Effects of mild induced hypothermia during experimental sepsis.

Abstract:

OBJECTIVES:The potential advantages of lowering core temperature during sepsis are to lower energy requirement and to activate various cell-protecting pathways. We experimentally investigated whether postconditioning temperature modifications influence survival duration during experimental sepsis. DESIGN:A prospective, randomized, experimental animal study. SETTING:University laboratory. SUBJECTS:Eighteen male Sprague-Dawley rats (median 326 g, range 310-347 g). INTERVENTIONS:After anesthesia, experimental sepsis was induced by cecal ligation and perforation. The animals were subsequently assigned a core temperature range: normothermia (37 degrees C), hyperthermia (42 degrees C), and mild hypothermia (32 degrees C). Anesthesia and analgesia were continuously maintained until death. MEASUREMENTS AND MAIN RESULTS:Plasma lactate and pyruvate concentrations were measured at sepsis induction (H0), 4 hrs later (H4), and/or at the time of death. A significant increase in lactate concentration was observed at the time of death in the 42 degrees C group (p = .04). Lactate-to-pyruvate ratio increased in the 32 degrees C (at H4) and 42 degrees C (at the time of death) groups (p = .04). A linear correlation between a longer survival duration and a lower assigned core temperature was observed (from 61 +/- 10 mins at 42 degrees C to 289 +/- 17 mins at 37 degrees C and to 533 +/- 69 mins at 32 degrees C; R = .959, p < .0001). CONCLUSIONS:The current results demonstrate that postconditioning hypothermia was associated with increased survival duration during experimental sepsis. Whether the observed benefits on survival duration are due to potential impacts on energy metabolism or to an anti-inflammatory effect of hypothermia requires further investigation.

journal_name

Crit Care Med

journal_title

Critical care medicine

authors

L'Her E,Amerand A,Vettier A,Sebert P

doi

10.1097/01.CCM.0000240231.76837.DC

subject

Has Abstract

pub_date

2006-10-01 00:00:00

pages

2621-3

issue

10

eissn

0090-3493

issn

1530-0293

journal_volume

34

pub_type

杂志文章
  • Radial Artery Applanation Tonometry for Continuous Noninvasive Cardiac Output Measurement: A Comparison With Intermittent Pulmonary Artery Thermodilution in Patients After Cardiothoracic Surgery.

    abstract:OBJECTIVES:Radial artery applanation tonometry allows completely noninvasive continuous cardiac output estimation. The aim of the present study was to compare cardiac output measurements obtained with applanation tonometry (AT-CO) using the T-Line system (Tensys Medical, San Diego, CA) with cardiac output measured by i...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/CCM.0000000000000979

    authors: Wagner JY,Sarwari H,Schön G,Kubik M,Kluge S,Reichenspurner H,Reuter DA,Saugel B

    更新日期:2015-07-01 00:00:00

  • Effects of norepinephrine on static and dynamic preload indicators in experimental hemorrhagic shock.

    abstract:OBJECTIVE:To investigate the effect of norepinephrine on static (right atrial pressure, pulmonary artery occlusion pressure ) and dynamic (pulse pressure variation and arterial systolic pressure variation) preload indicators in experimental hemorrhagic shock. DESIGN:Prospective controlled experimental study. SETTING:...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/01.ccm.0000182801.48137.13

    authors: Nouira S,Elatrous S,Dimassi S,Besbes L,Boukef R,Mohamed B,Abroug F

    更新日期:2005-10-01 00:00:00

  • Mortality of patients with heatstroke admitted to intensive care units during the 2003 heat wave in France: a national multiple-center risk-factor study.

    abstract:OBJECTIVE:Heatstroke requires active body cooling and organ failure supportive care. Although heat waves are expected to recur over the next decades, little is known about the risk factors for mortality in heatstroke patients. We examined the prognosis and risk factors for hospital mortality in patients with heatstroke...

