Effect of high-frequency oscillation on blood flow to an atelectatic lung in closed-chest dogs.

abstract：OBJECTIVE:To determine recent trends in severe sepsis-related rates of hospitalization, mortality, and hospital case fatality in a large geographic area and to determine the impact of age, race, and gender on these outcomes. DESIGN:Trend analysis for the period of 1995 to 2002. SETTING:Acute care hospitals in New Jer...

journal_title：Critical care medicine

authors： Dombrovskiy VY,Martin AA,Sunderram J,Paz HL

更新日期：2005-11-01 00:00:00

abstract：OBJECTIVES:Hepatic ischemia-reperfusion is a major clinical problem with limited treatment options. The pathophysiology of hepatic ischemia-reperfusion is characterized by mitochondrial dysfunction and cellular energy deficits. Sirtuin 1 is an energy-sensing enzyme known to modulate mitochondrial biogenesis. We hypothe...

journal_title：Critical care medicine

authors： Khader A,Yang WL,Godwin A,Prince JM,Nicastro JM,Coppa GF,Wang P

更新日期：2016-08-01 00:00:00

abstract：OBJECTIVE:To determine whether any advantage exists using racemic epinephrine instead of the more potent and less expensive levo(1)-epinephrine in the treatment of postextubation laryngeal edema. DESIGN:Prospective, double-blind, randomized study. SETTING:Pediatric intensive care unit in a university teaching hospita...

journal_title：Critical care medicine

authors： Nutman J,Brooks LJ,Deakins KM,Baldesare KK,Witte MK,Reed MD

更新日期：1994-10-01 00:00:00

abstract：OBJECTIVES:To synthesize the literature describing interventions to improve hand hygiene in ICUs, to evaluate the quality of the extant research, and to outline the type, and efficacy, of interventions described. DATA SOURCES:Systematic searches were conducted in November 2016 using five electronic databases: Medline,...

journal_title：Critical care medicine

authors： Lydon S,Power M,McSharry J,Byrne M,Madden C,Squires JE,O'Connor P

更新日期：2017-11-01 00:00:00

abstract：OBJECTIVES:In this study, we evaluated the inflammatory response in patients with severe acute respiratory infection due to the Middle East respiratory syndrome and non-Middle East respiratory syndrome and assessed the presence of distinct inflammatory subphenotypes using latent class analysis. DESIGN:Prospective coho...

journal_title：Critical care medicine

authors： Arabi YM,Jawdat D,Hajeer AH,Sadat M,Jose J,Vishwakarma RK,Almashaqbeh W,Al-Dawood A

更新日期：2021-02-01 00:00:00

abstract：OBJECTIVE:The clinical value of stroke volume variations to assess intravascular fluid status in critically ill patients is well known. Electrical impedance tomography is a noninvasive monitoring technology that has been primarily used to assess ventilation. We investigated the potential of electrical impedance tomogra...

journal_title：Critical care medicine

authors： Maisch S,Bohm SH,Solà J,Goepfert MS,Kubitz JC,Richter HP,Ridder J,Goetz AE,Reuter DA

更新日期：2011-09-01 00:00:00

abstract：:Conventional wisdom suggests that the "human factor" in critical care environments is reason for inadequate medication and patient safety. "Human factors" (or human factors engineering) is also a scientific discipline and practice of improving human performance. Using decades of human factors research, this paper eval...

journal_title：Critical care medicine

authors： Scanlon MC,Karsh BT

更新日期：2010-06-01 00:00:00

abstract：OBJECTIVES:To assess the relations between anemia, serum erythropoietin (EPO), iron status, and inflammatory mediators in multiply traumatized patients. DESIGN:Prospective observational study. SETTING:Intensive care unit. PATIENTS:Twenty-three patients suffering from severe trauma (injury severity score > or =30). ...

journal_title：Critical care medicine

authors： Hobisch-Hagen P,Wiedermann F,Mayr A,Fries D,Jelkmann W,Fuchs D,Hasibeder W,Mutz N,Klingler A,Schobersberger W

更新日期：2001-04-01 00:00:00

abstract：OBJECTIVE:Sepsis is a frequent cause of admission, but incidence rates based on administrative data have previously produced large differences in estimates. The aim of the study was to estimate the incidence of community-acquired sepsis based on patients' symptoms and clinical findings at arrival to the hospital. DESI...

journal_title：Critical care medicine

authors： Henriksen DP,Laursen CB,Jensen TG,Hallas J,Pedersen C,Lassen AT

更新日期：2015-01-01 00:00:00

abstract：:A polarographic conjunctival oxygen sensor was used to measure oxygen tension in a tissue bed supplied by the internal carotid artery. The shared vascular source of the conjunctiva and brain suggests that conjunctival PO2 monitoring may provide an index of cerebral perfusion. We studied the effects of hyperventilation...

