Endothelial cell apoptosis in sepsis.

abstract：:The current definition of sepsis is life-threatening, acute organ dysfunction secondary to a dysregulated host response to infection. Criteria to operationalize this definition can be judged by six domains of usefulness (reliability, content, construct and criterion validity, measurement burden, and timeliness). The r...

journal_title：Critical care medicine

authors： Seymour CW,Coopersmith CM,Deutschman CS,Gesten F,Klompas M,Levy M,Martin GS,Osborn TM,Rhee C,Warren DK,Watson RS,Angus DC

更新日期：2016-03-01 00:00:00

abstract：OBJECTIVES:Existing handheld glucose meters are glucose oxidase (GO)-based. Oxygen side reactions can introduce oxygen dependency, increase potential error, and limit clinical use. Our primary objectives were to: a) introduce a new glucose dehydrogenase (GD)-based electrochemical biosensor for point-of-care testing; b)...

journal_title：Critical care medicine

authors： Kost GJ,Vu HT,Lee JH,Bourgeois P,Kiechle FL,Martin C,Miller SS,Okorodudu AO,Podczasy JJ,Webster R,Whitlow KJ

更新日期：1998-03-01 00:00:00

abstract：OBJECTIVE:To evaluate the physiology and pharmacokinetics of a novel hemoglobin-based oxygen carrier of bovine origin. DESIGN:Randomized, single-blind, placebo-controlled, dose-escalation study. SETTING:The Upjohn Research Clinics (Kalamazoo, MI). SUBJECTS:Normal healthy adult men between the ages of 18 and 45 yrs. ...

journal_title：Critical care medicine

authors： Hughes GS Jr,Antal EJ,Locker PK,Francom SF,Adams WJ,Jacobs EE Jr

更新日期：1996-05-01 00:00:00

abstract：:A new iridium/iridium-oxide electrode heated to 42 degrees C was used to monitor transcutaneous carbon dioxide levels during surgery in 27 adult patients. The purpose of this study was to compare arterial and transcutaneous CO2 values. This metal electrode performed similarly to glass CO2 electrodes. In addition, its ...

journal_title：Critical care medicine

authors： Williams R,Riker R,Narkewicz M,Lucey JF

更新日期：1985-10-01 00:00:00

abstract：OBJECTIVE:To investigate the interrelationship between cardiac surgery, age, circulating concentrations of the vitamin D hormone 1,25-dihydroxyvitamin D, and clinical outcome. DESIGN:Prospective, monocentric, two-arm parallel study. SETTING:Tertiary Heart and Diabetes Center in the Federal State of North Rhine-Westph...

journal_title：Critical care medicine

authors： Börgermann J,Lazouski K,Kuhn J,Dreier J,Schmidt M,Gilis-Januszewski T,Knabbe C,Gummert JF,Zittermann A

更新日期：2012-07-01 00:00:00

abstract：OBJECTIVE:To examine the association between the performance of a tracheostomy and intensive care unit and postintensive care unit mortality, controlling for treatment selection bias and confounding variables. DESIGN:Prospective, observational, cohort study. SETTING:Twelve French medical or surgical intensive care un...

journal_title：Critical care medicine

authors： Clec'h C,Alberti C,Vincent F,Garrouste-Orgeas M,de Lassence A,Toledano D,Azoulay E,Adrie C,Jamali S,Zaccaria I,Cohen Y,Timsit JF

更新日期：2007-01-01 00:00:00

abstract：:Cardiac arrest has a poor prognosis, regardless of age group. Children who fail to respond to two standard doses of epinephrine (0.01 mg/kg) rarely survive to hospital discharge, and most die without the return of spontaneous circulation (ROSC). We treated seven consecutive children in cardiac arrest with high dose ep...

journal_title：Critical care medicine

authors： Goetting MG,Paradis NA

更新日期：1989-12-01 00:00:00

abstract：:A total of 2711 pulmonary artery wedge pressure (WP) measurement attempts were made prospectively from WP recordings in 44 (30 men) critically ill patients, using 77 flow-directed catheters. Of these, 322 (12%) failed to yield a WP measurement, and 521 (18%) were associated with technical problems. One half of these t...

journal_title：Critical care medicine

authors： Morris AH,Chapman RH,Gardner RM

更新日期：1984-03-01 00:00:00

abstract：:To achieve synchronized differential pulmonary ventilation, an Ohio 560 ventilator was modified through separation of the outputs of the deep breath bellows and the tidal volume bellows and providing independent volume, flow rate, PEEP, oxygen-humidification, and alarm systems. The described ventilator modification is...

journal_title：Critical care medicine

authors： Popovich J Jr,Sanders OJ Jr,Vij D,Polanski JJ,Conway WA

更新日期：1981-06-01 00:00:00

abstract：BACKGROUND:Procalcitonin (PCT), a marker of bacterial sepsis, may also act as a mediator of the inflammatory response to infection, and thus influence outcome. OBJECTIVE:To investigate the relationship between PCT, interleukin (IL)-10, tumor necrosis factor (TNF), organ failure, and mortality in pediatric septic shock...

