Prolonged mechanical ventilation alters diaphragmatic structure and function.

abstract：OBJECTIVE:To determine how top loads with different doses of carbon monoxide (CO)-saturated saline solutions (CO-saline) affect microvascular and systemic hemodynamics and to delineate the corresponding biochemical mechanisms. DESIGN:Prospective study. SETTING:University research laboratory. SUBJECTS:Male Golden Syr...

journal_title：Critical care medicine

authors： Hangai-Hoger N,Tsai AG,Cabrales P,Suematsu M,Intaglietta M

更新日期：2007-04-01 00:00:00

abstract：OBJECTIVE:Liquid lung ventilation has been demonstrated to improve cardiorespiratory function after cardiopulmonary bypass. We hypothesized that liquid lung ventilation (LLV) would decrease the pulmonary inflammatory response after cardiopulmonary bypass (CPB). DESIGN:Prospective, randomized, experimental, controlled,...

journal_title：Critical care medicine

authors： Williams EA,Welty SE,Geske RS,Hubble CL,Craig DM,Quick G,Meliones JN,Cheifetz IM

更新日期：2001-04-01 00:00:00

abstract：OBJECTIVE:To determine whether the energy expenditure of mechanically ventilated multiple trauma patients correlates with the severity of injury and illness indices before important systemic infection has complicated the clinical course, and to compare the energy expenditure with the energy expenditure expected from th...

journal_title：Critical care medicine

authors： Brandi LS,Santini L,Bertolini R,Malacarne P,Casagli S,Baraglia AM

更新日期：1999-12-01 00:00:00

abstract：OBJECTIVE:To evaluate the cardiopulmonary effects of the novel endothelin receptor antagonist tezosentan in endotoxin-induced lung injury in sheep and to assess the dose response to tezosentan and endothelin-1 in healthy sheep. DESIGN:Prospective, randomized, controlled experimental study. SETTING:University animal l...

journal_title：Critical care medicine

authors： Kuklin VN,Kirov MY,Evgenov OV,Sovershaev MA,Sjöberg J,Kirova SS,Bjertnaes LJ

更新日期：2004-03-01 00:00:00

abstract：OBJECTIVE:To describe critical illnesses that occur commonly in patients with human immunodeficiency virus (HIV) infection. METHODS:We reviewed and summarized the literature on critical illness in HIV infection using a computerized MEDLINE search. SUMMARY:In the last 10 yrs, our perception of HIV infection and acquir...

journal_title：Critical care medicine

authors： Rosen MJ,Narasimhan M

更新日期：2006-09-01 00:00:00

abstract：OBJECTIVE:Levosimendan is a novel inodilator that improves cardiac contractility by sensitizing troponin C to calcium. This drug has proved to be effective in treating advanced congestive heart failure but has not been evaluated in septic settings. The purpose of the present study was to study the effects of this drug ...

journal_title：Critical care medicine

authors： Oldner A,Konrad D,Weitzberg E,Rudehill A,Rossi P,Wanecek M

更新日期：2001-11-01 00:00:00

abstract：OBJECTIVE:Heatstroke is characterized by hyperthermia, vasoplegic shock, and cerebral ischemia and hypoxia. Hyperbaric oxygen (HBO) has been shown to reduce brain ischemia and behavioral dysfunction during cerebral artery occlusion. The efficacy of HBO therapy for resuscitation from heatstroke remains to be determined ...

journal_title：Critical care medicine

authors： Tsai HM,Gao CJ,Li WX,Lin MT,Niu KC

更新日期：2005-04-01 00:00:00

abstract：OBJECTIVE:Insulin reduces morbidity and mortality among critically ill patients, but the molecular mechanisms of its effect remain unknown. Insulin is a well-known inhibitor of glycogen synthase kinase-3, which may play an important role in systemic inflammation and shock. Here we investigate the role of blood glucose ...

journal_title：Critical care medicine

authors： Dugo L,Collin M,Allen DA,Murch O,Foster SJ,Yaqoob MM,Thiemermann C

更新日期：2006-05-01 00:00:00

abstract：OBJECTIVE:Acute renal failure remains a major challenge in critical care medicine. Both neutrophils and chemokines have been proposed as key components in the development of acute renal failure. Although the Duffy antigen receptor for chemokines (DARC) is present in several tissues and a highly specific ligand for vari...

journal_title：Critical care medicine

authors： Zarbock A,Schmolke M,Bockhorn SG,Scharte M,Buschmann K,Ley K,Singbartl K

更新日期：2007-09-01 00:00:00

abstract：OBJECTIVES:To evaluate the use of multifrequency bioelectrical impedance analysis to predict creatinine/urea clearance based on 24 hours urine collection. A practical formula was developed, and its performance was compared with that of established formulas such as Cockcroft-Gault, Modification of Diet in Renal Disease,...

