Propofol impairs neurogenesis and neurologic recovery and increases mortality rate in adult rats after traumatic brain injury.

abstract：OBJECTIVE:Patients with severe sepsis have high mortality that is improved by timely, often expensive, treatments. Patients without insurance are more likely to delay seeking care; they may also receive less intense care. DESIGN:We performed a retrospective analysis of administrative database-Healthcare Costs and Util...

journal_title：Critical care medicine

authors： Kumar G,Taneja A,Majumdar T,Jacobs ER,Whittle J,Nanchal R,Milwaukee Initiative in Critical Care Outcomes Research (MICCOR) Group of Investigators.

更新日期：2014-03-01 00:00:00

abstract：:The metabolic support of critically ill patients is a relatively new topic of active research and discussion, and surprisingly little is known about the effects of critical illness on metabolic physiology and activity. The metabolic changes seen in critical illness are highly complex, and how and when to treat them ar...

journal_title：Critical care medicine

authors： Vincent JL

更新日期：2007-09-01 00:00:00

abstract：OBJECTIVE:To determine whether plasma lipid hydroperoxides may be a useful marker for sepsis. DESIGN:Exploratory, open-label study. SETTING:Critical care unit at a university medical center. PATIENTS:Twelve patients with sepsis syndrome requiring hemodynamic monitoring with pulmonary artery catheters. Seven patients...

journal_title：Critical care medicine

authors： Keen RR,Stella L,Flanigan DP,Lands WE

更新日期：1991-09-01 00:00:00

abstract：OBJECTIVE:Citrate anticoagulation is an excellent alternative to heparin anticoagulation for critically ill patients requiring continuous renal replacement therapy. In this article, we provide a safe and an easy-to-handle citrate anticoagulation protocol with variable treatment doses and excellent control of the acid-b...

journal_title：Critical care medicine

authors： Morgera S,Schneider M,Slowinski T,Vargas-Hein O,Zuckermann-Becker H,Peters H,Kindgen-Milles D,Neumayer HH

更新日期：2009-06-01 00:00:00

abstract：OBJECTIVE:To study the pharmacokinetics of dopamine in hemodynamically stable adult patients. DESIGN:Prospective clinical study. SETTING:University hospital intensive care unit. PATIENTS:Fourteen patients (aged 43 to 73 yrs) recovering from esophageal surgery. INTERVENTION:Dopamine was infused and blood samples wer...

journal_title：Critical care medicine

authors： Le Corre P,Malledant Y,Tanguy M,Le Verge R

更新日期：1993-11-01 00:00:00

abstract：OBJECTIVE:The role of systemic corticosteroids in pathophysiology and treatment of acute respiratory distress syndrome is controversial. Use of prehospital systemic corticosteroid therapy may prevent the development of acute respiratory distress syndrome and improve hospital outcomes. DESIGN:This is a preplanned retro...

journal_title：Critical care medicine

authors： Karnatovskaia LV,Lee AS,Gajic O,Festic E,U.S. Critical Illness and Injury Trials Group: Lung Injury Prevention Study Investigators (USCIITG–LIPS).

更新日期：2013-07-01 00:00:00

abstract：OBJECTIVE:To compare two forms of continuous renal replacement therapy, continuous venovenous hemofiltration (CVVH) vs. continuous venovenous hemodialysis (CVVHD), in terms of the removal of inflammatory mediators from the blood of patients with systemic inflammatory response syndrome and acute renal failure. DESIGN:R...

journal_title：Critical care medicine

authors： Kellum JA,Johnson JP,Kramer D,Palevsky P,Brady JJ,Pinsky MR

更新日期：1998-12-01 00:00:00

abstract：OBJECTIVE:Tea has been around for centuries, and its medicinal properties have been purported in the literature but never fully confirmed. Interleukin-8 is a principle neutrophil chemoattractant and activator in humans. We determined the effects of theaflavin, a black tea-derived polyphenol, on tumor necrosis factor-al...

journal_title：Critical care medicine

authors： Aneja R,Odoms K,Denenberg AG,Wong HR

更新日期：2004-10-01 00:00:00

abstract：OBJECTIVES:a) To investigate whether the patient work of breathing needed to trigger inspiration is affected by the type of ventilator delivering pressure-support ventilation for mechanically ventilated pediatric patients. b) To determine whether changes in oxygen consumption (VO2) trend with changes in work of breathi...

journal_title：Critical care medicine

authors： el-Khatib MF,Chatburn RL,Potts DL,Blumer JL,Smith PG

更新日期：1994-12-01 00:00:00

abstract：OBJECTIVE:To investigate a role of the opiate system during acute hypoxic hypoxia, the effects of naloxone and morphine on hypoxic survival rate were investigated in awake adult mice. DESIGN:Prospective, randomized, animal trial. SETTING:University research laboratory. SUBJECTS:Male dd-Y mice (n = 864 in experiment ...

