Accurate and precise delivery of nitric oxide during high-frequency oscillatory ventilation.

abstract：OBJECTIVE:To cost adult intensive care by determining inputs to production, resource consumption per patient, and total cost per intensive care unit (ICU) stay. DESIGN:Prospective cost-accounting analysis of each patient stay in the ICU, over a 1-yr period. SETTING:An 11-bed, medical/surgical adult ICU, in a 932-bad ...

journal_title：Critical care medicine

authors： Noseworthy TW,Konopad E,Shustack A,Johnston R,Grace M

更新日期：1996-07-01 00:00:00

abstract：:The right atrial pressure (Pra) was compared to the pulmonary capillary wedge pressure (Pcw) in 54 patients. In patients with heart disease, the correlation of Pra with Pcw was poor. However, in patients without clinical heart disease, Pra approximated Pcw, in both absolute number and change. This finding was independ...

journal_title：Critical care medicine

authors： Risk C,Rudo N,Falltrick R,Feeley T,Don HF

更新日期：1978-05-01 00:00:00

abstract：OBJECTIVE:Peripheral perfusion in critically ill patients frequently is assessed by use of clinical signs. Recently, the pulse oximetry signal has been suggested to reflect changes in peripheral perfusion. A peripheral perfusion index based on analysis of the pulse oximetry signal has been implemented in monitoring sys...

journal_title：Critical care medicine

authors： Lima AP,Beelen P,Bakker J

更新日期：2002-06-01 00:00:00

abstract：BACKGROUND:Acute lung injury (ALI) and its more severe form, acute respiratory distress syndrome (ARDS), are devastating disorders of overwhelming pulmonary inflammation and hypoxemia, resulting in high morbidity and mortality. AIM:To provide the clinician with a summary of the literature on the epidemiology, diagnosi...

journal_title：Critical care medicine

authors： Randolph AG

更新日期：2009-08-01 00:00:00

abstract：OBJECTIVES:Evaluate clinicians' sentiments about participating in cardiac arrest resuscitations and identify factors associated with confidence in resuscitation of cardiac arrest. DESIGN:Electronic survey. SETTING:Twenty-one hospitals in Utah and Idaho. SUBJECTS:All attending physicians, residents, and nurses in a m...

journal_title：Critical care medicine

authors： Peltan ID,Poll J,Sorensen J,Guidry D,Chandler M,Beninati W,Brown SM

更新日期：2019-03-01 00:00:00

abstract：:Because determining cardiac output is difficult in premature infants, little is known about the hemodynamic effects of PEEP in this age group. We used pulsed-wave Doppler echocardiography to assess the hemodynamic effects of PEEP increments in ten premature infants with respiratory distress syndrome. At a PEEP of 4 cm...

journal_title：Critical care medicine

authors： Hausdorf G,Hellwege HH

更新日期：1987-07-01 00:00:00

abstract：OBJECTIVE:To determine the impact of Acinetobacter baumannii (AB) acquisition in intensive care unit (ICU) patients on mortality and length of stay (LOS). DESIGN:Pairwise matched 1:1 case-control study. SETTING:Medical-surgical ICU in a tertiary health care institution. PATIENTS:During 16 months, all patients admitt...

journal_title：Critical care medicine

authors： García-Garmendia JL,Ortiz-Leyba C,Garnacho-Montero J,Jiménez-Jiménez FJ,Monterrubio-Villar J,Gili-Miner M

更新日期：1999-09-01 00:00:00

abstract：OBJECTIVE:To investigate the interrelationship between cardiac surgery, age, circulating concentrations of the vitamin D hormone 1,25-dihydroxyvitamin D, and clinical outcome. DESIGN:Prospective, monocentric, two-arm parallel study. SETTING:Tertiary Heart and Diabetes Center in the Federal State of North Rhine-Westph...

journal_title：Critical care medicine

authors： Börgermann J,Lazouski K,Kuhn J,Dreier J,Schmidt M,Gilis-Januszewski T,Knabbe C,Gummert JF,Zittermann A

更新日期：2012-07-01 00:00:00

abstract：OBJECTIVE:To determine whether a continuous intravenous infusion of pentoxifylline, a methylxanthine derivative, alters the serum cytokine concentrations and/or hemodynamic measurements in patients with septic shock. DESIGN:A prospective, randomized, double-blind, placebo-controlled study. SETTING:Medical intensive c...

journal_title：Critical care medicine

authors： Zeni F,Pain P,Vindimian M,Gay JP,Gery P,Bertrand M,Page Y,Page D,Vermesch R,Bertrand JC

更新日期：1996-02-01 00:00:00

abstract：:Human hemoglobin (Hb) solution is being developed for use as an oxygen-delivering resuscitation fluid. Substantial improvements in the general purity and quality of experimental Hb solutions have been achieved by recent research efforts. Hb solutions now appear to be free of the undesirable biological effects that wer...

