Morphine Dose Optimization in Critically Ill Pediatric Patients With Acute Respiratory Failure: A Population Pharmacokinetic-Pharmacogenomic Study.

abstract：OBJECTIVE:To cost adult intensive care by determining inputs to production, resource consumption per patient, and total cost per intensive care unit (ICU) stay. DESIGN:Prospective cost-accounting analysis of each patient stay in the ICU, over a 1-yr period. SETTING:An 11-bed, medical/surgical adult ICU, in a 932-bad ...

journal_title：Critical care medicine

authors： Noseworthy TW,Konopad E,Shustack A,Johnston R,Grace M

更新日期：1996-07-01 00:00:00

abstract：OBJECTIVE:To test the hypothesis that the mortality rate of acutely ill patients admitted to a medical ward or medical ICU is higher for those patients who present with hypomagnesemia than for those patients who do not present with hypomagnesemia. DESIGN:Prospective, observational study. SETTING:Emergency Department ...

journal_title：Critical care medicine

authors： Rubeiz GJ,Thill-Baharozian M,Hardie D,Carlson RW

更新日期：1993-02-01 00:00:00

abstract：OBJECTIVE:To describe mechanical ventilation settings in adult patients treated for an acute respiratory distress syndrome with extracorporeal membrane oxygenation and assess the potential impact of mechanical ventilation settings on ICU mortality. DESIGN:Retrospective observational study. SETTING:Three international...

journal_title：Critical care medicine

authors： Schmidt M,Stewart C,Bailey M,Nieszkowska A,Kelly J,Murphy L,Pilcher D,Cooper DJ,Scheinkestel C,Pellegrino V,Forrest P,Combes A,Hodgson C

更新日期：2015-03-01 00:00:00

abstract：:A simple, safe, and effective system for umbilical artery monitoring controls continuous fluid infusion to prevent fluid overinfusion and keep the catheter from clotting. Accurate and continuous pressure measurements can be recorded simultaneously with fluid infusion. A convenient method for checking dynamic response ...

journal_title：Critical care medicine

authors： Gardner RM,Parker J,Feinauer LR

更新日期：1982-07-01 00:00:00

abstract：:A high rate of death from septic shock persists despite general improvements in care. The relative failure of mechanistically based therapies in various clinical trials should also trigger a reconsideration of such mechanistic approaches. Despite reversion of shock by hydrocortisone, the similar death rate compared wi...

journal_title：Critical care medicine

authors： Lukaszewicz AC,Payen D

更新日期：2010-10-01 00:00:00

abstract：OBJECTIVE:The elevation of the percentage of regulatory CD4+CD25+ T lymphocytes (Treg) has been recently described during septic shock. The objective of the present study was to investigate whether this increased percentage was due to Treg proliferation. DESIGN:Observational study. SETTING:Adult intensive care units ...

journal_title：Critical care medicine

authors： Venet F,Pachot A,Debard AL,Bohé J,Bienvenu J,Lepape A,Monneret G

更新日期：2004-11-01 00:00:00

abstract：INTRODUCTION:Ventilator settings for patients with severe acute respiratory distress syndrome supported by venovenous extracorporeal membrane oxygenation are currently set arbitrarily. The impact on serum and pulmonary biotrauma markers of the transition to ultra-protective ventilation settings following extracorporeal...

journal_title：Critical care medicine

authors： Rozencwajg S,Guihot A,Franchineau G,Lescroat M,Bréchot N,Hékimian G,Lebreton G,Autran B,Luyt CE,Combes A,Schmidt M

更新日期：2019-11-01 00:00:00

abstract：OBJECTIVES:To assess the impact of the percentage of fluid infused as Lactated Ringer (%LR) during the first 2 days of ICU admission in hospital mortality and occurrence of acute kidney injury. DESIGN:Retrospective cohort. SETTING:Analysis of a large public database (Multiparameter Intelligent Monitoring in Intensive...

journal_title：Critical care medicine

authors： Zampieri FG,Ranzani OT,Azevedo LC,Martins ID,Kellum JA,Libório AB

更新日期：2016-12-01 00:00:00

abstract：OBJECTIVE:Carbon monoxide (CO), an endogenous byproduct of heme metabolism, is produced at high levels in injured tissue via induction of heme-oxygenase-1 activity, where it contributes to the modulation of proinflammatory processes. Alone, CO has potent anti-inflammatory effects in models of acute and chronic inflamma...

journal_title：Critical care medicine

authors： Moore BA,Overhaus M,Whitcomb J,Ifedigbo E,Choi AM,Otterbein LE,Bauer AJ

更新日期：2005-06-01 00:00:00

abstract：OBJECTIVES:The results from the recent Targeted Temperature Management trial raised the question whether cooling or merely the avoidance of fever mediates better neurologic outcome in resuscitated patients. As temperature per se is a major determinant of cardiac function, we characterized the effects of hyperthermia (4...

journal_title：Critical care medicine

authors： Alogna A,Manninger M,Schwarzl M,Zirngast B,Steendijk P,Verderber J,Zweiker D,Maechler H,Pieske BM,Post H

