Massive airway leaks: an analysis of the role of endotracheal tubes.

abstract：OBJECTIVE:Keratinocyte growth factor (KGF) is expressed primarily by fibroblasts, is important for alveolar epithelial proliferation/function, and protects against lung injury in multiple animal models. We wished to determine whether acute lung injury/acute respiratory distress syndrome (ALI/ARDS) alveolar fluid induce...

journal_title：Critical care medicine

authors： Chandel NS,Budinger GR,Mutlu GM,Varga J,Synenki L,Donnelly HK,Zirk A,Eisenbart J,Jovanovic B,Jain M

更新日期：2009-05-01 00:00:00

abstract：OBJECTIVE:To determine whether low-dose dopamine administration reduces the incidence or severity of acute renal failure, need for dialysis, or mortality in patients with critical illness. DATA SOURCES AND STUDY SELECTION:We performed a MEDLINE search of literature published from 1966 to 2000 for studies addressing th...

journal_title：Critical care medicine

authors： Kellum JA,M Decker J

更新日期：2001-08-01 00:00:00

abstract：:We developed a method to measure accurately pressures at the airway opening (Pao) and in the trachea (Ptr) in neonates during high frequency oscillatory ventilation (HFOV) from 15-30 Hz. All component parts of the pressure-measuring system were tested as a unit against a reference transducer in a closed chamber in whi...

journal_title：Critical care medicine

authors： Boynton BR,Mannino FL,Meathe EA,Kopotic RJ,Friederichsen G

更新日期：1984-01-01 00:00:00

abstract：OBJECTIVE:To evaluate the prognostic value of short-latency median nerve somatosensory evoked potentials and brainstem auditory evoked potentials in outcome prediction for comatose cardiac arrest patients treated with hypothermia. DESIGN:Prospective, randomized, controlled trial of mild hypothermia after out-of-hospit...

journal_title：Critical care medicine

authors： Tiainen M,Kovala TT,Takkunen OS,Roine RO

更新日期：2005-08-01 00:00:00

abstract：OBJECTIVES:Measurement of blood lactate concentration in the early management of sepsis is an important step in severity assessment. High blood lactate levels in the early phase of sepsis have classically been thought to be related to tissue hypoxia, but other factors could intervene. We hypothesized that the activatio...

journal_title：Critical care medicine

authors： Contenti J,Occelli C,Corraze H,Lemoël F,Levraut J

更新日期：2015-12-01 00:00:00

abstract：OBJECTIVES:Myocardial ischemia plays a central role in the development of right ventricular failure after acute pulmonary embolism. This study investigates whether pulmonary mediators act specifically on coronary tone and cardiac contractile function in acute pulmonary microembolization and whether such effects are alt...

journal_title：Critical care medicine

authors： Dschietzig T,Laule M,Alexiou K,Schrör K,Baumann G,Stangl K

更新日期：1998-03-01 00:00:00

abstract：:Percutaneous cholecystostomy was employed successfully as an alternative to cholecystectomy for the treatment of acute cholecystitis with perforation in an elderly woman. The procedure, performed portably in the cardiac care unit, was selected because progressive cardiac and renal decompensation made the patient an ex...

journal_title：Critical care medicine

authors： Longmaid HE 3rd,Bassett JG,Gottlieb H

更新日期：1985-08-01 00:00:00

abstract：OBJECTIVES:Anxiety results from the anticipation of a threat and might be associated with poor outcome in the critically ill. This study aims at showing that anxiety at admission in critically ill patients is associated with new organ failure over the first 7 days of ICU hospitalization independently of baseline organ ...

journal_title：Critical care medicine

authors： Mazeraud A,Polito A,Sivanandamoorthy S,Porcher R,Heming N,Stoclin A,Hissem T,Antona M,Blot F,Gaillard R,Chrétien F,Annane D,Bozza FAB,Siami S,Sharshar T,Groupe d’Explorations Neurologiques en Réanimation (GENER).

更新日期：2020-10-01 00:00:00

abstract：OBJECTIVES:To understand when the use of high-frequency ventilation would be advantageous, we formulated the problem of achieving adequate alveolar ventilation at minimal pressure cost by dividing it into two simpler problems: a) the pressure cost per unit of convective oscillatory flow; and b) the convective flow cost...

journal_title：Critical care medicine

authors： Venegas JG,Fredberg JJ

更新日期：1994-09-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to evaluate the relationship of patient care variables to survival and functional outcome in the pediatric population with traumatic brain injury. DESIGN:Retrospective chart review. SETTING:A 16-bed pediatric critical care unit in an academic community children's hospital. PATIENT...

journal_title：Critical care medicine

authors： Hackbarth RM,Rzeszutko KM,Sturm G,Donders J,Kuldanek AS,Sanfilippo DJ

更新日期：2002-07-01 00:00:00

abstract：OBJECTIVES:Milrinone is a phosphodiesterase F-III inhibitor with positive inotropic and vasodilating activities. We investigated the hemodynamic response and pharmacokinetics of intravenous milrinone in patients with acute heart failure. DESIGN:Double-blind studies: a prospective, multicenter, double-blind, dose-findi...

