Targeted Inhibition of Leucine-Rich Repeat and Immunoglobulin Domain-Containing Protein 1 in Transplanted Neural Stem Cells Promotes Neuronal Differentiation and Functional Recovery in Rats Subjected to Spinal Cord Injury.

abstract：OBJECTIVE:Inflammation and immobility are comorbid etiological factors inducing muscle weakness in critically ill patients. This study establishes a rat model to examine the effect of inflammation and immobilization alone and in combination on muscle contraction, histology, and acetylcholine receptor regulation. DESIG...

journal_title：Critical care medicine

authors： Fink H,Helming M,Unterbuchner C,Lenz A,Neff F,Martyn JA,Blobner M

更新日期：2008-03-01 00:00:00

abstract：OBJECTIVES:Severe sepsis poses a major burden on the U.S. healthcare system. Previous epidemiologic studies have not differentiated community-acquired severe sepsis from healthcare-associated severe sepsis or hospital-acquired severe sepsis hospitalizations. We sought to compare and contrast community-acquired severe s...

journal_title：Critical care medicine

authors： Page DB,Donnelly JP,Wang HE

更新日期：2015-09-01 00:00:00

abstract：OBJECTIVE:The emergency department (ED) often serves as the first site for the recognition and treatment of patients with suspected severe sepsis. However, few evaluations of the national epidemiology and distribution of severe sepsis in the ED exist. We sought to determine national estimates of the number, timing, ED ...

journal_title：Critical care medicine

authors： Wang HE,Shapiro NI,Angus DC,Yealy DM

更新日期：2007-08-01 00:00:00

abstract：:Although recent clinical reports have noted hypokalemia after resuscitation from cardiac arrest, extensive animal work indicates that potassium is released from cells during ischemia. This study was undertaken to define the changes that occur in serum potassium ion during cardiac arrest and resuscitation in a canine m...

journal_title：Critical care medicine

authors： Martin GB,Carden DL,Nowak RM,Foreback C,Tomlanovich MC

更新日期：1986-04-01 00:00:00

abstract：BACKGROUND:Septic shock represents the major cause of infection-associated mortality in the intensive care unit. The possibility that combination antibiotic therapy of bacterial septic shock improves outcome is controversial. Current guidelines do not recommend combination therapy except for the express purpose of broa...

journal_title：Critical care medicine

authors： Kumar A,Zarychanski R,Light B,Parrillo J,Maki D,Simon D,Laporta D,Lapinsky S,Ellis P,Mirzanejad Y,Martinka G,Keenan S,Wood G,Arabi Y,Feinstein D,Kumar A,Dodek P,Kravetsky L,Doucette S,Cooperative Antimicrobial Thera

更新日期：2010-09-01 00:00:00

abstract：OBJECTIVE:Quality of care for patients admitted with pneumonia varies across hospitals, but causes of this variation are poorly understood. Whether hospitals with high ICU utilization for patients with pneumonia provide better quality care is unknown. We sought to investigate the relationship between a hospital's ICU a...

journal_title：Critical care medicine

authors： Sjoding MW,Prescott HC,Wunsch H,Iwashyna TJ,Cooke CR

更新日期：2015-06-01 00:00:00

abstract：OBJECTIVES:Hyperammonemia is a key contributing factor for cerebral edema in acute liver failure. Continuous renal replacement therapy may help reduce ammonia levels. However, the optimal timing, mode, intensity, and duration of continuous renal replacement therapy in this setting are unknown. We aimed to study continu...

journal_title：Critical care medicine

authors： Warrillow S,Fisher C,Bellomo R

更新日期：2020-02-01 00:00:00

abstract：OBJECTIVE:Vasopressin is a possible stimulus for both adrenocorticotropin (ACTH) and endothelin-1 release. The aim of this study was to compare plasma concentrations of ACTH, cortisol, and endothelin-1 after epinephrine or vasopressin administration in an experimental animal model of cardiopulmonary resuscitation (CPR)...

