Hypertonic saline-dextran improves intestinal perfusion and survival in porcine endotoxin shock.

abstract：OBJECTIVE:To determine if exogenous interleukin (IL)-10 will decrease the morbidity or mortality of sepsis induced by cecal ligation and puncture. DESIGN:Prospective, randomized, controlled study. SETTING:University research laboratory. SUBJECTS:Adult, female, Balb¿c mice. INTERVENTIONS:Balb¿c mice were subjected t...

journal_title：Critical care medicine

authors： Remick DG,Garg SJ,Newcomb DE,Wollenberg G,Huie TK,Bolgos GL

更新日期：1998-05-01 00:00:00

abstract：:The resolution time of pneumothorax in neonates requiring tube thoracotomy is not known. We found that 28%, 50%, and 83% of 54 pneumothoraces in 40 neonates resolved within 24, 96, and 168 h of tube thoracotomy, respectively. Pneumothoraces that persisted beyond 168 h were in infants requiring ventilatory assistance. ...

journal_title：Critical care medicine

authors： Bhatia J,Mathew OP

更新日期：1985-05-01 00:00:00

abstract：OBJECTIVES:A 2400-mOsm/L hypertonic solution (isosal) with a lower sodium content, compared with conventional 7.5% hypertonic saline, was formulated using a mixture of sodium chloride, glucose, and mixed amino acids. This solution was developed to minimize hypernatremia during resuscitation. We assessed the effects of ...

journal_title：Critical care medicine

authors： Sheikh AA,Matsuoka T,Wisner DH

更新日期：1996-07-01 00:00:00

abstract：OBJECTIVES:To measure pulmonary capillary pressure and pulmonary artery occlusion pressures both during control conditions and during acute lung injury and to evaluate the effects of inotropic therapy and volume loading on these measurements after lung injury. DESIGN:Prospective, randomized, controlled laboratory tria...

journal_title：Critical care medicine

authors： Pellett AA,Lord KC,Champagne MS,deBoisblanc BP,Johnson RW,Levitzky MG

更新日期：2002-02-01 00:00:00

abstract：OBJECTIVE:To review current knowledge about the impact of prolonged mechanical ventilation on diaphragmatic function and biology. MEASUREMENTS:Systematic literature review. CONCLUSIONS:Prolonged mechanical ventilation can promote diaphragmatic atrophy and contractile dysfunction. As few as 18 hrs of mechanical ventil...

journal_title：Critical care medicine

authors： Powers SK,Kavazis AN,Levine S

更新日期：2009-10-01 00:00:00

abstract：:The image of the physician as a therapist, as well as the general perception of the physician's role in society and in the life of patients and their families, has changed dramatically in past decades. In response, many conferences, editorials, and planning activities for medical and premedical curricula have been dev...

journal_title：Critical care medicine

authors： Detre K

更新日期：1988-10-01 00:00:00

abstract：OBJECTIVE:To study the course of gastric regional PCO2 (PrCO2) in patients with cardiogenic shock requiring intra-aortic balloon (IAB) counterpulsation and the prognostic value of PrCO2 in this patient population. DESIGN:A prospective, observational clinical study. SETTING:Medical intensive care unit in a university ...

journal_title：Critical care medicine

authors： Janssens U,Graf J,Koch KC,vom Dahl J,Hanrath P

更新日期：2000-10-01 00:00:00

abstract：OBJECTIVE:To determine the feasibility of utilizing a scintigraphic technique to differentiate patients with adult respiratory distress syndrome due to sepsis syndrome from control volunteers and patients with congestive heart failure. Gamma scintigraphy was compared with chest roentgenograms to predict mortality rate ...

journal_title：Critical care medicine

authors： Byrne K,Tatum JL,Henry DA,Hirsch JI,Crossland M,Barnes T,Thompson JA,Young J,Sugerman HJ

更新日期：1992-01-01 00:00:00

abstract：OBJECTIVE:We aim to describe current clinical practice, the past decade of experience and factors related to improved outcomes for pediatric patients receiving high-frequency oscillatory ventilation. We have also modeled predictive factors that could help stratify mortality risk and guide future high-frequency oscillat...

journal_title：Critical care medicine

authors： Rettig JS,Smallwood CD,Walsh BK,Rimensberger PC,Bachman TE,Bollen CW,Duval EL,Gebistorf F,Markhorst DG,Tinnevelt M,Todd M,Zurakowski D,Arnold JH

更新日期：2015-12-01 00:00:00

abstract：OBJECTIVE:To estimate the prevalence of, the risk factors associated with, and the outcome of tracheostomy in a heterogeneous population of mechanically ventilated patients. DESIGN:Prospective, observational cohort study. SETTING:A total of 361 intensive care units from 12 countries. PATIENTS:A cohort of 5,081 patie...

journal_title：Critical care medicine

authors： Frutos-Vivar F,Esteban A,Apezteguía C,Anzueto A,Nightingale P,González M,Soto L,Rodrigo C,Raad J,David CM,Matamis D,D' Empaire G,International Mechanical Ventilation Study Group.

