Microdialysis-evaluated myocardial cyclooxygenase-mediated inflammation and early circulatory depression in porcine endotoxemia.


OBJECTIVE:To evaluate the early myocardial biochemical inflammatory response with the microdialysis technique during porcine endotoxemia and to simultaneously monitor systemic hemodynamics. DESIGN:Prospective, randomized, placebo-controlled trial with parallel groups. SETTING:Animal research laboratory at the University Hospital of Uppsala, Sweden. SUBJECTS:Thirteen piglets aged 12-14 wks receiving general anesthesia. INTERVENTIONS:After thoracotomy and the insertion of microdialysis probes in standardized locations in the left ventricle of the heart and in the quadriceps muscle, seven pigs received a continuous infusion of endotoxin, initiating a severe endotoxemic shock. Six pigs received saline instead of endotoxin. MEASUREMENTS AND MAIN RESULTS:Endotoxemia caused a rapid and pronounced elevation of a metabolite obtained from prostaglandin degradation, 15-keto-dihydro-PGF(2alpha), in myocardial microdialysate fluid being specific of cyclooxygenase (COX)-mediated inflammation (p <.001 vs. saline-infused controls). Simultaneously, we observed a decrease in left ventricular stroke work index in the endotoxemic pigs (p <.01 vs. saline-infused controls). Endotoxemia did not alter 15-keto-dihydro-PGF(2alpha) levels in quadriceps muscle. Endotoxemia caused increases in taurine, hypoxanthine, and magnesium in myocardial microdialysate (p <.05 vs. saline-infused controls), whereas the contents of pyruvate, lactate, inosine, adenosine, and calcium were not significantly changed. CONCLUSION:Endotoxemia induced a myocardial COX-mediated inflammation without signs of ischemia. In parallel, a depletion of myocardial energy substrates and a deterioration in myocardial performance were seen.


Crit Care Med


Critical care medicine


Mutschler DK,Eriksson MB,Wikström BG,Lind L,Larsson A,Bergren-Kiiski R,Lagrange A,Nordgren A,Basu S




Has Abstract


2003-06-01 00:00:00












  • A comparison of hemodynamic parameters derived from transthoracic electrical bioimpedance with those parameters obtained by thermodilution and ventricular angiography.

    abstract:OBJECTIVE:To determine the limits of agreement between the cardiac output and volumetric data estimated by impedance cardiography with the cardiac output determined by thermodilution and the left ventricular ejection fraction and end-diastolic volume estimated from left ventriculography. DESIGN:A prospective study. S...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Marik PE,Pendelton JE,Smith R

    更新日期:1997-09-01 00:00:00

  • Energy expenditure and withdrawal of sedation in severe head-injured patients.

    abstract:OBJECTIVES:To determine the outcome of oxygen consumption (VO2) and energy expenditure after cessation of sedation in severe head-injured patients and to assess its usefulness as a predictor of neurologic severity. DESIGN:Prospective, descriptive study. SETTING:Neurosurgical intensive care unit (ICU) in a university ...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Bruder N,Lassegue D,Pelissier D,Graziani N,François G

    更新日期:1994-07-01 00:00:00

  • Lipiodol embolism following transarterial chemoembolization: an atypical case.

    abstract:OBJECTIVE:Transarterial chemoembolization is a widely used therapy for the treatment of hepatocellular carcinoma. A rare adverse event is acute respiratory distress syndrome from pulmonary embolization of Lipiodol, an iodinated oil commonly used during the procedure. The objective of this report is to describe an atypi...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Taupin D,Mukherjee V,Nathavitharana R,Green DA,Fridman D

    更新日期:2014-06-01 00:00:00

  • Effect of albumin dialysis on intracranial pressure increase in pigs with acute liver failure: a randomized study.

