Resuscitation with aged blood exacerbates liver injury in a hemorrhagic rat model.

abstract：OBJECTIVE:To determine the effect of two doses of prostaglandin E1 (PGE1, alprostadil) combined with unfractionated heparin on the hemofilter life-span and the coagulation profile during continuous venovenous hemofiltration. DESIGN:Prospective, randomized, controlled trial. SETTING:Intensive care unit at a university...

journal_title：Critical care medicine

authors： Kozek-Langenecker SA,Kettner SC,Oismueller C,Gonano C,Speiser W,Zimpfer M

更新日期：1998-07-01 00:00:00

abstract：OBJECTIVE:To determine risk factors for nosocomial pneumonia in critically ill trauma patients. DESIGN:Prospective cohort study. SETTING:The trauma intensive care unit (ICU) of a 1500-bed tertiary-care hospital. PATIENTS:All critically ill trauma patients (n = 103) admitted consecutively between November 1995 and Oc...

journal_title：Critical care medicine

authors： Tejada Artigas A,Bello Dronda S,Chacón Vallés E,Muñoz Marco J,Villuendas Usón MC,Figueras P,Suarez FJ,Hernández A

更新日期：2001-02-01 00:00:00

abstract：OBJECTIVES:Carbon monoxide poisoning affects 50,000 per year in the United States alone. Mortality is approximately 3%, and up to 40% of survivors suffer from permanent neurocognitive and affective deficits. Hyperbaric oxygen therapy has shown benefit on reducing the long-term neurologic sequelae of carbon monoxide poi...

journal_title：Critical care medicine

authors： Rose JJ,Nouraie M,Gauthier MC,Pizon AF,Saul MI,Donahoe MP,Gladwin MT

更新日期：2018-07-01 00:00:00

abstract：OBJECTIVE:Heatstroke requires active body cooling and organ failure supportive care. Although heat waves are expected to recur over the next decades, little is known about the risk factors for mortality in heatstroke patients. We examined the prognosis and risk factors for hospital mortality in patients with heatstroke...

journal_title：Critical care medicine

authors： Misset B,De Jonghe B,Bastuji-Garin S,Gattolliat O,Boughrara E,Annane D,Hausfater P,Garrouste-Orgeas M,Carlet J

更新日期：2006-04-01 00:00:00

abstract：OBJECTIVE:Cortisol clearance is reduced in sepsis and may contribute to the development of impaired adrenocortical function that is thought to contribute to the pathophysiology of critical illness-related corticosteroid insufficiency. We sought to assess adrenocortical function using computer-assisted numerical modelin...

journal_title：Critical care medicine

authors： Dorin RI,Qualls CR,Torpy DJ,Schrader RM,Urban FK 3rd

更新日期：2015-03-01 00:00:00

abstract：OBJECTIVE:To examine the effects of mechanical ventilation with a tidal volume of 6 mL/kg compared with 12 mL/kg predicted body weight on hemodynamics, vasopressor use, fluid balance, diuretics, sedation, and neuromuscular blockade within 48 hrs in patients with acute lung injury and acute respiratory distress syndrome...

journal_title：Critical care medicine

authors： Cheng IW,Eisner MD,Thompson BT,Ware LB,Matthay MA,Acute Respiratory Distress Syndrome Network.

更新日期：2005-01-01 00:00:00

abstract：OBJECTIVE:To compare the responses of noninvasively measured tissue oxygen saturation (StO2) and calculated muscle oxygen tension (PmO2) to standard hemodynamic variables for early detection of imminent hemodynamic instability during progressive central hypovolemia in humans. DESIGN:Prospective study. SETTING:Researc...

journal_title：Critical care medicine

authors： Soller BR,Ryan KL,Rickards CA,Cooke WH,Yang Y,Soyemi OO,Crookes BA,Heard SO,Convertino VA

更新日期：2008-01-01 00:00:00

abstract：OBJECTIVES:To describe the incident fracture rate in survivors of critical illness and to compare fracture risk with population-matched control subjects. DESIGN:Retrospective longitudinal case-cohort study. SETTING:A tertiary adult intensive care unit in Australia. PATIENTS:All patients ventilated admitted to intens...

journal_title：Critical care medicine

authors： Orford NR,Saunders K,Merriman E,Henry M,Pasco J,Stow P,Kotowicz M

更新日期：2011-06-01 00:00:00

abstract：:Clonidine may be a source of serious toxicity when ingested by toddlers. We describe 11 cases of clonidine ingestion by toddlers (mean dose 0.15 mg/kg; range 0.01 to 0.57). The source of the clonidine was a grand-parent in six of 11 cases. Symptoms included altered level of consciousness (n = 11), miosis (n = 5), brad...

journal_title：Critical care medicine

authors： Fiser DH,Moss MM,Walker W

更新日期：1990-10-01 00:00:00

abstract：OBJECTIVE:Limited data are available on the influence of sedation for critical care therapy with the widely used anesthetic propofol on recovery from acute traumatic brain injury. To establish the influence of propofol on endogenous neurogenesis and functional recovery after traumatic brain injury, rats were sedated wi...