journal_title：Critical care medicine

authors： Endoh H,Taga K,Yamakura T,Sato K,Watanabe I,Fukuda S,Shimoji K

更新日期：1999-09-01 00:00:00

abstract：BACKGROUND:Pneumonia accounts for almost half of intensive care unit (ICU) infections and nearly 60% of deaths from nosocomial infections. It increases hospital stay by 7-9 days, crude mortality by 70% and attributable mortality by 30%. OBJECTIVE:Our purpose was to assess the impact of standard operating procedures ad...

journal_title：Critical care medicine

authors： Nachtigall I,Tamarkin A,Tafelski S,Deja M,Halle E,Gastmeier P,Wernecke KD,Bauer T,Kastrup M,Spies C

更新日期：2009-01-01 00:00:00

abstract：OBJECTIVE:To review the rationale for the regionalization of adult critical care and discuss how lessons from the trauma experience may be relevant to this debate. DESIGN:Narrative review and opinion. RESULTS:Variation in the quality of critical care among hospitals has prompted calls for regionalization of care for ...

journal_title：Critical care medicine

authors： Kahn JM,Branas CC,Schwab CW,Asch DA

更新日期：2008-11-01 00:00:00

abstract：OBJECTIVE:To compare the outcomes and the short- and long-term complications of percutaneous translaryngeal tracheostomy (TLT) and surgical tracheostomy (ST). DESIGN:Prospective, randomized clinical trial with 1-yr double-blind follow-up. SETTING:A general intensive care unit of a university hospital. PATIENTS:A tot...

journal_title：Critical care medicine

authors： Antonelli M,Michetti V,Di Palma A,Conti G,Pennisi MA,Arcangeli A,Montini L,Bocci MG,Bello G,Almadori G,Paludetti G,Proietti R

更新日期：2005-05-01 00:00:00

abstract：:The validity of the urinary urea nitrogen (UUN) estimate of total urinary nitrogen (TUN) was tested in patients who required iv nutrition. UUN and TUN were determined in 120 urine collections from ten preoperative, 13 postoperative, and 11 stressed patients. The relationship between TUN and UUN was examined by linear ...

journal_title：Critical care medicine

authors： Loder PB,Kee AJ,Horsburgh R,Jones M,Smith RC

更新日期：1989-04-01 00:00:00

abstract：OBJECTIVE:To determine xanthine oxidase activity, free radical concentrations, and lipid peroxidation in patients with sepsis syndrome compared with noninfected critically ill patients. DESIGN:A prospective observational study. SETTING:A nine-bed intensive care unit in a university teaching hospital trust. PATIENTS:...

journal_title：Critical care medicine

authors： Galley HF,Davies MJ,Webster NR

更新日期：1996-10-01 00:00:00

abstract：OBJECTIVE:Acute renal failure can be treated with continuous renal replacement therapy (CRRT) or intermittent hemodialysis. There is no difference in mortality, although patients treated with CRRT may have a higher rate of renal recovery. Given these considerations, an estimate of the costs by modality may help in choo...

journal_title：Critical care medicine

authors： Manns B,Doig CJ,Lee H,Dean S,Tonelli M,Johnson D,Donaldson C

更新日期：2003-02-01 00:00:00

abstract：OBJECTIVES:In postcardiac surgery patients, we often noticed that monitored tidal volumes exceeded the ventilator settings. We investigated whether cardiogenic oscillation causes overestimation of tidal volume. DESIGN:Prospective, observational, clinical study. SETTING:Surgical intensive care unit in a national heart...

journal_title：Critical care medicine

authors： Imanaka H,Takeuchi M,Tachibana K,Nishimura M

更新日期：2004-07-01 00:00:00

abstract：:The definition of sepsis has been recently modified to accommodate emerging knowledge in the field, while at the same time being recognized as challenging, if not impossible, to define. Here, we seek to clarify the current understanding of sepsis as one that has been typically framed as a disorder of inflammation to o...

journal_title：Critical care medicine

authors： Alverdy JC,Krezalek MA

更新日期：2017-02-01 00:00:00

abstract：OBJECTIVE:Sepsis remains a major health threat in intensive care medicine. The renin-angiotensin system (ACE) affects inflammatory responses. In addition, angiotensin-converting enzyme inhibitors act to ameliorate lung injury. To investigate whether the widely used ACE inhibitor enalapril, used to treat hypertension, c...

journal_title：Critical care medicine

authors： Hagiwara S,Iwasaka H,Matumoto S,Hidaka S,Noguchi T

更新日期：2009-02-01 00:00:00

abstract：OBJECTIVE:To determine whether neutrophil depletion could eradicate intestinal bacterial translocation in bum-injured rats. DESIGN:Prospective, randomized, controlled study. SETTING:University research laboratory. SUBJECTS:Adult male Sprague-Dawley rats. INTERVENTIONS:The rats were intravenously administered a rabb...

journal_title：Critical care medicine

authors： Fazal N,Shamim M,Khan SS,Gamelli RL,Sayeed MM

更新日期：2000-05-01 00:00:00

abstract：OBJECTIVE:To test the hypothesis that therapeutic hypercapnia enhances the proinflammatory responses to endotoxemia in the lung and spleen of rats. DESIGN:Prospective randomized study. SETTINGS:Hospital research institute. SUBJECTS:Forty-eight adult male rats. INTERVENTIONS:Rats were randomly assigned for a 24-hr p...