    abstract:BACKGROUND:Increased intracranial pressure (ICP) worsens the outcome of acute liver failure (ALF). This study investigates the underlying pathophysiological mechanisms and evaluates the therapeutic effect of albumin dialysis in ALF with use of the Molecular Adsorbents Recirculating System without hemofiltration/dialysi...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Sen S,Rose C,Ytrebø LM,Davies NA,Nedredal GI,Drevland SS,Kjønnø M,Prinzen FW,Hodges SJ,Deutz NE,Williams R,Butterworth RF,Revhaug A,Jalan R

    更新日期:2006-01-01 00:00:00

  • Survival, cost of hospitalization, and prognosis in infants critically ill with respiratory distress syndrome requiring mechanical ventilation.

    abstract::It was found that, during 1974, it cost an average of $8842 ($12,909 in 1979) to care for a survivor of severe respiratory distress syndrome (RDS) who required mechanical ventilation in this ICU compared to $2448 ($3574 in 1979) for nonsurvivors. Death in 15 out of the 16 nonsurvivors was accompanied by grade III-IV i...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Shannon DC,Crone RK,Todres ID,Krishnamoorthy KS

    更新日期:1981-02-01 00:00:00

  • Positive-pressure ventilation with positive end-expiratory pressure and atrial natriuretic peptide release.

    abstract::The effect of positive-pressure ventilation (PPV) with PEEP on the release of alpha-atrial natriuretic peptide (ANP) was investigated in both humans and an experimental model. In the human study, systemic artery blood samples from 22 critically ill patients were analyzed for ANP. Seventeen of these patients received P...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Teba L,Dedhia HV,Schiebel FG,Blehschmidt NG,Lindner WJ

    更新日期:1990-08-01 00:00:00

  • Urea removal during continuous hemodiafiltration.

    abstract:OBJECTIVE:To compare urea nitrogen removal by continuous hemodiafiltration vs. functional native kidneys in critically ill, septic patients receiving > 2 g of amino acids/kg body weight per day. DESIGN:Prospective, comparative, unblinded study. SETTING:Trauma critical care units of a Level I adult trauma hospital. P...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Frankenfield DC,Reynolds HN,Wiles CE 3rd,Badellino MM,Siegel JH

    更新日期:1994-03-01 00:00:00

  • Importance of platelets and fibrinogen in neutrophil-endothelial cell interactions in septic shock.

    abstract:OBJECTIVE:To examine the role of platelets, fibrin, and adhesion molecules in mediating neutrophil-endothelial cell interactions in septic shock. DESIGN:Controlled experiments using phase contrast microscopy to examine neutrophil, platelet, and endothelial cell interactions in flowing cell suspensions under simulated ...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Kirschenbaum LA,McKevitt D,Rullan M,Reisbeck B,Fujii T,Astiz ME

    更新日期:2004-09-01 00:00:00

  • Effect of corticosteroid prophylaxis on lipopolysaccharide levels associated with intestinal ischemia in cats.

    abstract::Ischemia of the intestines damages the permeability of the intestinal wall, allowing lipopolysaccharide (LPS) (endotoxin) to leak from the gut lumen into the blood circulation, causing shock and death. We measured LPS levels associated with corticosteroid treatment vs. no treatment in cats whose superior mesenteric ar...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Gaffin SL,Gathiram P,Wells MT,Brock-Utne JG

    更新日期:1986-10-01 00:00:00

  • Titration of intravenous anesthetics for cardioversion: a comparison of propofol, methohexital, and midazolam.

    abstract:OBJECTIVE:To compare propofol, methohexital, and midazolam administered as titrated infusions for sedation during electrical cardioversion. DESIGN:A prospective, randomized, single-blind comparative study. SETTING:Coronary care unit in a military teaching hospital. PATIENTS:Thirty adult patients with atrial fibrilla...

    journal_title:Critical care medicine

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Gale DW,Grissom TE,Mirenda JV

    更新日期:1993-10-01 00:00:00

  • End-tidal CO2 as a guide to successful cardiopulmonary resuscitation: a preliminary report.

