Acute effects of tidal volume strategy on hemodynamics, fluid balance, and sedation in acute lung injury.

abstract：OBJECTIVE:To determine the abnormalities present in endotracheal tubes removed from mechanically ventilated patients for "massive airleak." "Massive airleak" was defined as a leak that the attending physician felt was indicative of endotracheal tube defect such that extubation (and reintubation, if needed) would be ind...

journal_title：Critical care medicine

authors： Kearl RA,Hooper RG

更新日期：1993-04-01 00:00:00

abstract：:We previously reported that small volume infusions of 7.5% NaCl in 6% dextran-70 (HSD) are superior to equal volumes of normal saline (NS) or 7.5% NaCl in the ability to resuscitate animals from an otherwise lethal hemorrhage. In the present experiment, we evaluated organ blood flow in unanesthetized swine bled 46 ml/...

journal_title：Critical care medicine

authors： Maningas PA

更新日期：1987-12-01 00:00:00

abstract：:The recommended rates for closed-chest cardiac compressions during CPR are based on physiologic variations with increasing age rather than experimental data. Using puppies, we compared mean arterial pressure, cardiac index (CI), and cerebral blood flow (CBF) at a slow (40/min, group 1) and a rapid (120/min, group 2) r...

journal_title：Critical care medicine

authors： Fleisher G,Delgado-Paredes C,Heyman S

更新日期：1987-10-01 00:00:00

abstract：OBJECTIVES:To determine whether excessive alcohol consumption increases the risk for intensive care unit (ICU)-acquired bacterial infection, especially ventilator-associated pneumonia (VAP), in nontrauma patients. DESIGN:Prospective observational cohort study. SETTING:A 21-bed polyvalent ICU in a university hospital....

journal_title：Critical care medicine

authors： Gacouin A,Legay F,Camus C,Volatron AC,Barbarot N,Donnio PY,Thomas R,Le Tulzo Y

更新日期：2008-06-01 00:00:00

abstract：:The Hemoccult slide test is used frequently to test for the presence of occult blood in samples of gastric juice obtained from critically ill patients. The purpose of this study was to investigate the accuracy of this test to determine the presence of blood in human gastric juice at various pH values. Gastric aspirate...

journal_title：Critical care medicine

authors： Long PC,Wilentz KV,Sudlow G,Skillman JJ

更新日期：1982-10-01 00:00:00

abstract：OBJECTIVE:To evaluate the effectiveness of lorazepam and midazolam for long-term sedation of critically ill, mechanically ventilated patients. DESIGN:Double-blind, randomized, controlled study. SETTING:Medical intensive care unit in a university teaching hospital. PATIENTS:Sixty-four evaluable adult patients admitte...

journal_title：Critical care medicine

authors： Swart EL,van Schijndel RJ,van Loenen AC,Thijs LG

更新日期：1999-08-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to determine whether changing heat and moisture exchangers (HMEs) every 96 hrs rather than 24 hrs would affect their efficacy to preserve the heat and moisture of inspiratory gases. The impact of a prolonged use of the HME on its microbial colonization was also assessed. DESIGN:Pros...

journal_title：Critical care medicine

authors： Thomachot L,Boisson C,Arnaud S,Michelet P,Cambon S,Martin C

更新日期：2000-03-01 00:00:00

abstract：OBJECTIVE:To determine the relative distribution of fluid within the extracellular fluid volume (ECFV) and the effect on oxygen delivery after infusing either normal saline or 5% albumin in cardiac surgical patients. DESIGN:Prospective, randomized, unblinded, interventional study. SETTING:Cardiac surgical intensive c...

journal_title：Critical care medicine

authors： Ernest D,Belzberg AS,Dodek PM

更新日期：2001-12-01 00:00:00

abstract：:Human hemoglobin (Hb) solution is being developed for use as an oxygen-delivering resuscitation fluid. Substantial improvements in the general purity and quality of experimental Hb solutions have been achieved by recent research efforts. Hb solutions now appear to be free of the undesirable biological effects that wer...

journal_title：Critical care medicine

authors： DeVenuto F

更新日期：1982-04-01 00:00:00

abstract：OBJECTIVES:Radiographic criteria for acute respiratory distress syndrome have been criticized for poor reliability. Our objective was to test an educational intervention to improve the radiographic identification of acute respiratory distress syndrome by participants in the Large Observational Study to Understand the G...

journal_title：Critical care medicine

authors： Goddard SL,Rubenfeld GD,Manoharan V,Dev SP,Laffey J,Bellani G,Pham T,Fan E

