Scientific evaluation of clinical interventions in resuscitation medicine.


:The image of the physician as a therapist, as well as the general perception of the physician's role in society and in the life of patients and their families, has changed dramatically in past decades. In response, many conferences, editorials, and planning activities for medical and premedical curricula have been devoted to the subject of restoring the elements of compassion and personal involvement to the relationship between physician and patient. Nonetheless, the change in the doctor-patient relationship might merely reflect the growing indifference to people as individuals that seems to pervade our society in all service-related areas. Although the loss is particularly objectionable for the sick, some may claim it is compensated by scientifically superior care in present-day medical practice. This paper will reflect briefly on past and present views of medical care and its evaluation. It will conclude that a scientifically sound evaluation of treatment might also offer a solution for restoration of human elements in the delivery of medical care.


Crit Care Med


Critical care medicine


Detre K




Has Abstract


1988-10-01 00:00:00












  • Decreased heart rate variability in significant cardiac events.

    abstract::The heart rate variability (HRV) of 82 patients exhibiting sinus rhythm and admitted for possible myocardial infarction (MI) was evaluated. Using a simple information entropy measure to quantify the HRV, patients subsequently diagnosed with MI or experiencing significant dysrhythmia (n = 35) exhibited less entropy (0....

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Zbilut JP,Lawson L

    更新日期:1988-01-01 00:00:00

  • Management of aneurysmal subarachnoid hemorrhage.

    abstract:OBJECTIVE:Acute aneurysmal subarachnoid hemorrhage (SAH) is a complex multifaceted disorder that plays out over days to weeks. Many patients with SAH are seriously ill and require a prolonged intensive care unit stay. Cardiopulmonary complications are common. The management of patients with SAH focuses on the anticipat...

    journal_title:Critical care medicine

    pub_type: 杂志文章,评审


    authors: Diringer MN

    更新日期:2009-02-01 00:00:00

  • Pentoxifylline prevents a decrease in arterial oxygen tension in oleic acid-induced lung injury.

    abstract:OBJECTIVES:a) To determine whether pentoxifylline has a preventive effect on the decrease in PaO2 that is caused by oleic acid, and whether pentoxifylline facilitates normalization of PaO2 from the decreased state. b) To examine whether pentoxifylline can attenuate an increase in pulmonary vascular permeability that is...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Moriuchi H,Yuizono T

    更新日期:1995-02-01 00:00:00

  • Endotracheal and endobronchial lidocaine administration: effects on plasma lidocaine concentration and blood gases.

    abstract:OBJECTIVE:To compare four different methods of endotracheal lidocaine administration with respect to the site of administration. DESIGN:Randomized controlled trial. SETTING:University hospital. PATIENTS:Thirty-two female patients (43.6 +/- 11.5 years old) undergoing elective gynecologic operations with an anesthesio...

    journal_title:Critical care medicine

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Prengel AW,Lindner KH,Hähnel J,Ahnefeld FW

    更新日期:1991-07-01 00:00:00

  • Energy expenditure and withdrawal of sedation in severe head-injured patients.

    abstract:OBJECTIVES:To determine the outcome of oxygen consumption (VO2) and energy expenditure after cessation of sedation in severe head-injured patients and to assess its usefulness as a predictor of neurologic severity. DESIGN:Prospective, descriptive study. SETTING:Neurosurgical intensive care unit (ICU) in a university ...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Bruder N,Lassegue D,Pelissier D,Graziani N,François G

    更新日期:1994-07-01 00:00:00

  • The cardiac output from blood pressure algorithms trial.

    abstract:OBJECTIVE:The value of different algorithms that estimate cardiac output (CO) by analysis of a peripheral arterial blood pressure (ABP) waveform has not been definitively identified. In this investigation, we developed a testing data set containing a large number of radial ABP waveform segments and contemporaneous refe...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Sun JX,Reisner AT,Saeed M,Heldt T,Mark RG

    更新日期:2009-01-01 00:00:00

  • Effectiveness of a multidimensional approach for prevention of ventilator-associated pneumonia in adult intensive care units from 14 developing countries of four continents: findings of the International Nosocomial Infection Control Consortium.

    abstract:OBJECTIVES:The aim of this study was to analyze the effect of the International Nosocomial Infection Control Consortium's multidimensional approach on the reduction of ventilator-associated pneumonia in patients hospitalized in intensive care units. DESIGN:A prospective active surveillance before-after study. The stud...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Rosenthal VD,Rodrigues C,Álvarez-Moreno C,Madani N,Mitrev Z,Ye G,Salomao R,Ulger F,Guanche-Garcell H,Kanj SS,Cuéllar LE,Higuera F,Mapp T,Fernández-Hidalgo R,INICC members.