journal_title：Critical care medicine

authors： Nisam M,Albertson TE,Panacek E,Rutherford W,Fisher CJ Jr

更新日期：1986-01-01 00:00:00

abstract：OBJECTIVE:Although hepatic cytochrome P-450 protein concentrations are altered following endotoxin shock, changes in P-450 isoforms in sepsis have not been fully investigated. The aim of this study was to determine whether the major P-450 isoform in rat liver (i.e., CYP1A2) is down-regulated during the progression of s...

journal_title：Critical care medicine

authors： Crawford JH,Yang S,Zhou M,Simms HH,Wang P

更新日期：2004-02-01 00:00:00

abstract：OBJECTIVE:To evaluate the prevalence and magnitude of weakness in patients receiving chronic mechanical ventilation and the impact of providing aggressive whole-body rehabilitation on conventional weaning variables, muscle strength, and overall functional status. DESIGN:Retrospective analysis of 49 consecutive patient...

journal_title：Critical care medicine

authors： Martin UJ,Hincapie L,Nimchuk M,Gaughan J,Criner GJ

更新日期：2005-10-01 00:00:00

abstract：:Many clinical conditions are associated with an increase in abdominal pressure. While the effects on venous return have been studied in the past, little attention has been given to the effect of abdominal pressure on left-sided hemodynamic events. The effects of acute changes in abdominal pressure (Pab) on left ventri...

journal_title：Critical care medicine

authors： Robotham JL,Wise RA,Bromberger-Barnea B

更新日期：1985-10-01 00:00:00

abstract：:Doppler ultrasound was used to study cerebral hemodynamics in the pericallosal artery of 21 newborn infants undergoing extracorporeal membrane oxygenation (ECMO) for intractable respiratory failure. Cerebral blood flow velocity waveforms were obtained pre-ECMO, after every major change in cardiopulmonary bypass flow d...

journal_title：Critical care medicine

authors： van de Bor M,Walther FJ,Gangitano ES,Snyder JR

更新日期：1990-01-01 00:00:00

abstract：OBJECTIVES:To measure pulmonary capillary pressure and pulmonary artery occlusion pressures both during control conditions and during acute lung injury and to evaluate the effects of inotropic therapy and volume loading on these measurements after lung injury. DESIGN:Prospective, randomized, controlled laboratory tria...

journal_title：Critical care medicine

authors： Pellett AA,Lord KC,Champagne MS,deBoisblanc BP,Johnson RW,Levitzky MG

更新日期：2002-02-01 00:00:00

abstract：OBJECTIVE:To determine whether chest wall vibration with tracheal gas insufflation during bronchoconstriction maintains gas exchange at lower airway and intrathoracic pressures than those that occur during positive pressure ventilation. DESIGN:Prospective study. SETTING:Experimental laboratory. SUBJECTS:Six anesthet...

journal_title：Critical care medicine

authors： Eckmann DM

更新日期：2000-07-01 00:00:00

abstract：OBJECTIVES:To explore the relationship between timing of continuous renal replacement therapy commencement and clinical outcomes in critically ill patients with acute kidney injury. The primary outcomes were all-cause mortality at 28 and 90 days. DESIGN:Nested observational cohort study using data from the Randomized ...

journal_title：Critical care medicine

authors： Jun M,Bellomo R,Cass A,Gallagher M,Lo S,Lee J,Randomized Evaluation of Normal Versus Augmented Level of Replacement Therapy (RENAL) Study Investigators.

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND:Resuscitation from hemorrhagic shock (HS) predisposes to subsequent infections. Susceptibility to infection following sepsis has been attributed to apoptosis. Interleukin (IL)-6 has been shown to have antiapoptotic properties and to decrease postresuscitation inflammation in rodent and porcine models of HS. ...

journal_title：Critical care medicine

authors： Arikan AA,Yu B,Mastrangelo MA,Tweardy DJ

更新日期：2006-03-01 00:00:00

abstract：OBJECTIVES:To describe long-term survival in patients with severe acute respiratory distress syndrome and assess differences in patient characteristics and outcomes among those who receive rescue therapies (prone position ventilation, inhaled nitric oxide, or inhaled epoprostenol) versus conventional treatment. DESIGN...

journal_title：Critical care medicine

authors： Khandelwal N,Hough CL,Bansal A,Veenstra DL,Treggiari MM

更新日期：2014-07-01 00:00:00

abstract：:In order to examine the prognostic value of pulmonary arterial hypertension (PAH) in patients with moderate and severe acute respiratory failure (ARF), 225 patients with ARF who had been treated with mechanical ventilation and admitted to our ICU during a 3-yr period (January, 1983 to January, 1986) were prospectively...

journal_title：Critical care medicine

authors： Villar J,Blazquez MA,Lubillo S,Quintana J,Manzano JL

更新日期：1989-06-01 00:00:00

abstract：OBJECTIVES:To determine the outcome of oxygen consumption (VO2) and energy expenditure after cessation of sedation in severe head-injured patients and to assess its usefulness as a predictor of neurologic severity. DESIGN:Prospective, descriptive study. SETTING:Neurosurgical intensive care unit (ICU) in a university ...