    abstract::Utilizing a well-established porcine model of cardiac arrest, we found that end-tidal CO2 concentration (ETCO2) strikingly decreased to approximately 24% of control levels, immediately after cardiac arrest and before precordial compression. During precordial compression, ETCO2 progressively increased to 46% of control...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Trevino RP,Bisera J,Weil MH,Rackow EC,Grundler WG

    更新日期:1985-11-01 00:00:00

  • Septic emboli caused by vascular catheters after surgery for congenital heart disease.

    abstract:OBJECTIVE:To review the incidence, diagnosis, and management of septic emboli caused by vascular catheters after surgery for congenital heart disease. DESIGN:Retrospective clinical review. All patients were computer registered. Our database includes daily follow-up and every sign of infection registered. SETTING:Pedi...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Erez E,Sharoni E,Ovadia B,Vidne BA,Dagan O

    更新日期:2000-03-01 00:00:00

  • Empiric treatment of hospital-acquired lower respiratory tract infections with meropenem or ceftazidime with tobramycin: a randomized study. Meropenem Lower Respiratory Infection Group.

    abstract:OBJECTIVE:To evaluate the efficacy and tolerability of intravenous empiric treatment with meropenem compared with ceftazidime-tobramycin in patients with hospital-acquired lower respiratory tract infections. DESIGN:Prospective, nonblind, randomized trial. SETTING:Multicenter trial conducted at 22 centers. PATIENTS:T...

    journal_title:Critical care medicine

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Sieger B,Berman SJ,Geckler RW,Farkas SA

    更新日期:1997-10-01 00:00:00

  • Understanding the antecedents of the acceptance of donation after cardiac death by healthcare professionals.

    abstract:OBJECTIVE:A 3-yr study funded by the U.S. Department of Health and Human Services was conducted to identify potential barriers to and opportunities for increasing the number hospitals with donation after cardiac death (DCD) protocols, the support of DCD by individuals involved in the donation request process, and the n...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: D'Alessandro AM,Peltier JW,Phelps JE

    更新日期:2008-04-01 00:00:00

  • Blunted erythropoietic response to anemia in multiply traumatized patients.

    abstract:OBJECTIVES:To assess the relations between anemia, serum erythropoietin (EPO), iron status, and inflammatory mediators in multiply traumatized patients. DESIGN:Prospective observational study. SETTING:Intensive care unit. PATIENTS:Twenty-three patients suffering from severe trauma (injury severity score > or =30). ...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Hobisch-Hagen P,Wiedermann F,Mayr A,Fries D,Jelkmann W,Fuchs D,Hasibeder W,Mutz N,Klingler A,Schobersberger W

    更新日期:2001-04-01 00:00:00

  • Systemic antifungal therapy in critically ill patients without invasive fungal infection*.

    abstract:OBJECTIVE:To determine the number of adult or pediatric intensive care unit patients without documented invasive fungal infection who receive systemic antifungal therapy. DESIGN:A 1-day cross-sectional cohort study. SETTING:One hundred sixty-nine intensive care units in France and Belgium. PATIENTS:All patients stay...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Azoulay E,Dupont H,Tabah A,Lortholary O,Stahl JP,Francais A,Martin C,Guidet B,Timsit JF

    更新日期:2012-03-01 00:00:00

  • Effects of a single-dose hypertonic saline hydroxyethyl starch on cerebral blood flow, long-term outcome, neurogenesis, and neuronal survival after cardiac arrest and cardiopulmonary resuscitation in rats*.

    abstract:OBJECTIVE:The beneficial effects of hypertonic saline on neuronal survival and on cerebral blood flow have been shown in several animal models of global and focal brain ischemia. Because of the potential benefits of hypertonic solutions, it is hypothesized that hydroxyethyl starch enhances cerebral blood flow and impro...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Noppens RR,Kelm RF,Lindemann R,Engelhard K,Werner C,Kempski O

