Effects of inhaled nitric oxide in a rat model of Pseudomonas aeruginosa pneumonia.

abstract：OBJECTIVE:To compare four different methods of endotracheal lidocaine administration with respect to the site of administration. DESIGN:Randomized controlled trial. SETTING:University hospital. PATIENTS:Thirty-two female patients (43.6 +/- 11.5 years old) undergoing elective gynecologic operations with an anesthesio...

journal_title：Critical care medicine

authors： Prengel AW,Lindner KH,Hähnel J,Ahnefeld FW

更新日期：1991-07-01 00:00:00

abstract：OBJECTIVE:To review published studies of the influence of platelet factor 4 (PF4) and other cationic proteins on the generation of activated protein C (APC) by the thrombomodulin-protein C system. DATA SOURCE:Using the PubMed citation index, literature published from 1973 to 2003 regarding cationic proteins, PF4, and ...

journal_title：Critical care medicine

authors： Slungaard A

更新日期：2004-05-01 00:00:00

abstract：OBJECTIVES:Mechanical ventilation can cause ventilator-induced brain injury via afferent vagal signaling and hippocampal neurotransmitter imbalances. The triggering mechanisms for vagal signaling during mechanical ventilation are unknown. The objective of this study was to assess whether pulmonary transient receptor po...

journal_title：Critical care medicine

authors： González-López A,López-Alonso I,Pickerodt PA,von Haefen C,Amado-Rodríguez L,Reimann H,Niendorf T,Kuebler W,Albaiceta GM,Francis RCE,Spies CD

更新日期：2019-11-01 00:00:00

abstract：OBJECTIVES:Increasing age is a well-recognized risk factor for in-hospital mortality in patients receiving extracorporeal membrane oxygenation for cardiogenic shock, but the shape of this relationship is unknown. In addition, the impact of age on hospital length of stay, patterns of patient disposition, and costs has b...

journal_title：Critical care medicine

authors： Chung M,Zhao Y,Strom JB,Shen C,Yeh RW

更新日期：2019-03-01 00:00:00

abstract：OBJECTIVE:Review data obtained from high-frequency oscillatory ventilation (HFOV) and mechanical test lung models with respect to delivered tidal volume, distal pressure transmission, endotracheal tube cuff leaks, and simulated clinical conditions. DESIGN:Review of selected studies from PubMed, published abstracts, an...

journal_title：Critical care medicine

authors： Van de Kieft M,Dorsey D,Morison D,Bravo L,Venticinque S,Derdak S

更新日期：2005-03-01 00:00:00

abstract：OBJECTIVE:To date, no study has systematically investigated the impact of drowning-induced asphyxia on hemostasis. Our objective was to test the hypothesis that asphyxia induces bleeding by hyperfibrinolytic disseminated intravascular coagulation. DESIGN:Observational study. SETTING:A 2,100-bed tertiary care facility...

journal_title：Critical care medicine

authors： Schwameis M,Schober A,Schörgenhofer C,Sperr WR,Schöchl H,Janata-Schwatczek K,Kürkciyan EI,Sterz F,Jilma B

更新日期：2015-11-01 00:00:00

abstract：:In the pathogenesis of sepsis, inflammation and coagulation play a pivotal role. Increasing evidence points to an extensive cross-talk between these two systems, whereby inflammation leads to activation of coagulation, and coagulation also considerably affects inflammatory activity. Molecular pathways that contribute ...

journal_title：Critical care medicine

authors： Levi M,van der Poll T

更新日期：2010-02-01 00:00:00

abstract：OBJECTIVE:To evaluate the tolerance and the efficacy of noninvasive continuous positive airway pressure (CPAP) in severe acute respiratory failure occurring in intensive care unit (ICU) neutropenic patients with hematologic malignancies, and to establish predictive variables of efficacy of this method. DESIGN:Prospect...

journal_title：Critical care medicine

authors： Hilbert G,Gruson D,Vargas F,Valentino R,Chene G,Boiron JM,Pigneux A,Reiffers J,Gbikpi-Benissan G,Cardinaud JP

更新日期：2000-09-01 00:00:00

abstract：:The fractional elimination rate of exogenous fat, and fat-mobilizing lipolysis in relation to plasma catecholamine (CA) levels were studied in seven ventilator-treated ICU patients. Blood levels of CA, triglycerides, cholesterol and free fatty acids (FFA) were also analyzed before and during constant infusion of a soy...

journal_title：Critical care medicine

authors： Lindholm M,Eklund JO,Hamberger B,Järnberg PO

更新日期：1984-11-01 00:00:00

abstract：OBJECTIVE:Although randomized trials yield less biased estimates of treatment effects than other study designs, unconcealed randomization and lack of blinding can lead to overestimates of the treatment benefit on the order of 15% to 40% on average. In applying the results of clinical trials to patient care, clinicians ...

