Collapse of the Microbiome, Emergence of the Pathobiome, and the Immunopathology of Sepsis.

abstract：:This report describes an unusual hemolytic transfusion reaction. A group O donor was inadvertently transfused with 100 ml of group A red cells during the course of plasmapheresis. Granulocytopenia, thrombocytopenia, hypofibrinogenemia and low levels of factors V, VIII, and IX developed immediately after the infusion. ...

journal_title：Critical care medicine

authors： McKenna PJ,Scheinman HZ

更新日期：1975-01-01 00:00:00

abstract：OBJECTIVES:The purpose of this study was to determine the accuracy of clinical diagnoses compared to autopsy findings in critically ill patients in the current medical era. DESIGN:We conducted a retrospective, blinded review of matched medical records and postmortem findings in patients who died between June 2006 and ...

journal_title：Critical care medicine

authors： Fröhlich S,Ryan O,Murphy N,McCauley N,Crotty T,Ryan D

更新日期：2014-02-01 00:00:00

abstract：OBJECTIVE:The purpose of this study was to examine the effect of proactive palliative care consultation on length of stay for high-risk patients in the medical intensive care unit (MICU). DESIGN:A prospective pre/post nonequivalent control group design was used for this performance improvement study. SETTING:Seventee...

journal_title：Critical care medicine

authors： Norton SA,Hogan LA,Holloway RG,Temkin-Greener H,Buckley MJ,Quill TE

更新日期：2007-06-01 00:00:00

abstract：OBJECTIVES:To compare the plasma volume (PV) expanding effect of a fast infusion rate with that of a slow infusion rate of a fixed volume of 5% albumin, of the synthetic colloids, 6% hydroxyethyl starch 130/0.4 and 4% gelatin, and of 0.9% NaCl in a rat sepsis model and to compare the plasma-expanding effect among these...

journal_title：Critical care medicine

authors： Bark BP,Persson J,Grände PO

更新日期：2013-03-01 00:00:00

abstract：OBJECTIVES:The objectives of the present study were to evaluate, in patients with persistent arterial hypotension in the immediate postcardiac surgery period, the effects of norepinephrine infusion on ventriculo-arterial coupling, its determinants: arterial elastance and end-systolic ventricular elastance, and to test ...

journal_title：Critical care medicine

authors： Guinot PG,Longrois D,Kamel S,Lorne E,Dupont H

更新日期：2018-01-01 00:00:00

abstract：OBJECTIVE:Although misperceptions about prognosis by surrogates in ICUs are common and influence treatment decisions, there is no validated, practical way to measure the effectiveness of prognostic communication. Surrogates' subjective ratings of quality of communication have been used in other domains as markers of ef...

journal_title：Critical care medicine

authors： Chiarchiaro J,Buddadhumaruk P,Arnold RM,White DB

更新日期：2015-03-01 00:00:00

abstract：OBJECTIVE:To examine the frequency of obtaining Institutional Review Board (IRB) approval and informed consent in critical care research. DATA SOURCES AND DATA EXTRACTION:One-year retrospective review of original critical care research in humans published in seven journals, including American Journal of Respiratory an...

journal_title：Critical care medicine

authors： Matot I,Pizov R,Sprung CL

更新日期：1998-09-01 00:00:00

abstract：OBJECTIVES:To determine the accuracy of intramucosal pH (pHi) calculated using arterial bicarbonate instead of mucosal capillary bicarbonate in the Henderson-Hasselbalch equation. DESIGN:Simulation of progressive ischemia in mucosal capillary blood. SETTING:University research laboratory. SUBJECTS:Normal human blood...

journal_title：Critical care medicine

authors： Morgan TJ,Venkatesh B,Endre ZH

更新日期：1999-11-01 00:00:00

abstract：OBJECTIVE:To study the therapeutic effect of granulocyte colony-stimulating factor (G-CSF) on the mortality rate and host defense pattern in fulminant intra-abdominal sepsis. DESIGN:Prospective, randomized, controlled trial. SETTING:Research laboratory in a university hospital. SUBJECTS:Adult male Wistar rats. INTE...

journal_title：Critical care medicine

authors： Lundblad R,Nesland JM,Giercksky KE

更新日期：1996-05-01 00:00:00

abstract：:We found that altering aspirating flow rate (ASR) and sample tubing length (STL) affected the response time and capnogram of 2 different side-stream capnometers. Increased flow rate shortened rise time, transit time, and total delay time (TDT), whereas increased STL increased transit and TDTs but not rise time. Increa...

