Decreased heart rate variability in significant cardiac events.

abstract：OBJECTIVE:To test whether spectral indices derived from the electroencephalogram (EEG), and especially the bispectral index (BIS), can be used as measures of neurologic status in unsedated, critically ill patients. DESIGN:Prospective, observational study. SETTING:Medical intensive care unit (ICU) of a university-affi...

journal_title：Critical care medicine

authors： Gilbert TT,Wagner MR,Halukurike V,Paz HL,Garland A

更新日期：2001-10-01 00:00:00

abstract：:Severe complications sometimes occur in critically ill patients during intrahospital transport. Possible causes may be inadequate ventilation, insufficient monitoring, interrupted application of vasoactive drugs, or disconnections and accidental extubation. We constructed a transport unit equipped with a respirator; c...

journal_title：Critical care medicine

authors： Link J,Krause H,Wagner W,Papadopoulos G

更新日期：1990-12-01 00:00:00

abstract：OBJECTIVES:To determine whether contemporary β-lactam anti-infective dosing recommendations in critically ill children achieve concentrations associated with maximal anti-infective activity. The secondary objective was to describe the microbiological and clinical outcomes associated with β-lactam therapeutic drug manag...

journal_title：Critical care medicine

authors： Cies JJ,Moore WS 2nd,Enache A,Chopra A

更新日期：2018-02-01 00:00:00

abstract：OBJECTIVE:Sepsis remains a major health threat in intensive care medicine. The renin-angiotensin system (ACE) affects inflammatory responses. In addition, angiotensin-converting enzyme inhibitors act to ameliorate lung injury. To investigate whether the widely used ACE inhibitor enalapril, used to treat hypertension, c...

journal_title：Critical care medicine

authors： Hagiwara S,Iwasaka H,Matumoto S,Hidaka S,Noguchi T

更新日期：2009-02-01 00:00:00

abstract：OBJECTIVE:To review recent advances in the use of transforming growth factor (TGF)-beta in acute lung injury and to apply this knowledge to understanding the pathophysiology of this syndrome. DATA SOURCES AND STUDY SELECTION:Published research and review articles in the English language related to the role of TGF-beta...

journal_title：Critical care medicine

authors： Dhainaut JF,Charpentier J,Chiche JD

更新日期：2003-04-01 00:00:00

abstract：:By definition, the acute respiratory distress syndrome is associated with diffuse cellular infiltration and proteinaceous edema. It is generally believed that the widespread injury that characterizes acute respiratory distress syndrome is a process that is launched almost synchronously throughout the lung, caused by b...

journal_title：Critical care medicine

authors： Marini JJ

更新日期：2010-10-01 00:00:00

abstract：OBJECTIVES:We recently reported that bacterial lipopolysaccharide stimulates release of tumor necrosis factor (TNF)-alpha from both human vascular tissue and cultured smooth muscle cells. In the current study, we tested the hypothesis that increased intracellular cyclic adenosine 3',5'-monophosphate (cAMP) could inhibi...

journal_title：Critical care medicine

authors： Zhang LM,Castresana MR,Shaker IJ,Dalton ML,Leeper-Woodford SK,Newman WH

更新日期：1997-11-01 00:00:00

abstract：:We studied prospectively 40 critically ill neurosurgical patients who required prolonged mechanical ventilation to determine the current incidence of stress-related gastroduodenal erosions and ulcers, and to assess endoscopically the efficacy of acid-reducing prophylactic treatment. Nineteen patients were randomized t...

journal_title：Critical care medicine

authors： Reusser P,Gyr K,Scheidegger D,Buchmann B,Buser M,Zimmerli W

更新日期：1990-03-01 00:00:00

abstract：OBJECTIVE:Acute aneurysmal subarachnoid hemorrhage (SAH) is a complex multifaceted disorder that plays out over days to weeks. Many patients with SAH are seriously ill and require a prolonged intensive care unit stay. Cardiopulmonary complications are common. The management of patients with SAH focuses on the anticipat...

journal_title：Critical care medicine

authors： Diringer MN

更新日期：2009-02-01 00:00:00

abstract：OBJECTIVE:When a patient is incompetent, the family is often considered to be a natural surrogate. The doctors' responsiveness to family wishes may vary. We explored if doctors' personal characteristics were associated with responsiveness to the relatives' wishes when admission to the intensive care unit (ICU) is consi...

journal_title：Critical care medicine

authors： Escher M,Perneger TV,Heidegger CP,Chevrolet JC

更新日期：2009-02-01 00:00:00

abstract：OBJECTIVE:To describe the management of patients in an ICU during failure of both primary and backup electrical systems, resulting in nonfunctioning monitors, mechanical ventilators, and other life-support equipment. DESIGN:Case report of power outage and discussion. SETTING:A 45-bed cardiothoracic surgical ICU in a ...