    journal_title:Critical care medicine

    pub_type: 评论,杂志文章,多中心研究

    doi:10.1097/01.CCM.0000206469.33615.02

    authors: Misset B,De Jonghe B,Bastuji-Garin S,Gattolliat O,Boughrara E,Annane D,Hausfater P,Garrouste-Orgeas M,Carlet J

    更新日期:2006-04-01 00:00:00

  • Procalcitonin for reduced antibiotic exposure in the critical care setting: a systematic review and an economic evaluation.

    abstract:OBJECTIVE:Procalcitonin may be associated with reduced antibiotic usage compared to usual care. However, individual randomized controlled trials testing this hypothesis were too small to rule out harm, and the full cost-benefit of this strategy has not been evaluated. The purpose of this analysis was to evaluate the ef...

    journal_title:Critical care medicine

    pub_type: 杂志文章,meta分析,评审

    doi:10.1097/CCM.0b013e31821201a5

    authors: Heyland DK,Johnson AP,Reynolds SC,Muscedere J

    更新日期:2011-07-01 00:00:00

  • Thrombocytopenia impairs host defense during murine Streptococcus pneumoniae pneumonia.

    abstract:OBJECTIVES:Streptococcus pneumoniae is the most common causative pathogen in community-acquired pneumonia. In patients, thrombocytopenia is correlated with an adverse outcome of pneumonia. Platelets can modulate the host response to infection in several ways, that is, by facilitating clot formation, production of antim...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/CCM.0000000000000853

    authors: van den Boogaard FE,Schouten M,de Stoppelaar SF,Roelofs JJ,Brands X,Schultz MJ,van't Veer C,van der Poll T

    更新日期:2015-03-01 00:00:00

  • Increased intracellular cyclic adenosine 3', 5'-monophosphate inhibits release of tumor necrosis factor-alpha from human vascular tissue and cultured smooth muscle cells.

    abstract:OBJECTIVES:We recently reported that bacterial lipopolysaccharide stimulates release of tumor necrosis factor (TNF)-alpha from both human vascular tissue and cultured smooth muscle cells. In the current study, we tested the hypothesis that increased intracellular cyclic adenosine 3',5'-monophosphate (cAMP) could inhibi...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-199711000-00025

    authors: Zhang LM,Castresana MR,Shaker IJ,Dalton ML,Leeper-Woodford SK,Newman WH

    更新日期:1997-11-01 00:00:00

  • Thoracic bioimpedance and Doppler cardiac output measurement: learning curve and interobserver reproducibility.

    abstract::Nine previously untrained health professionals learned to measure cardiac output (Qt) by suprasternal continuous-wave Doppler ultrasound (QtDopp) and by thoracic bioimpedance (Qtbi). Each received standardized written, videotaped, and individual instruction. First the novice, then the reference examiner, measured QtDo...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-198911000-00019

    authors: Wong DH,Onishi R,Tremper KK,Reeves C,Zaccari J,Wong AB,Miller JB,Cordero V,Davidson J

    更新日期:1989-11-01 00:00:00

  • Cardiovascular function during the postresuscitation phase after cardiac arrest in pigs: a comparison of epinephrine versus vasopressin.

    abstract:OBJECTIVE:The administration of vasopressin during cardiopulmonary resuscitation (CPR) provides significantly more vital organ blood flow when compared with epinephrine during cardiac arrest in pigs. The effects of this potent vasoconstrictor on postresuscitation cardiovascular function remain unknown. The purpose of t...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-199612000-00014

    authors: Prengel AW,Lindner KH,Keller A,Lurie KG

    更新日期:1996-12-01 00:00:00

  • A meta-analysis of three decades of validating thoracic impedance cardiography.

    abstract:OBJECTIVE:To provide a meta-analysis of current literature concerning the validation of thoracic impedance cardiography (TIC) and to explain the variations in the reported results from the differences in the studies. DATA SOURCES:A computer-assisted search of English-language, German, and Dutch literature was performe...

    journal_title:Critical care medicine

    pub_type: 杂志文章,meta分析

    doi:10.1097/00003246-199906000-00053

    authors: Raaijmakers E,Faes TJ,Scholten RJ,Goovaerts HG,Heethaar RM

    更新日期:1999-06-01 00:00:00

  • Core temperature measurement in the intensive care unit.