journal_title：Critical care medicine

authors： Bruder N,Lassegue D,Pelissier D,Graziani N,François G

更新日期：1994-07-01 00:00:00

abstract：OBJECTIVES:To study the relation between nitrite, nitrate, nitrotyrosine, and nitrosothiols as NO indices in human septic shock. DESIGN:A prospective clinical study. SETTING:Intensive care units in a university hospital and a central county hospital. PATIENTS:Sixteen patients admitted for septic shock. Nine healthy ...

journal_title：Critical care medicine

authors： Strand OA,Leone A,Giercksky KE,Kirkebøen KA

更新日期：2000-08-01 00:00:00

abstract：OBJECTIVE:To elucidate sources of variability in the estimate of treatment effects in a successful phase 3 trial in severe sepsis and to assess their implications on the design of future clinical trials. DESIGN:Retrospective evaluation of prospectively defined subgroups from a large phase 3, placebo-controlled clinica...

journal_title：Critical care medicine

authors： Macias WL,Vallet B,Bernard GR,Vincent JL,Laterre PF,Nelson DR,Derchak PA,Dhainaut JF

更新日期：2004-12-01 00:00:00

abstract：OBJECTIVE:Families and other surrogate decisionmakers for chronically critically ill patients often lack information about patient prognosis or options for care. This study describes an approach to develop and validate a printed information brochure about chronic critical illness aimed at improving comprehension of the...

journal_title：Critical care medicine

authors： Carson SS,Vu M,Danis M,Camhi SL,Scheunemann LP,Cox CE,Hanson LC,Nelson JE

更新日期：2012-01-01 00:00:00

abstract：OBJECTIVE:To explore the hypothesis that beta-1 adrenoreceptor blockade may be protective through the attenuation of sympathetic hyperactivity and catecholaminergic inflammatory effects on cardiac and hepatic function. DESIGN:Prospective, randomized, controlled study. SETTING:Animal laboratory in a university medical...

journal_title：Critical care medicine

authors： Ackland GL,Yao ST,Rudiger A,Dyson A,Stidwill R,Poputnikov D,Singer M,Gourine AV

更新日期：2010-02-01 00:00:00

abstract：OBJECTIVE:During pressure support ventilation, ventilator inspiration ends when inspiratory flow drops to a given percentage of the peak inspiratory flow cycling-off criteria. This study evaluated the effect of two different cycling-off criteria on breathing pattern, respiratory effort, and gas exchange in patients wit...

journal_title：Critical care medicine

authors： Chiumello D,Polli F,Tallarini F,Chierichetti M,Motta G,Azzari S,Colombo R,Rech R,Pelosi P,Raimondi F,Gattinoni L

更新日期：2007-11-01 00:00:00

abstract：BACKGROUND:One form of sepsis, or endotoxic shock, is a hyperactivated systemic response caused by excessive expression of proinflammatory mediators, which results from Gram-negative bacterial lipopolysaccharide-stimulated Toll-like receptor-4 signaling. This lipopolysaccharide signaling is known to consist of a MyD88-...

journal_title：Critical care medicine

authors： Benavides U,Gonzalez-Murguiondo M,Harii N,Lewis CJ,Schwartz AL,Giuliani C,Napolitano G,Dagia NM,Malgor R,McCall KD,Kohn LD

更新日期：2012-03-01 00:00:00

abstract：OBJECTIVES:Cardiac surgery-associated acute kidney injury occurs in up to 50% of patients and is associated with increased mortality and morbidity. This study aimed to discover if perioperative urinary alkalinization with sodium bicarbonate infusion reduces the prevalence of cardiac surgery-associated acute kidney inju...

journal_title：Critical care medicine

authors： McGuinness SP,Parke RL,Bellomo R,Van Haren FM,Bailey M

更新日期：2013-07-01 00:00:00

abstract：OBJECTIVE:The value of different algorithms that estimate cardiac output (CO) by analysis of a peripheral arterial blood pressure (ABP) waveform has not been definitively identified. In this investigation, we developed a testing data set containing a large number of radial ABP waveform segments and contemporaneous refe...

journal_title：Critical care medicine

authors： Sun JX,Reisner AT,Saeed M,Heldt T,Mark RG

更新日期：2009-01-01 00:00:00

abstract：OBJECTIVE:To develop a scheme for early identification of individuals at risk for symptomatic vasospasm after subarachnoid hemorrhage (SAH). DESIGN:Analysis of prospectively collected data from the placebo-treated group in a multicenter clinical trial. SETTINGS:Fifty-four neurosurgical centers in North America. MEAS...

journal_title：Critical care medicine

authors： Qureshi AI,Sung GY,Razumovsky AY,Lane K,Straw RN,Ulatowski JA

更新日期：2000-04-01 00:00:00