journal_title：Critical care medicine

authors： Kornberger E,Prengel AW,Krismer A,Schwarz B,Wenzel V,Lindner KH,Mair P

更新日期：2000-10-01 00:00:00

abstract：OBJECTIVE:Anesthetic preconditioning appears to be a viable strategy to treat ischemic cerebral injury. Here we investigated 1) whether the protection conferred by sevoflurane preconditioning sustains in time; 2) whether sevoflurane preconditioning diminishes mitochondrial dysfunction following cerebral ischemia; and 3...

journal_title：Critical care medicine

authors： Ye R,Yang Q,Kong X,Li N,Zhang Y,Han J,Xiong L,Liu X,Zhao G

更新日期：2012-09-01 00:00:00

abstract：OBJECTIVE:To assess clinician perceptions of a machine learning-based early warning system to predict severe sepsis and septic shock (Early Warning System 2.0). DESIGN:Prospective observational study. SETTING:Tertiary teaching hospital in Philadelphia, PA. PATIENTS:Non-ICU admissions November-December 2016. INTERVE...

journal_title：Critical care medicine

authors： Ginestra JC,Giannini HM,Schweickert WD,Meadows L,Lynch MJ,Pavan K,Chivers CJ,Draugelis M,Donnelly PJ,Fuchs BD,Umscheid CA

更新日期：2019-11-01 00:00:00

abstract：OBJECTIVE:To compare the classification performance of the Revised Atlanta Classification, the Determinant-Based Classification, and a new modified Determinant-Based Classification according to observed mortality and morbidity. DESIGN:A prospective multicenter observational study conducted in 1-year period. SETTING:F...

journal_title：Critical care medicine

authors： Zubia-Olaskoaga F,Maraví-Poma E,Urreta-Barallobre I,Ramírez-Puerta MR,Mourelo-Fariña M,Marcos-Neira MP,Epidemiology of Acute Pancreatitis in Intensive Care Medicine Study Group.

更新日期：2016-05-01 00:00:00

abstract：OBJECTIVE:To assess the effectiveness of routine intensive care unit surveillance compared with frequent 12-lead electrocardiogram monitoring for detecting electrocardiogram evidence suggestive of prolonged myocardial ischemia in vascular surgery patients. DESIGN:Prospective cohort trial. SETTING:Intensive care unit....

journal_title：Critical care medicine

authors： Martinez EA,Kim LJ,Faraday N,Rosenfeld B,Bass EB,Perler BA,Williams GM,Dorman T,Pronovost PJ

更新日期：2003-09-01 00:00:00

abstract：OBJECTIVES:Previous workers have demonstrated that controlled mechanical ventilation results in diaphragm inactivity and elicits a rapid development of diaphragm weakness as a result of both contractile dysfunction and fiber atrophy. Limited data exist regarding the impact of pressure support ventilation, a commonly us...

journal_title：Critical care medicine

authors： Hudson MB,Smuder AJ,Nelson WB,Bruells CS,Levine S,Powers SK

更新日期：2012-04-01 00:00:00

abstract：:Clinically, asystole or a bradyarrhythmia may follow countershock of ventricular fibrillation (VF) in up to 40% of attempts. This study evaluated the effects of artificial cardiac pacing, calcium chloride (CaCl2), and epinephrine in postcountershock asystole/bradycardia. Micromanometer catheters were positioned in the...

journal_title：Critical care medicine

authors： Niemann JT,Adomian GE,Garner D,Rosborough JP

更新日期：1985-09-01 00:00:00

abstract：OBJECTIVES:To investigate whether admission B-type natriuretic peptide levels predict the development of acute kidney injury in acute coronary syndromes. DESIGN:Prospective study. SETTING:Single-center study, 13-bed intensive cardiac care unit at a University Cardiological Center. PATIENTS:Six-hundred thirty-nine ac...