journal_title：Critical care medicine

authors： Hatherill M,Tibby SM,Turner C,Ratnavel N,Murdoch IA

更新日期：2000-07-01 00:00:00

abstract：OBJECTIVE:Oxygenation measured 24 hours after acute respiratory distress syndrome onset more accurately stratifies risk, relative to oxygenation at onset, in both children and adults. However, waiting 24 hours is problematic, especially for interventions that are more efficacious early in the disease course. We aimed t...

journal_title：Critical care medicine

authors： Yehya N,Thomas NJ,Khemani RG

更新日期：2018-04-01 00:00:00

abstract：:offstudied hemodynamic and renal effects of increasing the dosage of dopamine (DP) by 5 micrograms/kg X min, in 7 patients with peritonitis and clinical findings of septic shock, all of whom were already receiving variable dosages of DP. Stroke index (SI) (p less than .01), except in 3 cases, and mean arterial pressur...

journal_title：Critical care medicine

authors： de la Cal MA,Miravalles E,Pascual T,Esteban A,Ruiz-Santana S

更新日期：1984-01-01 00:00:00

abstract：:Intermittent Mandatory Ventilation (IMV) provides an alternative method of support to assisted and controlled mechanical ventilation in neonates with acute respiratory failure. Specific advantages include the use of only the level of mechanical support which is required on an individual basis. Because intrapleural pre...

journal_title：Critical care medicine

authors： Kirby RR

更新日期：1977-01-01 00:00:00

abstract：:By definition, the acute respiratory distress syndrome is associated with diffuse cellular infiltration and proteinaceous edema. It is generally believed that the widespread injury that characterizes acute respiratory distress syndrome is a process that is launched almost synchronously throughout the lung, caused by b...

journal_title：Critical care medicine

authors： Marini JJ

更新日期：2010-10-01 00:00:00

abstract：:Paranasal sinusitis is reported as a complication of prolonged nasal intubation and the source of sepsis in adult intensive care patients. In surgical neonates with congenital malformations, prolonged intubation with a nasotracheal (NT) or NG tube is often necessary, but sinusitis with complicating sepsis is seldom re...

journal_title：Critical care medicine

authors： Bos AP,Tibboel D,Hazebroek FW,Hoeve H,Meradji M,Molenaar JC

更新日期：1989-09-01 00:00:00

abstract：:Recent strides in computational biology and high-throughput technologies have generated considerable interest in understanding complex biological systems. The application of these technologies to critical illness and injury offers the potential to define adaptive and maladaptive programs of gene expression induced by ...

journal_title：Critical care medicine

authors： Cobb JP,Suffredini AF,Danner RL

更新日期：2008-10-01 00:00:00

abstract：:The fractional elimination rate of exogenous fat, and fat-mobilizing lipolysis in relation to plasma catecholamine (CA) levels were studied in seven ventilator-treated ICU patients. Blood levels of CA, triglycerides, cholesterol and free fatty acids (FFA) were also analyzed before and during constant infusion of a soy...

journal_title：Critical care medicine

authors： Lindholm M,Eklund JO,Hamberger B,Järnberg PO

更新日期：1984-11-01 00:00:00

abstract：OBJECTIVES:Intensive insulin therapy with tight glucose control is known to result in reduced morbidity and mortality in inflammation-related critical illness. Tumor necrosis factor (TNF)-alpha induction in myocardial infarction may trigger inflammation and have detrimental effects on cardiomyocytes. This study was des...

journal_title：Critical care medicine

authors： Li J,Zhang H,Wu F,Nan Y,Ma H,Guo W,Wang H,Ren J,Das UN,Gao F

更新日期：2008-05-01 00:00:00

abstract：OBJECTIVES:High physical activity levels are associated with wide-ranging health benefits, disease prevention, and longevity. In the present study, we examined the impact of regular physical exercise on the severity of organ injury and survival probability, as well as characteristics of the systemic immune and metaboli...

journal_title：Critical care medicine

authors： Sossdorf M,Fischer J,Meyer S,Dahlke K,Wissuwa B,Seidel C,Schrepper A,Bockmeyer CL,Lupp A,Neugebauer S,Schmerler D,Rödel J,Claus RA,Otto GP

更新日期：2013-10-01 00:00:00

abstract：OBJECTIVE:When a patient is incompetent, the family is often considered to be a natural surrogate. The doctors' responsiveness to family wishes may vary. We explored if doctors' personal characteristics were associated with responsiveness to the relatives' wishes when admission to the intensive care unit (ICU) is consi...

journal_title：Critical care medicine

authors： Escher M,Perneger TV,Heidegger CP,Chevrolet JC

更新日期：2009-02-01 00:00:00

abstract：OBJECTIVE:Information booklets have not been assessed by the families of intensive care unit (ICU) patients. This study explored the information that the relatives of adult ICU patients wanted to find in the information booklets. DESIGN:Multicenter survey. SETTING:Twenty-three French ICUs. SUBJECTS:One close relativ...

journal_title：Critical care medicine

authors： Soltner C,Lassalle V,Galienne-Bouygues S,Pottecher J,Floccard B,Delapierre L,Jungfer F,Sargentini C,Alberti C,Beydon L,Lifrea Group.