    abstract:OBJECTIVE:To compare three devices that measure core body temperature at the bedside in ICU patients. DESIGN:Prospective, consecutive sample. SETTING:Voluntary community teaching hospital. PATIENTS:Fifteen patients, 78 +/- 6 (SD) yrs of age, admitted to the medical ICU over a 5-month period who had pulmonary artery ...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-199106000-00015

    authors: Nierman DM

    更新日期:1991-06-01 00:00:00

  • A direct relationship between ionized calcium and arterial pressure among patients in an intensive care unit.

    abstract::Serum ionized calcium (Ca+2), creatinine, magnesium, phosphate, and arterial pH were measured in patients on admission to the medical ICU (MICU). Patients were classified into three groups: a) hypotensive (n = 38), those who received vasopressor support for frank hypotension; b) hypertensive (n = 21), those who requir...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-198806000-00002

    authors: Desai TK,Carlson RW,Thill-Baharozian M,Geheb MA

    更新日期:1988-06-01 00:00:00

  • Comparison of the renal effects of low to high doses of dopamine and dobutamine in critically ill patients: a single-blind randomized study.

    abstract:OBJECTIVE:The renal effects of dopamine in critically ill patients remain controversial. Low-dose dobutamine has been reported to improve renal function. We compared the effects of various doses of dopamine and dobutamine on renal function in critically ill patients. DESIGN:Prospective, single-blind, randomized study....

    journal_title:Critical care medicine

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00003246-200004000-00002

    authors: Ichai C,Soubielle J,Carles M,Giunti C,Grimaud D

    更新日期:2000-04-01 00:00:00

  • Intracranial pressure monitoring and case mix-adjusted mortality in intracranial hemorrhage.

    abstract:OBJECTIVE:Intracranial pressure (ICP) monitoring is frequently used in intensive care treatment of patients with intracranial hemorrhage. Data demonstrating an improved outcome from this intervention are lacking. We analyzed standardized mortality ratios in patients with and without ICP monitoring to determine its effi...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/01.CCM.0000065270.53951.9E

    authors: Valentin A,Lang T,Karnik R,Ammerer HP,Ploder J,Slany J

    更新日期:2003-05-01 00:00:00

  • Practices in Triage and Transfer of Critically Ill Patients: A Qualitative Systematic Review of Selection Criteria.

    abstract:OBJECTIVES:To identify and appraise articles describing criteria used to prioritize or withhold a critical care admission. DATA SOURCES:PubMed, Embase, Medline, EBM Reviews, and CINAHL Complete databases. Gray literature searches and a manual review of references were also performed. Preferred Reporting Items for Syst...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/CCM.0000000000004624

    authors: Dahine J,Hébert PC,Ziegler D,Chenail N,Ferrari N,Hébert R

    更新日期:2020-11-01 00:00:00

  • System for umbilical artery monitoring.

    abstract::A simple, safe, and effective system for umbilical artery monitoring controls continuous fluid infusion to prevent fluid overinfusion and keep the catheter from clotting. Accurate and continuous pressure measurements can be recorded simultaneously with fluid infusion. A convenient method for checking dynamic response ...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-198207000-00009

    authors: Gardner RM,Parker J,Feinauer LR

    更新日期:1982-07-01 00:00:00

  • Phase II, randomized, controlled trial of high-dose N-acetylcysteine in high-risk cardiac surgery patients.

    abstract:OBJECTIVE:To assess the effect of high-dose N-acetylcysteine on renal function in cardiac surgery patients at higher risk of postoperative renal failure. DESIGN:Multiblind, placebo-controlled, randomized, phase II clinical trial. SETTING:Operating rooms and intensive care units of two tertiary referral hospitals. PA...

    journal_title:Critical care medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/01.CCM.0000261887.69976.12

    authors: Haase M,Haase-Fielitz A,Bagshaw SM,Reade MC,Morgera S,Seevenayagam S,Matalanis G,Buxton B,Doolan L,Bellomo R