journal_title：Critical care medicine

authors： DeVenuto F

更新日期：1982-04-01 00:00:00

abstract：OBJECTIVES:Centers for Disease Control and Prevention built up new surveillance paradigms for the patients on mechanical ventilation and the ventilator-associated events, comprising ventilator-associated conditions and infection-related ventilator-associated complications. We assess 1) the current epidemiology of venti...

journal_title：Critical care medicine

authors： Bouadma L,Sonneville R,Garrouste-Orgeas M,Darmon M,Souweine B,Voiriot G,Kallel H,Schwebel C,Goldgran-Toledano D,Dumenil AS,Argaud L,Ruckly S,Jamali S,Planquette B,Adrie C,Lucet JC,Azoulay E,Timsit JF,OUTCOMEREA Study

更新日期：2015-09-01 00:00:00

abstract：:Assessment of creatinine clearance (CC) in ICU patients was compared using three methods. The reference method (CC 24 h) used measurements of serum creatinine and urinary creatinine after collection of urine over a 24-h period. The other two methods were predictive methods: the Kampmann nomogram and the formula develo...

journal_title：Critical care medicine

authors： Martin C,Alaya M,Bras J,Saux P,Gouin F

更新日期：1990-11-01 00:00:00

abstract：OBJECTIVES:Ventilator-associated pneumonia diagnosis remains a debatable topic. New definitions of ventilator-associated conditions involving worsening oxygenation have been recently proposed to make surveillance of events possibly linked to ventilator-associated pneumonia as objective as possible. The objective of the...

journal_title：Critical care medicine

authors： Damas P,Frippiat F,Ancion A,Canivet JL,Lambermont B,Layios N,Massion P,Morimont P,Nys M,Piret S,Lancellotti P,Wiesen P,D'orio V,Samalea N,Ledoux D

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVE:Clinical trial designs that randomize patients to fixed treatment regimens may disrupt preexisting relationships between illness severity and level of therapy. The practice misalignments created by such designs may have unintended effects on trial results and safety. METHODS:To illustrate this problem, the T...

journal_title：Critical care medicine

authors： Deans KJ,Minneci PC,Suffredini AF,Danner RL,Hoffman WD,Ciu X,Klein HG,Schechter AN,Banks SM,Eichacker PQ,Natanson C

更新日期：2007-06-01 00:00:00

abstract：OBJECTIVES:To investigate aortic functional alterations in the acute phase of aneurysmal subarachnoid hemorrhage and to evaluate the relationship between potential cardiovascular alterations and delayed cerebral infarctions or poor Glasgow Outcome Scale score at discharge from critical care unit. DESIGN:Prospective ob...

journal_title：Critical care medicine

authors： Papanikolaou J,Makris D,Karakitsos D,Saranteas T,Karabinis A,Kostopanagiotou G,Zakynthinos E

更新日期：2012-01-01 00:00:00

abstract：OBJECTIVES:Sepsis results in organ dysfunction caused by a dysregulated host response, in part related to the immune response of a severe infection. Mesenchymal stromal cells are known to modulate the immune response, and expression of stromal cell-derived factor-1 regulates mobilization of neutrophils from the bone ma...

journal_title：Critical care medicine

authors： Kwon MY,Ghanta S,Ng J,Tsoyi K,Lederer JA,Bronson RT,El-Chemaly S,Chung SW,Liu X,Perrella MA

更新日期：2020-05-01 00:00:00

abstract：OBJECTIVE:Blood loss and transfusion are frequent among patients undergoing liver surgery. Concerns have been raised about the safety and efficacy of transfusing stored blood. The influence of transfusing fresh vs. stored blood on the liver has not been studied to date. We tested the hypothesis that transfusion of stor...

journal_title：Critical care medicine

authors： Matot I,Katz M,Pappo O,Zelig O,Corchia N,Yedgar S,Barshtein G,Bennett-Guerrero E,Abramovitch R

更新日期：2013-03-01 00:00:00

abstract：OBJECTIVE:To examine the effect of hypertonic saline on bacterial translocation and the number and function of natural killer and T cells in controlled hemorrhagic shock. DESIGN:Randomized controlled study. Duration of follow-up was 24 hrs. SETTING:University research laboratory. SUBJECTS:Adult male Sprague-Dawley r...

journal_title：Critical care medicine

authors： Hirsh M,Dyugovskaya L,Bashenko Y,Krausz MM

更新日期：2002-04-01 00:00:00

abstract：OBJECTIVE:To explore the hypothesis that beta-1 adrenoreceptor blockade may be protective through the attenuation of sympathetic hyperactivity and catecholaminergic inflammatory effects on cardiac and hepatic function. DESIGN:Prospective, randomized, controlled study. SETTING:Animal laboratory in a university medical...

journal_title：Critical care medicine

authors： Ackland GL,Yao ST,Rudiger A,Dyson A,Stidwill R,Poputnikov D,Singer M,Gourine AV

更新日期：2010-02-01 00:00:00

abstract：OBJECTIVE:This study determined the time course for inhibition of lipopolysaccharide-induced acute lung injury following a single dose of genistein. In addition, the study investigated whether a multiple dosing schedule with genistein retained the inhibitory effects on acute lung injury, nuclear factor-kappaB activatio...

