Efficacy of flow-by during continuous positive airway pressure ventilation.


:We investigated clinically the differences in respiratory work of patients imposed by three modes of one ventilator: the flow-by system, the demand valve system, and the pressure support system. Inspiratory work using flow-by and pressure support systems was reduced sufficiently when compared to the demand valve system. Moreover, fluctuation of the airway pressure was minimal with the flow-by mode. These results suggest that the flow-by mode is beneficial to patients breathing spontaneously with continuous positive airway pressure.


Crit Care Med


Critical care medicine


Saito S,Tokioka H,Kosaka F




Has Abstract


1990-06-01 00:00:00












  • Lithium dilution cardiac output measurement: a comparison with thermodilution.

    abstract:OBJECTIVE:To compare the results of cardiac output measurements obtained by lithium dilution and thermodilution. DESIGN:Case series, observational study. SETTING:High-dependency postoperative unit and intensive care unit of a teaching hospital. PATIENTS:Forty patients were studied. Thirty-four patients had undergoin...

    journal_title:Critical care medicine

    pub_type: 临床试验,杂志文章


    authors: Linton R,Band D,O'Brien T,Jonas M,Leach R

    更新日期:1997-11-01 00:00:00

  • Blood pressure excursions below the cerebral autoregulation threshold during cardiac surgery are associated with acute kidney injury.

    abstract:OBJECTIVES:To determine whether mean arterial blood pressure excursions below the lower limit of cerebral blood flow autoregulation during cardiopulmonary bypass are associated with acute kidney injury after surgery. SETTING:Tertiary care medical center. PATIENTS:Four hundred ten patients undergoing cardiac surgery w...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Ono M,Arnaoutakis GJ,Fine DM,Brady K,Easley RB,Zheng Y,Brown C,Katz NM,Grams ME,Hogue CW

    更新日期:2013-02-01 00:00:00

  • Does IV Iron Induce Plasma Oxidative Stress in Critically Ill Patients? A Comparison With Healthy Volunteers.

    abstract:OBJECTIVE:To compare the oxidative stress induced by IV iron infusion in critically ill patients and in healthy volunteers. DESIGN:Multicenter, interventional study. SETTING:Two ICUs and one clinical research center. SUBJECTS:Anemic critically ill patients treated with IV iron and healthy volunteers. INTERVENTIONS:...

    journal_title:Critical care medicine

    pub_type: 杂志文章,多中心研究


    authors: Lasocki S,Piednoir P,Couffignal C,Rineau E,Dufour G,Lefebvre T,Puy H,Duval X,Driss F,Schilte C

    更新日期:2016-03-01 00:00:00

  • Pulmonary effects of ventilatory pattern following cardiopulmonary bypass.

    abstract::Twenty-one patients who underwent cardiopulmonary bypass for myocardial revascularization received postoperatively controlled mechanical ventilation (CMV) or intermittent mandatory ventilation (IMV), with or without positive end-expiratory pressure (PEEP). Functional residual capacity (FRC), right-to-left intrapulmona...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Downs JB,Mitchell LA

    更新日期:1976-11-01 00:00:00

  • Neurologic Injury in Adults Supported With Veno-Venous Extracorporeal Membrane Oxygenation for Respiratory Failure: Findings From the Extracorporeal Life Support Organization Database.

    abstract:OBJECTIVES:To assess in-hospital neurologic (CNS) complications in adult patients undergoing veno-venous extracorporeal membrane oxygenation for respiratory failure. DESIGN:Retrospective analysis of the Extracorporeal Life Support Organization's data registry. SETTING:Data reported to Extracorporeal Life Support Orga...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Lorusso R,Gelsomino S,Parise O,Di Mauro M,Barili F,Geskes G,Vizzardi E,Rycus PT,Muellenbach R,Mueller T,Pesenti A,Combes A,Peek G,Frenckner B,Di Nardo M,Swol J,Maessen J,Thiagarajan RR

    更新日期:2017-08-01 00:00:00

  • Heparin treatment in thrombin-induced disseminated intravascular coagulation in the baboon.

    abstract:BACKGROUND AND METHODS:We postulated that low-dose heparin (10 IU/kg.hr) administered as a continuous iv infusion may prevent or ameliorate the induction of thrombin-induced disseminated intravascular coagulation in baboons under general anesthesia. In a nonrandomized experiment lasting 8 hrs, animals were divided into...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: du Toit HJ,Coetzee AR,Chalton DO

    更新日期:1991-09-01 00:00:00

  • Right ventricular end-diastolic volume index as a predictor of preload status in patients on positive end-expiratory pressure.