更新日期：2016-03-01 00:00:00

abstract：OBJECTIVE:Emergency preservation and resuscitation (EPR) comprise a novel approach for resuscitation of exsanguination cardiac arrest victims. EPR uses a cold aortic flush to induce deep hypothermic preservation, followed by resuscitation with cardiopulmonary bypass. Development of a rat EPR model would enable study of...

journal_title：Critical care medicine

authors： Drabek T,Stezoski J,Garman RH,Wu X,Tisherman SA,Stezoski SW,Fisk JA,Jenkins L,Kochanek PM

更新日期：2007-02-01 00:00:00

abstract：OBJECTIVE:In 1991, the American College of Chest Physicians (ACCP) and the Society of Critical Care Medicine (SCCM) convened a "Consensus Conference," the goals of which were "to provide a conceptual and a practical framework to define the systemic inflammatory response to infection, which is a progressive injurious pr...

journal_title：Critical care medicine

authors： Levy MM,Fink MP,Marshall JC,Abraham E,Angus D,Cook D,Cohen J,Opal SM,Vincent JL,Ramsay G,SCCM\/ESICM\/ACCP\/ATS\/SIS.

更新日期：2003-04-01 00:00:00

abstract：OBJECTIVES:To evaluate the use of multifrequency bioelectrical impedance analysis to predict creatinine/urea clearance based on 24 hours urine collection. A practical formula was developed, and its performance was compared with that of established formulas such as Cockcroft-Gault, Modification of Diet in Renal Disease,...

journal_title：Critical care medicine

authors： de Jong LAA,Otten-Helmers AG,Spronk PE,van Kan HJM

更新日期：2019-12-01 00:00:00

abstract：OBJECTIVE:To determine the influence of a selective, sterile central nervous system surgery on immune reactivity, particularly whether a decrease of monocytic human leukocyte antigen-DR expression, indicating immunodepression, occurs after neurosurgery and if this measurement is useful for identification of patients wi...

journal_title：Critical care medicine

authors： Asadullah K,Woiciechowsky C,Döcke WD,Liebenthal C,Wauer H,Kox W,Volk HD,Vogel S,Von Baehr R

更新日期：1995-12-01 00:00:00

abstract：OBJECTIVES:Less than half of the thousands of children who suffer in-hospital cardiac arrests annually survive, and neurologic injury is common among survivors. Hemodynamic-directed cardiopulmonary resuscitation improves short-term survival, but its impact on longer term survival and mitochondrial respiration-a potenti...

journal_title：Critical care medicine

authors： Lautz AJ,Morgan RW,Karlsson M,Mavroudis CD,Ko TS,Licht DJ,Nadkarni VM,Berg RA,Sutton RM,Kilbaugh TJ

更新日期：2019-03-01 00:00:00

abstract：OBJECTIVES:The purpose of this study was to determine the accuracy of clinical diagnoses compared to autopsy findings in critically ill patients in the current medical era. DESIGN:We conducted a retrospective, blinded review of matched medical records and postmortem findings in patients who died between June 2006 and ...

journal_title：Critical care medicine

authors： Fröhlich S,Ryan O,Murphy N,McCauley N,Crotty T,Ryan D

更新日期：2014-02-01 00:00:00

abstract：OBJECTIVE:Our aim was to determine the frequency and the clinical and epidemiologic characteristics of sepsis in a hospital-based population in Colombia. DESIGN:Prospective cohort. SETTING:Ten general hospitals in the four main cities of Colombia. PATIENTS:Consecutive patients admitted in emergency rooms, intensive ...

journal_title：Critical care medicine

authors： Rodríguez F,Barrera L,De La Rosa G,Dennis R,Dueñas C,Granados M,Londoño D,Molina F,Ortiz G,Jaimes F

更新日期：2011-07-01 00:00:00

abstract：OBJECTIVES:To define the hemodynamic and gastric intramucosal PCO2 (PiCO2) changes during the first 48 hrs after burn trauma and to analyze their relationship with outcome. DESIGN:Prospective, observational study in a cohort of consecutively admitted critically ill burn patients. SETTING:Intensive care burn unit in a...

journal_title：Critical care medicine

authors： Lorente JA,Ezpeleta A,Esteban A,Gordo F,de la Cal MA,Díaz C,Arévalo JM,Tejedor C,Pascual T

更新日期：2000-06-01 00:00:00

abstract：OBJECTIVE:Acute aneurysmal subarachnoid hemorrhage (SAH) is a complex multifaceted disorder that plays out over days to weeks. Many patients with SAH are seriously ill and require a prolonged intensive care unit stay. Cardiopulmonary complications are common. The management of patients with SAH focuses on the anticipat...

journal_title：Critical care medicine

authors： Diringer MN

更新日期：2009-02-01 00:00:00

abstract：OBJECTIVE:To determine whether mechanical ventilation using high tidal volume is associated with nonpulmonary organ dysfunction that can be attenuated by dexamethasone. DESIGN:Prospective randomized animal intervention study. SETTING:Animal care facility in a university hospital. SUBJECTS:Sedated and tracheostomized...