更新日期：2018-05-01 00:00:00

abstract：PURPOSE:To describe the dark side of pediatric intensive care fellowship training and offer educational approaches for understanding feelings of fallibility, anger, frustration, and loss. DATA SOURCES:Listening and observing fellows in the courses of their pediatric intensive care training and later careers. STUDY SE...

journal_title：Critical care medicine

authors： Jellinek MS,Todres ID,Catlin EA,Cassem EH,Salzman A

更新日期：1993-05-01 00:00:00

abstract：OBJECTIVE:The goals of this review article are to review the importance and value of standardized definitions in clinical research, as well as to propose the necessary tools and infrastructure needed to advance nosology and medial taxonomy to improve the quality of clinical trials in the field of critical care. DATA S...

journal_title：Critical care medicine

authors： Singh JM,Ferguson ND

更新日期：2009-01-01 00:00:00

abstract：OBJECTIVE:To determine whether clinically relevant airspace concentrations of beta2-adrenergic agonists stimulated maximal alveolar fluid clearance rates and to determine whether beta2 agonist therapy decreased pulmonary edema in experimental acute lung injury. DESIGN:Prospective randomized laboratory investigation. ...

journal_title：Critical care medicine

authors： McAuley DF,Frank JA,Fang X,Matthay MA

更新日期：2004-07-01 00:00:00

abstract：OBJECTIVES:To outline the concepts involved in optimizing antibacterial dosing in critically ill patients with acute renal failure undergoing continuous renal replacement therapy (CRRT), provide a strategy for optimizing dosing, and summarize the data required to implement the strategy. DATA SOURCES:MEDLINE search fro...

journal_title：Critical care medicine

authors： Choi G,Gomersall CD,Tian Q,Joynt GM,Freebairn R,Lipman J

更新日期：2009-07-01 00:00:00

abstract：:Cardiac arrest is most commonly encountered as the end result of severe derangements in metabolic homeostasis. These derangements may include toxic, ischemic, or electrophysiological causes of circulatory and/or respiratory arrests. Occasionally, mechanical obstruction or impediment to circulation may cause cardiac ar...

journal_title：Critical care medicine

authors： Ewer MS,Ali MK,Frazier OH

更新日期：1982-03-01 00:00:00

abstract：:Malaria is one of the most common infectious diseases in the world, and severe respiratory complications have been described mainly in association with Plasmodium falciparum. We describe a case of acute respiratory distress syndrome complicating infection with P. vivax in the setting of relatively low parasitemia in a...

journal_title：Critical care medicine

authors： Tanios MA,Kogelman L,McGovern B,Hassoun PM

更新日期：2001-03-01 00:00:00

abstract：OBJECTIVE:To alert health professionals to the need for early detection and prevention of shock in critically ill patients. By describing the associations between intramucosal acidosis in the gut and multiple system organ failure, the author demonstrates how noninvasive measurement of gut intramucosal pH can be used to...

journal_title：Critical care medicine

authors： Fiddian-Green RG

更新日期：1993-02-01 00:00:00

abstract：BACKGROUND:The 2003 global outbreak of severe acute respiratory syndrome (SARS) provided numerous challenges to the delivery of critical care. The Toronto critical care community has learned important lessons from SARS, which will help in preparation for future disease outbreaks. OBJECTIVES:The objectives of this stud...

journal_title：Critical care medicine

authors： Booth CM,Stewart TE

更新日期：2005-01-01 00:00:00

abstract：OBJECTIVE:To discuss a potential role for endothelial cell apoptosis in the pathogenesis of sepsis. DATA SOURCES:Studies published in biomedical journals and studies from the authors' laboratory. STUDY SELECTION:In vitro and in vivo studies of endothelial cell apoptosis in endotoxin and sepsis models. DATA EXTRACTIO...

journal_title：Critical care medicine

authors： Hotchkiss RS,Tinsley KW,Swanson PE,Karl IE

更新日期：2002-05-01 00:00:00

abstract：:The effect of positive end-expiratory pressure (PEEP) on PaO2 during collapse of a single pulmonary lobe was investigated in seven dogs. Increasing PEEP to the ventilated region of lung increased the proportion of cardiac output flowing to the collapsed lobe and decreased PaO2 and pH. PaCO2 increased at the onset of l...

journal_title：Critical care medicine

authors： Sánchez De León R,Orchard C,Sykes K,Brajkovich I

更新日期：1985-05-01 00:00:00

abstract：OBJECTIVE:To systematically investigate the effect of altering release time during airway pressure release ventilation in a neonatal animal model before and after oleic acid-induced acute lung injury. DESIGN:Prospective, nonrandomized, controlled study with repeated measures. SETTING:University research laboratory. ...

