Hypophosphatemia induced by mechanical ventilation in patients with chronic obstructive pulmonary disease.

abstract：OBJECTIVE:To evaluate the ability of two prognostic systems to predict hospital mortality in adult intensive care patients. DESIGN:Prospective cohort study. SETTING:A mixed medical and surgical intensive care unit (ICU) in the United Kingdom. PATIENTS:A total of 1,144 patients consecutively admitted to the study. I...

journal_title：Critical care medicine

authors： Beck DH,Taylor BL,Millar B,Smith GB

更新日期：1997-01-01 00:00:00

abstract：OBJECTIVE:To describe the effects of inhaled prostacyclin administered after cardiopulmonary bypass (CPB) to a patient with severe pulmonary hypertension. DESIGN:Case report and literature review. SETTING:Cardiac surgical operating rooms and postoperative recovery unit. PATIENTS:A 63-yr-old female who had undergone ...

journal_title：Critical care medicine

authors： Lowson SM,Doctor A,Walsh BK,Doorley PA

更新日期：2002-12-01 00:00:00

abstract：OBJECTIVE:Patients with severe sepsis have high mortality that is improved by timely, often expensive, treatments. Patients without insurance are more likely to delay seeking care; they may also receive less intense care. DESIGN:We performed a retrospective analysis of administrative database-Healthcare Costs and Util...

journal_title：Critical care medicine

authors： Kumar G,Taneja A,Majumdar T,Jacobs ER,Whittle J,Nanchal R,Milwaukee Initiative in Critical Care Outcomes Research (MICCOR) Group of Investigators.

更新日期：2014-03-01 00:00:00

abstract：OBJECTIVES:Preclinical studies reveal the neuroprotective properties of xenon, especially when combined with hypothermia. The purpose of this study was to investigate the feasibility and cardiac safety of inhaled xenon treatment combined with therapeutic hypothermia in out-of-hospital cardiac arrest patients. DESIGN:A...

journal_title：Critical care medicine

authors： Arola OJ,Laitio RM,Roine RO,Grönlund J,Saraste A,Pietilä M,Airaksinen J,Perttilä J,Scheinin H,Olkkola KT,Maze M,Laitio TT

更新日期：2013-09-01 00:00:00

abstract：OBJECTIVE:To assess the statistical association of the Acute Physiology and Chronic Health Evaluation (APACHE II) score with multiple intervention and outcome variables in surgical ICU patients. DESIGN:Continuous data collection on every patient admitted to the surgical ICU for a 21-month period. MATERIALS AND METHOD...

journal_title：Critical care medicine

authors： Rutledge R,Fakhry SM,Rutherford EJ,Muakkassa F,Baker CC,Koruda M,Meyer AA

更新日期：1991-08-01 00:00:00

abstract：OBJECTIVE:The objective of this study was to test the hypothesis that cocaine-induced cerebral vasodilation in newborn sheep is mediated via beta-adrenergic receptor activation. DESIGN:The cerebral effects of a single intravenous injection of cocaine (4 mg/kg) given 30 mins after pretreatment with propranolol (1 mg/kg...

journal_title：Critical care medicine

authors： O'Brien TP,Pane MA,Traystman RJ,Gleason CA

更新日期：1999-04-01 00:00:00

abstract：OBJECTIVE:Mitochondrial damage and dysfunction are thought to play an important role in the pathogenesis of sepsis-induced organ failures. Unfortunately, specific markers of mitochondrial damage in vital organs do not currently exist. Recently, carbomyl phosphate synthase (CPS)-1, a protein primarily localized to liver...

journal_title：Critical care medicine

authors： Crouser ED,Julian MW,Huff JE,Struck J,Cook CH

更新日期：2006-09-01 00:00:00

abstract：OBJECTIVES:To compare the assessment of decision-making capacity of ICU patients by attending clinicians (physicians, nurses, and residents) with a capacity score measured by the Mini-Mental Status Examination, completed by Aid to Capacity Evaluation if necessary. The primary outcome was agreement between physicians' a...

journal_title：Critical care medicine

authors： Bertrand PM,Pereira B,Adda M,Timsit JF,Wolff M,Hilbert G,Gruson D,Garrouste-Orgeas M,Argaud L,Constantin JM,Chabanne R,Quenot JP,Bohe J,Guerin C,Papazian L,Jonquet O,Klouche K,Delahaye A,Riu B,Zieleskiewicz L,Darm

更新日期：2019-03-01 00:00:00

abstract：OBJECTIVES:Measurement of blood lactate concentration in the early management of sepsis is an important step in severity assessment. High blood lactate levels in the early phase of sepsis have classically been thought to be related to tissue hypoxia, but other factors could intervene. We hypothesized that the activatio...

journal_title：Critical care medicine

authors： Contenti J,Occelli C,Corraze H,Lemoël F,Levraut J

更新日期：2015-12-01 00:00:00

abstract：OBJECTIVE:Chronic diabetes mellitus (DM) is a known cause of multisystem injury. The effect of DM in acute critical illness may also be detrimental, but is not specifically known. We hypothesized that the preexisting diagnosis of DM is an independent risk factor for mortality in critically ill patients. DESIGN:Paralle...