    abstract:OBJECTIVE:To evaluate the clinical utility of right ventricular end-diastolic volume index (RVEDVI) and pulmonary artery occlusion pressure (PAOP) as measures of preload status in patients with acute respiratory failure receiving treatment with positive end-expiratory pressure. DESIGN:Prospective, cohort study. SETTI...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Cheatham ML,Nelson LD,Chang MC,Safcsak K

    更新日期:1998-11-01 00:00:00

  • Case of fulminant hepatic failure due to unrecognized peripartum cardiomyopathy.

    abstract:OBJECTIVE:To describe a postpartum patient who presented with fulminant hepatic failure and hepatic coma as a result of unrecognized peripartum cardiomyopathy. DESIGN:Case report. SETTING:Medical intensive care unit of a tertiary care academic medical center. PATIENT:A 35-yr-old woman 5 wks postpartum from an uneven...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Fussell KM,Awad JA,Ware LB

    更新日期:2005-04-01 00:00:00

  • Effects of clonidine on prolonged postoperative sympathetic response.

    abstract:OBJECTIVE:Surgical trauma results in diffuse sympathoadrenal activation which is thought to contribute to perioperative cardiovascular complications in high-risk patients. Regional anesthetic and analgesic techniques can attenuate this "stress response" and reduce the occurrence rate of adverse perioperative events; ho...

    journal_title:Critical care medicine

    pub_type: 临床试验,杂志文章


    authors: Dorman T,Clarkson K,Rosenfeld BA,Shanholtz C,Lipsett PA,Breslow MJ

    更新日期:1997-07-01 00:00:00

  • Prospective validation of the intensive care unit admission Mortality Probability Model (MPM0-III).

    abstract:OBJECTIVE:To validate performance characteristics of the intensive care unit (ICU) admission mortality probability model, version III (MPM0-III) on Project IMPACT data submitted in 2004 and 2005. This data set was external from the MPM0-III developmental and internal validation data collected between 2001 and 2004. DE...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Higgins TL,Kramer AA,Nathanson BH,Copes W,Stark M,Teres D

    更新日期:2009-05-01 00:00:00

  • National estimates of severe sepsis in United States emergency departments.

    abstract:OBJECTIVE:The emergency department (ED) often serves as the first site for the recognition and treatment of patients with suspected severe sepsis. However, few evaluations of the national epidemiology and distribution of severe sepsis in the ED exist. We sought to determine national estimates of the number, timing, ED ...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Wang HE,Shapiro NI,Angus DC,Yealy DM

    更新日期:2007-08-01 00:00:00

  • Recombinant human erythropoietin pretreatment attenuates acute renal tubular injury against ischemia-reperfusion by restoring transient receptor potential channel-6 expression and function in collecting ducts.

    abstract:OBJECTIVE:Acute renal tubular injury is a serious complication in the postoperative period, which is associated with high mortality and increased ICU stay. We aimed to demonstrate the protective effect of rhEPO against acute tubular injury induced by ischemia-reperfusion and to explore the mechanism of canonical transi...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Shen S,Jin Y,Li W,Liu X,Zhang T,Xia W,Wang Y,Ma K

    更新日期:2014-10-01 00:00:00

  • Rocuronium exacerbates mechanical ventilation-induced diaphragm dysfunction in rats.

    abstract:OBJECTIVE:Nondepolarizing neuromuscular blocking agents are commonly used in the intensive care setting, but they have occasionally been associated with development of myopathy. In addition, diaphragmatic atrophy and a reduction in diaphragmatic force were reported after short-term controlled mechanical ventilation in ...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Testelmans D,Maes K,Wouters P,Gosselin N,Deruisseau K,Powers S,Sciot R,Decramer M,Gayan-Ramirez G

    更新日期:2006-12-01 00:00:00

  • Sex-based differences in serum cardiac troponin I, a specific marker for myocardial injury, after cardiac surgery.

    abstract:BACKGROUND:Prevalence and causes of sex-based differences in morbidity and mortality secondary to cardiovascular disease remain controversial. Cardiac troponin I (cTnI) is a sensitive and specific marker for myocardial injury. Serial cTnI measurements have been used to identify perioperative myocardial cell injury. OB...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Schwarzenberger JC,Sun LS,Pesce MA,Heyer EJ,Delphin E,Almeida GM,Wood M

    更新日期:2003-03-01 00:00:00

  • Intramyocardial hypercarbic acidosis during cardiac arrest and resuscitation.

    abstract:OBJECTIVE:To define changes in intramyocardial pH and PCO2 during cardiac arrest and resuscitation. DESIGN:Prospective and observational trial. SETTING:Mammalian research laboratory utilizing a porcine model of cardiac arrest. SUBJECTS:Sixteen domestic pigs. INTERVENTIONS:Ventricular fibrillation was induced by an ...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Kette F,Weil MH,Gazmuri RJ,Bisera J,Rackow EC