    更新日期:2012-12-01 00:00:00

  • Patterns of prescribing and administering drugs for agitation and pain in patients in a surgical intensive care unit.

    abstract:OBJECTIVES:To describe the variety of medications prescribed along with the doses administered and routes of administration, and to delineate the clarity of orders written and the accuracy of transcription of drugs used for sedation, anxiety, pain, and neuromuscular blockade in a surgical intensive care unit (ICU). DE...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Dasta JF,Fuhrman TM,McCandles C

    更新日期:1994-06-01 00:00:00

  • The Fourth National Institutes of Health Symposium on the Functional Genomics of Critical Injury: Surviving stress from organ systems to molecules.

    abstract::Recent strides in computational biology and high-throughput technologies have generated considerable interest in understanding complex biological systems. The application of these technologies to critical illness and injury offers the potential to define adaptive and maladaptive programs of gene expression induced by ...

    journal_title:Critical care medicine

    pub_type: 杂志文章,评审


    authors: Cobb JP,Suffredini AF,Danner RL

    更新日期:2008-10-01 00:00:00

  • Ceramide mediates radiation-induced death of endothelium.

    abstract::The sphingomyelin (SM) pathway is an ubiquitous, evolutionarily conserved signaling system, analogous to conventional systems such as the cAMP and phosphoinositide pathways. Ceramide is generated from SM by the action of a neutral or acid SMase, or by de novo synthesis coordinated through the enzyme ceramide synthase....

    journal_title:Critical care medicine

    pub_type: 杂志文章,评审


    authors: Lin X,Fuks Z,Kolesnick R

    更新日期:2000-04-01 00:00:00

  • Optimal release time during airway pressure release ventilation in neonatal sheep.

    abstract:OBJECTIVE:To systematically investigate the effect of altering release time during airway pressure release ventilation in a neonatal animal model before and after oleic acid-induced acute lung injury. DESIGN:Prospective, nonrandomized, controlled study with repeated measures. SETTING:University research laboratory. ...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Martin LD,Wetzel RC

    更新日期:1994-03-01 00:00:00

  • Early treatment with ACTH-(1-24) in a rat model of hemorrhagic shock prolongs survival and extends the time-limit for blood reinfusion to be effective.

    abstract::The ability of ACTH-(1-24) to prolong survival and to extend the deadline for effective blood reinfusion has been studied in a model of lethal hypovolemic shock in the rat. Anesthetized rats were bled to a mean arterial pressure of 18 to 25 mm Hg and then subjected to one of the following iv treatments: a) saline; b) ...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Guarini S,Tagliavini S,Bazzani C,Ferrari W,Bertolini A

    更新日期:1990-08-01 00:00:00

  • Protective effects of a selective neutrophil elastase inhibitor (sivelestat) on lipopolysaccharide-induced acute dysfunction of the pulmonary microcirculation.

    abstract:OBJECTIVE:The purpose of this study was to evaluate the effect of a neutrophil elastase inhibitor, sivelestat, on lipopolysaccharide-induced acute lung injury through analysis of hemodynamic changes in the pulmonary microcirculation. DESIGN:Randomized animal study. SETTING:Medical school laboratory. SUBJECTS:Twenty-...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Inoue Y,Seiyama A,Tanaka H,Ukai I,Akimau P,Nishino M,Shimazu T,Sugimoto H

    更新日期:2005-08-01 00:00:00

  • Prospectively validated prediction of physiologic variables and organ failure in septic patients: The Systemic Mediator Associated Response Test (SMART).

    abstract:OBJECTIVE:Conventional outcomes research provides only percentage risk of such end points as mortality rate, utilization of resources, and/or broad groupings of multiple organ system dysfunction. These prognostications generally are not applicable to individual patients. The purpose of the present study was to determin...

    journal_title:Critical care medicine

    pub_type: 临床试验,杂志文章


    authors: Slotman GJ

    更新日期:2002-05-01 00:00:00

  • Prediction of outcome of cardiopulmonary resuscitation from end-tidal carbon dioxide concentration.

    abstract::Capnography is a valuable tool in the management of cardiac arrest, since end-tidal CO2 (PetCO2) correlates well with cardiac output and there are no other suitable noninvasive ways to measure this important variable during resuscitation. Animal studies also suggest that PetCO2 correlates well with the likelihood of r...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Callaham M,Barton C