journal_title：Critical care medicine

authors： Schena J,Thompson J,Crone RK

更新日期：1984-08-01 00:00:00

abstract：:The focus on improving education in critical care medicine must begin early in medical school training and further be promoted during residency if there is to be an increase in intensivists in the hospital workforce. This is "critical" to healthcare reform movements that are endorsing full-time critical care coverage ...

journal_title：Critical care medicine

authors： Croley WC,Rothenberg DM

更新日期：2007-02-01 00:00:00

abstract：OBJECTIVE:In children, like in adults, tracheal intubation is a painful procedure that may induce hypertension, tachycardia, and other undesirable hemodynamic disorders. Although premature neonates are very sensitive to pain and vulnerable to its long-term effects, the need for sedation before tracheal intubation is st...

journal_title：Critical care medicine

authors： Simon L,Trifa M,Mokhtari M,Hamza J,Treluyer JM

更新日期：2004-02-01 00:00:00

abstract：OBJECTIVE:The successful management of an influenza pandemic will be reliant on the expertise of healthcare workers at high risk for occupationally acquired influenza. Recommended infection control measures for healthcare workers include surgical masks to protect against droplet-spread respiratory transmissible infecti...

journal_title：Critical care medicine

authors： Gralton J,McLaws ML

更新日期：2010-02-01 00:00:00

abstract：OBJECTIVE:The neuroprotective effects of the noble gas xenon are well known. Argon, in contrast to xenon, is abundant, inexpensive, and therefore widely applicable. In this study, we analyzed the possible neuroprotective role of argon in an in vivo rat model of acute focal cerebral ischemia. DESIGN:Controlled laborato...

journal_title：Critical care medicine

authors： Ryang YM,Fahlenkamp AV,Rossaint R,Wesp D,Loetscher PD,Beyer C,Coburn M

更新日期：2011-06-01 00:00:00

abstract：OBJECTIVE:To identify factors associated with granting or refusing intensive care unit (ICU) admission, to analyze ICU characteristics and triage decisions, and to describe mortality in admitted and refused patients. DESIGN:Observational, prospective, multiple-center study. SETTING:Four university hospitals and seven...

journal_title：Critical care medicine

authors： Garrouste-Orgeas M,Montuclard L,Timsit JF,Reignier J,Desmettre T,Karoubi P,Moreau D,Montesino L,Duguet A,Boussat S,Ede C,Monseau Y,Paule T,Misset B,Carlet J,French ADMISSIONREA Study Group.

更新日期：2005-04-01 00:00:00

abstract：:It has become accepted that nitric oxide serves important functions in biological systems as a second messenger. Another diatomic gaseous molecule, carbon monoxide (CO), is also rapidly gaining acceptance as a signaling agent. Some of the activities of CO are analogous to those of nitric oxide in the vascular system a...

journal_title：Critical care medicine

authors： Morse D,Sethi J,Choi AM

更新日期：2001-01-01 00:00:00

abstract：OBJECTIVES:Although highly active antiretroviral therapy has led to improved survival in HIV-infected individuals, outcomes for HIV-infected patients with sepsis in the post-highly active antiretroviral therapy era are conflicting. Access to highly active antiretroviral therapy and healthcare disparities continue to af...

journal_title：Critical care medicine

authors： Cribbs SK,Tse C,Andrews J,Shenvi N,Martin GS

更新日期：2015-08-01 00:00:00

abstract：OBJECTIVES:To compare the incidence of withdrawal or withholding of life support (WD/WHLS), and to identify similarities and differences in the process of the withdrawal of life support (WDLS) between teaching and community hospitals' intensive care units (ICUs). DESIGN:Prospective cohort study, with some data obtaine...

journal_title：Critical care medicine

authors： Keenan SP,Busche KD,Chen LM,Esmail R,Inman KJ,Sibbald WJ

更新日期：1998-02-01 00:00:00

abstract：OBJECTIVE:Conventional outcomes research provides only percentage risk of such end points as mortality rate, utilization of resources, and/or broad groupings of multiple organ system dysfunction. These prognostications generally are not applicable to individual patients. The purpose of the present study was to determin...

journal_title：Critical care medicine

authors： Slotman GJ

更新日期：2002-05-01 00:00:00

abstract：OBJECTIVES:We previously reported gene expression-based endotypes of pediatric septic shock, endotypes A and B, and that corticosteroid exposure was independently associated with increased mortality among pediatric endotype A patients. The Vasopressin vs Norepinephrine as Initial Therapy in Septic Shock trial tested th...

journal_title：Critical care medicine

authors： Wong HR,Hart KW,Lindsell CJ,Sweeney TE

更新日期：2021-01-01 00:00:00

abstract：OBJECTIVE:To define the occurrence rate of acute respiratory distress syndrome (ARDS) using established criteria in a well-defined general patient population, to study the clinical course of ARDS when patients were ventilated using a "lung-protective" strategy, and to define the total costs of care. DESIGN:A 3-yr (199...