journal_title：Critical care medicine

authors： O'Hara JF Jr,Higgins TL

更新日期：1992-06-01 00:00:00

abstract：OBJECTIVE:To examine the effect of glycosylated recombinant human tumor necrosis factor binding protein-1 (r-hTNF binding protein-1), the extracellular domain of the tumor necrosis factor receptor p55 produced in mammalian cells, in a rabbit model of circulatory shock due to Escherichia coli. DESIGN:Prospective, rando...

journal_title：Critical care medicine

authors： Porat R,Paddock HN,Schwaitzberg SD,Connolly RJ,Wilkens T,Dasch JR,Gascon MP,Hutchison JS,Ythier A,Wallach D

更新日期：1995-06-01 00:00:00

abstract：:Accurate assessment and rapid decision-making are essential to save lives and improve performance in critical care medicine. Real-time point-of-care ultrasound has become an invaluable adjunct to the clinical evaluation of critically ill and injured patients both for pre- and in-hospital situations. However, a high le...

journal_title：Critical care medicine

authors： Neri L,Storti E,Lichtenstein D

更新日期：2007-05-01 00:00:00

abstract：OBJECTIVE:To determine the blood discard volume, as a multiple of deadspace, that is required for accurate arterial blood gas and electrolyte testing from arterial catheters. DESIGN:Prospective, controlled, crossover trial. SETTING:Eighteen-bed intensive care unit of a metropolitan teaching hospital. PATIENTS:A tota...

journal_title：Critical care medicine

authors： Rickard CM,Couchman BA,Schmidt SJ,Dank A,Purdie DM

更新日期：2003-06-01 00:00:00

abstract：OBJECTIVES:To evaluate the impact of an emergency department mechanical ventilation protocol on clinical outcomes and adherence to lung-protective ventilation in patients with acute respiratory distress syndrome. DESIGN:Quasi-experimental, before-after trial. SETTING:Emergency department and ICUs of an academic cente...

journal_title：Critical care medicine

authors： Fuller BM,Ferguson IT,Mohr NM,Drewry AM,Palmer C,Wessman BT,Ablordeppey E,Keeperman J,Stephens RJ,Briscoe CC,Kolomiets AA,Hotchkiss RS,Kollef MH

更新日期：2017-04-01 00:00:00

abstract：OBJECTIVES:Extracorporeal membrane oxygenation is used to stabilize severe cardiocirculatory and/or respiratory failure. However, extracorporeal membrane oxygenation is associated with a coagulopathy characterized by thromboembolic and hemorrhagic complications. This study aimed to characterize the pathomechanism of th...

journal_title：Critical care medicine

authors： Granja T,Hohenstein K,Schüssel P,Fischer C,Prüfer T,Schibilsky D,Wendel HP,Jaschonek K,Serna-Higuita L,Schlensak C,Häberle H,Rosenberger P,Straub A

更新日期：2020-05-01 00:00:00

abstract：OBJECTIVE:Physiologic and pathologic comparison of two modes of assisted ventilation, nasal intermittent positive-pressure ventilation (NIPPV) and synchronized intermittent mandatory ventilation (SIMV), in spontaneously breathing term newborn piglets with saline lavage-induced lung injury. DESIGN:After inducing acute ...

journal_title：Critical care medicine

authors： Lampland AL,Meyers PA,Worwa CT,Swanson EC,Mammel MC

更新日期：2008-01-01 00:00:00

abstract：:We developed a method to measure accurately pressures at the airway opening (Pao) and in the trachea (Ptr) in neonates during high frequency oscillatory ventilation (HFOV) from 15-30 Hz. All component parts of the pressure-measuring system were tested as a unit against a reference transducer in a closed chamber in whi...

journal_title：Critical care medicine

authors： Boynton BR,Mannino FL,Meathe EA,Kopotic RJ,Friederichsen G

更新日期：1984-01-01 00:00:00

abstract：OBJECTIVES:Regional tidal lung strain may trigger local inflammation during mechanical ventilation, particularly when additional inflammatory stimuli are present. However, it is unclear whether inflammation develops proportionally to tidal strain or only above a threshold. We aimed to 1) assess the relationship between...

journal_title：Critical care medicine

authors： Wellman TJ,Winkler T,Costa EL,Musch G,Harris RS,Zheng H,Venegas JG,Vidal Melo MF

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND:Early excision with autograft-allograft closure is standard in severe burn management. Cadaver skin is associated with risks such as antigenicity, infection, and limited availability and shelf life. Previous studies have shown that Integra is safe to use in burns of <20% total body surface area. However, the...

journal_title：Critical care medicine

authors： Branski LK,Herndon DN,Pereira C,Mlcak RP,Celis MM,Lee JO,Sanford AP,Norbury WB,Zhang XJ,Jeschke MG

更新日期：2007-11-01 00:00:00

abstract：:Subcutaneous, transcutaneous, and conjunctival oxygen tensions (PscO2, PtcO2, and PcjO2, respectively) were measured in anesthetized dogs subjected sequentially to normoxia, hyperoxia, and hypoxia. Intravascular pressure, hemodynamic and oxygen transport variables were measured simultaneously. PtcO2 and PcjO2 closely ...