journal_title：Critical care medicine

authors： Kunz R,Neumayer HH,Khan KS

更新日期：2002-07-01 00:00:00

abstract：OBJECTIVE:To develop clinical practice guidelines for the use of restraining therapies to maintain physical and psychological safety of adult and pediatric patients in the intensive care unit. PARTICIPANTS:A multidisciplinary, multispecialty task force of experts in critical care practice was convened from the members...

journal_title：Critical care medicine

authors： Maccioli GA,Dorman T,Brown BR,Mazuski JE,McLean BA,Kuszaj JM,Rosenbaum SH,Frankel LR,Devlin JW,Govert JA,Smith B,Peruzzi WT,American College of Critical Care Medicine, Society of Critical Care Medicine.

更新日期：2003-11-01 00:00:00

abstract：:The resolution time of pneumothorax in neonates requiring tube thoracotomy is not known. We found that 28%, 50%, and 83% of 54 pneumothoraces in 40 neonates resolved within 24, 96, and 168 h of tube thoracotomy, respectively. Pneumothoraces that persisted beyond 168 h were in infants requiring ventilatory assistance. ...

journal_title：Critical care medicine

authors： Bhatia J,Mathew OP

更新日期：1985-05-01 00:00:00

abstract：OBJECTIVE:Acute aneurysmal subarachnoid hemorrhage (SAH) is a complex multifaceted disorder that plays out over days to weeks. Many patients with SAH are seriously ill and require a prolonged intensive care unit stay. Cardiopulmonary complications are common. The management of patients with SAH focuses on the anticipat...

journal_title：Critical care medicine

authors： Diringer MN

更新日期：2009-02-01 00:00:00

abstract：OBJECTIVES:To evaluate the use of multifrequency bioelectrical impedance analysis to predict creatinine/urea clearance based on 24 hours urine collection. A practical formula was developed, and its performance was compared with that of established formulas such as Cockcroft-Gault, Modification of Diet in Renal Disease,...

journal_title：Critical care medicine

authors： de Jong LAA,Otten-Helmers AG,Spronk PE,van Kan HJM

更新日期：2019-12-01 00:00:00

abstract：:Intralipid elimination patterns were compared in 25 healthy controls, 12 patients recovering from uncomplicated cholecystectomy, and 25 critically ill patients. The intravenous fat tolerance test revealed a similar fractional removal rate (k2) in healthy controls and critically ill patients, but k2 was increased in ch...

journal_title：Critical care medicine

authors： Lindh A,Lindholm M,Rössner S

更新日期：1986-05-01 00:00:00

abstract：OBJECTIVES:Although studies have indicated that adrenal insufficiency occurs after severe trauma and hemorrhagic shock, it remains controversial whether adrenal function is depressed during the late stage of polymicrobial sepsis. DESIGN:Prospective, controlled animal study. SETTING:A university research laboratory. ...

journal_title：Critical care medicine

authors： Koo DJ,Jackman D,Chaudry IH,Wang P

更新日期：2001-03-01 00:00:00

abstract：OBJECTIVES:To examine perceptions of nurses and physicians in regard to ethical decision-making climate in the ICU and to test the hypothesis that the worse the ethical decision-making climate, the greater the discordance between nurses' and physicians' rating of ethical decision-making climate with physicians hypothes...

journal_title：Critical care medicine

authors： Jensen HI,Hebsgaard S,Hansen TCB,Johnsen RFA,Hartog CS,Soultati I,Szucs O,Wilson ME,van den Bulcke B,Benoit DD,Piers R

更新日期：2019-12-01 00:00:00

abstract：OBJECTIVE:To determine the maternal morbidity and mortality in patients with eclampsia admitted to an intensive care unit (ICU), and to establish the efficacy of the Acute Physiology and Chronic Health Evaluation (APACHE) II score, the organ system failure score as defined by Knaus, and the Glasgow Coma Scale (GCS) sco...

journal_title：Critical care medicine

authors： Bhagwanjee S,Paruk F,Moodley J,Muckart DJ

更新日期：2000-01-01 00:00:00

abstract：OBJECTIVES:To determine whether excessive alcohol consumption increases the risk for intensive care unit (ICU)-acquired bacterial infection, especially ventilator-associated pneumonia (VAP), in nontrauma patients. DESIGN:Prospective observational cohort study. SETTING:A 21-bed polyvalent ICU in a university hospital....

journal_title：Critical care medicine

authors： Gacouin A,Legay F,Camus C,Volatron AC,Barbarot N,Donnio PY,Thomas R,Le Tulzo Y

