Decreased heart rate variability in significant cardiac events.


:The heart rate variability (HRV) of 82 patients exhibiting sinus rhythm and admitted for possible myocardial infarction (MI) was evaluated. Using a simple information entropy measure to quantify the HRV, patients subsequently diagnosed with MI or experiencing significant dysrhythmia (n = 35) exhibited less entropy (0.28 +/- 0.15) within the first 24 h after admission than those patients (n = 45) with no MI (0.36 +/- 0.14; p less than .01). Although correlations between entropy and age and heart rate (HR) were significant (p less than .01), the additional explained variance was minimal. The groups were compared for sex, age, mean HR, past medical history and medications taken and were found to be statistically similar. In our patients without significant dysrhythmias on admission, HRV appeared to be an index for significant cardiac events, and thus may prove to be a useful tool in clinical situations where other objective decision criteria are lacking.


Crit Care Med


Critical care medicine


Zbilut JP,Lawson L




Has Abstract


1988-01-01 00:00:00












  • Impact of a pediatric clinical pharmacist in the pediatric intensive care unit.

    abstract:OBJECTIVE:To study the impact of a clinical pharmacist in a pediatric intensive care unit. The goals of the study were to determine the type and quantity of patient care interventions recommended by a clinical pharmacist and to specifically examine cost savings (or loss) that resulted from clinical pharmacist recommend...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Krupicka MI,Bratton SL,Sonnenthal K,Goldstein B

    更新日期:2002-04-01 00:00:00

  • Meconium and amniotic fluid embolism: effects on coagulation in pregnant mini-pigs.

    abstract:OBJECTIVE:A hallmark of amniotic fluid embolism is the induction of coagulation defects. Little is known about the nature of these defects or the causative agent or agents. The purpose of this study was to assess the effects of meconium containing (native) meconium-amniotic-fluid infusion (MAFI) and meconium-free (cent...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Petroianu GA,Altmannsberger SH,Maleck WH,Assmus HP,Friedberg C,Bergler WF,Rüfer R

    更新日期:1999-02-01 00:00:00

  • Acute renal failure in the newborn.

    abstract::Recent advances in prenatal and neonatal care have increased the number of live births and extended the life expectancy of critically ill premature infants. These infants represent a formidable therapeutic challenge in that multisystem involvement and previously uncommon conditions, such as intravascular coagulation, ...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Aschinberh LC,Zeis PM,Hageman JR,Vidyasagar D

    更新日期:1977-01-01 00:00:00

  • Intra-aortic balloon pump effects on macrocirculation and microcirculation in cardiogenic shock patients supported by venoarterial extracorporeal membrane oxygenation*.

    abstract:OBJECTIVES:This study was designed to assess the effects on macrocirculation and microcirculation of adding an intra-aortic balloon pump to peripheral venoarterial extracorporeal membrane oxygenation in patients with severe cardiogenic shock and little/no residual left ventricular ejection. DESIGN:A prospective, singl...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Petroni T,Harrois A,Amour J,Lebreton G,Brechot N,Tanaka S,Luyt CE,Trouillet JL,Chastre J,Leprince P,Duranteau J,Combes A

    更新日期:2014-09-01 00:00:00

  • Oxygen saturation determined from deep muscle, not thenar tissue, is an early indicator of central hypovolemia in humans.

    abstract:OBJECTIVE:To compare the responses of noninvasively measured tissue oxygen saturation (StO2) and calculated muscle oxygen tension (PmO2) to standard hemodynamic variables for early detection of imminent hemodynamic instability during progressive central hypovolemia in humans. DESIGN:Prospective study. SETTING:Researc...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Soller BR,Ryan KL,Rickards CA,Cooke WH,Yang Y,Soyemi OO,Crookes BA,Heard SO,Convertino VA

    更新日期:2008-01-01 00:00:00

  • Epidemiology of Chronic Critical Illness in Japan: A Nationwide Inpatient Database Study.

    abstract:OBJECTIVES:The epidemiology of chronic critical illness is not well known. We aimed to estimate the prevalence, mortality, and costs associated with chronic critical illness in Japan. DESIGN:A nationwide inpatient administrative database study in Japan from April 2011 to March 2018. SETTING:Six hundred seventy-nine a...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Ohbe H,Matsui H,Fushimi K,Yasunaga H

    更新日期:2021-01-01 00:00:00

  • Neuronal nitric oxide synthase and its interaction with soluble guanylate cyclase is a key factor for the vascular dysfunction of experimental sepsis.

    abstract:OBJECTIVE:Vascular dysfunction plays a central role in sepsis, and it is characterized by hypotension and hyporesponsiveness to vasoconstrictors. Nitric oxide is regarded as a central element of sepsis vascular dysfunction. The high amounts of nitric oxide produced during sepsis are mainly derived from the inducible is...

