Steady-state pharmacokinetics of dopamine in adult patients.

abstract：OBJECTIVE:As the Surviving Sepsis Campaign was assessing patient-level data over multiple countries, we sought to evaluate the use of a pragmatic and parsimonious severity-of-illness scoring system for patients with sepsis in an attempt to provide appropriate comparisons with practical application. DESIGN:Prospective,...

journal_title：Critical care medicine

authors： Osborn TM,Phillips G,Lemeshow S,Townsend S,Schorr CA,Levy MM,Dellinger RP

更新日期：2014-09-01 00:00:00

abstract：OBJECTIVE:Intrahospital transport of critically ill patients is often necessary for optimal patient care. However, transport of intensive care unit (ICU) patients within the hospital has been associated with a high rate of potentially detrimental complications. This study was designed to determine the occurrence rate o...

journal_title：Critical care medicine

authors： Szem JW,Hydo LJ,Fischer E,Kapur S,Klemperer J,Barie PS

更新日期：1995-10-01 00:00:00

abstract：OBJECTIVES:To assess the amount of nutrients delivered, prescribed, and required for critically ill patients and to identify the reasons for discrepancies between prescriptions and requirements and between prescriptions and actual delivery of nutrition. DESIGN:Prospective cohort study. SETTING:Twelve-bed medical inte...

journal_title：Critical care medicine

authors： De Jonghe B,Appere-De-Vechi C,Fournier M,Tran B,Merrer J,Melchior JC,Outin H

更新日期：2001-01-01 00:00:00

abstract：OBJECTIVES:To examine whether niacin attenuates lung inflammation and improves survival during sepsis and to determine whether the beneficial effects of niacin are associated with downregulation of the nuclear factor (NF)-κB pathway. DESIGN:Prospective laboratory study. SETTING:University laboratory. SUBJECTS:Male S...

journal_title：Critical care medicine

authors： Kwon WY,Suh GJ,Kim KS,Kwak YH

更新日期：2011-02-01 00:00:00

abstract：:The heart rate variability (HRV) of 82 patients exhibiting sinus rhythm and admitted for possible myocardial infarction (MI) was evaluated. Using a simple information entropy measure to quantify the HRV, patients subsequently diagnosed with MI or experiencing significant dysrhythmia (n = 35) exhibited less entropy (0....

journal_title：Critical care medicine

authors： Zbilut JP,Lawson L

更新日期：1988-01-01 00:00:00

abstract：OBJECTIVE:To compare the effects of continuous negative extrathoracic pressure (CNEP) and positive end-expiratory pressure (PEEP) at the same level of transpulmonary pressure. DESIGN:Prospective analysis. SETTING:Medical intensive care unit of a university hospital. PATIENTS:Nine consecutive acute lung injury patien...

journal_title：Critical care medicine

authors： Borelli M,Benini A,Denkewitz T,Acciaro C,Foti G,Pesenti A

更新日期：1998-06-01 00:00:00

abstract：:In April 2009, Mexican, American, and Canadian authorities announced that a novel influenza virus with pandemic potential had been identified in large segments of the population. Within weeks, it became apparent that the world was dealing with the first influenza pandemic in >40 yrs. Despite the unpredictable nature o...

journal_title：Critical care medicine

authors： Lagacé-Wiens PR,Rubinstein E,Gumel A

更新日期：2010-04-01 00:00:00

abstract：OBJECTIVE:To test the hypothesis that trauma-hemorrhagic shock (T/HS)-induced changes in red blood cells (RBC) contribute to the reduction of blood flow in distant organs. DESIGN:Laboratory study. SETTING:Academic medical center laboratory. SUBJECTS:Specific pathogen-free male Sprague-Dawley rats weighing between 25...

journal_title：Critical care medicine

authors： Machiedo GW,Zaets SB,Berezina TL,Xu DZ,Feketova E,Spolarics Z,Deitch EA

更新日期：2009-03-01 00:00:00

abstract：OBJECTIVE:The demand for intensive care beds far exceeds their availability in many European countries. Consequently, many critically ill patients occupy hospital beds outside intensive care units, throughout the hospital. The outcome of patients who fit intensive care unit admission criteria but are hospitalized in re...

journal_title：Critical care medicine

authors： Simchen E,Sprung CL,Galai N,Zitser-Gurevich Y,Bar-Lavi Y,Gurman G,Klein M,Lev A,Levi L,Zveibil F,Mandel M,Mnatzaganian G

更新日期：2004-08-01 00:00:00

abstract：OBJECTIVE:Sepsis-induced multi-organ failure continues to have a high mortality. The liver is an organ central to the disease pathogenesis. The objective of this study was to identify the liver proteins that change in abundance with sepsis and subsequently identify new drug targets. DESIGN:Proteomic discovery study an...

journal_title：Critical care medicine

authors： Dear JW,Leelahavanichkul A,Aponte A,Hu X,Constant SL,Hewitt SM,Yuen PS,Star RA