journal_title：Critical care medicine

authors： de Jong LAA,Otten-Helmers AG,Spronk PE,van Kan HJM

更新日期：2019-12-01 00:00:00

abstract：OBJECTIVE:To test the hypothesis that the hypocalcemia and hypoparathyroidism that follow severe burn injury are related to up-regulation of the parathyroid gland calcium-sensing receptor (CaR), which may reduce the set-point for suppression of circulating parathyroid hormone by blood calcium. DESIGN:A controlled but ...

journal_title：Critical care medicine

authors： Murphey ED,Chattopadhyay N,Bai M,Kifor O,Harper D,Traber DL,Hawkins HK,Brown EM,Klein GL

更新日期：2000-12-01 00:00:00

abstract：:Hemodynamic effects of iso-oncotic 3% dextran-60, 6% dextran-70, and Ringer's acetate were compared in 28 male pigs (25 to 30 kg) subjected to experimental trauma and hemorrhage. The animals were kept anesthetized with 75% N2O/25% O2, 0.8% halothane. Hemodynamic and respiratory conditions were allowed to stabilize for...

journal_title：Critical care medicine

authors： Schött U,Lindbom LO,Sjöstrand U

更新日期：1988-04-01 00:00:00

abstract：OBJECTIVE:Heatstroke requires active body cooling and organ failure supportive care. Although heat waves are expected to recur over the next decades, little is known about the risk factors for mortality in heatstroke patients. We examined the prognosis and risk factors for hospital mortality in patients with heatstroke...

journal_title：Critical care medicine

authors： Misset B,De Jonghe B,Bastuji-Garin S,Gattolliat O,Boughrara E,Annane D,Hausfater P,Garrouste-Orgeas M,Carlet J

更新日期：2006-04-01 00:00:00

abstract：OBJECTIVE:To compare silver-coated and uncoated central venous catheters regarding bacterial colonization. To assess the relative contribution of catheter hub and skin colonization to catheter tip colonization. DESIGN:Prospective, randomized clinical trial. SETTING:Intensive care unit in a university hospital. PATIE...

journal_title：Critical care medicine

authors： Bach A,Eberhardt H,Frick A,Schmidt H,Böttiger BW,Martin E

更新日期：1999-03-01 00:00:00

abstract：OBJECTIVES:Low tidal volume (= tidal volume ≤ 6 mL/kg, predicted body weight) ventilation using volume control benefits patients with acute respiratory distress syndrome. Airway pressure release ventilation is an alternative to low tidal volume-volume control ventilation, but the release breaths generated are variable ...

journal_title：Critical care medicine

authors： Hirshberg EL,Lanspa MJ,Peterson J,Carpenter L,Wilson EL,Brown SM,Dean NC,Orme J,Grissom CK

更新日期：2018-12-01 00:00:00

abstract：OBJECTIVE:To determine the impact of adding a month of critical care training in the postgraduate year (PGY)-2 on the critical care skills of PGY-3 residents. DESIGN:Prospective, nonrandomized. SETTING:The internal medicine (IM) residency program of a tertiary care medical center. STUDY SUBJECTS:The study subjects i...

journal_title：Critical care medicine

authors： Mullon JJ,Gajic O,Gali B,Ficalora RD,Kolars JC,Afessa B

更新日期：2009-04-01 00:00:00

abstract：OBJECTIVE:The role of family interests in medical decision making is controversial. Physicians who routinely treat incompetent patients may have preferred strategies for addressing family interests as they are encountered in surrogate medical decision making. We sought to determine how physicians view the role of famil...

journal_title：Critical care medicine

authors： Hardart GE,Truog RD

更新日期：2003-07-01 00:00:00

abstract：OBJECTIVE:To evaluate the role of continuous lateral rotational therapy on the development of ventilator-associated pneumonia in patients requiring long-term mechanical ventilation. DESIGN:Prospective control study. SETTING:Chronic ventilator unit in tertiary care hospital. METHODS:Thirty-seven patients requiring lo...

journal_title：Critical care medicine

authors： Kirschenbaum L,Azzi E,Sfeir T,Tietjen P,Astiz M

更新日期：2002-09-01 00:00:00

abstract：OBJECTIVE:Clinical trial designs that randomize patients to fixed treatment regimens may disrupt preexisting relationships between illness severity and level of therapy. The practice misalignments created by such designs may have unintended effects on trial results and safety. METHODS:To illustrate this problem, the T...

journal_title：Critical care medicine

authors： Deans KJ,Minneci PC,Suffredini AF,Danner RL,Hoffman WD,Ciu X,Klein HG,Schechter AN,Banks SM,Eichacker PQ,Natanson C

更新日期：2007-06-01 00:00:00

abstract：:Although recent clinical reports have noted hypokalemia after resuscitation from cardiac arrest, extensive animal work indicates that potassium is released from cells during ischemia. This study was undertaken to define the changes that occur in serum potassium ion during cardiac arrest and resuscitation in a canine m...