    更新日期:2007-05-01 00:00:00

  • Role of regulatory T cells in long-term immune dysfunction associated with severe sepsis.

    abstract:OBJECTIVE:To investigate the role of regulatory T cells in the modulation of long-term immune dysfunction during experimental sepsis. It is well established that sepsis predisposes to development of a pronounced immunosuppression. Nevertheless, the mechanisms underlying the immune dysfunction after sepsis are still not...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/CCM.0b013e3181e78ad0

    authors: Nascimento DC,Alves-Filho JC,Sônego F,Fukada SY,Pereira MS,Benjamim C,Zamboni DS,Silva JS,Cunha FQ

    更新日期:2010-08-01 00:00:00

  • Endogenous protein C activation in patients with severe sepsis.

    abstract:OBJECTIVE:To review how endogenous protein C activation might change in disease states and to discuss the implications of these findings in the context of severe sepsis. DATA SOURCE:A review of the published literature in PubMed together with data from abstracts from 2001 to present. DATA EXTRACTION AND SYNTHESIS:Act...

    journal_title:Critical care medicine

    pub_type: 杂志文章,评审

    doi:10.1097/01.ccm.0000126125.79861.d3

    authors: Liaw PC

    更新日期:2004-05-01 00:00:00

  • Slow versus rapid closed-chest cardiac compression during cardiopulmonary resuscitation in puppies.

    abstract::The recommended rates for closed-chest cardiac compressions during CPR are based on physiologic variations with increasing age rather than experimental data. Using puppies, we compared mean arterial pressure, cardiac index (CI), and cerebral blood flow (CBF) at a slow (40/min, group 1) and a rapid (120/min, group 2) r...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-198710000-00009

    authors: Fleisher G,Delgado-Paredes C,Heyman S

    更新日期:1987-10-01 00:00:00

  • Tumor necrosis factor-alpha and interleukin-10 gene expression in peripheral blood mononuclear cells after cardiac surgery.

    abstract:OBJECTIVE:Cytokine response after cardiac surgery may be genetically influenced. A study was carried out to investigate the relation between cytokine gene expression in peripheral blood mononuclear cells, genotype, and clinical events after cardiac surgery. DESIGN:A case-control study was performed. SETTING:Cardiac i...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/01.CCM.0000227647.77356.AB

    authors: Duggan E,Caraher E,Gately K,O'Dwyer M,McGovern E,Kelleher D,McManus R,Ryan T

    更新日期:2006-08-01 00:00:00

  • Critical care problems of the newborn: insensible water loss in small premature infants.

    abstract::During the control period in this study, small premature infants, 1500 g in birth weight, had insensible water loss (IWL) of 2.28 g/kg/hr (equivlaent to 54 ml/kg/day), which is considerably higher than in full term infants. Under phototherapy, there was a significant increase in IWL (3.14 g/kg/hr) associated with incr...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-197511000-00006

    authors: Yeh TF,Vidyasagar D,Pildes RS

    更新日期:1975-11-01 00:00:00

  • A randomized, controlled trial of computerized physiologic trend monitoring in an intensive care unit.

    abstract:OBJECTIVE:To assess whether the provision of computerized physiologic trend data could improve outcome in newborn infants requiring intensive care. DESIGN:Randomized, controlled trial, with subsidiary questionnaire studies. SETTING:Tertiary neonatal intensive care unit with 12 intensive care cots. PATIENTS:All infan...

    journal_title:Critical care medicine

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00003246-199812000-00040

    authors: Cunningham S,Deere S,Symon A,Elton RA,McIntosh N

    更新日期:1998-12-01 00:00:00

  • Accurate and precise delivery of nitric oxide during high-frequency oscillatory ventilation.

    abstract:BACKGROUND:We have previously described a method for the precise delivery of inhaled nitric oxide (iNO) via a conventional, continuous-flow, pressure-limited, time-cycled ventilator. Because of the augmented effect of iNO decreasing pulmonary vascular resistance with high-frequency oscillatory ventilation (HFOV), we de...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-199911000-00038

    authors: Espinosa RM,Marks KH

    更新日期:1999-11-01 00:00:00

  • Helicobacter pylori infection in intensive care: increased prevalence and a new nosocomial infection.