journal_title：Critical care medicine

authors： Seino Y,Momomura S,Takano T,Hayakawa H,Katoh K

更新日期：1996-09-01 00:00:00

abstract：OBJECTIVE:To study whether noninvasive pressure support ventilation (NIPSV) with helium/oxygen (He/oxygen), which can reduce dyspnea, PaCO2, and work of breathing more than NIPSV with air/oxygen in decompensated chronic obstructive pulmonary disease, could have beneficial consequences on outcome and hospitalization cos...

journal_title：Critical care medicine

authors： Jolliet P,Tassaux D,Roeseler J,Burdet L,Broccard A,D'Hoore W,Borst F,Reynaert M,Schaller MD,Chevrolet JC

更新日期：2003-03-01 00:00:00

abstract：:Changes in pulmonary function and the development of atelectasis in the postoperative period have been well documented in the adult population. The use of incentive spirometry has been shown to be effective in the prevention of these postoperative complications. At the Hospital of Sick Children, we studied 17 children...

journal_title：Critical care medicine

authors： Krastins I,Corey ML,McLeod A,Edmonds J,Levison H,Moes F

更新日期：1982-08-01 00:00:00

abstract：OBJECTIVE:Inflammation and immobility are comorbid etiological factors inducing muscle weakness in critically ill patients. This study establishes a rat model to examine the effect of inflammation and immobilization alone and in combination on muscle contraction, histology, and acetylcholine receptor regulation. DESIG...

journal_title：Critical care medicine

authors： Fink H,Helming M,Unterbuchner C,Lenz A,Neff F,Martyn JA,Blobner M

更新日期：2008-03-01 00:00:00

abstract：:During a consecutive 17 month period, 15 trauma patients were diagnosed as having a myocardial contusion on the basis of abnormal ECG in 14 patients, elevated creatinine phosphokinase (CPK) in 13 patients, and elevated CPK-Muscle Brain (CPK-MB) isoenzyme determination in 11 patients. Using these screening modalities, ...

journal_title：Critical care medicine

authors： Torres-Mirabal P,Gruenberg JC,Talbert JG,Brown RS

更新日期：1982-01-01 00:00:00

abstract：:End tidal CO2 tension (PetCO2) and transcutaneous CO2 tension (PtcCO2) were compared with arterial CO2 (PaCO2) before and after withdrawal of mechanical ventilation in 20 patients predisposed to hypercarbia. With stable PaCO2 during mechanical ventilation, the correlation coefficient (r) between PaCO2 and PetCO2 was ....

journal_title：Critical care medicine

authors： Healey CJ,Fedullo AJ,Swinburne AJ,Wahl GW

更新日期：1987-08-01 00:00:00

abstract：OBJECTIVE:To compare the effectiveness and safety of the hemoglobin-based nitric oxide scavenger, pyridoxalated hemoglobin polyoxyethylene, against placebo in patients with vasopressor-dependent distributive shock. DESIGN:Multicenter, randomized, placebo-controlled, open-label study. SETTING:Sixty-one participating I...

journal_title：Critical care medicine

authors： Vincent JL,Privalle CT,Singer M,Lorente JA,Boehm E,Meier-Hellmann A,Darius H,Ferrer R,Sirvent JM,Marx G,DeAngelo J

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVE:To derive a target range of optimal sedation for the COMFORT Scale and to prospectively test that target range against intensivist assessment of adequacy of sedation. DESIGN:Serial prospective agreement cohort studies. SETTING:Twelve-bed pediatric intensive care unit in an urban academic teaching hospital. ...

journal_title：Critical care medicine

authors： Marx CM,Smith PG,Lowrie LH,Hamlett KW,Ambuel B,Yamashita TS,Blumer JL

更新日期：1994-01-01 00:00:00

abstract：OBJECTIVE:To determine if autopsies performed on patients who die in the medical intensive care unit (ICU) provide clinically important new information. DESIGN:Retrospective review. SETTING:A 16-bed medical-coronary ICU. PATIENTS:Patients who underwent autopsy during a 1-yr period. INTERVENTIONS:Pre mortem diagnose...

journal_title：Critical care medicine

authors： Blosser SA,Zimmerman HE,Stauffer JL

更新日期：1998-08-01 00:00:00

abstract：OBJECTIVE:This pilot study was designed to identify which contextual factors facilitate/hinder the implementation of the awakening, breathing, coordination, delirium, and early mobility (ABCDE) bundle for guidance in future studies. DESIGN:The sources of data for this study included document review, planned site visit...