journal_title：Critical care medicine

authors： Martin LD,Wetzel RC

更新日期：1994-03-01 00:00:00

abstract：OBJECTIVE:The purpose of this study was to evaluate the effect of a neutrophil elastase inhibitor, sivelestat, on lipopolysaccharide-induced acute lung injury through analysis of hemodynamic changes in the pulmonary microcirculation. DESIGN:Randomized animal study. SETTING:Medical school laboratory. SUBJECTS:Twenty-...

journal_title：Critical care medicine

authors： Inoue Y,Seiyama A,Tanaka H,Ukai I,Akimau P,Nishino M,Shimazu T,Sugimoto H

更新日期：2005-08-01 00:00:00

abstract：OBJECTIVES:Centers for Disease Control and Prevention built up new surveillance paradigms for the patients on mechanical ventilation and the ventilator-associated events, comprising ventilator-associated conditions and infection-related ventilator-associated complications. We assess 1) the current epidemiology of venti...

journal_title：Critical care medicine

authors： Bouadma L,Sonneville R,Garrouste-Orgeas M,Darmon M,Souweine B,Voiriot G,Kallel H,Schwebel C,Goldgran-Toledano D,Dumenil AS,Argaud L,Ruckly S,Jamali S,Planquette B,Adrie C,Lucet JC,Azoulay E,Timsit JF,OUTCOMEREA Study

更新日期：2015-09-01 00:00:00

abstract：:Right ventricular size and contractility were evaluated using two-dimensional echocardiography during the first days of respiratory support in 23 patients requiring mechanical ventilation for acute respiratory failure. Nine patients had normal echocardiographic right ventricular function, and nine other patients had a...

journal_title：Critical care medicine

authors： Jardin F,Gueret P,Dubourg O,Farcot JC,Margairaz A,Bourdarias JP

更新日期：1985-11-01 00:00:00

abstract：OBJECTIVES:The impact of recruitment maneuvers on gas exchange, hemodynamics, alveolar recruitment, and hyperinflation is highly variable among patients with acute respiratory distress syndrome. The objective was to determine whether differences in lung morphology, defined as differences in the pulmonary distribution o...

journal_title：Critical care medicine

authors： Constantin JM,Grasso S,Chanques G,Aufort S,Futier E,Sebbane M,Jung B,Gallix B,Bazin JE,Rouby JJ,Jaber S

更新日期：2010-04-01 00:00:00

abstract：OBJECTIVE:To test the hypothesis that the mortality rate of acutely ill patients admitted to a medical ward or medical ICU is higher for those patients who present with hypomagnesemia than for those patients who do not present with hypomagnesemia. DESIGN:Prospective, observational study. SETTING:Emergency Department ...

journal_title：Critical care medicine

authors： Rubeiz GJ,Thill-Baharozian M,Hardie D,Carlson RW

更新日期：1993-02-01 00:00:00

abstract：OBJECTIVES:Case fatality in pregnancy-associated severe sepsis or septic shock appears reduced compared with nonpregnant women with severe sepsis or septic shock. It remains unclear if this difference is due to pregnancy or better baseline health status, among others. Our study compared adverse outcomes of pregnancy-as...

journal_title：Critical care medicine

authors： Kidson KM,Henderson WR,Hutcheon JA

更新日期：2018-11-01 00:00:00

abstract：OBJECTIVE:To determine the impact of the rotation of antimicrobial agents on the rates of infection, intestinal colonization, and acquisition with antimicrobial-resistant Gram-negative bacteria. DESIGN:Pre- and postintervention design. SETTING:A 19-bed, medical intensive care unit. PATIENTS:Individuals admitted to t...

journal_title：Critical care medicine

authors： Warren DK,Hill HA,Merz LR,Kollef MH,Hayden MK,Fraser VJ,Fridkin SK

更新日期：2004-12-01 00:00:00

abstract：OBJECTIVES:Recently, the definition of sepsis has changed from a physiologic derangement (Sepsis-1 and -2) to organ dysfunction (Sepsis-3) based. We sought to determine the concordance between the different sepsis phenotypes and how that affected mortality. DESIGN:Retrospective, multicenter study. SETTING:Three acade...

journal_title：Critical care medicine

authors： Engoren M,Seelhammer T,Freundlich RE,Maile MD,Sigakis MJG,Schwann TA

更新日期：2020-09-01 00:00:00

abstract：:Among Gram-positive pathogens, Staphylococcus aureus is the leading cause of death from nosocomial pneumonia. The bacterium developed progressive resistance to beta-lactams, and methicillin-resistant strains emerged in the 1980s. In consequence, vancomycin has become the drug of choice for treatment of this infection ...

journal_title：Critical care medicine

authors： Bodi M,Ardanuy C,Rello J

更新日期：2001-04-01 00:00:00