journal_title：Critical care medicine

authors： Graham BB,Keniston A,Gajic O,Trillo Alvarez CA,Medvedev S,Douglas IS

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND AND METHODS:A study was performed to examine the effects of the calcium-channel blocker levemopamil on neurologic outcome and neuropathology in a clinically relevant model of complete global cerebral ischemia (ventricular fibrillation in cats). Levemopamil was administered to cats starting 5 mins after resus...

journal_title：Critical care medicine

authors： Fleischer JE,Nakakimura K,Drummond JC,Scheller MS,Zornow MH,Grafe MR,Shapiro HM

更新日期：1992-01-01 00:00:00

abstract：OBJECTIVES:To evaluate the cardiovascular response and acute stress reaction after arousal induced by a benzodiazepine antagonist, flumazenil, in patients sedated with midazolam. DESIGN:Prospective study. SETTING:Emergency center in a university hospital. PATIENTS:A total of 12 patients were ventilated mechanically ...

journal_title：Critical care medicine

authors： Kamijo Y,Masuda T,Nishikawa T,Tsuruta H,Ohwada T

更新日期：2000-02-01 00:00:00

abstract：:We investigated clinically the differences in respiratory work of patients imposed by three modes of one ventilator: the flow-by system, the demand valve system, and the pressure support system. Inspiratory work using flow-by and pressure support systems was reduced sufficiently when compared to the demand valve syste...

journal_title：Critical care medicine

authors： Saito S,Tokioka H,Kosaka F

更新日期：1990-06-01 00:00:00

abstract：OBJECTIVES:Cardiovascular dysfunction occurs in the majority of asphyxiated neonates and has been suggested to be a major cause of neonatal morbidity and mortality. We previously demonstrated that cyclosporine A treatment during resuscitation can significantly improve cardiovascular performance in asphyxiated newborn p...

journal_title：Critical care medicine

authors： Gill RS,Lee TF,Manouchehri N,Liu JQ,Lopaschuk G,Bigam DL,Cheung PY

更新日期：2013-04-01 00:00:00

abstract：OBJECTIVE:The mitogen-activated protein kinase/extracellular signal-regulated kinase signaling pathway is an essential component of innate immunity necessary for mediating proinflammatory responses in the setting of sepsis. We previously demonstrated that the mitogen-activated protein kinase 1/2 inhibitor trametinib pr...

journal_title：Critical care medicine

authors： Smith JA,Mayeux PR,Schnellmann RG

更新日期：2016-08-01 00:00:00

abstract：OBJECTIVE:To examine the effects of hypertonic (7.5%) saline-6% dextran 70 (HSD) and isotonic (0.9%) saline-6% dextran 70 (ISD) on cardiovascular function and intestinal perfusion in experimental endotoxin shock. DESIGN:Experimental, randomized, unblinded, interventional study. SETTING:University experimental animal ...

journal_title：Critical care medicine

authors： Oi Y,Aneman A,Svensson M,Ewert S,Dahlqvist M,Haljamäe H

更新日期：2000-08-01 00:00:00

abstract：:End tidal CO2 tension (PetCO2) and transcutaneous CO2 tension (PtcCO2) were compared with arterial CO2 (PaCO2) before and after withdrawal of mechanical ventilation in 20 patients predisposed to hypercarbia. With stable PaCO2 during mechanical ventilation, the correlation coefficient (r) between PaCO2 and PetCO2 was ....

journal_title：Critical care medicine

authors： Healey CJ,Fedullo AJ,Swinburne AJ,Wahl GW

更新日期：1987-08-01 00:00:00

abstract：OBJECTIVES:Fever is common and associated with increased mortality among patients admitted to adult ICUs, yet recent literature suggests that the incidence of fever may be decreasing. The objective of this study was to determine whether the incidence of fever in adult ICUs changed over time and the factors responsible ...

journal_title：Critical care medicine

authors： Niven DJ,Stelfox HT,Shahpori R,Laupland KB

更新日期：2013-08-01 00:00:00

abstract：OBJECTIVE:This pilot study was designed to identify which contextual factors facilitate/hinder the implementation of the awakening, breathing, coordination, delirium, and early mobility (ABCDE) bundle for guidance in future studies. DESIGN:The sources of data for this study included document review, planned site visit...

journal_title：Critical care medicine

authors： Carrothers KM,Barr J,Spurlock B,Ridgely MS,Damberg CL,Ely EW

更新日期：2013-09-01 00:00:00

abstract：OBJECTIVE:To directly compare the cerebrovascular effects of norepinephrine and dopamine in patients with acute traumatic brain injury. DESIGN:Prospective randomized crossover trial. SETTING:Neurosciences critical care unit of a university hospital. PATIENTS:Ten acutely head-injured patients requiring vasoactive dru...

journal_title：Critical care medicine

authors： Steiner LA,Johnston AJ,Czosnyka M,Chatfield DA,Salvador R,Coles JP,Gupta AK,Pickard JD,Menon DK

