Augmentation of endotoxin-induced pulmonary responses by mononuclear cell phagocytosis in the reticuloendothelial system.

abstract：OBJECTIVE:Sepsis-induced multi-organ failure continues to have a high mortality. The liver is an organ central to the disease pathogenesis. The objective of this study was to identify the liver proteins that change in abundance with sepsis and subsequently identify new drug targets. DESIGN:Proteomic discovery study an...

journal_title：Critical care medicine

authors： Dear JW,Leelahavanichkul A,Aponte A,Hu X,Constant SL,Hewitt SM,Yuen PS,Star RA

更新日期：2007-10-01 00:00:00

abstract：OBJECTIVES:To assess the specific host responses to systemic endotoxemia and tumor necrosis factor (TNF) activation after abdominal aortic aneurysm surgery by measuring antiendotoxin core antibodies (EndoCab) immunoglobulin (Ig)G and IgM, and soluble p55TNF receptor concentrations. The role of the gut in initiating the...

journal_title：Critical care medicine

authors： Soong CV,Halliday MI,Barclay GR,Hood JM,Rowlands BJ,Barros D'Sa AA

更新日期：1997-09-01 00:00:00

abstract：:Critically ill patients who fear impending death may die suddenly. We studied prospectively the incidence of death in critically ill surgical patients who articulated the fear that they were about to die. Physiologic, environmental, and behavioral correlates which might influence perceptions of impending death were ex...

journal_title：Critical care medicine

authors： Poulton TJ,Butdorf MB

更新日期：1986-07-01 00:00:00

abstract：:Medical technology is a two-edged sword, capable of saving and improving life but also of ending and harming life. Finding the right stance toward technology requires great balance and sensitivity. It has seductive powers because of its expected benefits, the social and professional pressures to use it, and a frequent...

journal_title：Critical care medicine

authors： Callahan D

更新日期：2003-05-01 00:00:00

abstract：BACKGROUND AND METHODS:In the present study, we evaluated the effect of N-acetylcysteine treatment in a nonseptic shock model induced by zymosan in the rat. Animals were randomly divided into eight groups (ten animals in each group). The first group was treated with ip administration of saline solution (0.90% NaCl) and...

journal_title：Critical care medicine

authors： Cuzzocrea S,Costantino G,Mazzon E,Caputi AP

更新日期：1999-08-01 00:00:00

abstract：:High-frequency jet ventilation using a jet injector located at the right mainstem bronchus was superimposed on standard mechanical ventilation to ventilate the injured lung of a patient with unilateral massive atelectasis secondary to pulmonary hemorrhage. This technique of differential ventilation markedly improved a...

journal_title：Critical care medicine

authors： Nishimura M,Takezawa J,Nishijima MK,Taenaka N,Shimada Y,Yoshiya I,Fujimoto Y

更新日期：1984-09-01 00:00:00

abstract：OBJECTIVES:There is growing recognition that high-quality care for patients and families in the ICU requires exemplary interprofessional collaboration and communication. One important aspect is how the ICU team makes complex decisions. However, no recommendations have been published on interprofessional shared decision...

journal_title：Critical care medicine

authors： Michalsen A,Long AC,DeKeyser Ganz F,White DB,Jensen HI,Metaxa V,Hartog CS,Latour JM,Truog RD,Kesecioglu J,Mahn AR,Curtis JR

更新日期：2019-09-01 00:00:00

abstract：OBJECTIVE:Physiologic and pathologic comparison of two modes of assisted ventilation, nasal intermittent positive-pressure ventilation (NIPPV) and synchronized intermittent mandatory ventilation (SIMV), in spontaneously breathing term newborn piglets with saline lavage-induced lung injury. DESIGN:After inducing acute ...

journal_title：Critical care medicine

authors： Lampland AL,Meyers PA,Worwa CT,Swanson EC,Mammel MC

更新日期：2008-01-01 00:00:00

abstract：OBJECTIVE:To compare three devices that measure core body temperature at the bedside in ICU patients. DESIGN:Prospective, consecutive sample. SETTING:Voluntary community teaching hospital. PATIENTS:Fifteen patients, 78 +/- 6 (SD) yrs of age, admitted to the medical ICU over a 5-month period who had pulmonary artery ...

journal_title：Critical care medicine

authors： Nierman DM

更新日期：1991-06-01 00:00:00

abstract：OBJECTIVES:To determine the frequency of advance directives or directives disclosed by healthcare agents and their influence on decisions to withdraw/withhold life-sustaining care in neurocritically ill adults. DATA SOURCES:PubMed, Embase, and Cochrane databases. STUDY SELECTION:Screening was performed using predefin...