journal_title：Critical care medicine

authors： Martin GB,Carden DL,Nowak RM,Foreback C,Tomlanovich MC

更新日期：1986-04-01 00:00:00

abstract：:A difference between potassium concentrations in arterial plasma and venous serum was evaluated. The difference was 0.5 mM/litre, with a range of 0.1 to 1.1 mM/liter. Multiple factors operating primarily upon the venous sample are responsible for this difference. The value for arterial plasma potassium is stable and p...

journal_title：Critical care medicine

authors： Ward CF,Arkin DB,Benumof JL,Saidman LJ

更新日期：1978-09-01 00:00:00

abstract：:The educational objectives in use in our Pediatric ICU are described. These have importance for educational programs in critical care medicine, in particular, where patient care needs can easily overwhelm educational needs. It is important not to overlook our role as teachers in the development of proper attitudes and...

journal_title：Critical care medicine

authors： Kravath RE

更新日期：1977-05-01 00:00:00

abstract：:Right ventricular size and contractility were evaluated using two-dimensional echocardiography during the first days of respiratory support in 23 patients requiring mechanical ventilation for acute respiratory failure. Nine patients had normal echocardiographic right ventricular function, and nine other patients had a...

journal_title：Critical care medicine

authors： Jardin F,Gueret P,Dubourg O,Farcot JC,Margairaz A,Bourdarias JP

更新日期：1985-11-01 00:00:00

abstract：OBJECTIVES:To perform a complete immunological characterization of compensatory anti-inflammatory response syndrome in patients with sepsis and to explore the relationship between these changes and clinical outcomes of 28-day mortality and secondary infections. DESIGN:Prospective single-center study conducted between ...

journal_title：Critical care medicine

authors： Gomez HG,Gonzalez SM,Londoño JM,Hoyos NA,Niño CD,Leon AL,Velilla PA,Rugeles MT,Jaimes FA

更新日期：2014-04-01 00:00:00

abstract：OBJECTIVE:We investigated whether serum levels of neuron-specific enolase (NSE) and S-100beta protein could be used to evaluate cerebral injury and to predict outcome in severe sepsis and severe septic shock. DESIGN:Prospective study. SETTING:University hospital. PATIENTS AND MEASUREMENTS:In 170 consecutively enroll...

journal_title：Critical care medicine

authors： Nguyen DN,Spapen H,Su F,Schiettecatte J,Shi L,Hachimi-Idrissi S,Huyghens L

更新日期：2006-07-01 00:00:00

abstract：OBJECTIVES:Augmented renal clearance might lead to subtherapeutic plasma levels of drugs with predominant renal clearance. Early identification of augmented renal clearance remains challenging for the ICU physician. We developed and validated our augmented renal clearance predictor, a clinical prediction model for augm...

journal_title：Critical care medicine

authors： Gijsen M,Huang CY,Flechet M,Van Daele R,Declercq P,Debaveye Y,Meersseman P,Meyfroidt G,Wauters J,Spriet I

更新日期：2020-12-01 00:00:00

abstract：OBJECTIVE:To compare the classification performance of the Revised Atlanta Classification, the Determinant-Based Classification, and a new modified Determinant-Based Classification according to observed mortality and morbidity. DESIGN:A prospective multicenter observational study conducted in 1-year period. SETTING:F...

journal_title：Critical care medicine

authors： Zubia-Olaskoaga F,Maraví-Poma E,Urreta-Barallobre I,Ramírez-Puerta MR,Mourelo-Fariña M,Marcos-Neira MP,Epidemiology of Acute Pancreatitis in Intensive Care Medicine Study Group.

更新日期：2016-05-01 00:00:00

abstract：:Critical care clinicians no longer consider family members as visitors in the intensive care unit. Family-centered care has emerged from the results of qualitative and quantitative studies evaluating the specific needs of families of patients dying in the intensive care unit. In addition, interventional studies have e...

journal_title：Critical care medicine

authors： Lautrette A,Ciroldi M,Ksibi H,Azoulay E

更新日期：2006-11-01 00:00:00

abstract：OBJECTIVE:Perfluorocarbon liquid ventilation has been shown to enhance pulmonary mechanics and gas exchange in the setting of respiratory failure. To optimize the total liquid ventilation process, we developed a volume-limited, time-cycled liquid ventilatory support, consisting of an electrically actuated, microprocess...

journal_title：Critical care medicine

authors： Meinhardt JP,Quintel M,Hirschl RB

更新日期：2000-05-01 00:00:00

abstract：:End tidal CO2 tension (PetCO2) and transcutaneous CO2 tension (PtcCO2) were compared with arterial CO2 (PaCO2) before and after withdrawal of mechanical ventilation in 20 patients predisposed to hypercarbia. With stable PaCO2 during mechanical ventilation, the correlation coefficient (r) between PaCO2 and PetCO2 was ....

journal_title：Critical care medicine

authors： Healey CJ,Fedullo AJ,Swinburne AJ,Wahl GW

更新日期：1987-08-01 00:00:00