journal_title：Critical care medicine

authors： Kang JL,Lee HW,Lee HS,Pack IS,Castranova V,Koh Y

更新日期：2003-02-01 00:00:00

abstract：OBJECTIVE:To examine the frequency of obtaining Institutional Review Board (IRB) approval and informed consent in critical care research. DATA SOURCES AND DATA EXTRACTION:One-year retrospective review of original critical care research in humans published in seven journals, including American Journal of Respiratory an...

journal_title：Critical care medicine

authors： Matot I,Pizov R,Sprung CL

更新日期：1998-09-01 00:00:00

abstract：OBJECTIVE:Mitochondrial damage and dysfunction are thought to play an important role in the pathogenesis of sepsis-induced organ failures. Unfortunately, specific markers of mitochondrial damage in vital organs do not currently exist. Recently, carbomyl phosphate synthase (CPS)-1, a protein primarily localized to liver...

journal_title：Critical care medicine

authors： Crouser ED,Julian MW,Huff JE,Struck J,Cook CH

更新日期：2006-09-01 00:00:00

abstract：OBJECTIVES:Our primary goal was to evaluate the impact on in-hospital mortality rate of adequate empirical antibiotic therapy, after controlling for confounding variables, in a cohort of patients admitted to the intensive care unit (ICU) with sepsis. The impact of adequate empirical antibiotic therapy on early (<3 days...

journal_title：Critical care medicine

authors： Garnacho-Montero J,Garcia-Garmendia JL,Barrero-Almodovar A,Jimenez-Jimenez FJ,Perez-Paredes C,Ortiz-Leyba C

更新日期：2003-12-01 00:00:00

abstract：:Gastric mucosal damage produced by topical application of necrotizing agents is diminished by topical or systemic pretreatment with a variety of E and F prostaglandins. The rat restraint model of gastric mucosal injury is more analogous to clinical stress ulceration than are models using intragastric application of to...

journal_title：Critical care medicine

authors： Ephgrave KS,Horton J,Burns D

更新日期：1989-01-01 00:00:00

abstract：OBJECTIVES:To determine whether relative hyperglycemia was associated with in-hospital mortality in critically ill patients independent of other prognostic variables and whether this association is affected by background glycemia. DESIGN:Prospective observational study. SETTING:Mixed medical-surgical ICU in a metropo...

journal_title：Critical care medicine

authors： Lee TF,Drake SM,Roberts GW,Bersten A,Stranks SN,Heilbronn LK,Mangoni AA,Burt MG

更新日期：2020-02-01 00:00:00

abstract：OBJECTIVES:To assess the specific host responses to systemic endotoxemia and tumor necrosis factor (TNF) activation after abdominal aortic aneurysm surgery by measuring antiendotoxin core antibodies (EndoCab) immunoglobulin (Ig)G and IgM, and soluble p55TNF receptor concentrations. The role of the gut in initiating the...

journal_title：Critical care medicine

authors： Soong CV,Halliday MI,Barclay GR,Hood JM,Rowlands BJ,Barros D'Sa AA

更新日期：1997-09-01 00:00:00

abstract：:Trauma is the leading cause of both morbidity and mortality in the pediatric population, and traumatic injury causes > 50% of all childhood deaths. Significant mortality rates have been reported for children with traumatic brain injury. Although children have better survival rates as compared with adults with traumati...

journal_title：Critical care medicine

authors： Mazzola CA,Adelson PD

更新日期：2002-11-01 00:00:00

abstract：OBJECTIVE:To determine the association of pulmonary artery catheter (PAC) use with in-hospital mortality. DESIGN:Prospective, observational study. SETTING:The medical intensive care units (MICU) of two teaching hospitals. METHODS:The study included 751 adults who were admitted to the MICU, excluding those who stayed...

journal_title：Critical care medicine

authors： Afessa B,Spencer S,Khan W,LaGatta M,Bridges L,Freire AX

更新日期：2001-06-01 00:00:00

abstract：OBJECTIVES:To compare the frequency and preventability of adverse drug events and potential adverse drug events in intensive care units (ICUs) and non-ICUs. To evaluate systems factors involving the individual caregivers, care unit teams, and patients involved in each adverse drug event by comparing ICUs with non-ICUs ...

journal_title：Critical care medicine

authors： Cullen DJ,Sweitzer BJ,Bates DW,Burdick E,Edmondson A,Leape LL

更新日期：1997-08-01 00:00:00

abstract：OBJECTIVE:Using a modification of the Bohr equation, single-breath carbon dioxide capnography is a noninvasive technology for calculating physiologic dead space (V(D)/V(T)). The objective of this study was to identify a minimal V(D)/V(T) value for predicting successful extubation from mechanical ventilation in pediatri...

journal_title：Critical care medicine

authors： Hubble CL,Gentile MA,Tripp DS,Craig DM,Meliones JN,Cheifetz IM

更新日期：2000-06-01 00:00:00