Clinical Outcomes and Mortality Impact of Hyperbaric Oxygen Therapy in Patients With Carbon Monoxide Poisoning.

Abstract:

OBJECTIVES:Carbon monoxide poisoning affects 50,000 per year in the United States alone. Mortality is approximately 3%, and up to 40% of survivors suffer from permanent neurocognitive and affective deficits. Hyperbaric oxygen therapy has shown benefit on reducing the long-term neurologic sequelae of carbon monoxide poisoning but has not demonstrated improved survival. The objective of this study is to assess the efficacy of hyperbaric oxygen for acute and long-term mortality in carbon monoxide poisoning using a large clinical databank. DESIGN:Retrospective analysis. SETTING:University of Pittsburgh Medical Center healthcare system (Pittsburgh, PA). PATIENTS:One-thousand ninety-nine unique encounters of adult patients with carbon monoxide poisoning. INTERVENTIONS:None. MEASUREMENTS AND MAIN RESULTS:Baseline demographics, laboratory values, hospital charge transactions, discharge disposition, and clinical information from charting were obtained from the electronic medical record. In propensity-adjusted analysis, hyperbaric oxygen therapy was associated with a reduction in inpatient mortality (absolute risk reduction, 2.1% [3.7-0.9%]; p = 0.001) and a reduction in 1-year mortality (absolute risk reduction, 2.1% [3.8-0.4%]; p = 0.013). CONCLUSIONS:These data demonstrate that hyperbaric oxygen is associated with reduced acute and reduced 1-year mortality. Further studies are needed on the mortality effects of hyperbaric oxygen therapy in carbon monoxide poisoning.

journal_name

Crit Care Med

journal_title

Critical care medicine

authors

Rose JJ,Nouraie M,Gauthier MC,Pizon AF,Saul MI,Donahoe MP,Gladwin MT

doi

10.1097/CCM.0000000000003135

subject

Has Abstract

pub_date

2018-07-01 00:00:00

pages

e649-e655

issue

7

eissn

0090-3493

issn

1530-0293

journal_volume

46

pub_type

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