    更新日期:1993-06-01 00:00:00

  • Usefulness of transcranial echography in patients with decompressive craniectomy: a comparison with computed tomography scan.

    abstract:OBJECTIVE:To assess the agreement between computed tomography and transcranial sonography in patients after decompressive craniectomy. DESIGN:Prospective study. SETTING:The medical intensive care unit of a university-affiliated teaching hospital. PATIENTS:Thirty head-injured patients consecutively admitted to the in...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Caricato A,Mignani V,Bocci MG,Pennisi MA,Sandroni C,Tersali A,Antonaci A,de Waure C,Antonelli M

    更新日期:2012-06-01 00:00:00

  • Old Mice Demonstrate Organ Dysfunction as well as Prolonged Inflammation, Immunosuppression, and Weight Loss in a Modified Surgical Sepsis Model.

    abstract:OBJECTIVES:Our goal was to "reverse translate" the human response to surgical sepsis into the mouse by modifying a widely adopted murine intra-abdominal sepsis model to engender a phenotype that conforms to current sepsis definitions and follows the most recent expert recommendations for animal preclinical sepsis resea...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Stortz JA,Hollen MK,Nacionales DC,Horiguchi H,Ungaro R,Dirain ML,Wang Z,Wu Q,Wu KK,Kumar A,Foster TC,Stewart BD,Ross JA,Segal M,Bihorac A,Brakenridge S,Moore FA,Wohlgemuth SE,Leeuwenburgh C,Mohr AM,Moldawer LL,E

    更新日期:2019-11-01 00:00:00

  • Meta-analysis of subclavian insertion and nontunneled central venous catheter-associated infection risk reduction in critically ill adults.

    abstract:OBJECTIVE:Catheter-associated infections are common, costly, and potentially lethal. The impact of catheter insertion site on infection risk remains controversial. We aimed to establish whether nontunneled central venous catheters inserted in the subclavian vein are associated with lower risk of catheter-associated inf...

    journal_title:Critical care medicine

    pub_type: 杂志文章,meta分析


    authors: Parienti JJ,du Cheyron D,Timsit JF,Traoré O,Kalfon P,Mimoz O,Mermel LA

    更新日期:2012-05-01 00:00:00

  • Extracellular Mitochondrial DNA and N-Formyl Peptides in Trauma and Critical Illness: A Systematic Review.

    abstract:OBJECTIVES:Extracellular mitochondrial DNA and N-formyl peptides released following tissue damage may contribute to systemic inflammation through stimulation of the innate immune system. In this review, we evaluate existing in vivo human data regarding a role for mitochondrial DNA and N-formyl peptides in producing sys...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Lubkin DT,Bishawi M,Barbas AS,Brennan TV,Kirk AD

    更新日期:2018-12-01 00:00:00

  • Carbon Monoxide Exerts Functional Neuroprotection After Cardiac Arrest Using Extracorporeal Resuscitation in Pigs.

    abstract:OBJECTIVES:Neurologic damage following cardiac arrest remains a major burden for modern resuscitation medicine. Cardiopulmonary resuscitation with extracorporeal circulatory support holds the potential to reduce morbidity and mortality. Furthermore, the endogenous gasotransmitter carbon monoxide attracts attention in r...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Wollborn J,Steiger C,Doostkam S,Schallner N,Schroeter N,Kari FA,Meinel L,Buerkle H,Schick MA,Goebel U

    更新日期:2020-04-01 00:00:00

  • Use of glucose-insulin-potassium (GIK) in human septic shock.

    abstract::Fifteen patients with septic shock and perfusion failure received a 20-min infusion of glucose-insulin-potassium (GIK, glucose 50%, 1 g/kg body weight; insulin 1.5 U/kg, potassium, 10 mMol) after volume loading and vasoactive medication had failed to eliminate hypotension and lactacidemia. Hemodynamic and oxygen measu...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Bronsveld W,van den Bos GC,Thijs LG

    更新日期:1985-07-01 00:00:00

  • β1-Adrenergic Inhibition Improves Cardiac and Vascular Function in Experimental Septic Shock.

    abstract:OBJECTIVE:Preliminary experimental data suggest that selective β1-blockers may improve ex vivo cardiac function in animal sepsis. Currently, the effects of esmolol on in vivo cardiac function and on vascular function are unknown. The present study was designed to examine the effects of the β1-selective blocker esmolol ...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Kimmoun A,Louis H,Al Kattani N,Delemazure J,Dessales N,Wei C,Marie PY,Issa K,Levy B

    更新日期:2015-09-01 00:00:00

  • Hypoxia-reoxygenation is as damaging as ischemia-reperfusion in the rat liver.