journal_title：Critical care medicine

authors： Valta P,Uusaro A,Nunes S,Ruokonen E,Takala J

更新日期：1999-11-01 00:00:00

abstract：OBJECTIVE:Exosomes are small, cell-released vesicles (40-100 nm in size) with the potential to transfer proteins, lipids, small RNAs, messenger RNAs, or DNA between cells via interstitial fluids. Due to their role in tissue homeostasis, exosomes have emerged as a new type of therapeutic and diagnostic (theranostic) too...

journal_title：Critical care medicine

authors： Terrasini N,Lionetti V

更新日期：2017-06-01 00:00:00

abstract：:Computerized gamma scintigraphy revealed a significant (p less than 0.001) rising lung:heart radioactivity ratio, which has been called "slope of injury" or "slope index", with both 99mTechnetium-tagged human serum albumin (99mTc-HSA) and 99mTechnetium-tagged red blood cells (99Tc-RBC) after 0.05 or 0.2 ml/kg iv oleic...

journal_title：Critical care medicine

authors： Sugerman HJ,Hirsch JI,Tatum JL,Strash AM,Sharp DE,Greenfield LJ

更新日期：1982-01-01 00:00:00

abstract：:Doppler ultrasound has been used extensively in assessing adequacy of circulation. We have found it to be convenient in the identification of blood flow, particularly in hypotensive states where percutaneous radial artery cannulation of the vessel is tedious and difficult to perform. The technique is simple, atraumati...

journal_title：Critical care medicine

authors： Nagabhushan S,Colella JJ Jr,Wagner R

更新日期：1976-11-01 00:00:00

abstract：OBJECTIVES:Vital organ hypoperfusion significantly contributes to the dismal survival rates observed with manual cardiopulmonary resuscitation after cardiac arrest. The impedance threshold device is a valve which reduces air entry into lungs during chest recoil between chest compressions, producing a potentially benefi...

journal_title：Critical care medicine

authors： Cabrini L,Beccaria P,Landoni G,Biondi-Zoccai GG,Sheiban I,Cristofolini M,Fochi O,Maj G,Zangrillo A

更新日期：2008-05-01 00:00:00

abstract：OBJECTIVE:We hypothesized that the extent of injury and release of xanthine oxidase, an oxidant generator, into the circulation would be less in normal-flow hypoxia-reoxygenation than in equal duration no-flow ischemia-reperfusion. DESIGN:Randomized study. SETTING:University-based animal research facility. SUBJECTS:...

journal_title：Critical care medicine

authors： Tan S,Yokoyama Y,Wang Z,Zhou F,Nielsen V,Murdoch AD,Adams C,Parks DA

更新日期：1998-06-01 00:00:00

abstract：OBJECTIVES:To determine the incidence and characteristics of children with brain death in the pediatric intensive care unit (ICU), and to assess the incidence of the clinical triad (Turner's triad) of central diabetes insipidus, low glucose demand, and low CO2 production. DESIGN:Retrospective review of medical records...

journal_title：Critical care medicine

authors： Staworn D,Lewison L,Marks J,Turner G,Levin D

更新日期：1994-08-01 00:00:00

abstract：:During a consecutive 17 month period, 15 trauma patients were diagnosed as having a myocardial contusion on the basis of abnormal ECG in 14 patients, elevated creatinine phosphokinase (CPK) in 13 patients, and elevated CPK-Muscle Brain (CPK-MB) isoenzyme determination in 11 patients. Using these screening modalities, ...

journal_title：Critical care medicine

authors： Torres-Mirabal P,Gruenberg JC,Talbert JG,Brown RS

更新日期：1982-01-01 00:00:00

abstract：:The resolution time of pneumothorax in neonates requiring tube thoracotomy is not known. We found that 28%, 50%, and 83% of 54 pneumothoraces in 40 neonates resolved within 24, 96, and 168 h of tube thoracotomy, respectively. Pneumothoraces that persisted beyond 168 h were in infants requiring ventilatory assistance. ...

journal_title：Critical care medicine

authors： Bhatia J,Mathew OP

更新日期：1985-05-01 00:00:00

abstract：OBJECTIVE:To evaluate the prevalence and magnitude of weakness in patients receiving chronic mechanical ventilation and the impact of providing aggressive whole-body rehabilitation on conventional weaning variables, muscle strength, and overall functional status. DESIGN:Retrospective analysis of 49 consecutive patient...

journal_title：Critical care medicine

authors： Martin UJ,Hincapie L,Nimchuk M,Gaughan J,Criner GJ

更新日期：2005-10-01 00:00:00