更新日期：2008-06-01 00:00:00

abstract：OBJECTIVES:Increases in exhaled nitric oxide have been demonstrated to originate from the lungs of rats after septic lung injury. The aim of this study was to investigate whether treatment with the nitric oxide synthase inhibitor N-nitro-L-arginine methyl ester (L-NAME) would prevent lipopolysaccharide (LPS)-induced in...

journal_title：Critical care medicine

authors： Aaron SD,Valenza F,Volgyesi G,Mullen JB,Slutsky AS,Stewart TE

更新日期：1998-02-01 00:00:00

abstract：OBJECTIVE:To investigate relationships between acute adrenergic stress, plasma catecholamine concentrations, and beta 2-adrenergic receptors. DESIGN:Prospective, descriptive study. SETTING:Emergency medical service at a university hospital. PATIENTS:Twenty-seven patients with out-of-hospital cardiac arrest (n = 11),...

journal_title：Critical care medicine

authors： Prengel AW,Lindner KH,Anhäupl T,Trunk E,Georgieff M,Lurie KG

更新日期：1997-04-01 00:00:00

abstract：OBJECTIVE:Sepsis and acute lung injury continue to be major causes of morbidity and mortality worldwide despite advances in our understanding of pathophysiology and the discovery of new management strategies. Recent investigations show that stem cells may be beneficial as prognostic biomarkers and novel therapeutic str...

journal_title：Critical care medicine

authors： Cribbs SK,Matthay MA,Martin GS

更新日期：2010-12-01 00:00:00

abstract：OBJECTIVE:To assess whether the provision of computerized physiologic trend data could improve outcome in newborn infants requiring intensive care. DESIGN:Randomized, controlled trial, with subsidiary questionnaire studies. SETTING:Tertiary neonatal intensive care unit with 12 intensive care cots. PATIENTS:All infan...

journal_title：Critical care medicine

authors： Cunningham S,Deere S,Symon A,Elton RA,McIntosh N

更新日期：1998-12-01 00:00:00

abstract：:Several variables may account for the response of electrochemical skin surface PO2 sensors to anesthetic gases: cathode material and size, pH of the electrolyte and membrane material. These variables cannot be chosen arbitrarily and their influence has been tested with two types of sensors. In one type (LSC), a large ...

journal_title：Critical care medicine

authors： Eberhard P,Mindt W

更新日期：1981-10-01 00:00:00

abstract：:Previously, we determined that a colloid concentration of about 3% was optimal for resuscitation of lethal ischemic intestinal shock model in rats. Maximal volumes of lactated Ringer's solution (RL) alone only expanded plasma volume (PV) to 80% of preshock level, while increasing volumes of 3% albumin (ALB) in RL line...

journal_title：Critical care medicine

authors： Dawidson IJ,Willms C,Sandor ZF,Armstrong J,Wilson L

更新日期：1990-01-01 00:00:00

abstract：:The endothelium is a highly dynamic cell layer that is involved in a multitude of physiologic functions, including the control of vasomotor tone, the trafficking of cells and nutrients, the maintenance of blood fluidity, and the growth of new blood vessels. Over the past several decades, advances in basic research of ...

journal_title：Critical care medicine

authors： Aird WC

更新日期：2004-05-01 00:00:00

abstract：:A computer program is presented which analyzes acid-base and respiratory variables. This program's advantages include limited data input, hand-held portability, error identification, and succinct analysis statements. It is a useful adjunct to daily care of the critically ill. ...

journal_title：Critical care medicine

authors： Lynn LA,Sunderrajan EV

更新日期：1986-01-01 00:00:00

abstract：OBJECTIVES:Clinical applications of inhaled nitric oxide (NO) therapy resulted in the development of delivery systems and monitoring devices applicable to routine clinical care. This article presents the various components necessary for an adequate clinical use of inhaled NO, and discusses the NO gas mixture cylinders,...

journal_title：Critical care medicine

authors： Francoe M,Troncy E,Blaise G

更新日期：1998-04-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to investigate whether hyperglycemia enhances the systemic inflammatory response and oxidative stress induced by endotoxin. DESIGN:Laboratory investigation. SETTING:University medical school. SUBJECTS:Forty-one male Sprague-Dawley rats. INTERVENTIONS:A hyperglycemic condition was...

journal_title：Critical care medicine

authors： Ling PR,Smith RJ,Bistrian BR

更新日期：2005-05-01 00:00:00

abstract：OBJECTIVE:To determine if exogenous interleukin (IL)-10 will decrease the morbidity or mortality of sepsis induced by cecal ligation and puncture. DESIGN:Prospective, randomized, controlled study. SETTING:University research laboratory. SUBJECTS:Adult, female, Balb¿c mice. INTERVENTIONS:Balb¿c mice were subjected t...

journal_title：Critical care medicine

authors： Remick DG,Garg SJ,Newcomb DE,Wollenberg G,Huie TK,Bolgos GL

更新日期：1998-05-01 00:00:00