更新日期：2007-10-01 00:00:00

abstract：OBJECTIVE:To examine the efficacy and safety of proton pump inhibitors in comparison with histamine-2 receptor antagonists for stress-related upper gastrointestinal bleeding prophylaxis among critical care patients. DATA SOURCES:PubMed, EMBASE, Cochrane Library, and ClinicalTrials.gov. STUDY SELECTION:Randomized, con...

journal_title：Critical care medicine

authors： Lin PC,Chang CH,Hsu PI,Tseng PL,Huang YB

更新日期：2010-04-01 00:00:00

abstract：:The venous-arterial PCO2 gradient may increase in certain low-flow states, such as CPR and canine endotoxemia. To determine whether venous hypercarbia also occurs in hemorrhagic shock, we studied 12 anesthetized, mechanically ventilated dogs. We performed laparotomies on the animals, inserting catheters into their ren...

journal_title：Critical care medicine

authors： Benjamin E,Paluch TA,Berger SR,Premus G,Wu C,Iberti TJ

更新日期：1987-05-01 00:00:00

abstract：OBJECTIVE:To study the importance of endothelin-1-induced vasoconstriction in a model of acute and maintained low cardiac output, by investigating regional changes within the mesenteric and particularly the intestinal mucosal circulation. DESIGN:Prospective, controlled animal study. SETTING:University-affiliated rese...

journal_title：Critical care medicine

authors： Burgener D,Laesser M,Treggiari-Venzi M,Oi Y,Jolliet P,Strasser S,Hadengue A,Aneman A

更新日期：2001-08-01 00:00:00

abstract：OBJECTIVE:To investigate the relationship between behavioral alterations and changes in monoaminergic systems provoked by ischemia-reperfusion liver injury in rats. DESIGN:Prospective, randomized, controlled animal study. SETTING:University animal laboratory. SUBJECTS:Male Wistar rats. INTERVENTIONS:Acute liver fai...

journal_title：Critical care medicine

authors： Adachi N,Inoue H,Arai T

更新日期：1998-04-01 00:00:00

abstract：:The records of 101 drowning or near-drowning victims admitted to Children's Hospital of Los Angeles (CHLA) between January 1975 and June 1978 were reviewed. The admission Glasgow coma score could be assigned retrospectively to 94 patients. A low score (less than 5) predicted a high risk group of patients with 80% mort...

journal_title：Critical care medicine

authors： Dean JM,Kaufman ND

更新日期：1981-07-01 00:00:00

abstract：OBJECTIVE:To describe and identify factors associated with mortality rate and quality of life 1 yr after prolonged mechanical ventilation. DESIGN:Prospective, observational cohort study with patient recruitment over 26 months and follow-up for 1 yr. SETTING:Intensive care units at a tertiary care university hospital....

journal_title：Critical care medicine

authors： Chelluri L,Im KA,Belle SH,Schulz R,Rotondi AJ,Donahoe MP,Sirio CA,Mendelsohn AB,Pinsky MR

更新日期：2004-01-01 00:00:00

abstract：OBJECTIVE:To characterize the withholding or withdrawing of life support from patients with severe head injury. SETTING:San Francisco General Hospital, a city and county hospital with a Level I trauma center. DESIGN:A standardized questionnaire was used to collect data on demographics and functional outcome of severe...

journal_title：Critical care medicine

authors： O'Callahan JG,Fink C,Pitts LH,Luce JM

更新日期：1995-09-01 00:00:00

abstract：OBJECTIVE:To describe a severe axonal polyneuropathy that follows acute respiratory failure and, in turn, causes continued ventilator dependence and paralysis after resolution of the primary illness. DESIGN:Retrospective chart review of three patients and prospective analysis of two patients. SETTING:Respiratory and ...

journal_title：Critical care medicine

authors： Gorson KC,Ropper AH

更新日期：1993-02-01 00:00:00

abstract：OBJECTIVE:Exposure of neutrophils to low doses of bacterial lipopolysaccharides enhances their readiness to respond with inflammatory mediator generation including oxygen radical formation to a subsequently applied inflammatory stimulus ("priming"). In the present study, we investigated the role of lipid mediator synth...

journal_title：Critical care medicine

authors： Sibelius U,Hattar K,Hoffmann S,Mayer K,Grandel U,Schenkel A,Seeger W,Grimminger F

更新日期：2002-10-01 00:00:00

abstract：BACKGROUND:Noninvasive positive-pressure ventilation (NPPV) has been shown to be effective in select patients enrolled in clinical trials. However, few data are available on the use of NPPV as routine standard medical care for patients with respiratory failure outside of controlled trials. MEASUREMENTS AND MAIN RESULT...