journal_title：Critical care medicine

authors： Sutter R,Meyer-Zehnder B,Baumann SM,Marsch S,Pargger H

更新日期：2020-08-01 00:00:00

abstract：OBJECTIVE:To test whether spectral indices derived from the electroencephalogram (EEG), and especially the bispectral index (BIS), can be used as measures of neurologic status in unsedated, critically ill patients. DESIGN:Prospective, observational study. SETTING:Medical intensive care unit (ICU) of a university-affi...

journal_title：Critical care medicine

authors： Gilbert TT,Wagner MR,Halukurike V,Paz HL,Garland A

更新日期：2001-10-01 00:00:00

abstract：OBJECTIVE:To examine the ways in which healthcare professionals work together in the ICU setting, through a consideration of the contextual, organizational, processual, and relational factors that impact their interprofessional collaboration. DESIGN:Data from over 350 hours of ethnographic observation and 35 semistruc...

journal_title：Critical care medicine

authors： Alexanian JA,Kitto S,Rak KJ,Reeves S

更新日期：2015-09-01 00:00:00

abstract：OBJECTIVES:The Fragility Index, which represents the number of patients responsible for a statistically significant finding, has been suggested as an aid for interpreting the robustness of results from clinical trials. A small Fragility Index indicates that the statistical significance of a trial depends on only a few ...

journal_title：Critical care medicine

authors： Grolleau F,Collins GS,Smarandache A,Pirracchio R,Gakuba C,Boutron I,Busse JW,Devereaux PJ,Le Manach Y

更新日期：2019-03-01 00:00:00

abstract：OBJECTIVE:To evaluate the relationship between the acute inflammatory response after surgical trauma and changes in hepatic cytochrome P450 3A4 activity, compare changes in cytochrome P450 3A4 activity after procedures with varying degrees of surgical stress, and to explore the time course of any potential drug-cytokin...

journal_title：Critical care medicine

authors： Haas CE,Kaufman DC,Jones CE,Burstein AH,Reiss W

更新日期：2003-05-01 00:00:00

abstract：:Computers are commonly used to serve many functions in today's modern intensive care unit. One of the most intriguing and perhaps most challenging applications of computers has been to attempt to improve medical education. With the introduction of the first computer, medical educators began looking for ways to incorpo...

journal_title：Critical care medicine

authors： Tegtmeyer K,Ibsen L,Goldstein B

更新日期：2001-08-01 00:00:00

abstract：OBJECTIVE:Neutrophils are an important component of the inflammatory response that characterizes acute lung injury (ALI). This discussion aims to review the contribution of neutrophils to the development and progression of ALI and to highlight the major intracellular signaling pathways that are involved in neutrophil a...

journal_title：Critical care medicine

authors： Abraham E

更新日期：2003-04-01 00:00:00

abstract：OBJECTIVE:High-frequency oscillation has been proposed for use in adult acute respiratory distress syndrome. However, limited data are available on the effect of pressure amplitude and rate (Hz) on tidal volumes delivered during high-frequency oscillation in adults. DESIGN:Prospective, animal model, lung injury study....

journal_title：Critical care medicine

authors： Sedeek KA,Takeuchi M,Suchodolski K,Kacmarek RM

更新日期：2003-01-01 00:00:00

abstract：OBJECTIVE:Although misperceptions about prognosis by surrogates in ICUs are common and influence treatment decisions, there is no validated, practical way to measure the effectiveness of prognostic communication. Surrogates' subjective ratings of quality of communication have been used in other domains as markers of ef...

journal_title：Critical care medicine

authors： Chiarchiaro J,Buddadhumaruk P,Arnold RM,White DB

更新日期：2015-03-01 00:00:00

abstract：OBJECTIVE:Initial success with chimeric antigen receptor-modified T cell therapy for relapsed/refractory acute lymphoblastic leukemia is leading to expanded use through multicenter trials. Cytokine release syndrome, the most severe toxicity, presents a novel critical illness syndrome with limited data regarding diagnos...

journal_title：Critical care medicine

authors： Fitzgerald JC,Weiss SL,Maude SL,Barrett DM,Lacey SF,Melenhorst JJ,Shaw P,Berg RA,June CH,Porter DL,Frey NV,Grupp SA,Teachey DT

更新日期：2017-02-01 00:00:00

abstract：OBJECTIVE:To assess the feasibility and safety of delivering early goal-directed sedation compared with standard sedation. DESIGN:Pilot prospective, multicenter, randomized, controlled trial. SETTING:Six ICUs. PATIENTS:Critically ill adults mechanically ventilated for greater than 24 hours. INTERVENTIONS:Patients r...

journal_title：Critical care medicine

authors： Shehabi Y,Bellomo R,Reade MC,Bailey M,Bass F,Howe B,McArthur C,Murray L,Seppelt IM,Webb S,Weisbrodt L,Sedation Practice in Intensive Care Evaluation Study Investigators.,Australian and New Zealand Intensive Care Society Clinical

