Dehydroepiandrosterone decreases mortality rate and improves cellular immune function during polymicrobial sepsis.

abstract：OBJECTIVE:Our goal was to demonstrate explicitly that lower-frequency positive-pressure ventilation not only preserves adequate oxygenation and acid-base status in hemorrhagic states, but also that "normal" or higher respiratory rates significantly compromise hemodynamics, even with moderate degrees of hemorrhage. DES...

journal_title：Critical care medicine

authors： Pepe PE,Lurie KG,Wigginton JG,Raedler C,Idris AH

更新日期：2004-09-01 00:00:00

abstract：OBJECTIVE:Antimicrobial effects of nitric oxide (NO) have been demonstrated in vitro against a variety of infectious pathogens, yet in vivo evidence of a potential therapeutic role for exogenous NO as an antimicrobial agent is limited. Thus, we assessed the effects of inhaled NO on pulmonary infection, leukocyte infilt...

journal_title：Critical care medicine

authors： Webert KE,Vanderzwan J,Duggan M,Scott JA,McCormack DG,Lewis JF,Mehta S

更新日期：2000-07-01 00:00:00

abstract：:The disadvantages of external ventricular drainage are the threat of sepsis and the nuisance of dislodging a precarious system in routine care. The experience of the authors with nearly 200 cases using a long ventricular catheter demonstrates that a subgaleal tunnel can be easily made for the ventricular catheter usin...

journal_title：Critical care medicine

authors： Saunders RL,Lyons TA

更新日期：1979-12-01 00:00:00

abstract：OBJECTIVE:To report a case of fatal hyperkalemia owing to succinylcholine administration in a patient with mucositis secondary to chemotherapy. DESIGN:Case report. SETTING:Adult intensive care unit (ICU) at Dartmouth-Hitchcock Medical Center. PATIENTS:One patient with mucositis secondary to chemotherapy. MEASUREMEN...

journal_title：Critical care medicine

authors： Al-Khafaji AH,Dewhirst WE,Cornell CJ Jr,Quill TJ

更新日期：2001-06-01 00:00:00

abstract：OBJECTIVES:To determine the outcome of oxygen consumption (VO2) and energy expenditure after cessation of sedation in severe head-injured patients and to assess its usefulness as a predictor of neurologic severity. DESIGN:Prospective, descriptive study. SETTING:Neurosurgical intensive care unit (ICU) in a university ...

journal_title：Critical care medicine

authors： Bruder N,Lassegue D,Pelissier D,Graziani N,François G

更新日期：1994-07-01 00:00:00

abstract：OBJECTIVE:Acute-phase proteins, such as C-reactive protein and albumin, may be related with course and outcome in status epilepticus, as changes of cytokine levels and blood-brain barrier breakdown during status epilepticus have been demonstrated. The aim of this study was to elucidate the association of C-reactive pro...

journal_title：Critical care medicine

authors： Sutter R,Grize L,Fuhr P,Rüegg S,Marsch S

更新日期：2013-06-01 00:00:00

abstract：OBJECTIVES:The Fragility Index, which represents the number of patients responsible for a statistically significant finding, has been suggested as an aid for interpreting the robustness of results from clinical trials. A small Fragility Index indicates that the statistical significance of a trial depends on only a few ...

journal_title：Critical care medicine

authors： Grolleau F,Collins GS,Smarandache A,Pirracchio R,Gakuba C,Boutron I,Busse JW,Devereaux PJ,Le Manach Y

更新日期：2019-03-01 00:00:00

abstract：OBJECTIVES:To determine whether relative hyperglycemia was associated with in-hospital mortality in critically ill patients independent of other prognostic variables and whether this association is affected by background glycemia. DESIGN:Prospective observational study. SETTING:Mixed medical-surgical ICU in a metropo...

journal_title：Critical care medicine

authors： Lee TF,Drake SM,Roberts GW,Bersten A,Stranks SN,Heilbronn LK,Mangoni AA,Burt MG

更新日期：2020-02-01 00:00:00

abstract：OBJECTIVES:Regional tidal lung strain may trigger local inflammation during mechanical ventilation, particularly when additional inflammatory stimuli are present. However, it is unclear whether inflammation develops proportionally to tidal strain or only above a threshold. We aimed to 1) assess the relationship between...

journal_title：Critical care medicine

authors： Wellman TJ,Winkler T,Costa EL,Musch G,Harris RS,Zheng H,Venegas JG,Vidal Melo MF

更新日期：2014-07-01 00:00:00

abstract：OBJECTIVE:Quality of care for patients admitted with pneumonia varies across hospitals, but causes of this variation are poorly understood. Whether hospitals with high ICU utilization for patients with pneumonia provide better quality care is unknown. We sought to investigate the relationship between a hospital's ICU a...

journal_title：Critical care medicine

authors： Sjoding MW,Prescott HC,Wunsch H,Iwashyna TJ,Cooke CR

更新日期：2015-06-01 00:00:00

abstract：OBJECTIVE:To determine the relationship between sublingual and intestinal mucosal microcirculatory perfusion. DESIGN:Observational, experimental study. SETTING:University-affiliated large animal laboratory. SUBJECTS:Ten fasted, anesthetized, mechanically ventilated, male pigs randomized to a sham group (n = 3) or to...