    journal_title:Critical care medicine

    pub_type: 杂志文章,随机对照试验


    authors: Nardi GM,Scheschowitsch K,Ammar D,de Oliveira SK,Arruda TB,Assreuy J

    更新日期:2014-06-01 00:00:00

  • Postresuscitation cyclosporine treatment attenuates myocardial and cardiac mitochondrial injury in newborn piglets with asphyxia-reoxygenation.

    abstract:OBJECTIVES:Cardiovascular dysfunction occurs in the majority of asphyxiated neonates and has been suggested to be a major cause of neonatal morbidity and mortality. We previously demonstrated that cyclosporine A treatment during resuscitation can significantly improve cardiovascular performance in asphyxiated newborn p...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Gill RS,Lee TF,Manouchehri N,Liu JQ,Lopaschuk G,Bigam DL,Cheung PY

    更新日期:2013-04-01 00:00:00

  • Heart-lung interactions measured by electrical impedance tomography.

    abstract:OBJECTIVE:The clinical value of stroke volume variations to assess intravascular fluid status in critically ill patients is well known. Electrical impedance tomography is a noninvasive monitoring technology that has been primarily used to assess ventilation. We investigated the potential of electrical impedance tomogra...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Maisch S,Bohm SH,Solà J,Goepfert MS,Kubitz JC,Richter HP,Ridder J,Goetz AE,Reuter DA

    更新日期:2011-09-01 00:00:00

  • Therapeutic hypercapnia enhances the inflammatory response to endotoxin in the lung of spontaneously breathing rats.

    abstract:OBJECTIVE:To test the hypothesis that therapeutic hypercapnia enhances the proinflammatory responses to endotoxemia in the lung and spleen of rats. DESIGN:Prospective randomized study. SETTINGS:Hospital research institute. SUBJECTS:Forty-eight adult male rats. INTERVENTIONS:Rats were randomly assigned for a 24-hr p...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Norozian FM,Leoncio M,Torbati D,Meyer K,Raszynski A,Totapally BR

    更新日期:2011-06-01 00:00:00

  • The effects of a fluctuating Fio2 on metabolic measurements in mechanically ventilated patients.

    abstract::The determination of minute oxygen consumption (VO2) for metabolic studies on patients using either the Beckman Metabolic Cart (MMC) or the Respiratory Monitoring System (RMS) requires a stable fractional inspired oxygen concentration (FIO2). Measurement of VO2 on mechanically ventilated patients using the Bourns BEAR...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Browning JA,Linberg SE,Turney SZ,Chodoff P

    更新日期:1982-02-01 00:00:00

  • Endotoxin increases plasma leptin and ghrelin levels in dogs.

    abstract:OBJECTIVE:Evaluations of plasma leptin and ghrelin levels and their relations with circulating levels of proinflammatory mediators, stress hormones, and biochemical markers of hepatorenal injury during experimental endotoxemia in dogs. SETTING:Uludag University. DESIGN:Placebo-controlled animal study. ANIMALS:Adult ...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Yilmaz Z,Ilcol YO,Ulus IH

    更新日期:2008-03-01 00:00:00

  • Translational Sepsis Research: Spanning the Divide.

    abstract:OBJECTIVE:Our knowledge of the molecular mechanisms of sepsis has attained exponential growth. Yet, the pillars of its care remain antibiotics, fluid resuscitation, and physiologic support of failing organ systems. The inability to bring biologic breakthroughs to the bedside is not for lack of effort. Over 60 clinical ...

    journal_title:Critical care medicine

    pub_type: 杂志文章,评审


    authors: Lewis AJ,Lee JS,Rosengart MR

    更新日期:2018-09-01 00:00:00

  • Evaluation of the utility of computed tomography in the initial assessment of the critical care patient with chest trauma.

    abstract:OBJECTIVE:To determine the utility of thoracic computed tomography (TCT) in the initial assessment of critically ill patients with chest injuries. DESIGN:Prospective observational study of cohorts. SETTING:Trauma intensive care unit (ICU) of a Spanish Level III hospital (US equivalent Level I). PATIENTS:Three hundre...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Guerrero-López F,Vázquez-Mata G,Alcázar-Romero PP,Fernández-Mondéjar E,Aguayo-Hoyos E,Linde-Valverde CM

    更新日期:2000-05-01 00:00:00

  • Mortality and intensive care volume in ventilated patients from 1995 to 2009 in the Australian and New Zealand binational adult patient intensive care database*.

    abstract:OBJECTIVES:The mortality outcome of mechanical ventilation, a key intervention in the critically ill, has been variously reported to be determined by intensive care patient volume. We determined the volume-(mortality)-outcome relationship of mechanically ventilated patients whose records were contributed to the Austral...

    journal_title:Critical care medicine

    pub_type: 杂志文章,多中心研究


    authors: Moran JL,Solomon PJ,ANZICS Centre for Outcome and Resource Evaluation of the Australian and New Zealand Intensive Care Society.

