Comparative scintigraphy in oleic acid pulmonary microvascular injury.

Abstract:

:Computerized gamma scintigraphy revealed a significant (p less than 0.001) rising lung:heart radioactivity ratio, which has been called "slope of injury" or "slope index", with both 99mTechnetium-tagged human serum albumin (99mTc-HSA) and 99mTechnetium-tagged red blood cells (99Tc-RBC) after 0.05 or 0.2 ml/kg iv oleic acid administration to dogs. This slope index was significantly greater with 99mTc-HSA than 99mTc-RBC (p less than 0.001). These findings verify that the scintigraphic 99mTc-HSA slope of injury is a result of a pulmonary capillary protein leak and not oleic acid induced changes in pulmonary blood or air volume. The leak of red blood cells noted with scintigraphy was confirmed by light microscopy and examination of the tracheal edema fluid. The leak of albumin, however, was much greater than the leak of red blood cells by microscopy and tracheal fluid examination, confirming the scintigraphic data. This study provides further evidence that computerized gamma scintigraphy will be of value for the diagnosis of permeability pulmonary edema and its response to treatment.

journal_name

Crit Care Med

journal_title

Critical care medicine

authors

Sugerman HJ,Hirsch JI,Tatum JL,Strash AM,Sharp DE,Greenfield LJ

doi

10.1097/00003246-198201000-00008

subject

Has Abstract

pub_date

1982-01-01 00:00:00

pages

31-3

issue

1

eissn

0090-3493

issn

1530-0293

journal_volume

10

pub_type

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