更新日期：2005-02-01 00:00:00

abstract：BACKGROUND:The randomized two-way factorial Dressing Study (1,636 patients, 28,931 catheter days) showed that a chlorhexidine-impregnated sponge decreased the incidence of major catheter-related infections from 1.4‰ to 0.6‰ catheter days, and that scheduled dressing changes every 7 days was not inferior to scheduled ch...

journal_title：Critical care medicine

authors： Schwebel C,Lucet JC,Vesin A,Arrault X,Calvino-Gunther S,Bouadma L,Timsit JF

更新日期：2012-01-01 00:00:00

abstract：OBJECTIVE:Keratinocyte growth factor (KGF) is expressed primarily by fibroblasts, is important for alveolar epithelial proliferation/function, and protects against lung injury in multiple animal models. We wished to determine whether acute lung injury/acute respiratory distress syndrome (ALI/ARDS) alveolar fluid induce...

journal_title：Critical care medicine

authors： Chandel NS,Budinger GR,Mutlu GM,Varga J,Synenki L,Donnelly HK,Zirk A,Eisenbart J,Jovanovic B,Jain M

更新日期：2009-05-01 00:00:00

abstract：OBJECTIVES:To assess the feasibility, biochemical efficacy, and safety of liberal versus conventional glucose control in ICU patients with diabetes. DESIGN:Prospective, open-label, sequential period study. SETTING:A 22-bed mixed ICU of a tertiary hospital in Australia. PATIENTS:We compared 350 consecutive patients w...

journal_title：Critical care medicine

authors： Luethi N,Cioccari L,Biesenbach P,Lucchetta L,Kagaya H,Morgan R,Di Muzio F,Presello B,Gaafar D,Hay A,Crisman M,Toohey R,Russell H,Glassford NJ,Eastwood GM,Ekinci EI,Deane AM,Bellomo R,Mårtensson J

更新日期：2018-06-01 00:00:00

abstract：OBJECTIVES:To explore the relationship between timing of continuous renal replacement therapy commencement and clinical outcomes in critically ill patients with acute kidney injury. The primary outcomes were all-cause mortality at 28 and 90 days. DESIGN:Nested observational cohort study using data from the Randomized ...

journal_title：Critical care medicine

authors： Jun M,Bellomo R,Cass A,Gallagher M,Lo S,Lee J,Randomized Evaluation of Normal Versus Augmented Level of Replacement Therapy (RENAL) Study Investigators.

更新日期：2014-08-01 00:00:00

abstract：:Critical care clinicians no longer consider family members as visitors in the intensive care unit. Family-centered care has emerged from the results of qualitative and quantitative studies evaluating the specific needs of families of patients dying in the intensive care unit. In addition, interventional studies have e...

journal_title：Critical care medicine

authors： Lautrette A,Ciroldi M,Ksibi H,Azoulay E

更新日期：2006-11-01 00:00:00

abstract：:One hundred patients were ventilated with high-frequency jet ventilation (HFJV) during the initial 24-h postoperative period in the surgical and neurosurgical ICUs. Eighty-three were successfully weaned, 2 could not be ventilated adequately with HFJV, and 15 with criteria of acute respiratory failure received HFJV for...

journal_title：Critical care medicine

authors： Sladen A,Guntupalli K,Marquez J,Klain M

更新日期：1984-09-01 00:00:00

abstract：OBJECTIVE:To test the effects of three hemoglobin solutions on liver function and hepatic morphology after resuscitation from severe hemorrhagic shock. DESIGN:Prospective study. SETTING:Laboratory. SUBJECTS:Thirty-three beagle dogs. INTERVENTION:Hemorrhagic shock was induced in anesthetized dogs by removal of blood...

journal_title：Critical care medicine

authors： Eldridge J,Russell R,Christenson R,Sakamoto R,Williams J,Parr M,Trump B,Delaney P,Mackenzie CF

更新日期：1996-04-01 00:00:00

abstract：OBJECTIVE:To describe the management of patients in an ICU during failure of both primary and backup electrical systems, resulting in nonfunctioning monitors, mechanical ventilators, and other life-support equipment. DESIGN:Case report of power outage and discussion. SETTING:A 45-bed cardiothoracic surgical ICU in a ...

journal_title：Critical care medicine

authors： O'Hara JF Jr,Higgins TL

更新日期：1992-06-01 00:00:00

abstract：OBJECTIVE:Levosimendan is a novel inodilator that improves cardiac contractility by sensitizing troponin C to calcium. This drug has proved to be effective in treating advanced congestive heart failure but has not been evaluated in septic settings. The purpose of the present study was to study the effects of this drug ...

journal_title：Critical care medicine

authors： Oldner A,Konrad D,Weitzberg E,Rudehill A,Rossi P,Wanecek M

更新日期：2001-11-01 00:00:00

abstract：OBJECTIVES:To investigate the frequency, types, and implications of complications during intensive care in patients after status epilepticus has been successfully terminated. DESIGN:Retrospective study. SETTING:ICUs at a Swiss tertiary academic medical care center. PATIENTS:Data were collected from the digital patie...