journal_title：Critical care medicine

authors： Thal SC,Timaru-Kast R,Wilde F,Merk P,Johnson F,Frauenknecht K,Sebastiani A,Sommer C,Staib-Lasarzik I,Werner C,Engelhard K

更新日期：2014-01-01 00:00:00

abstract：:A safe, simple, reliable technique for sampling uncontaminated peripheral bronchial secretions in patients with endotracheal tubes has been developed. It is easily performed and requires no special training or equipment. This report summarizes the techniques's usefulness in providing diagnostic samples of peripheral a...

journal_title：Critical care medicine

authors： Matthew EB,Holstrom FM,Kaspar RL

更新日期：1977-03-01 00:00:00

abstract：:The sphingomyelin (SM) pathway is an ubiquitous, evolutionarily conserved signaling system, analogous to conventional systems such as the cAMP and phosphoinositide pathways. Ceramide is generated from SM by the action of a neutral or acid SMase, or by de novo synthesis coordinated through the enzyme ceramide synthase....

journal_title：Critical care medicine

authors： Lin X,Fuks Z,Kolesnick R

更新日期：2000-04-01 00:00:00

abstract：OBJECTIVE:Conventional outcomes research provides only percentage risk of such end points as mortality rate, utilization of resources, and/or broad groupings of multiple organ system dysfunction. These prognostications generally are not applicable to individual patients. The purpose of the present study was to determin...

journal_title：Critical care medicine

authors： Slotman GJ

更新日期：2002-05-01 00:00:00

abstract：OBJECTIVE:To discuss a potential role for endothelial cell apoptosis in the pathogenesis of sepsis. DATA SOURCES:Studies published in biomedical journals and studies from the authors' laboratory. STUDY SELECTION:In vitro and in vivo studies of endothelial cell apoptosis in endotoxin and sepsis models. DATA EXTRACTIO...

journal_title：Critical care medicine

authors： Hotchkiss RS,Tinsley KW,Swanson PE,Karl IE

更新日期：2002-05-01 00:00:00

abstract：OBJECTIVES:There is growing recognition that high-quality care for patients and families in the ICU requires exemplary interprofessional collaboration and communication. One important aspect is how the ICU team makes complex decisions. However, no recommendations have been published on interprofessional shared decision...

journal_title：Critical care medicine

authors： Michalsen A,Long AC,DeKeyser Ganz F,White DB,Jensen HI,Metaxa V,Hartog CS,Latour JM,Truog RD,Kesecioglu J,Mahn AR,Curtis JR

更新日期：2019-09-01 00:00:00

abstract：OBJECTIVES:To assess whether sepsis-associated coagulopathy predicts hospital mortality. DESIGN:Retrospective cohort study. SETTING:One-thousand three-hundred beds urban academic medical center. PATIENTS:Six-thousand one-hundred forty-eight consecutive patients hospitalized between January 1, 2010, and December 31, ...

journal_title：Critical care medicine

authors： Lyons PG,Micek ST,Hampton N,Kollef MH

更新日期：2018-05-01 00:00:00

abstract：:Perfluorocarbon (PFC) emulsions are promising oxygen-carrying blood supplements for the treatment of shock and in organ preservation for transplantation. We used the isolated, blood-perfused, canine right lower lung lobe (RLL) to determine the effect of a PFC emulsion, Oxypherol (FC-43), upon lung fluid balance and he...

journal_title：Critical care medicine

authors： Hall JE,Ehrhart IC,Hofman WF

更新日期：1985-12-01 00:00:00

abstract：OBJECTIVE:This study aims to explore the relationship between team-leadership skills and quality of cardiopulmonary resuscitation in an adult cardiac-arrest simulation. Factors affecting team-leadership skills were also assessed. DESIGN:Forty advanced life-support providers leading a cardiac arrest team in a standardi...

journal_title：Critical care medicine

authors： Yeung JH,Ong GJ,Davies RP,Gao F,Perkins GD

更新日期：2012-09-01 00:00:00

abstract：:Given the limitations of high-dose diuretics and vasodilators and the increasing literature showing that inotropes, regardless of the dose used, have a detrimental effect on mortality, a variety of new agents are under investigation for the treatment of pulmonary and systemic congestion and restoration of cardiac outp...

journal_title：Critical care medicine

authors： Tavares M,Rezlan E,Vostroknoutova I,Khouadja H,Mebazaa A

更新日期：2008-01-01 00:00:00

abstract：OBJECTIVES:Hyperammonemia is a key contributing factor for cerebral edema in acute liver failure. Continuous renal replacement therapy may help reduce ammonia levels. However, the optimal timing, mode, intensity, and duration of continuous renal replacement therapy in this setting are unknown. We aimed to study continu...