journal_title：Critical care medicine

authors： Nin N,Peñuelas O,de Paula M,Lorente JA,Fernández-Segoviano P,Esteban A

更新日期：2006-04-01 00:00:00

abstract：OBJECTIVE:Hypoxemic reperfusion attenuates brain injury secondary to severe cerebral ischemia, myocardial, and intestinal injury occurring in intestinal postischemic shock, and offers hemodynamic stabilization and attenuation of inflammatory response when applied in the resuscitation from hemorrhagic shock. In this stu...

journal_title：Critical care medicine

authors： Douzinas EE,Orfanos SE,Livaditi O,Augustatou K,Villiotou V,Kavantzas N,Flevari A,Korkolopoulou P,Roussos C,Patsouris E

更新日期：2009-03-01 00:00:00

abstract：OBJECTIVES:To determine the accuracy of intramucosal pH (pHi) calculated using arterial bicarbonate instead of mucosal capillary bicarbonate in the Henderson-Hasselbalch equation. DESIGN:Simulation of progressive ischemia in mucosal capillary blood. SETTING:University research laboratory. SUBJECTS:Normal human blood...

journal_title：Critical care medicine

authors： Morgan TJ,Venkatesh B,Endre ZH

更新日期：1999-11-01 00:00:00

abstract：:We used metoprolol orally or iv in 25 patients with multifocal atrial tachycardia that was complicating severe cardiopulmonary illness, and we observed its effect on heart rate and rhythm, BP, and arterial blood gases. All patients showed a dramatic slowing of heart rate, averaging 54.0 +/- 4.0 beat/min (p less than ....

journal_title：Critical care medicine

authors： Hazard PB,Burnett CR

更新日期：1987-01-01 00:00:00

abstract：BACKGROUND:The randomized two-way factorial Dressing Study (1,636 patients, 28,931 catheter days) showed that a chlorhexidine-impregnated sponge decreased the incidence of major catheter-related infections from 1.4‰ to 0.6‰ catheter days, and that scheduled dressing changes every 7 days was not inferior to scheduled ch...

journal_title：Critical care medicine

authors： Schwebel C,Lucet JC,Vesin A,Arrault X,Calvino-Gunther S,Bouadma L,Timsit JF

更新日期：2012-01-01 00:00:00

abstract：OBJECTIVES:To evaluate the association between length of ICU stay and 1-year mortality for elderly patients who survived to hospital discharge in the United States. DESIGN:Retrospective cohort study of a random sample of Medicare beneficiaries who survived to hospital discharge, with 1- and 3-year follow-up, stratifie...

journal_title：Critical care medicine

authors： Moitra VK,Guerra C,Linde-Zwirble WT,Wunsch H

更新日期：2016-04-01 00:00:00

abstract：:A small, double-blind crossover study compared the efficacy of aminophylline and doxapram in ventilator weaning of eight premature infants recovering from respiratory distress syndrome (RDS). Although neither drug was significantly better than the other, four infants were weaned from mechanical ventilation after drug ...

journal_title：Critical care medicine

authors： Eyal FG,Sagi EF,Alpan G,Glick B,Arad I

更新日期：1985-02-01 00:00:00

abstract：:The pericardium serves many important functions, but it is not essential for life. Pericardial heart disease comprises only pericarditis and its complications, tamponade and constriction, and congenital lesions. However, the pericardium is affected by virtually every category of disease. The critical care physician is...

journal_title：Critical care medicine

authors： Hoit BD

更新日期：2007-08-01 00:00:00

abstract：:This study was performed to determine if particulate material within the pulmonary vascular bed could be sampled by aspirating blood from a wedged pulmonary artery catheter. 99mTechnetium-labeled albumin microspheres (20 micrometers) were injected and embolized into the precapillary pulmonary vasculature of 6 critical...

journal_title：Critical care medicine

authors： Allen WG,Olsen GN,Williams WH,Yergin BM

更新日期：1983-04-01 00:00:00

abstract：OBJECTIVE:The aim of this study is to test the hypothesis that recruitment maneuvers (RMs) might act differently in models of pulmonary (p) and extrapulmonary (exp) acute lung injury (ALI) with similar transpulmonary pressure changes. DESIGN:Prospective, randomized, controlled experimental study. SETTING:University r...

journal_title：Critical care medicine

authors： Riva DR,Oliveira MB,Rzezinski AF,Rangel G,Capelozzi VL,Zin WA,Morales MM,Pelosi P,Rocco PR

更新日期：2008-06-01 00:00:00

abstract：OBJECTIVE:Cerebral perfusion pressure<40 mm Hg following pediatric traumatic brain injury has been associated with increased mortality independent of age, and current guidelines recommend maintaining cerebral perfusion pressure between 40 mm Hg-60 mm Hg. Although adult traumatic brain injury studies have observed an in...

journal_title：Critical care medicine

authors： Friess SH,Smith C,Kilbaugh TJ,Frangos SG,Ralston J,Helfaer MA,Margulies SS

更新日期：2012-08-01 00:00:00