journal_title：Critical care medicine

authors： Carrothers KM,Barr J,Spurlock B,Ridgely MS,Damberg CL,Ely EW

更新日期：2013-09-01 00:00:00

abstract：OBJECTIVES:Previous studies in adults suggest that various types of physiologic stress appear to decrease phagocytic cell function. Adherence and chemotaxis of, and phagocytosis and bacterial killing by, neonatal neutrophils are altered compared with adult neutrophil function. Stresses encountered by the fetus and neon...

journal_title：Critical care medicine

authors： Beachy JC,Weisman LE

更新日期：1993-12-01 00:00:00

abstract：OBJECTIVE:Leucine-rich repeat and immunoglobulin domain-containing protein (LINGO)-1 is expressed in neural stem cells, and its neutralization results in sustained neuronal immaturity. Thus, targeted inhibition of LINGO-1 via RNA interference may enhance transplanted neural stem cell survival and neuronal differentiati...

journal_title：Critical care medicine

authors： Chen N,Cen JS,Wang J,Qin G,Long L,Wang L,Wei F,Xiang Q,Deng DY,Wan Y

更新日期：2016-03-01 00:00:00

abstract：OBJECTIVE:Addressing the quality gap in ICU-based palliative care is limited by uncertainty about acceptable models of collaborative specialist and generalist care. Therefore, we characterized the attitudes of physicians and nurses about palliative care delivery in an ICU environment. DESIGN:Mixed-methods study. SETT...

journal_title：Critical care medicine

authors： Wysham NG,Hua M,Hough CL,Gundel S,Docherty SL,Jones DM,Reagan O,Goucher H,Mcfarlin J,Cox CE

更新日期：2017-04-01 00:00:00

abstract：OBJECTIVE:To determine the relationship between sublingual and intestinal mucosal microcirculatory perfusion. DESIGN:Observational, experimental study. SETTING:University-affiliated large animal laboratory. SUBJECTS:Ten fasted, anesthetized, mechanically ventilated, male pigs randomized to a sham group (n = 3) or to...

journal_title：Critical care medicine

authors： Verdant CL,De Backer D,Bruhn A,Clausi CM,Su F,Wang Z,Rodriguez H,Pries AR,Vincent JL

更新日期：2009-11-01 00:00:00

abstract：OBJECTIVES:Although discussing a prognosis is a duty of physicians caring for critically ill patients, little is known about surrogate decision-makers' beliefs about physicians' ability to prognosticate. We sought to determine: 1) surrogates' beliefs about whether physicians can accurately prognosticate for critically ...

journal_title：Critical care medicine

authors： Zier LS,Burack JH,Micco G,Chipman AK,Frank JA,Luce JM,White DB

更新日期：2008-08-01 00:00:00

abstract：OBJECTIVE:Delirium is common in mechanically ventilated patients in the ICU and associated with short- and long-term morbidity and mortality. The use of systemic corticosteroids is also common in the ICU. Outside the ICU setting, corticosteroids are a recognized risk factor for delirium, but their relationship with del...

journal_title：Critical care medicine

authors： Schreiber MP,Colantuoni E,Bienvenu OJ,Neufeld KJ,Chen KF,Shanholtz C,Mendez-Tellez PA,Needham DM

更新日期：2014-06-01 00:00:00

abstract：OBJECTIVE:Phenylephrine is often used for management of cerebral perfusion pressure after traumatic brain injury, but can have undesirable actions. Few studies have evaluated alternatives. The hypothesis was that arginine vasopressin was as effective as phenylephrine for maintaining tissue oxygenation during cerebral p...

journal_title：Critical care medicine

authors： Dudkiewicz M,Proctor KG

更新日期：2008-09-01 00:00:00

abstract：:Trauma is the leading cause of both morbidity and mortality in the pediatric population, and traumatic injury causes > 50% of all childhood deaths. Significant mortality rates have been reported for children with traumatic brain injury. Although children have better survival rates as compared with adults with traumati...

journal_title：Critical care medicine

authors： Mazzola CA,Adelson PD

更新日期：2002-11-01 00:00:00

abstract：OBJECTIVE:To develop a pharmacokinetic-pharmacogenomic population model of morphine in critically ill children with acute respiratory failure. DESIGN:Prospective pharmacokinetic-pharmacogenomic observational study. SETTING:Thirteen PICUs across the United States. PATIENTS:Pediatric subjects (n = 66) mechanically ven...

journal_title：Critical care medicine

authors： Zuppa AF,Benitez GR,Zane NR,Curley MAQ,Bradfield J,Hakonarson H,Gastonguay MS,Moorthy G,Prodell J,Gastonguay MR

更新日期：2019-06-01 00:00:00

abstract：:Patient awareness of intermittent positive-pressure ventilation (IPPV) treatment in the ICU was studied in 304 patients. These ICU patients were divided into three groups: those treated for internal medical diseases (IMD; n = 129), patients admitted after major surgical procedures (MSP; n = 126), and patients treated ...

journal_title：Critical care medicine

authors： Bergbom-Engberg I,Haljamäe H

更新日期：1989-01-01 00:00:00