    更新日期:1990-04-01 00:00:00

  • Fiber atrophy, but not changes in acetylcholine receptor expression, contributes to the muscle dysfunction after immobilization.

    abstract:OBJECTIVES:Muscle weakness associated with critical illness can be due to the illness itself, immobilization associated with it, and/or to concomitant use of drugs that affect neuromuscular transmission. This study investigated the contribution of immobilization per se to the muscle dysfunction, as well as the associat...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Ibebunjo C,Martyn JA

    更新日期:1999-02-01 00:00:00

  • Comparison of recorded values from six pulse oximeters.

    abstract::Recorded values (SpO2) of oxygen saturation from six noninvasive pulse oximeters were compared to each other and to the value from a cooximeter. Simultaneous measurements were obtained from each instrument in eight healthy nonsmoking volunteers rendered hypoxic greater than 70% SpO2. Functional arterial oxygen saturat...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Choe H,Tashiro C,Fukumitsu K,Yagi M,Yoshiya I

    更新日期:1989-07-01 00:00:00

  • Migration of human monocytes in response to procalcitonin.

    abstract:OBJECTIVE:Circulating serum levels of procalcitonin rise significantly during bacterial infection. Because calcitonin is known to be a monocyte chemoattractant, we investigated whether procalcitonin, a prohormone of calcitonin, also affects leukocyte migration. DESIGN:Prospective, controlled in vitro study. SETTING:U...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Wiedermann FJ,Kaneider N,Egger P,Tiefenthaler W,Wiedermann CJ,Lindner KH,Schobersberger W

    更新日期:2002-05-01 00:00:00

  • Diabetes mellitus does not adversely affect outcomes from a critical illness.

    abstract:OBJECTIVE:Chronic diabetes mellitus (DM) is a known cause of multisystem injury. The effect of DM in acute critical illness may also be detrimental, but is not specifically known. We hypothesized that the preexisting diagnosis of DM is an independent risk factor for mortality in critically ill patients. DESIGN:Paralle...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Graham BB,Keniston A,Gajic O,Trillo Alvarez CA,Medvedev S,Douglas IS

    更新日期:2010-01-01 00:00:00

  • Plasma L-arginine concentration, oxygenation index, and systemic blood pressure in premature infants.

    abstract:OBJECTIVE:To determine the relationships between plasma L-arginine concentrations and the severity of respiratory distress syndrome (RDS) or systemic blood pressure in premature infants. DESIGN:Prospective, observational study. SETTING:Neonatal intensive care, tertiary referral hospital. SUBJECTS:Fifty-three prematu...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Zamora SA,Amin HJ,McMillan DD,Fick GH,Butzner JD,Parsons HG,Scott RB

    更新日期:1998-07-01 00:00:00

  • Protective effect of a novel, potent inhibitor of poly(adenosine 5'-diphosphate-ribose) synthetase in a porcine model of severe bacterial sepsis.

    abstract:OBJECTIVE:To determine whether activation of the nuclear enzyme poly(adenosine 5'-diphosphate [ADP]-ribose) synthetase (PARS) contributes to mortality rate, myocardial dysfunction, and cardiovascular collapse in a porcine model of sepsis induced by implantation of an infected clot. DESIGN:Prospective, random animal st...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Goldfarb RD,Marton A,Szabó E,Virág L,Salzman AL,Glock D,Akhter I,McCarthy R,Parrillo JE,Szabó C

    更新日期:2002-05-01 00:00:00

  • ICU Utilization for Patients With Acute Exacerbation of Chronic Obstructive Pulmonary Disease Receiving Noninvasive Ventilation.

    abstract:OBJECTIVES:We investigated whether patients with chronic obstructive pulmonary disease could safely receive noninvasive ventilation outside of the ICU. DESIGN:Retrospective cohort study. SETTING:Twelve states with ICU utilization flag from the State Inpatient Database from 2014. PATIENTS:Patients greater than or equ...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Myers LC,Faridi MK,Currier P,Camargo CA Jr

    更新日期:2019-05-01 00:00:00

  • Critical care of immunocompromised patients: human immunodeficiency virus.

    abstract:OBJECTIVE:To describe critical illnesses that occur commonly in patients with human immunodeficiency virus (HIV) infection. METHODS:We reviewed and summarized the literature on critical illness in HIV infection using a computerized MEDLINE search. SUMMARY:In the last 10 yrs, our perception of HIV infection and acquir...

    journal_title:Critical care medicine

    pub_type: 杂志文章,评审


    authors: Rosen MJ,Narasimhan M

    更新日期:2006-09-01 00:00:00

  • Clinical correlates of successful weaning from mechanical ventilation in severe bronchopulmonary dysplasia.