更新日期：2004-04-01 00:00:00

abstract：OBJECTIVES:Sepsis remains a serious clinical problem despite intensive research efforts and numerous attempts to improve outcome by modifying the inflammatory response. Substance P, the principal ligand for the neurokinin-1 receptor, is a potent proinflammatory mediator that exacerbates inflammatory responses and cardi...

journal_title：Critical care medicine

authors： Mella JR,Chiswick E,Stepien D,Moitra R,Duffy ER,Stucchi A,Remick D

更新日期：2017-02-01 00:00:00

abstract：OBJECTIVES:Extracorporeal membrane oxygenation is used to stabilize severe cardiocirculatory and/or respiratory failure. However, extracorporeal membrane oxygenation is associated with a coagulopathy characterized by thromboembolic and hemorrhagic complications. This study aimed to characterize the pathomechanism of th...

journal_title：Critical care medicine

authors： Granja T,Hohenstein K,Schüssel P,Fischer C,Prüfer T,Schibilsky D,Wendel HP,Jaschonek K,Serna-Higuita L,Schlensak C,Häberle H,Rosenberger P,Straub A

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:Nutritional support is an essential component of the management of critically ill and injured ICU patients. Optimal provision of calories and protein has been demonstrated to reduce morbidity, mortally, and length of ICU and hospital stay. Yet, a large proportion of ICU patients receive inadequate nutrition....

journal_title：Critical care medicine

authors： Marik PE

更新日期：2014-04-01 00:00:00

abstract：OBJECTIVE:An increasing number of ICU patients survive and develop mental, cognitive, or physical impairments. Various interventions support recovery from this postintensive care syndrome. Physicians in charge of post-ICU patients need to know which interventions are effective. DATA SOURCES:Systematic literature searc...

journal_title：Critical care medicine

authors： Mehlhorn J,Freytag A,Schmidt K,Brunkhorst FM,Graf J,Troitzsch U,Schlattmann P,Wensing M,Gensichen J

更新日期：2014-05-01 00:00:00

abstract：OBJECTIVES:Extracorporeal membrane oxygenation is increasingly used in the management of severe acute respiratory distress syndrome. With extracorporeal membrane oxygenation, select patients with acute respiratory distress syndrome can be managed without mechanical ventilation, sedation, or neuromuscular blockade. Publ...

journal_title：Critical care medicine

authors： Kurihara C,Walter JM,Singer BD,Cajigas H,Shayan S,Al-Qamari A,DeCamp MM,Wunderink R,Budinger GRS,Bharat A

更新日期：2018-11-01 00:00:00

abstract：OBJECTIVE:To determine the occurrence rate of complications and mortality in patients with severe asthma requiring endotracheal intubation and mechanical ventilation. DESIGN:Retrospective review of medical records from September 1982 to July 1988. SETTING:Urban, teaching hospital serving primarily indigent patients. ...

journal_title：Critical care medicine

authors： Zimmerman JL,Dellinger RP,Shah AN,Taylor RW

更新日期：1993-11-01 00:00:00

abstract：OBJECTIVE:In rodent models, enhanced formation of nitric oxide and formation of peroxynitrite have been implicated in the pathogenesis of various forms of shock. Here we examined the effect of mercaptoethylguanidine (MEG), an inducible nitric oxide synthase inhibitor and peroxynitrite scavenger, in a severe hemorrhagic...

journal_title：Critical care medicine

authors： Szabó A,Hake P,Salzman AL,Szabó C

更新日期：1999-07-01 00:00:00

abstract：OBJECTIVE:In children, like in adults, tracheal intubation is a painful procedure that may induce hypertension, tachycardia, and other undesirable hemodynamic disorders. Although premature neonates are very sensitive to pain and vulnerable to its long-term effects, the need for sedation before tracheal intubation is st...

journal_title：Critical care medicine

authors： Simon L,Trifa M,Mokhtari M,Hamza J,Treluyer JM

更新日期：2004-02-01 00:00:00

abstract：OBJECTIVE:To test the hypothesis that therapeutic hypercapnia enhances the proinflammatory responses to endotoxemia in the lung and spleen of rats. DESIGN:Prospective randomized study. SETTINGS:Hospital research institute. SUBJECTS:Forty-eight adult male rats. INTERVENTIONS:Rats were randomly assigned for a 24-hr p...

journal_title：Critical care medicine

authors： Norozian FM,Leoncio M,Torbati D,Meyer K,Raszynski A,Totapally BR

更新日期：2011-06-01 00:00:00

abstract：:The right atrial pressure (Pra) was compared to the pulmonary capillary wedge pressure (Pcw) in 54 patients. In patients with heart disease, the correlation of Pra with Pcw was poor. However, in patients without clinical heart disease, Pra approximated Pcw, in both absolute number and change. This finding was independ...

journal_title：Critical care medicine

authors： Risk C,Rudo N,Falltrick R,Feeley T,Don HF

更新日期：1978-05-01 00:00:00