journal_title：Critical care medicine

authors： Gottrup F,Gellett S,Kirkegaard L,Hansen ES,Johannsen G

更新日期：1988-12-01 00:00:00

abstract：OBJECTIVE:Trauma induces a complex immune response that requires a systems biology research approach. Here, we used a novel technology, mass cytometry by time-of-flight, to comprehensively characterize the multicellular response to trauma. DESIGN:Peripheral blood mononuclear cells samples were stained with a 38-marker...

journal_title：Critical care medicine

authors： Seshadri A,Brat GA,Yorkgitis BK,Keegan J,Dolan J,Salim A,Askari R,Lederer JA

更新日期：2017-09-01 00:00:00

abstract：OBJECTIVE:To evaluate a new technique for pressure-volume curve tracing. DESIGN:Prospective experimental study. SETTING:Animal research laboratory. SUBJECTS:Six anesthetized rats. INTERVENTIONS:Two pressure-volume curves were obtained by means of the super-syringe method (gold standard) and the continuous positive ...

journal_title：Critical care medicine

authors： Albaiceta GM,Piacentini E,Villagrá A,Lopez-Aguilar J,Taboada F,Blanch L

更新日期：2003-10-01 00:00:00

abstract：OBJECTIVE:To assess the effects of dopexamine on splanchnic blood flow and splanchnic oxygen uptake in septic patients. DESIGN:A prospective, controlled trial. SETTING:A ten-bed intensive care unit (ICU) in a university hospital. PATIENTS:Twelve patients with severe sepsis (according to the criteria of the 1992 Amer...

journal_title：Critical care medicine

authors： Meier-Hellmann A,Bredle DL,Specht M,Hannemann L,Reinhart K

更新日期：1999-10-01 00:00:00

abstract：:Twenty-four pediatric patients undergoing corrective posterior spinal fusion surgery for idiopathic scoliosis were studied to determine the frequency with which the syndrome of inappropriate antidiuretic hormone secretion (SIADH) developed. We measured arterial blood gases, serum and urine electrolytes and osmolalitie...

journal_title：Critical care medicine

authors： Burrows FA,Shutack JG,Crone RK

更新日期：1983-07-01 00:00:00

abstract：OBJECTIVE:To determine the ability of somatosensory evoked potentials (SEP) compared with clinical findings to monitor and predict recovery in patients suffering from closed head injury with predominantly diffuse axonal injury (DAI). DESIGN:Prospective cohort study. SETTING:Neurologic intensive care unit (ICU) of a u...

journal_title：Critical care medicine

authors： Claassen J,Hansen HC

更新日期：2001-03-01 00:00:00

abstract：OBJECTIVES:The American College of Critical Care Medicine provided 2002 and 2007 guidelines for hemodynamic support of newborn and pediatric septic shock. Provide the 2014 update of the 2007 American College of Critical Care Medicine "Clinical Guidelines for Hemodynamic Support of Neonates and Children with Septic Shoc...

journal_title：Critical care medicine

authors： Davis AL,Carcillo JA,Aneja RK,Deymann AJ,Lin JC,Nguyen TC,Okhuysen-Cawley RS,Relvas MS,Rozenfeld RA,Skippen PW,Stojadinovic BJ,Williams EA,Yeh TS,Balamuth F,Brierley J,de Caen AR,Cheifetz IM,Choong K,Conway E Jr,Cor

更新日期：2017-06-01 00:00:00

abstract：OBJECTIVES:To compare the incidence of withdrawal or withholding of life support (WD/WHLS), and to identify similarities and differences in the process of the withdrawal of life support (WDLS) between teaching and community hospitals' intensive care units (ICUs). DESIGN:Prospective cohort study, with some data obtaine...

journal_title：Critical care medicine

authors： Keenan SP,Busche KD,Chen LM,Esmail R,Inman KJ,Sibbald WJ

更新日期：1998-02-01 00:00:00

abstract：OBJECTIVE:To investigate glycemic dynamics and its relation with mortality in critically ill patients. We searched for differences in complexity of the glycemic profile between survivors and nonsurvivors in patients admitted to a multidisciplinary intensive care unit. DESIGN:Prospective, observational study, convenien...

journal_title：Critical care medicine

authors： Lundelin K,Vigil L,Bua S,Gomez-Mestre I,Honrubia T,Varela M

更新日期：2010-03-01 00:00:00

abstract：OBJECTIVE:The value of different algorithms that estimate cardiac output (CO) by analysis of a peripheral arterial blood pressure (ABP) waveform has not been definitively identified. In this investigation, we developed a testing data set containing a large number of radial ABP waveform segments and contemporaneous refe...

journal_title：Critical care medicine

authors： Sun JX,Reisner AT,Saeed M,Heldt T,Mark RG

更新日期：2009-01-01 00:00:00