journal_title：Critical care medicine

authors： Schettino G,Altobelli N,Kacmarek RM

更新日期：2008-02-01 00:00:00

abstract：OBJECTIVES:Lung contusion is a major risk factor for the development of acute respiratory distress syndrome. We set to determine the role of toll-like receptor 3 and the binding of double-stranded RNA in the pathogenesis of sterile injury following lung contusion. DESIGN:Toll-like receptor 3 expression was analyzed in...

journal_title：Critical care medicine

authors： Suresh MV,Thomas B,Machado-Aranda D,Dolgachev VA,Kumar Ramakrishnan S,Talarico N,Cavassani K,Sherman MA,Hemmila MR,Kunkel SL,Walter NG,Hogaboam CM,Raghavendran K

更新日期：2016-11-01 00:00:00

abstract：OBJECTIVE:To develop a pharmacokinetic-pharmacogenomic population model of morphine in critically ill children with acute respiratory failure. DESIGN:Prospective pharmacokinetic-pharmacogenomic observational study. SETTING:Thirteen PICUs across the United States. PATIENTS:Pediatric subjects (n = 66) mechanically ven...

journal_title：Critical care medicine

authors： Zuppa AF,Benitez GR,Zane NR,Curley MAQ,Bradfield J,Hakonarson H,Gastonguay MS,Moorthy G,Prodell J,Gastonguay MR

更新日期：2019-06-01 00:00:00

abstract：OBJECTIVES:Randomized trials have suggested that hypertonic saline solutions may be superior to mannitol for the treatment of elevated intracranial pressure, but their impact on clinical practice has been limited, partly by their small size. We therefore combined their findings in a meta-analysis. DATA SOURCES:We sear...

journal_title：Critical care medicine

authors： Kamel H,Navi BB,Nakagawa K,Hemphill JC 3rd,Ko NU

更新日期：2011-03-01 00:00:00

abstract：OBJECTIVE:To evaluate the effectiveness of lorazepam and midazolam for long-term sedation of critically ill, mechanically ventilated patients. DESIGN:Double-blind, randomized, controlled study. SETTING:Medical intensive care unit in a university teaching hospital. PATIENTS:Sixty-four evaluable adult patients admitte...

journal_title：Critical care medicine

authors： Swart EL,van Schijndel RJ,van Loenen AC,Thijs LG

更新日期：1999-08-01 00:00:00

abstract：OBJECTIVE:To examine the effects of mechanical ventilation with a tidal volume of 6 mL/kg compared with 12 mL/kg predicted body weight on hemodynamics, vasopressor use, fluid balance, diuretics, sedation, and neuromuscular blockade within 48 hrs in patients with acute lung injury and acute respiratory distress syndrome...

journal_title：Critical care medicine

authors： Cheng IW,Eisner MD,Thompson BT,Ware LB,Matthay MA,Acute Respiratory Distress Syndrome Network.

更新日期：2005-01-01 00:00:00

abstract：:The use of epidural opioids for postoperative analgesia has been associated with respiratory depression. This report demonstrates the ability of nalbuphine to rapidly reverse the respiratory depression caused by epidural sufentanil while maintaining postoperative pain relief. ...

journal_title：Critical care medicine

authors： Cheng EY,May J

更新日期：1989-04-01 00:00:00

abstract：OBJECTIVE:With limited community services, the complex rehabilitation period after critical illness is often the responsibility of family members who, as a result, may experience negative health outcomes. The objectives of this research were to a) identify aspects of the caregiving situation that are associated with ca...

journal_title：Critical care medicine

authors： Cameron JI,Herridge MS,Tansey CM,McAndrews MP,Cheung AM

更新日期：2006-01-01 00:00:00

abstract：OBJECTIVE:Because anemia of inflammation is common in ICU patients and hepcidin is the key regulator of iron homeostasis, we examined time-dependent changes in hepcidin, erythropoietin, iron, and inflammatory markers in surgical ICU patients with anemia. DESIGN:Prospective single-center clinical noninterventional stud...

journal_title：Critical care medicine

authors： Cherry-Bukowiec JR,Engoren M,Wiktor A,Raghavendran K,Napolitano LM

更新日期：2018-06-01 00:00:00

abstract：OBJECTIVE:Develop a scoring system that can assess the management of septic shock by individuals and teams. DESIGN:Retrospective review of videotapes of critical care house staff managing a standardized simulation of septic shock. SETTING:Academic medical center; videotapes were made in a recreated intensive care uni...

journal_title：Critical care medicine

authors： Ottestad E,Boulet JR,Lighthall GK

更新日期：2007-03-01 00:00:00

abstract：OBJECTIVES:We investigated whether preexisting kidney function determines if ICU patients may benefit from increased (2.0 g/kg/d) protein intake. DESIGN:Post hoc, hypothesis-generating, subgroup analysis of a multicenter, phase 2, randomized clinical trial. All analyses were conducted by intention to treat and maintai...

journal_title：Critical care medicine

authors： Zhu R,Allingstrup MJ,Perner A,Doig GS,Nephro-Protective Trial Investigators Group.

更新日期：2018-08-01 00:00:00