更新日期：2009-07-01 00:00:00

abstract：OBJECTIVE:During cardiopulmonary bypass, inflammation and immunosuppression is present. We measured circulating mediators and monocyte-based functions and tested the hypothesis that these variables are influenced by methylprednisolone (MP) or tirilazad mesylate (TM) treatment. DESIGN:Randomized, controlled, double-bli...

journal_title：Critical care medicine

authors： Volk T,Schmutzler M,Engelhardt L,Döcke WD,Volk HD,Konertz W,Kox WJ

更新日期：2001-11-01 00:00:00

abstract：OBJECTIVE:To evaluate whether current criteria for the diagnosis of brain death fulfill the requirement for the "irreversible cessation of all functions of the entire brain, including the brainstem." DATA SOURCES:Clinical, philosophical, legal, and public policy literature on the subject of brain death. DATA EXTRACTI...

journal_title：Critical care medicine

authors： Truog RD,Fackler JC

更新日期：1992-12-01 00:00:00

abstract：OBJECTIVE:Addressing the quality gap in ICU-based palliative care is limited by uncertainty about acceptable models of collaborative specialist and generalist care. Therefore, we characterized the attitudes of physicians and nurses about palliative care delivery in an ICU environment. DESIGN:Mixed-methods study. SETT...

journal_title：Critical care medicine

authors： Wysham NG,Hua M,Hough CL,Gundel S,Docherty SL,Jones DM,Reagan O,Goucher H,Mcfarlin J,Cox CE

更新日期：2017-04-01 00:00:00

abstract：:The clearance of amikacin during hemodialysis (HD) was determined in eight critically ill patients. The dialysis period averaged 3.4 h with a blood flow of 200 ml/min. The average amikacin clearance between dialysis was 7.30 +/- 4.78 (SD) ml/min which increased to 37.5 +/- 8.01 ml/min during dialysis. The average seru...

journal_title：Critical care medicine

authors： Armstrong DK,Hodgman T,Visconti JA,Reilley TE,Garner WL,Dasta JF

更新日期：1988-05-01 00:00:00

abstract：OBJECTIVE:To determine the association between symptomatic central venous line-related deep venous thrombosis and a mortality-adjusted measure of duration of mechanical ventilation in critically ill children with central venous lines. DESIGN:Retrospective matched cohort study. SETTING:Eleven pediatric intensive care ...

journal_title：Critical care medicine

authors： Faustino EV,Lawson KA,Northrup V,Higgerson RA

更新日期：2011-05-01 00:00:00

abstract：:This study evaluates the recall of 100 patients after ICU admission. There was a wide spectrum of race, religion, occupation, and educational levels. The more common diagnoses included asthma, pneumonia, trauma, and adult respiratory distress syndrome. The average Acute Physiology and Chronic Health Evaluation (APACHE...

journal_title：Critical care medicine

authors： Turner JS,Briggs SJ,Springhorn HE,Potgieter PD

更新日期：1990-09-01 00:00:00

abstract：OBJECTIVE:To review current knowledge about cell-free hemoglobin solutions. DATA SOURCES:All studies involving cell-free hemoglobin were retrieved from a computerized MEDLINE search from 1980 to 1998. We also reviewed the reference lists of all available review articles and primary studies to identify references not f...

journal_title：Critical care medicine

authors： Creteur J,Sibbald W,Vincent JL

更新日期：2000-08-01 00:00:00

abstract：:Chest physiotherapy (CPT) is used frequently in the ICU, but there is little available information that quantitates its effect on cardiac or respiratory function. Nineteen mechanically ventilated patients with post-traumatic respiratory failure were studied before, immediately after, and 2 h after CPT was used to mana...

journal_title：Critical care medicine

authors： Mackenzie CF,Shin B

更新日期：1985-06-01 00:00:00

abstract：:We found that altering aspirating flow rate (ASR) and sample tubing length (STL) affected the response time and capnogram of 2 different side-stream capnometers. Increased flow rate shortened rise time, transit time, and total delay time (TDT), whereas increased STL increased transit and TDTs but not rise time. Increa...

journal_title：Critical care medicine

authors： Schena J,Thompson J,Crone RK

更新日期：1984-08-01 00:00:00