    更新日期:2012-07-01 00:00:00

  • Soluble human leukocyte antigen-G5 in septic shock: marked and persisting elevation as a predictor of survival.

    abstract:OBJECTIVE:Although it is established that septic shock induces immunosuppression, the mechanisms for this phenomenon remain poorly understood. Human leukocyte antigen-G exerts strong inhibitory effects that are directed at different arms of the immune system. The main objective of the current study was to measure human...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Monneret G,Voirin N,Krawice-Radanne I,Bohé J,Lepape A,Rouas-Freiss N,Carosella ED

    更新日期:2007-08-01 00:00:00

  • Stem cells in sepsis and acute lung injury.

    abstract:OBJECTIVE:Sepsis and acute lung injury continue to be major causes of morbidity and mortality worldwide despite advances in our understanding of pathophysiology and the discovery of new management strategies. Recent investigations show that stem cells may be beneficial as prognostic biomarkers and novel therapeutic str...

    journal_title:Critical care medicine

    pub_type: 杂志文章,评审


    authors: Cribbs SK,Matthay MA,Martin GS

    更新日期:2010-12-01 00:00:00

  • Hepatic Compartment Syndrome Following Percutaneous Cholecystostomy: A Case Report.

    abstract:OBJECTIVE:To describe a case of hepatic subcapsular hematoma causing an acute Budd-Chiari-like syndrome, leading to hepatic compartment syndrome, which combines compression of intrahepatic vessels on CT, acute liver failure, and refractory shock. DESIGN:Case report. SETTING:Surgical ICU of a university teaching hospi...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Marcaire F,Malavieille F,Pichot-Delahaye V,Floccard B,Rimmelé T

    更新日期:2016-03-01 00:00:00

  • Comparison between selective and nonselective nitric oxide synthase inhibition and phenylephrine in normal and endotoxic swine.

    abstract:OBJECTIVE:To compare the cardiopulmonary and peripheral circulatory effects of the nonselective nitric oxide synthase (NOS) inhibitor NG-nitro-L-arginine methyl ester (L-NAME) to the more selective inducible NOS inhibitor S-methylisothiourea (SMT) and to phenylephrine (PE) in endotoxic and normal swine. DESIGN:Prospec...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Cohen RI,Shapir Y,Davis A,Loona R,Scharf SM

    更新日期:2000-09-01 00:00:00

  • Measurement properties of the Clinical Risk Index for Babies--reliabilty, validity beyond the first 12 hours, and responsiveness over 7 days.

    abstract:OBJECTIVES:Clinical Risk Index for Babies (CRIB) is a simple instrument used to measure clinical risk and illness severity in very low birth-weight infants. We assessed its reliability, validity beyond the first 12 hrs after birth, and responsiveness to individual change in condition after 7 days. DESIGN:Cohort study....

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Fowlie PW,Gould CR,Tarnow-Mordi WO,Strang D

    更新日期:1998-01-01 00:00:00

  • Pulmonary fluid balance and hemodynamics after perfluorocarbon infusion in the dog lung.

    abstract::Perfluorocarbon (PFC) emulsions are promising oxygen-carrying blood supplements for the treatment of shock and in organ preservation for transplantation. We used the isolated, blood-perfused, canine right lower lung lobe (RLL) to determine the effect of a PFC emulsion, Oxypherol (FC-43), upon lung fluid balance and he...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Hall JE,Ehrhart IC,Hofman WF

    更新日期:1985-12-01 00:00:00

  • Extracorporeal Membrane Oxygenation Use in Cardiogenic Shock: Impact of Age on In-Hospital Mortality, Length of Stay, and Costs.

    abstract:OBJECTIVES:Increasing age is a well-recognized risk factor for in-hospital mortality in patients receiving extracorporeal membrane oxygenation for cardiogenic shock, but the shape of this relationship is unknown. In addition, the impact of age on hospital length of stay, patterns of patient disposition, and costs has b...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Chung M,Zhao Y,Strom JB,Shen C,Yeh RW