journal_title：Critical care medicine

authors： Baumann SM,Semmlack S,De Marchis GM,Hunziker S,Rüegg S,Marsch S,Sutter R

更新日期：2020-12-01 00:00:00

abstract：OBJECTIVE:Increasing evidence, including publication of the Transfusion Requirements in Critical Care trial in 1999, supports a lower hemoglobin threshold for RBC transfusion in ICU patients. However, little is known regarding the influence of this evidence on clinical practice over time in a large population-based coh...

journal_title：Critical care medicine

authors： Murphy DJ,Needham DM,Netzer G,Zeger SL,Colantuoni E,Ness P,Pronovost PJ,Berenholtz SM

更新日期：2013-10-01 00:00:00

abstract：OBJECTIVE:Our knowledge of the molecular mechanisms of sepsis has attained exponential growth. Yet, the pillars of its care remain antibiotics, fluid resuscitation, and physiologic support of failing organ systems. The inability to bring biologic breakthroughs to the bedside is not for lack of effort. Over 60 clinical ...

journal_title：Critical care medicine

authors： Lewis AJ,Lee JS,Rosengart MR

更新日期：2018-09-01 00:00:00

abstract：OBJECTIVE:Circulating serum levels of procalcitonin rise significantly during bacterial infection. Because calcitonin is known to be a monocyte chemoattractant, we investigated whether procalcitonin, a prohormone of calcitonin, also affects leukocyte migration. DESIGN:Prospective, controlled in vitro study. SETTING:U...

journal_title：Critical care medicine

authors： Wiedermann FJ,Kaneider N,Egger P,Tiefenthaler W,Wiedermann CJ,Lindner KH,Schobersberger W

更新日期：2002-05-01 00:00:00

abstract：OBJECTIVE:The aim of this study is to test the hypothesis that recruitment maneuvers (RMs) might act differently in models of pulmonary (p) and extrapulmonary (exp) acute lung injury (ALI) with similar transpulmonary pressure changes. DESIGN:Prospective, randomized, controlled experimental study. SETTING:University r...

journal_title：Critical care medicine

authors： Riva DR,Oliveira MB,Rzezinski AF,Rangel G,Capelozzi VL,Zin WA,Morales MM,Pelosi P,Rocco PR

更新日期：2008-06-01 00:00:00

abstract：OBJECTIVE:To describe the current status and the clinical data related to the effects of tight glucose control by intensive insulin therapy in critically ill patients. DESIGN:Review article. SETTING:University hospital. PATIENTS:Medical and surgical critically ill patients in whom a correlation between blood glucose...

journal_title：Critical care medicine

authors： Preiser JC,Devos P

更新日期：2007-09-01 00:00:00

abstract：OBJECTIVE:Pump-driven extracorporeal gas exchange systems have been advocated in patients suffering from severe acute respiratory distress syndrome who are at risk for life-threatening hypoxemia and/or hypercapnia. This requires extended technical and staff support. DESIGN:We report retrospectively our experience with...

journal_title：Critical care medicine

authors： Bein T,Weber F,Philipp A,Prasser C,Pfeifer M,Schmid FX,Butz B,Birnbaum D,Taeger K,Schlitt HJ

更新日期：2006-05-01 00:00:00

abstract：OBJECTIVE:Acute aneurysmal subarachnoid hemorrhage (SAH) is a complex multifaceted disorder that plays out over days to weeks. Many patients with SAH are seriously ill and require a prolonged intensive care unit stay. Cardiopulmonary complications are common. The management of patients with SAH focuses on the anticipat...

journal_title：Critical care medicine

authors： Diringer MN

更新日期：2009-02-01 00:00:00

abstract：:Prolonged therapeutic paralysis with pancuronium is commonly used in ICUs to facilitate mechanical ventilation of patients with respiratory failure. Sedation is usually given concomitantly to reduce patient discomfort, but assessment of its adequacy is made difficult by the paralysis. We recently cared for a former IC...

journal_title：Critical care medicine

authors： Parker MM,Schubert W,Shelhamer JH,Parrillo JE

更新日期：1984-01-01 00:00:00

abstract：CONTEXT:Reducing aspiration of gastric contents by placing mechanically ventilated patients in a semirecumbent position has been associated with lower incidences of ventilator-associated pneumonia (VAP). The feasibility and efficacy of this intervention in a larger patient population, however, are unknown. OBJECTIVE:A...

journal_title：Critical care medicine

authors： van Nieuwenhoven CA,Vandenbroucke-Grauls C,van Tiel FH,Joore HC,van Schijndel RJ,van der Tweel I,Ramsay G,Bonten MJ

更新日期：2006-02-01 00:00:00

abstract：:The disciplines of critical care and palliative care may initially seem to be polar opposites, yet they share fundamental features. Both focus on the sickest patients in the healthcare system. Each discipline's primary goal-extending life for critical care and comfort and quality of life for palliative care-represents...

journal_title：Critical care medicine

authors： Byock I

更新日期：2006-11-01 00:00:00