journal_title：Critical care medicine

authors： Moltrasio M,Cabiati A,Milazzo V,Rubino M,De Metrio M,Discacciati A,Rumi P,Marana I,Marenzi G

更新日期：2014-03-01 00:00:00

abstract：OBJECTIVE:To compare the effects of two different antibiotic regimes on the colonization and infection rates of critically ill pediatric patients. DESIGN:A prospective randomized trial. SETTING:A pediatric ICU in a university hospital. PATIENTS:Fifty critically ill pediatric patients who required intensive care for ...

journal_title：Critical care medicine

authors： Zobel G,Kuttnig M,Grubbauer HM,Semmelrock HJ,Thiel W

更新日期：1991-10-01 00:00:00

abstract：OBJECTIVE:To define the occurrence rate of acute respiratory distress syndrome (ARDS) using established criteria in a well-defined general patient population, to study the clinical course of ARDS when patients were ventilated using a "lung-protective" strategy, and to define the total costs of care. DESIGN:A 3-yr (199...

journal_title：Critical care medicine

authors： Valta P,Uusaro A,Nunes S,Ruokonen E,Takala J

更新日期：1999-11-01 00:00:00

abstract：OBJECTIVE:The aim of this study is to test the hypothesis that recruitment maneuvers (RMs) might act differently in models of pulmonary (p) and extrapulmonary (exp) acute lung injury (ALI) with similar transpulmonary pressure changes. DESIGN:Prospective, randomized, controlled experimental study. SETTING:University r...

journal_title：Critical care medicine

authors： Riva DR,Oliveira MB,Rzezinski AF,Rangel G,Capelozzi VL,Zin WA,Morales MM,Pelosi P,Rocco PR

更新日期：2008-06-01 00:00:00

abstract：:The image of the physician as a therapist, as well as the general perception of the physician's role in society and in the life of patients and their families, has changed dramatically in past decades. In response, many conferences, editorials, and planning activities for medical and premedical curricula have been dev...

journal_title：Critical care medicine

authors： Detre K

更新日期：1988-10-01 00:00:00

abstract：:offstudied hemodynamic and renal effects of increasing the dosage of dopamine (DP) by 5 micrograms/kg X min, in 7 patients with peritonitis and clinical findings of septic shock, all of whom were already receiving variable dosages of DP. Stroke index (SI) (p less than .01), except in 3 cases, and mean arterial pressur...

journal_title：Critical care medicine

authors： de la Cal MA,Miravalles E,Pascual T,Esteban A,Ruiz-Santana S

更新日期：1984-01-01 00:00:00

abstract：:Cessation of massive hemoptysis after iatrogenic balloon catheter rupture of the pulmonary artery was observed after a 2-ml inflation of the balloon. A wedge angiogram showed a small cavity near the rupture. Secondary lobectomy was performed; however, the patient died 1 month later. Therapeutic approaches of this life...

journal_title：Critical care medicine

authors： Thomas R,Siproudhis L,Laurent JF,Bouget J,Bousser J,Camus C,Michelet C

更新日期：1987-03-01 00:00:00

abstract：:Disseminated intravascular coagulation (DIC) is an acquired syndrome characterized by intravascular fibrin formation occurring in the course of a variety of severe diseases. In gram-negative sepsis, endotoxin is the bacterial component eliciting a cascade of tissue factor dependent hypercoagulable reactions mediated b...

journal_title：Critical care medicine

authors： ten Cate H

更新日期：2000-09-01 00:00:00

abstract：OBJECTIVE:Granulocyte colony-stimulating factor is widely prescribed to hasten recovery from cancer chemotherapy-induced neutropenia and has been reported to induce pulmonary toxicity. However, circumstances and mechanisms of this toxicity remain poorly known. DESIGN:To reproduce a routine situation in cancer patients...