journal_title：Critical care medicine

authors： Norozian FM,Leoncio M,Torbati D,Meyer K,Raszynski A,Totapally BR

更新日期：2011-06-01 00:00:00

abstract：OBJECTIVE:To examine the effects of hypertonic (7.5%) saline-6% dextran 70 (HSD) and isotonic (0.9%) saline-6% dextran 70 (ISD) on cardiovascular function and intestinal perfusion in experimental endotoxin shock. DESIGN:Experimental, randomized, unblinded, interventional study. SETTING:University experimental animal ...

journal_title：Critical care medicine

authors： Oi Y,Aneman A,Svensson M,Ewert S,Dahlqvist M,Haljamäe H

更新日期：2000-08-01 00:00:00

abstract：OBJECTIVE:To determine whether naloxone administration after hemorrhagic shock has any beneficial or deleterious effect on immune responses. BACKGROUND DATA:Hemorrhagic shock is known to produce immunodepression in both humans and experimental animals. Although studies suggest that endogenous opioids play a role in im...

journal_title：Critical care medicine

authors： Wichmann MW,Zellweger R,Ayala A,Chaudry IH

更新日期：2000-01-01 00:00:00

abstract：OBJECTIVES:We aimed to implement our Smart Use of Antibiotics Program to ensure the proper use of antimicrobials, improve patient care and outcomes, and reduce the risks of adverse effects and antimicrobial resistance. DESIGN:We compared the time periods before (baseline) and after (intervention) the implementation of...

journal_title：Critical care medicine

authors： Lu C,Liu Q,Yuan H,Wang L

更新日期：2019-01-01 00:00:00

abstract：OBJECTIVES:To address the association between the 2003 heat wave in Paris (France) and the occurrence of out-of-hospital cardiac arrest. DESIGN:: An analysis of the interventions of the medical mobile intensive care units of the City of Paris for out-of-hospital cardiac arrest and prehospital myocardial infarctions, w...

journal_title：Critical care medicine

authors： Empana JP,Sauval P,Ducimetiere P,Tafflet M,Carli P,Jouven X

更新日期：2009-12-01 00:00:00

abstract：OBJECTIVE:During pressure support ventilation, ventilator inspiration ends when inspiratory flow drops to a given percentage of the peak inspiratory flow cycling-off criteria. This study evaluated the effect of two different cycling-off criteria on breathing pattern, respiratory effort, and gas exchange in patients wit...

journal_title：Critical care medicine

authors： Chiumello D,Polli F,Tallarini F,Chierichetti M,Motta G,Azzari S,Colombo R,Rech R,Pelosi P,Raimondi F,Gattinoni L

更新日期：2007-11-01 00:00:00

abstract：OBJECTIVE:To test the reliability and validity of a modified moral distress tool, originally developed for the nursing profession, on respiratory care practitioners. To describe the relationship between moral distress, career dissatisfaction, and job turnover in respiratory care. DESIGN:A 28-question survey was develo...

journal_title：Critical care medicine

authors： Schwenzer KJ,Wang L

更新日期：2006-12-01 00:00:00

abstract：OBJECTIVE:To investigate the mechanism by which methylprednisolone protects the liver from hypoxia-induced injury. DESIGN:Prospective control study using the isolated rat liver. SETTING:Animal research facility. SUBJECTS:Male, fasted, pathogen-free Sprague-Dawley rats. INTERVENTIONS:Low-flow hypoxia was produced by...

journal_title：Critical care medicine

authors： Motoyama S,Saito S,Minamiya Y,Saito R,Nakamura M,Okuyama M,Imano H,Ogawa J

更新日期：2003-05-01 00:00:00

abstract：OBJECTIVES:To evaluate the prevalence of cardiac injury and its association with mortality in hospitalized patients infected with avian influenza A (H7N9) virus. DESIGN:Retrospective cohort study. SETTING:A total of 133 hospitals in 17 provinces, autonomous regions, and municipalities of mainland China that admitted ...

journal_title：Critical care medicine

authors： Gao C,Wang Y,Gu X,Shen X,Zhou D,Zhou S,Huang JA,Cao B,Guo Q,Community-Acquired Pneumonia–China Network.

更新日期：2020-04-01 00:00:00

abstract：:Computerized gamma scintigraphy revealed a significant (p less than 0.001) rising lung:heart radioactivity ratio, which has been called "slope of injury" or "slope index", with both 99mTechnetium-tagged human serum albumin (99mTc-HSA) and 99mTechnetium-tagged red blood cells (99Tc-RBC) after 0.05 or 0.2 ml/kg iv oleic...

journal_title：Critical care medicine

authors： Sugerman HJ,Hirsch JI,Tatum JL,Strash AM,Sharp DE,Greenfield LJ

更新日期：1982-01-01 00:00:00