更新日期：2013-08-01 00:00:00

abstract：OBJECTIVE:To determine the association between symptomatic central venous line-related deep venous thrombosis and a mortality-adjusted measure of duration of mechanical ventilation in critically ill children with central venous lines. DESIGN:Retrospective matched cohort study. SETTING:Eleven pediatric intensive care ...

journal_title：Critical care medicine

authors： Faustino EV,Lawson KA,Northrup V,Higgerson RA

更新日期：2011-05-01 00:00:00

abstract：OBJECTIVE:To study the epidemiology, style of management, and outcome of intensive care patients with acute renal failure requiring replacement therapy in Australia. DESIGN:Prospective epidemiologic study. SETTING:Australian adult intensive care units providing acute renal replacement therapy. PATIENTS:Adult intensi...

journal_title：Critical care medicine

authors： Silvester W,Bellomo R,Cole L

更新日期：2001-10-01 00:00:00

abstract：OBJECTIVE:Heatstroke is characterized by hyperthermia, vasoplegic shock, and cerebral ischemia and hypoxia. Hyperbaric oxygen (HBO) has been shown to reduce brain ischemia and behavioral dysfunction during cerebral artery occlusion. The efficacy of HBO therapy for resuscitation from heatstroke remains to be determined ...

journal_title：Critical care medicine

authors： Tsai HM,Gao CJ,Li WX,Lin MT,Niu KC

更新日期：2005-04-01 00:00:00

abstract：OBJECTIVES:To define the features of human amniotic mesenchymal stromal cell secretome and its protective properties in experimental models of acute brain injury. DESIGN:Prospective experimental study. SETTING:Laboratory research. SUBJECTS:C57Bl/6 mice. INTERVENTIONS:Mice subjected to sham or traumatic brain injury...

journal_title：Critical care medicine

authors： Pischiutta F,Brunelli L,Romele P,Silini A,Sammali E,Paracchini L,Marchini S,Talamini L,Bigini P,Boncoraglio GB,Pastorelli R,De Simoni MG,Parolini O,Zanier ER

更新日期：2016-11-01 00:00:00

abstract：:In a prospective 30-month study of nosocomial infections in a pediatric ICU (PICU), the incidence, sites, and causes of infection were determined. Factors associated with increased risk of infection were investigated. In 1,388 patients who remained in the PICU for a minimum of 72 h, 116 infections occurred (6.1 infect...

journal_title：Critical care medicine

authors： Milliken J,Tait GA,Ford-Jones EL,Mindorff CM,Gold R,Mullins G

更新日期：1988-03-01 00:00:00

abstract：OBJECTIVE:To investigate the impact of circulating histones on cardiac injury and dysfunction in a murine model and patients with sepsis. DESIGN:Prospective, observational clinical study with in vivo and ex vivo translational laboratory investigations. SETTING:General ICU and university research laboratory. SUBJECTS...

journal_title：Critical care medicine

authors： Alhamdi Y,Abrams ST,Cheng Z,Jing S,Su D,Liu Z,Lane S,Welters I,Wang G,Toh CH

更新日期：2015-10-01 00:00:00

abstract：OBJECTIVES:A growing number of patients survive sepsis hospitalizations each year and are at high risk for readmission. However, little is known about temporal trends in hospital-based acute care (emergency department treat-and-release visits and hospital readmission) after sepsis. Our primary objective was to measure ...

journal_title：Critical care medicine

authors： Meyer N,Harhay MO,Small DS,Prescott HC,Bowles KH,Gaieski DF,Mikkelsen ME

更新日期：2018-03-01 00:00:00

abstract：OBJECTIVE:To test the hypothesis that a pretransport Pediatric Risk of Mortality (PRISM) score underestimates the requirement for both intensive care and interventions during pediatric interhospital transport. DESIGN:Prospective, descriptive study. SETTING:All children were treated in a regional hospital and then tra...

journal_title：Critical care medicine

authors： Orr RA,Venkataraman ST,Cinoman MI,Hogue BL,Singleton CA,McCloskey KA

更新日期：1994-01-01 00:00:00

abstract：:Sixty-four (48%) of 133 children with hematologic malignancy who were admitted to three pediatric ICUs died. Children who required management because of airway obstruction or after general anesthesia had the best outlook (mortality rate of 7% or less); those children who required major circulatory support or mechanica...

journal_title：Critical care medicine

authors： Butt W,Barker G,Walker C,Gillis J,Kilham H,Stevens M

更新日期：1988-08-01 00:00:00

abstract：OBJECTIVE:The successful management of an influenza pandemic will be reliant on the expertise of healthcare workers at high risk for occupationally acquired influenza. Recommended infection control measures for healthcare workers include surgical masks to protect against droplet-spread respiratory transmissible infecti...

journal_title：Critical care medicine

authors： Gralton J,McLaws ML

更新日期：2010-02-01 00:00:00