journal_title：Critical care medicine

authors： Warrillow S,Fisher C,Bellomo R

更新日期：2020-02-01 00:00:00

abstract：OBJECTIVE:To determine whether mortality rates among intensive care unit (ICU) patients differ according to the time of ICU admission, we compared the death rates for patients admitted during weekday day shifts and off hours (from 6:30 pm to 8:29 am the next day for night shifts, from Saturday 1:00 pm to Monday 8:29 am...

journal_title：Critical care medicine

authors： Luyt CE,Combes A,Aegerter P,Guidet B,Trouillet JL,Gibert C,Chastre J

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Remarkable progress has been made during the last decade in defining the molecular mechanisms that underlie septic shock. This rapidly expanding field is leading to new therapeutic opportunities in the management of severe sepsis. AIM:To provide the clinician with a timely summary of the molecular biology o...

journal_title：Critical care medicine

authors： Cinel I,Opal SM

更新日期：2009-01-01 00:00:00

abstract：OBJECTIVES:Radial artery pressure is known to differ from central arterial pressure in normal patients (distal pulse amplification) and in the early postcardiopulmonary bypass period. The adequacy of the radial artery as a site for blood pressure monitoring in critically ill patients receiving high-dose vasopressors ha...

journal_title：Critical care medicine

authors： Dorman T,Breslow MJ,Lipsett PA,Rosenberg JM,Balser JR,Almog Y,Rosenfeld BA

更新日期：1998-10-01 00:00:00

abstract：OBJECTIVE:To determine whether a continuous intravenous infusion of pentoxifylline, a methylxanthine derivative, alters the serum cytokine concentrations and/or hemodynamic measurements in patients with septic shock. DESIGN:A prospective, randomized, double-blind, placebo-controlled study. SETTING:Medical intensive c...

journal_title：Critical care medicine

authors： Zeni F,Pain P,Vindimian M,Gay JP,Gery P,Bertrand M,Page Y,Page D,Vermesch R,Bertrand JC

更新日期：1996-02-01 00:00:00

abstract：OBJECTIVE:To determine the frequency and effects of weaning-related myocardial ischemia on weaning outcomes in patients with coronary artery disease. DESIGN:Prospective cohort study. SETTING:Medical and cardiac intensive care units of a 300-bed teaching community hospital. MEASUREMENTS AND MAIN RESULTS:Three-lead ST...

journal_title：Critical care medicine

authors： Srivastava S,Chatila W,Amoateng-Adjepong Y,Kanagasegar S,Jacob B,Zarich S,Manthous CA

更新日期：1999-10-01 00:00:00

abstract：OBJECTIVE:Several studies report calcium mishandling, sarcomere disarray, and caspase activation during heart failure. Although active caspases have been shown to cleave myofibrillar proteins, little is known regarding their effects on calcium handling proteins. Therefore, we aimed to explore how endotoxin-induced casp...

journal_title：Critical care medicine

authors： Neviere R,Hassoun SM,Decoster B,Bouazza Y,Montaigne D,Maréchal X,Marciniak C,Marchetti P,Lancel S

更新日期：2010-10-01 00:00:00

abstract：OBJECTIVE:To test the hypothesis that therapeutic hypercapnia enhances the proinflammatory responses to endotoxemia in the lung and spleen of rats. DESIGN:Prospective randomized study. SETTINGS:Hospital research institute. SUBJECTS:Forty-eight adult male rats. INTERVENTIONS:Rats were randomly assigned for a 24-hr p...

journal_title：Critical care medicine

authors： Norozian FM,Leoncio M,Torbati D,Meyer K,Raszynski A,Totapally BR

更新日期：2011-06-01 00:00:00

abstract：OBJECTIVE:To evaluate a new technique for pressure-volume curve tracing. DESIGN:Prospective experimental study. SETTING:Animal research laboratory. SUBJECTS:Six anesthetized rats. INTERVENTIONS:Two pressure-volume curves were obtained by means of the super-syringe method (gold standard) and the continuous positive ...

journal_title：Critical care medicine

authors： Albaiceta GM,Piacentini E,Villagrá A,Lopez-Aguilar J,Taboada F,Blanch L

更新日期：2003-10-01 00:00:00

abstract：OBJECTIVE:To determine whether treatment with patient-controlled analgesia (PCA) alone or in combination with nonsteroidal anti-inflammatory drugs can prevent postoperative pulmonary complications after cardiac surgery, when compared with conventional nurse-controlled analgesia. DESIGN:Randomized controlled trial. SE...

journal_title：Critical care medicine

authors： Gust R,Pecher S,Gust A,Hoffmann V,Böhrer H,Martin E

更新日期：1999-10-01 00:00:00

abstract：:The effect of halothane on electrodes covered with polypropylene and FEP teflon membranes, used for monitoring transcutaneous oxygen tension, was compared in vitro and in patients anesthetized with halothane. In vitro experiments with halothane showed a false increase in PO2 measured by the electrode covered with poly...

journal_title：Critical care medicine

authors： Samra SK

更新日期：1983-08-01 00:00:00