journal_title：Critical care medicine

authors： Azoulay E,Attalah H,Yang K,Jouault H,Schlemmer B,Brun-Buisson C,Brochard L,Harf A,Delclaux C

更新日期：2002-09-01 00:00:00

abstract：OBJECTIVE:To evaluate the impact of a newly appointed neurointensivist on neurosciences intensive care unit (NICU) patient outcomes and quality of care variables. DESIGN:Observational cohort with historical controls. SETTING:Ten-bed neurointensive care unit in tertiary university hospital. PATIENTS:Mortality, length...

journal_title：Critical care medicine

authors： Varelas PN,Conti MM,Spanaki MV,Potts E,Bradford D,Sunstrom C,Fedder W,Hacein Bey L,Jaradeh S,Gennarelli TA

更新日期：2004-11-01 00:00:00

abstract：:During the control period in this study, small premature infants, 1500 g in birth weight, had insensible water loss (IWL) of 2.28 g/kg/hr (equivlaent to 54 ml/kg/day), which is considerably higher than in full term infants. Under phototherapy, there was a significant increase in IWL (3.14 g/kg/hr) associated with incr...

journal_title：Critical care medicine

authors： Yeh TF,Vidyasagar D,Pildes RS

更新日期：1975-11-01 00:00:00

abstract：OBJECTIVES:Radial artery pressure is known to differ from central arterial pressure in normal patients (distal pulse amplification) and in the early postcardiopulmonary bypass period. The adequacy of the radial artery as a site for blood pressure monitoring in critically ill patients receiving high-dose vasopressors ha...

journal_title：Critical care medicine

authors： Dorman T,Breslow MJ,Lipsett PA,Rosenberg JM,Balser JR,Almog Y,Rosenfeld BA

更新日期：1998-10-01 00:00:00

abstract：OBJECTIVE:As the Surviving Sepsis Campaign was assessing patient-level data over multiple countries, we sought to evaluate the use of a pragmatic and parsimonious severity-of-illness scoring system for patients with sepsis in an attempt to provide appropriate comparisons with practical application. DESIGN:Prospective,...

journal_title：Critical care medicine

authors： Osborn TM,Phillips G,Lemeshow S,Townsend S,Schorr CA,Levy MM,Dellinger RP

更新日期：2014-09-01 00:00:00

abstract：OBJECTIVE:High-frequency oscillation has been proposed for use in adult acute respiratory distress syndrome. However, limited data are available on the effect of pressure amplitude and rate (Hz) on tidal volumes delivered during high-frequency oscillation in adults. DESIGN:Prospective, animal model, lung injury study....

journal_title：Critical care medicine

authors： Sedeek KA,Takeuchi M,Suchodolski K,Kacmarek RM

更新日期：2003-01-01 00:00:00

abstract：OBJECTIVES:The electronic health record is a primary source of information for all professional groups participating in ICU rounds. We previously demonstrated that, individually, all professional groups involved in rounds have significant blind spots in recognition of patient safety issues in the electronic health reco...

journal_title：Critical care medicine

authors： Bordley J,Sakata KK,Bierman J,McGrath K,Mulanax A,Nguyen L,Mohan V,Gold JA

更新日期：2018-10-01 00:00:00

abstract：OBJECTIVES:To use a standardized tool for a multicenter assessment of antibiotic appropriateness in ICUs and identify local antibiotic stewardship improvement opportunities. DESIGN:Pilot point prevalence conducted on October 5, 2016; point prevalence survey conducted on March 1, 2017. SETTING:ICUs in 12 U.S. acute ca...

journal_title：Critical care medicine

authors： Trivedi KK,Bartash R,Letourneau AR,Abbo L,Fleisher J,Gagliardo C,Kelley S,Nori P,Rieg GK,Silver P,Srinivasan A,Vargas J,Ostrowsky B,Partnership for Quality Care (PQC) Inpatient Antimicrobial Stewardship Working Group.

更新日期：2020-07-01 00:00:00