journal_title：Critical care medicine

authors： Verdant CL,De Backer D,Bruhn A,Clausi CM,Su F,Wang Z,Rodriguez H,Pries AR,Vincent JL

更新日期：2009-11-01 00:00:00

abstract：OBJECTIVE:Trauma induces a complex immune response that requires a systems biology research approach. Here, we used a novel technology, mass cytometry by time-of-flight, to comprehensively characterize the multicellular response to trauma. DESIGN:Peripheral blood mononuclear cells samples were stained with a 38-marker...

journal_title：Critical care medicine

authors： Seshadri A,Brat GA,Yorkgitis BK,Keegan J,Dolan J,Salim A,Askari R,Lederer JA

更新日期：2017-09-01 00:00:00

abstract：OBJECTIVE:This study determines whether acid-base data obtained in the emergency department correlate with outcome from major vascular injury. DESIGN:Observational, retrospective record review of trauma patients requiring vascular repair (torso or extremity, January 1988 to December 1997). Data included age, Injury Se...

journal_title：Critical care medicine

authors： Kaplan LJ,Kellum JA

更新日期：2004-05-01 00:00:00

abstract：OBJECTIVE:The role of systemic corticosteroids in pathophysiology and treatment of acute respiratory distress syndrome is controversial. Use of prehospital systemic corticosteroid therapy may prevent the development of acute respiratory distress syndrome and improve hospital outcomes. DESIGN:This is a preplanned retro...

journal_title：Critical care medicine

authors： Karnatovskaia LV,Lee AS,Gajic O,Festic E,U.S. Critical Illness and Injury Trials Group: Lung Injury Prevention Study Investigators (USCIITG–LIPS).

更新日期：2013-07-01 00:00:00

abstract：OBJECTIVES:a) To determine whether pentoxifylline has a preventive effect on the decrease in PaO2 that is caused by oleic acid, and whether pentoxifylline facilitates normalization of PaO2 from the decreased state. b) To examine whether pentoxifylline can attenuate an increase in pulmonary vascular permeability that is...

journal_title：Critical care medicine

authors： Moriuchi H,Yuizono T

更新日期：1995-02-01 00:00:00

abstract：OBJECTIVE:The purpose of this study was to determine the prognostic value of sublingual PCO2 (P(SL)CO2), lactate concentration, and mixed venous oxygen saturation (S(MV)O2) in hemodynamically unstable intensive care patients and, additionally, to compare the temporal changes of these variables in response to treatment....

journal_title：Critical care medicine

authors： Marik PE,Bankov A

更新日期：2003-03-01 00:00:00

abstract：:During a consecutive 17 month period, 15 trauma patients were diagnosed as having a myocardial contusion on the basis of abnormal ECG in 14 patients, elevated creatinine phosphokinase (CPK) in 13 patients, and elevated CPK-Muscle Brain (CPK-MB) isoenzyme determination in 11 patients. Using these screening modalities, ...

journal_title：Critical care medicine

authors： Torres-Mirabal P,Gruenberg JC,Talbert JG,Brown RS

更新日期：1982-01-01 00:00:00

abstract：OBJECTIVE:To determine the utility of thoracic computed tomography (TCT) in the initial assessment of critically ill patients with chest injuries. DESIGN:Prospective observational study of cohorts. SETTING:Trauma intensive care unit (ICU) of a Spanish Level III hospital (US equivalent Level I). PATIENTS:Three hundre...

journal_title：Critical care medicine

authors： Guerrero-López F,Vázquez-Mata G,Alcázar-Romero PP,Fernández-Mondéjar E,Aguayo-Hoyos E,Linde-Valverde CM

更新日期：2000-05-01 00:00:00

abstract：OBJECTIVES:To characterize the landscape of process of care and safety outcomes for tracheal intubation across pediatric intensive care units BACKGROUND:Procedural process of care and safety outcomes of tracheal intubation across pediatric intensive care units has not been described. We hypothesize that the novel Nati...

journal_title：Critical care medicine

authors： Nishisaki A,Turner DA,Brown CA 3rd,Walls RM,Nadkarni VM,National Emergency Airway Registry for Children (NEAR4KIDS).,Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network.

更新日期：2013-03-01 00:00:00

abstract：OBJECTIVE:To investigate if prone position delays the progression of experimental ventilator-induced lung injury, possibly due to a more homogeneous distribution of strain within lung parenchyma. DESIGN:Prospective, randomized, controlled trial. SETTING:Animal laboratory of a university hospital. SUBJECTS:Thirty-fiv...

journal_title：Critical care medicine

authors： Valenza F,Guglielmi M,Maffioletti M,Tedesco C,Maccagni P,Fossali T,Aletti G,Porro GA,Irace M,Carlesso E,Carboni N,Lazzerini M,Gattinoni L