    更新日期:2019-03-01 00:00:00

  • Clinical Outcomes and Mortality Impact of Hyperbaric Oxygen Therapy in Patients With Carbon Monoxide Poisoning.

    abstract:OBJECTIVES:Carbon monoxide poisoning affects 50,000 per year in the United States alone. Mortality is approximately 3%, and up to 40% of survivors suffer from permanent neurocognitive and affective deficits. Hyperbaric oxygen therapy has shown benefit on reducing the long-term neurologic sequelae of carbon monoxide poi...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Rose JJ,Nouraie M,Gauthier MC,Pizon AF,Saul MI,Donahoe MP,Gladwin MT

    更新日期:2018-07-01 00:00:00

  • Total liquid ventilation with perfluorocarbons increases pulmonary end-expiratory volume and compliance in the setting of lung atelectasis.

    abstract:OBJECTIVE:To compare compliance and end-expiratory lung volume during reexpansion of normal and surfactant-deficient ex vivo atelectatic lungs with either gas or total liquid ventilation. DESIGN:Controlled, animal study using an ex vivo lung preparation. SETTING:A research laboratory at a university medical center. ...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Tooley R,Hirschl RB,Parent A,Bartlett RH

    更新日期:1996-02-01 00:00:00

  • Effects of epinephrine, norepinephrine, or the combination of norepinephrine and dobutamine on gastric mucosa in septic shock.

    abstract:OBJECTIVES:To compare in the same patient with septic shock, respective effects of epinephrine, norepinephrine, and the combination of norepinephrine and dobutamine (5 microg/kg/min) on systemic hemodynamic parameters and gastric mucosal perfusion using gastric tonometry and laser-Doppler flowmetry techniques. DESIGN:...

    journal_title:Critical care medicine

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Duranteau J,Sitbon P,Teboul JL,Vicaut E,Anguel N,Richard C,Samii K

    更新日期:1999-05-01 00:00:00

  • Endotoxemia reduces cerebral perfusion but enhances dynamic cerebrovascular autoregulation at reduced arterial carbon dioxide tension.

    abstract:OBJECTIVE:The administration of endotoxin to healthy humans reduces cerebral blood flow but its influence on dynamic cerebral autoregulation remains unknown. We considered that a reduction in arterial carbon dioxide tension would attenuate cerebral perfusion and improve dynamic cerebral autoregulation in healthy subjec...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Brassard P,Kim YS,van Lieshout J,Secher NH,Rosenmeier JB

    更新日期:2012-06-01 00:00:00

  • The role of ω-3 fatty acid supplemented parenteral nutrition in critical illness in adults: a systematic review and meta-analysis.

    abstract:OBJECTIVE:To determine whether the supplementation of parenteral nutrition with ω-3 fatty acids confers treatment benefits to critically ill adult patients. DATA SOURCE:We performed computerized searches for relevant articles from 1996 to June 2011 on MEDLINE, EMBASE, and the Cochrane register of controlled trials and...

    journal_title:Critical care medicine

    pub_type: 杂志文章,meta分析,评审


    authors: Palmer AJ,Ho CK,Ajibola O,Avenell A

    更新日期:2013-01-01 00:00:00

  • Evaluation of the utility of computed tomography in the initial assessment of the critical care patient with chest trauma.

    abstract:OBJECTIVE:To determine the utility of thoracic computed tomography (TCT) in the initial assessment of critically ill patients with chest injuries. DESIGN:Prospective observational study of cohorts. SETTING:Trauma intensive care unit (ICU) of a Spanish Level III hospital (US equivalent Level I). PATIENTS:Three hundre...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Guerrero-López F,Vázquez-Mata G,Alcázar-Romero PP,Fernández-Mondéjar E,Aguayo-Hoyos E,Linde-Valverde CM

    更新日期:2000-05-01 00:00:00