High dose epinephrine in refractory pediatric cardiac arrest.

Abstract:

:Cardiac arrest has a poor prognosis, regardless of age group. Children who fail to respond to two standard doses of epinephrine (0.01 mg/kg) rarely survive to hospital discharge, and most die without the return of spontaneous circulation (ROSC). We treated seven consecutive children in cardiac arrest with high dose epinephrine (0.2 mg/kg) after failure to respond to two standard doses. Six had prompt and sustained ROSC. By comparison, in the previous 20 consecutive pediatric patients with cardiac arrest in which there was no response to two standard doses of epinephrine, none had ROSC. Previous animal data as well as anecdotal human experience suggest that the standard epinephrine dose (0.01 mg/kg) may be much too low.

journal_name

Crit Care Med

journal_title

Critical care medicine

authors

Goetting MG,Paradis NA

doi

10.1097/00003246-198912000-00004

subject

Has Abstract

pub_date

1989-12-01 00:00:00

pages

1258-62

issue

12

eissn

0090-3493

issn

1530-0293

journal_volume

17

pub_type

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