更新日期：2005-02-01 00:00:00

abstract：OBJECTIVE:Our intent was to evolve a prognosticator that would predict the likelihood that an electrical shock would restore a perfusing rhythm. Such a prognosticator was to be based on conventional electrocardiographic signals but without constraints caused by artifacts resulting from precordial compression. The adver...

journal_title：Critical care medicine

authors： Marn-Pernat A,Weil MH,Tang W,Pernat A,Bisera J

更新日期：2001-12-01 00:00:00

abstract：OBJECTIVE:To determine whether a correlation exists between concentrations of intracellular and extracellular potassium and to determine the frequency of ventricular ectopy in patients after cardiac operations. DESIGN:Prospective, observational clinical evaluation. SETTING:Surgical-respiratory intensive care unit of ...

journal_title：Critical care medicine

authors： Johnson RG,Shafique T,Sirois C,Weintraub RM,Comunale ME

更新日期：1999-11-01 00:00:00

abstract：OBJECTIVES:We previously reported gene expression-based endotypes of pediatric septic shock, endotypes A and B, and that corticosteroid exposure was independently associated with increased mortality among pediatric endotype A patients. The Vasopressin vs Norepinephrine as Initial Therapy in Septic Shock trial tested th...

journal_title：Critical care medicine

authors： Wong HR,Hart KW,Lindsell CJ,Sweeney TE

更新日期：2021-01-01 00:00:00

abstract：OBJECTIVES:To compare the effects of two lung-protective ventilation strategies on pulmonary vascular mechanics in early acute respiratory distress syndrome. DESIGN:Experimental study. SETTING:University animal research laboratory. SUBJECTS:Twelve pigs (30.8 ± 2.5 kg). INTERVENTIONS:Acute respiratory distress syndr...

journal_title：Critical care medicine

authors： Santos A,Gomez-Peñalver E,Monge-Garcia MI,Retamal J,Borges JB,Tusman G,Hedenstierna G,Larsson A,Suarez-Sipmann F

更新日期：2017-11-01 00:00:00

abstract：:Nine previously untrained health professionals learned to measure cardiac output (Qt) by suprasternal continuous-wave Doppler ultrasound (QtDopp) and by thoracic bioimpedance (Qtbi). Each received standardized written, videotaped, and individual instruction. First the novice, then the reference examiner, measured QtDo...

journal_title：Critical care medicine

authors： Wong DH,Onishi R,Tremper KK,Reeves C,Zaccari J,Wong AB,Miller JB,Cordero V,Davidson J

更新日期：1989-11-01 00:00:00

abstract：:Standard techniques for measuring pulmonary resistance (RP) to gas flow in newborn infants yield results that are widely dispersed and difficult to interpret. The purpose of this study is to describe and evaluate a new improved method for determining RP which utilizes a sinusoidal pressure wave generator. Measurements...

journal_title：Critical care medicine

authors： Richardson P,Carlstrom JR

更新日期：1983-07-01 00:00:00

abstract：:Although ICUs generate attention as consumers of resources, no national data on utilization and costs were available in Canada. U.S. estimates are too old for current comparison. Based on national hospital survey data from Statistics Canada, we calculated the utilization of ICUs in all Canadian general hospitals from ...

journal_title：Critical care medicine

authors： Jacobs P,Noseworthy TW

更新日期：1990-11-01 00:00:00

abstract：:Intravenous dobutamine was used in ten patients requiring aggressive therapy for massive pulmonary embolism with circulatory failure. Except in one patient who rapidly died, a 30-min dobutamine infusion (8.3 +/- 2.7 micrograms/kg . min) increased both cardiac index (from 1.7 +/- 0.4 to 2.3 +/- 0.6 L/min . m2, p less t...

journal_title：Critical care medicine

authors： Jardin F,Genevray B,Brun-Ney D,Margairaz A

更新日期：1985-12-01 00:00:00

abstract：OBJECTIVE:Cardiogenic shock remains an important therapeutic challenge, with high in-hospital mortality rates. Mechanical circulatory support may be beneficial in these patients. Since the efficacy of the intra-aortic balloon pump seems limited, new percutaneously placed mechanical left ventricular support devices, suc...

journal_title：Critical care medicine

authors： Engström AE,Cocchieri R,Driessen AH,Sjauw KD,Vis MM,Baan J,de Jong M,Lagrand WK,van der Sloot JA,Tijssen JG,de Winter RJ,de Mol BA,Piek JJ,Henriques JP

更新日期：2011-09-01 00:00:00

abstract：OBJECTIVES:To use a standardized tool for a multicenter assessment of antibiotic appropriateness in ICUs and identify local antibiotic stewardship improvement opportunities. DESIGN:Pilot point prevalence conducted on October 5, 2016; point prevalence survey conducted on March 1, 2017. SETTING:ICUs in 12 U.S. acute ca...

journal_title：Critical care medicine

authors： Trivedi KK,Bartash R,Letourneau AR,Abbo L,Fleisher J,Gagliardo C,Kelley S,Nori P,Rieg GK,Silver P,Srinivasan A,Vargas J,Ostrowsky B,Partnership for Quality Care (PQC) Inpatient Antimicrobial Stewardship Working Group.

更新日期：2020-07-01 00:00:00