making for incompetent patients.

    abstract:OBJECTIVE:The role of family interests in medical decision making is controversial. Physicians who routinely treat incompetent patients may have preferred strategies for addressing family interests as they are encountered in surrogate medical decision making. We sought to determine how physicians view the role of famil...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Hardart GE,Truog RD

    更新日期:2003-07-01 00:00:00

  • The efficacy of loop diuretics in acute renal failure: assessment using Bayesian evidence synthesis techniques.

    abstract:OBJECTIVE:To quantify the therapeutic efficacy of loop diuretics in acute renal failure using Bayesian evidence synthesis, because despite widespread use, the role of diuretics is controversial. DATA SOURCE:Randomized controlled trials or nonrandomized studies, 1966 to January 2007, identified from MEDLINE and EMBASE ...

    journal_title:Critical care medicine

    pub_type: 杂志文章,评审


    authors: Sampath S,Moran JL,Graham PL,Rockliff S,Bersten AD,Abrams KR

    更新日期:2007-11-01 00:00:00

  • Report on the development of a procedure to prevent placement of feeding tubes into the lungs using end-tidal CO2 measurements.

    abstract:OBJECTIVE:To determine the accuracy of a technique using capnography to prevent inadvertent placement of small-bore feeding tubes and Salem sump tubes into the lungs. SETTING:Twelve-bed medical intensive care unit (MICU) in a 557-bed teaching hospital. PATIENTS:A total of 25 ventilated adult MICU patients were studie...

    journal_title:Critical care medicine

    pub_type: 临床试验,杂志文章


    authors: Burns SM,Carpenter R,Truwit JD

    更新日期:2001-05-01 00:00:00

  • Current approaches to the diagnosis of bacterial and fungal bloodstream infections in the intensive care unit.

    abstract::Healthcare systems spend considerable resources collecting and processing blood cultures for the detection of blood stream pathogens. The process is initiated with the collection of blood cultures that depend upon proper skin disinfection, collection of an adequate number of specimens and volume of blood, and prompt p...

    journal_title:Critical care medicine

    pub_type: 杂志文章,评审


    authors: Murray PR,Masur H

    更新日期:2012-12-01 00:00:00

  • Phase II, randomized, controlled trial of high-dose N-acetylcysteine in high-risk cardiac surgery patients.

    abstract:OBJECTIVE:To assess the effect of high-dose N-acetylcysteine on renal function in cardiac surgery patients at higher risk of postoperative renal failure. DESIGN:Multiblind, placebo-controlled, randomized, phase II clinical trial. SETTING:Operating rooms and intensive care units of two tertiary referral hospitals. PA...

    journal_title:Critical care medicine

    pub_type: 杂志文章,随机对照试验


    authors: Haase M,Haase-Fielitz A,Bagshaw SM,Reade MC,Morgera S,Seevenayagam S,Matalanis G,Buxton B,Doolan L,Bellomo R

    更新日期:2007-05-01 00:00:00

  • Inappropriate secretion of antidiuretic hormone in a postsurgical pediatric population.

    abstract::Twenty-four pediatric patients undergoing corrective posterior spinal fusion surgery for idiopathic scoliosis were studied to determine the frequency with which the syndrome of inappropriate antidiuretic hormone secretion (SIADH) developed. We measured arterial blood gases, serum and urine electrolytes and osmolalitie...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Burrows FA,Shutack JG,Crone RK

    更新日期:1983-07-01 00:00:00

  • Effects of a single-dose hypertonic saline hydroxyethyl starch on cerebral blood flow, long-term outcome, neurogenesis, and neuronal survival after cardiac arrest and cardiopulmonary resuscitation in rats*.

    abstract:OBJECTIVE:The beneficial effects of hypertonic saline on neuronal survival and on cerebral blood flow have been shown in several animal models of global and focal brain ischemia. Because of the potential benefits of hypertonic solutions, it is hypothesized that hydroxyethyl starch enhances cerebral blood flow and impro...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Noppens RR,Kelm RF,Lindemann R,Engelhard K,Werner C,Kempski O

    更新日期:2012-07-01 00:00:00

  • High-frequency jet ventilation in the postoperative period: a review of 100 patients.

    abstract::One hundred patients were ventilated with high-frequency jet ventilation (HFJV) during the initial 24-h postoperative period in the surgical and neurosurgical ICUs. Eighty-three were successfully weaned, 2 could not be ventilated adequately with HFJV, and 15 with criteria of acute respiratory failure received HFJV for...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Sladen A,Guntupalli K,Marquez J,Klain M

    更新日期:1984-09-01 00:00:00