    更新日期:2012-03-01 00:00:00

  • Effect of different cycling-off criteria and positive end-expiratory pressure during pressure support ventilation in patients with chronic obstructive pulmonary disease.

    abstract:OBJECTIVE:During pressure support ventilation, ventilator inspiration ends when inspiratory flow drops to a given percentage of the peak inspiratory flow cycling-off criteria. This study evaluated the effect of two different cycling-off criteria on breathing pattern, respiratory effort, and gas exchange in patients wit...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Chiumello D,Polli F,Tallarini F,Chierichetti M,Motta G,Azzari S,Colombo R,Rech R,Pelosi P,Raimondi F,Gattinoni L

    更新日期:2007-11-01 00:00:00

  • Comparison between selective and nonselective nitric oxide synthase inhibition and phenylephrine in normal and endotoxic swine.

    abstract:OBJECTIVE:To compare the cardiopulmonary and peripheral circulatory effects of the nonselective nitric oxide synthase (NOS) inhibitor NG-nitro-L-arginine methyl ester (L-NAME) to the more selective inducible NOS inhibitor S-methylisothiourea (SMT) and to phenylephrine (PE) in endotoxic and normal swine. DESIGN:Prospec...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Cohen RI,Shapir Y,Davis A,Loona R,Scharf SM

    更新日期:2000-09-01 00:00:00

  • Clinical practice guidelines for the maintenance of patient physical safety in the intensive care unit: use of restraining therapies--American College of Critical Care Medicine Task Force 2001-2002.

    abstract:OBJECTIVE:To develop clinical practice guidelines for the use of restraining therapies to maintain physical and psychological safety of adult and pediatric patients in the intensive care unit. PARTICIPANTS:A multidisciplinary, multispecialty task force of experts in critical care practice was convened from the members...

    journal_title:Critical care medicine

    pub_type: 杂志文章,评审


    authors: Maccioli GA,Dorman T,Brown BR,Mazuski JE,McLean BA,Kuszaj JM,Rosenbaum SH,Frankel LR,Devlin JW,Govert JA,Smith B,Peruzzi WT,American College of Critical Care Medicine, Society of Critical Care Medicine.

    更新日期:2003-11-01 00:00:00

  • A survey of successful FFARACS candidates in Australasia.

    abstract::As of October 1985, 37 candidates have passed the final examination in intensive care for the Diploma of Fellow of the Faculty of Anaesthetists, Royal Australasian College of Surgeons (FFARACS). In September 1984, 23 of these successful candidates responded to a questionnaire seeking information on their educational e...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Byth PL,Harrison GA

    更新日期:1986-06-01 00:00:00

  • Therapeutic hypothermia after cardiac arrest in clinical practice: review and compilation of recent experiences.

    abstract:OBJECTIVES:We sought to review findings from recent literature on the postresuscitation care of cardiac arrest patients using therapeutic hypothermia as part of nontrial treatment. DESIGN:Literature review. SETTING:Hospital-based environment. SUBJECTS:Patients initially resuscitated from cardiac arrest who underwent...

    journal_title:Critical care medicine

    pub_type: 杂志文章,评审


    authors: Sagalyn E,Band RA,Gaieski DF,Abella BS

    更新日期:2009-07-01 00:00:00

  • Perceptions of Ethical Decision-Making Climate Among Clinicians Working in European and U.S. ICUs: Differences Between Nurses and Physicians.

    abstract:OBJECTIVES:To examine perceptions of nurses and physicians in regard to ethical decision-making climate in the ICU and to test the hypothesis that the worse the ethical decision-making climate, the greater the discordance between nurses' and physicians' rating of ethical decision-making climate with physicians hypothes...

    journal_title:Critical care medicine

    pub_type: 杂志文章,多中心研究


    authors: Jensen HI,Hebsgaard S,Hansen TCB,Johnsen RFA,Hartog CS,Soultati I,Szucs O,Wilson ME,van den Bulcke B,Benoit DD,Piers R

    更新日期:2019-12-01 00:00:00

  • Understanding the pressure cost of ventilation: why does high-frequency ventilation work?

    abstract:OBJECTIVES:To understand when the use of high-frequency ventilation would be advantageous, we formulated the problem of achieving adequate alveolar ventilation at minimal pressure cost by dividing it into two simpler problems: a) the pressure cost per unit of convective oscillatory flow; and b) the convective flow cost...

