Hyperkalemia during cardiac arrest and resuscitation in the canine model.

Abstract:

:Although recent clinical reports have noted hypokalemia after resuscitation from cardiac arrest, extensive animal work indicates that potassium is released from cells during ischemia. This study was undertaken to define the changes that occur in serum potassium ion during cardiac arrest and resuscitation in a canine model. Fourteen dogs were subjected to 5 min of cardiac arrest followed by 30 min of closed-chest CPR (CCPR). Resuscitation was performed according to a standardized protocol. Serum potassium increased significantly (p less than .001) from baseline, remained elevated 5 min after return of spontaneous circulation (ROSC), but declined to baseline levels at 15 min post-ROSC. Increases in interstitial potassium would be expected to be even greater due to the poor exchange between interstitial and intravascular compartments during CCPR. Interstitial hyperkalemia may play a role in the genesis of wide-complex electromechanical dissociation and may explain the reported success of calcium chloride in treating this problem.

journal_name

Crit Care Med

journal_title

Critical care medicine

authors

Martin GB,Carden DL,Nowak RM,Foreback C,Tomlanovich MC

doi

10.1097/00003246-198604000-00012

subject

Has Abstract

pub_date

1986-04-01 00:00:00

pages

300-2

issue

4

eissn

0090-3493

issn

1530-0293

journal_volume

14

pub_type

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