    abstract:OBJECTIVE:We hypothesized that the extent of injury and release of xanthine oxidase, an oxidant generator, into the circulation would be less in normal-flow hypoxia-reoxygenation than in equal duration no-flow ischemia-reperfusion. DESIGN:Randomized study. SETTING:University-based animal research facility. SUBJECTS:...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Tan S,Yokoyama Y,Wang Z,Zhou F,Nielsen V,Murdoch AD,Adams C,Parks DA

    更新日期:1998-06-01 00:00:00

  • Continuous noninvasive estimation of cardiac output by electrical bioimpedance: an experimental study in dogs.

    abstract::A new device has been developed to estimate continuously and noninvasively cardiac output from the thoracic electrical bioimpedance (CObi). CObi was compared to cardiac output by thermodilution (COtd) in five anesthetized dogs. Blood pressure, blood volume, and blood flow were manipulated by hemorrhage and infusions o...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Tremper KK,Hufstedler SM,Barker SJ,Zaccari J,Harris D,Anderson S,Roohk V

    更新日期:1986-03-01 00:00:00

  • Disagreement Between Clinicians and Score in Decision-Making Capacity of Critically Ill Patients.

    abstract:OBJECTIVES:To compare the assessment of decision-making capacity of ICU patients by attending clinicians (physicians, nurses, and residents) with a capacity score measured by the Mini-Mental Status Examination, completed by Aid to Capacity Evaluation if necessary. The primary outcome was agreement between physicians' a...

    journal_title:Critical care medicine

    pub_type: 杂志文章,多中心研究


    authors: Bertrand PM,Pereira B,Adda M,Timsit JF,Wolff M,Hilbert G,Gruson D,Garrouste-Orgeas M,Argaud L,Constantin JM,Chabanne R,Quenot JP,Bohe J,Guerin C,Papazian L,Jonquet O,Klouche K,Delahaye A,Riu B,Zieleskiewicz L,Darm

    更新日期:2019-03-01 00:00:00

  • Survival and functional outcome in pediatric traumatic brain injury: a retrospective review and analysis of predictive factors.

    abstract:OBJECTIVE:The aim of this study was to evaluate the relationship of patient care variables to survival and functional outcome in the pediatric population with traumatic brain injury. DESIGN:Retrospective chart review. SETTING:A 16-bed pediatric critical care unit in an academic community children's hospital. PATIENT...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Hackbarth RM,Rzeszutko KM,Sturm G,Donders J,Kuldanek AS,Sanfilippo DJ

    更新日期:2002-07-01 00:00:00

  • Iontophoretic delivery of calcium for experimental hydrofluoric acid burns.

    abstract:OBJECTIVE:To examine the efficacy of iontophoretic delivery of calcium to experimental hydrofluoric acid burns. DESIGN:Prospective, controlled study. SETTING:Institutional laboratory. SUBJECTS:Male nude rats. INTERVENTIONS:For the in vitro experiment, a full-thickness skin from the back was set in a vertical flow-t...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Yamashita M,Yamashita M,Suzuki M,Hirai H,Kajigaya H

    更新日期:2001-08-01 00:00:00

  • Microdialysis-evaluated myocardial cyclooxygenase-mediated inflammation and early circulatory depression in porcine endotoxemia.

    abstract:OBJECTIVE:To evaluate the early myocardial biochemical inflammatory response with the microdialysis technique during porcine endotoxemia and to simultaneously monitor systemic hemodynamics. DESIGN:Prospective, randomized, placebo-controlled trial with parallel groups. SETTING:Animal research laboratory at the Univers...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Mutschler DK,Eriksson MB,Wikström BG,Lind L,Larsson A,Bergren-Kiiski R,Lagrange A,Nordgren A,Basu S

    更新日期:2003-06-01 00:00:00

  • Comparison of prone positioning and continuous rotation of patients with adult respiratory distress syndrome: results of a pilot study.

    abstract:OBJECTIVE:To compare prone positioning and continuous rotational therapy with respect to oxygenation and hemodynamics in patients suffering from adult respiratory distress syndrome (ARDS). DESIGN:Randomized, prospective pilot study. SETTING:Intensive care unit at a university hospital. PATIENTS:Twenty-six mechanical...

    journal_title:Critical care medicine

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Staudinger T,Kofler J,Müllner M,Locker GJ,Laczika K,Knapp S,Losert H,Frass M

    更新日期:2001-01-01 00:00:00

  • Can Concurrent Abnormalities in Free Light Chains and Immunoglobulin Concentrations Identify a Target Population for Immunoglobulin Trials in Sepsis?

    abstract:OBJECTIVES:Light chains κ and λ are immunoglobulin constituents but also circulate independently in blood as free light chains. We investigated whether a concomitant abnormality in free light chain and immunoglobulin levels could identify a high risk of death sepsis subpopulation to inform future IV immunoglobulin tria...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Shankar-Hari M,Singer M,Spencer J

    更新日期:2017-11-01 00:00:00