    abstract::The hospital records of 7 patients with severe bronchopulmonary dysplasia (BPD) were reviewed. All patients were ventilator dependent for prolonged periods (mean duration intermittent mandatory ventilation (IMV) 14.3 +/- 3.5 months) but eventually were successfully weaned from mechanical ventilation and sent home. The...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Morray JP,Fox WW,Kettrick RG,Downes JJ

    更新日期:1981-12-01 00:00:00

  • Activated protein C in normal human pregnancy and pregnancies complicated by severe preeclampsia: a therapeutic opportunity?

    abstract:OBJECTIVES:Given the efficacy and safety of recombinant human activated protein C (rhAPC) in the systemic inflammatory response syndrome, this study was designed to review the evidence for a role for APC in the pathogenesis of preeclampsia. Preeclampsia is a proinflammatory and procoagulant state, and it is a pregnancy...

    journal_title:Critical care medicine

    pub_type: 临床试验,杂志文章,随机对照试验,评审


    authors: von Dadelszen P,Magee LA,Lee SK,Stewart SD,Simone C,Koren G,Walley KR,Russell JA

    更新日期:2002-08-01 00:00:00

  • Amino acid alterations and encephalopathy in the sepsis syndrome.

    abstract:OBJECTIVE:To evaluate the role of amino acid profiles in septic encephalopathy. DESIGN:Retrospective analysis. SETTING:Medical wards and medical ICU of a university hospital. PATIENTS:Patients with infections and normal mental status were compared with patients with septic shock and altered sensorium. INTERVENTIONS...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Sprung CL,Cerra FB,Freund HR,Schein RM,Konstantinides FN,Marcial EH,Pena M

    更新日期:1991-06-01 00:00:00

  • A multicenter, prospective validation of disseminated intravascular coagulation diagnostic criteria for critically ill patients: comparing current criteria.

    abstract:OBJECTIVES:To validate scoring algorithm criteria established by the Japanese Association for Acute Medicine (JAAM) for disseminated intravascular coagulation (DIC) and to evaluate its diagnostic property by comparing the two leading scoring systems for DIC, from the Japanese Ministry of Health and Welfare (JMHW) and I...

    journal_title:Critical care medicine

    pub_type: 杂志文章,多中心研究


    authors: Gando S,Iba T,Eguchi Y,Ohtomo Y,Okamoto K,Koseki K,Mayumi T,Murata A,Ikeda T,Ishikura H,Ueyama M,Ogura H,Kushimoto S,Saitoh D,Endo S,Shimazaki S,Japanese Association for Acute Medicine Disseminated Intravascular Coagulati

    更新日期:2006-03-01 00:00:00

  • Sepsis-Associated Coagulopathy Severity Predicts Hospital Mortality.

    abstract:OBJECTIVES:To assess whether sepsis-associated coagulopathy predicts hospital mortality. DESIGN:Retrospective cohort study. SETTING:One-thousand three-hundred beds urban academic medical center. PATIENTS:Six-thousand one-hundred forty-eight consecutive patients hospitalized between January 1, 2010, and December 31, ...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Lyons PG,Micek ST,Hampton N,Kollef MH

    更新日期:2018-05-01 00:00:00

  • Predictors of intensive care unit refusal in French intensive care units: a multiple-center study.

    abstract:OBJECTIVE:To identify factors associated with granting or refusing intensive care unit (ICU) admission, to analyze ICU characteristics and triage decisions, and to describe mortality in admitted and refused patients. DESIGN:Observational, prospective, multiple-center study. SETTING:Four university hospitals and seven...

    journal_title:Critical care medicine

    pub_type: 杂志文章,多中心研究


    authors: Garrouste-Orgeas M,Montuclard L,Timsit JF,Reignier J,Desmettre T,Karoubi P,Moreau D,Montesino L,Duguet A,Boussat S,Ede C,Monseau Y,Paule T,Misset B,Carlet J,French ADMISSIONREA Study Group.

    更新日期:2005-04-01 00:00:00

  • Unmeasured anions in critically ill patients: can they predict mortality?

    abstract:OBJECTIVE:To determine whether base excess, base excess caused by unmeasured anions, and anion gap can predict lactate in adult critically ill patients, and also to determine whether acid-base variables can predict mortality in these patients. DESIGN:Retrospective study. SETTING:Adult intensive care unit of tertiary ...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Rocktaeschel J,Morimatsu H,Uchino S,Bellomo R

    更新日期:2003-08-01 00:00:00