    journal_title:Critical care medicine

    pub_type: 杂志文章,评审


    authors: Venegas JG,Fredberg JJ

    更新日期:1994-09-01 00:00:00

  • Perceptions of a critically ill patient experiencing therapeutic paralysis in an ICU.

    abstract::Prolonged therapeutic paralysis with pancuronium is commonly used in ICUs to facilitate mechanical ventilation of patients with respiratory failure. Sedation is usually given concomitantly to reduce patient discomfort, but assessment of its adequacy is made difficult by the paralysis. We recently cared for a former IC...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Parker MM,Schubert W,Shelhamer JH,Parrillo JE

    更新日期:1984-01-01 00:00:00

  • Assessment of patients' experience of discomforts during respirator therapy.

    abstract::Patients (n = 158) who had been respirator-treated and who could remember the treatment were retrospectively (after greater than 2 months) interviewed about their experiences. Of all patients, 47% had felt anxiety and/or fear during the treatment. These feelings were intimately related to the experience of agony/panic...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Bergbom-Engberg I,Haljamäe H

    更新日期:1989-10-01 00:00:00

  • The Impella 2.5 and 5.0 devices for ST-elevation myocardial infarction patients presenting with severe and profound cardiogenic shock: the Academic Medical Center intensive care unit experience.

    abstract:OBJECTIVE:Cardiogenic shock remains an important therapeutic challenge, with high in-hospital mortality rates. Mechanical circulatory support may be beneficial in these patients. Since the efficacy of the intra-aortic balloon pump seems limited, new percutaneously placed mechanical left ventricular support devices, suc...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Engström AE,Cocchieri R,Driessen AH,Sjauw KD,Vis MM,Baan J,de Jong M,Lagrand WK,van der Sloot JA,Tijssen JG,de Winter RJ,de Mol BA,Piek JJ,Henriques JP

    更新日期:2011-09-01 00:00:00

  • Pentoxifylline improves tissue oxygenation following anesthesia and operation.

    abstract::Pentoxifylline has been shown to increase red blood cell malleability, thus increasing capillary blood flow in a number of disease states. The present study was undertaken to determine whether pentoxifylline might improve tissue oxygenation after anesthesia and during an operation in rats. Rats were anesthetized and d...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Soliman MH,O'Neal K,Waxman K

    更新日期:1987-02-01 00:00:00

  • Propofol does not induce pulmonary dysfunction in stressed endotoxic pigs receiving Intralipid.

    abstract:OBJECTIVE:To assess the effect of diisopropyl phenol (propofol), with and without Intralipid, on the cardiopulmonary system and on thromboxane production in endotoxic pigs. DESIGN:Prospective, randomized animal study. SETTING:Animal research laboratory at a major teaching hospital. SUBJECTS:Twenty-four pigs, divided...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Ziser A,Strickland RA,Murray MJ

    更新日期:2003-07-01 00:00:00

  • Experience of diffusion tensor imaging and 1H spectroscopy for outcome prediction in severe traumatic brain injury: Preliminary results.

    abstract:OBJECTIVE:The objective of the study is to test whether multimodal magnetic resonance imaging can provide a reliable outcome prediction of the clinical status, focusing on consciousness at 1 year after severe traumatic brain injury (TBI). DESIGN:Single center prospective cohort with consecutive inclusions. SETTING:Cr...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Tollard E,Galanaud D,Perlbarg V,Sanchez-Pena P,Le Fur Y,Abdennour L,Cozzone P,Lehericy S,Chiras J,Puybasset L

    更新日期:2009-04-01 00:00:00

  • Vecuronium by continuous infusion for neuromuscular blockade in infants and children.

    abstract::Vecuronium's short half-life and minimal cardiopulmonary side-effects make it a suitable drug for continuous infusion. Vecuronium is used frequently in critically ill patients to increase their total compliance and to minimize the adverse effects of mechanical ventilation. This crossover, prospective study evaluates t...

    journal_title:Critical care medicine

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Eldadah MK,Newth CJ

    更新日期:1989-10-01 00:00:00

  • Recombinant human activated protein C attenuates the inflammatory response in endothelium and monocytes by modulating nuclear factor-kappaB.

    abstract:OBJECTIVE:To review the anti-inflammatory and anti-apoptotic properties of drotrecogin alfa (activated) (recombinant human activated protein C), emphasizing its modulatory effects on endothelial nuclear factor-kappaB. We propose a broad anti-inflammatory effect of drotrecogin alfa (activated), acting on both endotheliu...

    journal_title:Critical care medicine

    pub_type: 杂志文章,评审


    authors: Joyce DE,Grinnell BW

    更新日期:2002-05-01 00:00:00