    abstract:OBJECTIVE:The pathogenesis of acute gastric stress ulceration in the seriously ill is uncertain, and any role of Helicobacter pylori infection is unknown. We aimed to assess the relationship between H. pylori serological status and stress ulceration in seriously ill patients, as well as H. pylori serological status in ...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-199907000-00010

    authors: Robertson MS,Cade JF,Clancy RL

    更新日期:1999-07-01 00:00:00

  • Sleep and Work in ICU Physicians During a Randomized Trial of Nighttime Intensivist Staffing.

    abstract:OBJECTIVES:To compare sleep, work hours, and behavioral alertness in faculty and fellows during a randomized trial of nighttime in-hospital intensivist staffing compared with a standard daytime intensivist model. DESIGN:Prospective observational study. SETTING:Medical ICU of a tertiary care academic medical center du...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/CCM.0000000000003773

    authors: Bakhru RN,Basner M,Kerlin MP,Halpern SD,Hansen-Flaschen J,Rosen IM,Dinges DF,Schweickert WD

    更新日期:2019-07-01 00:00:00

  • Pulmonary fluid balance and hemodynamics after perfluorocarbon infusion in the dog lung.

    abstract::Perfluorocarbon (PFC) emulsions are promising oxygen-carrying blood supplements for the treatment of shock and in organ preservation for transplantation. We used the isolated, blood-perfused, canine right lower lung lobe (RLL) to determine the effect of a PFC emulsion, Oxypherol (FC-43), upon lung fluid balance and he...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-198512000-00006

    authors: Hall JE,Ehrhart IC,Hofman WF

    更新日期:1985-12-01 00:00:00

  • Augmentation of endotoxin-induced pulmonary responses by mononuclear cell phagocytosis in the reticuloendothelial system.

    abstract:OBJECTIVE:To test the hypothesis that the effects of intravenous injection of latex particles would demonstrate the contribution of phagocytosis by mononuclear phagocytes to the development of Escherichia coli-induced acute lung injury in neutropenic guinea pigs. DESIGN:Prospective, controlled, experimental study. Int...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-199606000-00025

    authors: Ishizaka A,Hasegawa N,Sayama K,Urano T,Nakamura H,Sakamaki F,Soejima K,Waki Y,Tasaka S,Nakamura M,Matsubara H,Kanazawa M

    更新日期:1996-06-01 00:00:00

  • Prediction of outcome of cardiopulmonary resuscitation from end-tidal carbon dioxide concentration.

    abstract::Capnography is a valuable tool in the management of cardiac arrest, since end-tidal CO2 (PetCO2) correlates well with cardiac output and there are no other suitable noninvasive ways to measure this important variable during resuscitation. Animal studies also suggest that PetCO2 correlates well with the likelihood of r...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-199004000-00002

    authors: Callaham M,Barton C

    更新日期:1990-04-01 00:00:00

  • What's in a day? Determining intensive care unit length of stay.

    abstract:OBJECTIVE:Intensive care unit (ICU) length of stay (LOS) and hospital LOS are common indices used to compare performance of hospitals and are yardsticks used in efforts to contain costs, yet there is no standardized method of quantitating this outcome variable. Attempts have been made to correct LOS according to diseas...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-200006000-00071

    authors: Marik PE,Hedman L

    更新日期:2000-06-01 00:00:00

  • Sepsis-related cardiogenic shock.

    abstract::To further define cardiovascular abnormalities in patients with septic shock, serial conventional hemodynamic measurements combined with two-dimensional echocardiographic studies were performed at the bedside in 21 patients admitted for an acute episode of sepsis-related circulatory failure. Measurements obtained duri...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-199010000-00001

    authors: Jardin F,Brun-Ney D,Auvert B,Beauchet A,Bourdarias JP

    更新日期:1990-10-01 00:00:00